S-adenosyl-methyltransferase mraW-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosyl-methyltransferase mraW-like protein

Species:

Leishmania infantum

UniProt:

A4I0H6_LEIIN

TriTrypDb:

LINF_230020900

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0H6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	12
GO:0032259	methylation	2	12
GO:0000154	rRNA modification	6	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070475	rRNA base methylation	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0008170	N-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016434	rRNA (cytosine) methyltransferase activity	6	1
GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.505
CLV_NRD_NRD_1	135	137	PF00675	0.538
CLV_NRD_NRD_1	292	294	PF00675	0.252
CLV_NRD_NRD_1	323	325	PF00675	0.261
CLV_NRD_NRD_1	473	475	PF00675	0.496
CLV_NRD_NRD_1	76	78	PF00675	0.588
CLV_NRD_NRD_1	79	81	PF00675	0.619
CLV_NRD_NRD_1	88	90	PF00675	0.630
CLV_PCSK_FUR_1	290	294	PF00082	0.274
CLV_PCSK_FUR_1	77	81	PF00082	0.638
CLV_PCSK_KEX2_1	135	137	PF00082	0.513
CLV_PCSK_KEX2_1	2	4	PF00082	0.481
CLV_PCSK_KEX2_1	292	294	PF00082	0.253
CLV_PCSK_KEX2_1	323	325	PF00082	0.261
CLV_PCSK_KEX2_1	473	475	PF00082	0.511
CLV_PCSK_KEX2_1	48	50	PF00082	0.518
CLV_PCSK_KEX2_1	78	80	PF00082	0.624
CLV_PCSK_KEX2_1	8	10	PF00082	0.469
CLV_PCSK_KEX2_1	88	90	PF00082	0.699
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.513
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.481
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.541
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.581
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.469
CLV_PCSK_SKI1_1	204	208	PF00082	0.257
CLV_PCSK_SKI1_1	231	235	PF00082	0.257
CLV_PCSK_SKI1_1	24	28	PF00082	0.414
DEG_Nend_UBRbox_1	1	4	PF02207	0.495
DEG_SCF_FBW7_1	276	282	PF00400	0.474
DOC_CKS1_1	276	281	PF01111	0.474
DOC_CYCLIN_yClb5_NLxxxL_5	37	46	PF00134	0.437
DOC_MAPK_FxFP_2	452	455	PF00069	0.559
DOC_MAPK_gen_1	88	96	PF00069	0.526
DOC_PP1_RVXF_1	361	368	PF00149	0.461
DOC_PP4_FxxP_1	452	455	PF00568	0.559
DOC_USP7_MATH_1	112	116	PF00917	0.628
DOC_USP7_MATH_1	121	125	PF00917	0.546
DOC_USP7_MATH_1	177	181	PF00917	0.536
DOC_USP7_MATH_1	219	223	PF00917	0.476
DOC_USP7_MATH_1	270	274	PF00917	0.519
DOC_USP7_MATH_1	279	283	PF00917	0.385
DOC_USP7_MATH_1	480	484	PF00917	0.694
DOC_USP7_MATH_1	87	91	PF00917	0.708
DOC_WW_Pin1_4	275	280	PF00397	0.463
DOC_WW_Pin1_4	475	480	PF00397	0.583
LIG_14-3-3_CanoR_1	138	143	PF00244	0.413
LIG_14-3-3_CanoR_1	198	207	PF00244	0.491
LIG_14-3-3_CanoR_1	323	329	PF00244	0.508
LIG_14-3-3_CanoR_1	416	424	PF00244	0.384
LIG_14-3-3_CanoR_1	9	16	PF00244	0.453
LIG_BRCT_BRCA1_1	123	127	PF00533	0.529
LIG_BRCT_BRCA1_1	328	332	PF00533	0.461
LIG_BRCT_BRCA1_1	443	447	PF00533	0.482
LIG_BRCT_BRCA1_1	477	481	PF00533	0.600
LIG_CaM_NSCaTE_8	372	379	PF13499	0.536
LIG_DLG_GKlike_1	138	145	PF00625	0.400
LIG_FHA_1	104	110	PF00498	0.613
LIG_FHA_1	153	159	PF00498	0.483
LIG_FHA_1	164	170	PF00498	0.419
LIG_FHA_1	248	254	PF00498	0.552
LIG_FHA_2	222	228	PF00498	0.459
LIG_Integrin_isoDGR_2	161	163	PF01839	0.355
LIG_LIR_Apic_2	451	455	PF02991	0.469
LIG_LIR_Gen_1	124	134	PF02991	0.641
LIG_LIR_Gen_1	141	149	PF02991	0.261
LIG_LIR_Gen_1	209	219	PF02991	0.450
LIG_LIR_Gen_1	273	279	PF02991	0.536
LIG_LIR_Gen_1	327	336	PF02991	0.563
LIG_LIR_LC3C_4	361	366	PF02991	0.461
LIG_LIR_Nem_3	124	130	PF02991	0.634
LIG_LIR_Nem_3	141	145	PF02991	0.297
LIG_LIR_Nem_3	191	196	PF02991	0.457
LIG_LIR_Nem_3	209	215	PF02991	0.434
LIG_LIR_Nem_3	273	277	PF02991	0.503
LIG_LIR_Nem_3	468	472	PF02991	0.494
LIG_MYND_1	19	23	PF01753	0.539
LIG_Pex14_2	149	153	PF04695	0.536
LIG_SH2_CRK	165	169	PF00017	0.461
LIG_SH2_CRK	196	200	PF00017	0.532
LIG_SH2_GRB2like	258	261	PF00017	0.450
LIG_SH2_STAP1	165	169	PF00017	0.461
LIG_SH2_STAP1	391	395	PF00017	0.474
LIG_SH2_STAT5	165	168	PF00017	0.461
LIG_SH2_STAT5	258	261	PF00017	0.450
LIG_SH2_STAT5	422	425	PF00017	0.477
LIG_SH3_3	13	19	PF00018	0.452
LIG_SUMO_SIM_par_1	118	125	PF11976	0.463
LIG_SUMO_SIM_par_1	354	361	PF11976	0.458
LIG_TRAF2_1	304	307	PF00917	0.546
LIG_TRAF2_1	371	374	PF00917	0.475
LIG_TRAF2_1	434	437	PF00917	0.564
LIG_TRAF2_1	50	53	PF00917	0.460
LIG_TYR_ITIM	140	145	PF00017	0.341
MOD_CK1_1	406	412	PF00069	0.517
MOD_CK2_1	177	183	PF00069	0.498
MOD_CK2_1	221	227	PF00069	0.450
MOD_CK2_1	387	393	PF00069	0.476
MOD_GlcNHglycan	10	13	PF01048	0.597
MOD_GlcNHglycan	109	112	PF01048	0.697
MOD_GlcNHglycan	115	118	PF01048	0.685
MOD_GlcNHglycan	124	127	PF01048	0.373
MOD_GlcNHglycan	150	153	PF01048	0.298
MOD_GlcNHglycan	179	182	PF01048	0.343
MOD_GlcNHglycan	267	270	PF01048	0.277
MOD_GlcNHglycan	443	446	PF01048	0.409
MOD_GlcNHglycan	89	92	PF01048	0.715
MOD_GSK3_1	103	110	PF00069	0.657
MOD_GSK3_1	148	155	PF00069	0.555
MOD_GSK3_1	275	282	PF00069	0.498
MOD_GSK3_1	319	326	PF00069	0.494
MOD_GSK3_1	375	382	PF00069	0.517
MOD_GSK3_1	412	419	PF00069	0.393
MOD_GSK3_1	424	431	PF00069	0.392
MOD_N-GLC_1	122	127	PF02516	0.570
MOD_N-GLC_1	457	462	PF02516	0.423
MOD_NEK2_1	113	118	PF00069	0.594
MOD_NEK2_1	122	127	PF00069	0.499
MOD_NEK2_1	145	150	PF00069	0.475
MOD_NEK2_1	332	337	PF00069	0.450
MOD_NEK2_1	376	381	PF00069	0.498
MOD_NEK2_1	424	429	PF00069	0.442
MOD_NEK2_2	279	284	PF00069	0.474
MOD_PIKK_1	221	227	PF00454	0.449
MOD_PIKK_1	316	322	PF00454	0.474
MOD_PIKK_1	379	385	PF00454	0.555
MOD_PIKK_1	414	420	PF00454	0.501
MOD_PIKK_1	424	430	PF00454	0.456
MOD_PKA_1	323	329	PF00069	0.537
MOD_PKA_1	8	14	PF00069	0.502
MOD_PKA_2	104	110	PF00069	0.667
MOD_PKA_2	323	329	PF00069	0.555
MOD_PKA_2	406	412	PF00069	0.421
MOD_PKA_2	8	14	PF00069	0.469
MOD_PKA_2	87	93	PF00069	0.690
MOD_PKB_1	136	144	PF00069	0.431
MOD_Plk_1	122	128	PF00069	0.571
MOD_Plk_1	145	151	PF00069	0.450
MOD_Plk_1	175	181	PF00069	0.499
MOD_Plk_1	208	214	PF00069	0.474
MOD_Plk_1	436	442	PF00069	0.454
MOD_Plk_1	457	463	PF00069	0.424
MOD_Plk_4	418	424	PF00069	0.484
MOD_ProDKin_1	275	281	PF00069	0.463
MOD_ProDKin_1	475	481	PF00069	0.590
MOD_SUMO_rev_2	201	206	PF00179	0.474
MOD_SUMO_rev_2	368	377	PF00179	0.532
TRG_DiLeu_BaEn_1	230	235	PF01217	0.461
TRG_ENDOCYTIC_2	142	145	PF00928	0.329
TRG_ENDOCYTIC_2	165	168	PF00928	0.461
TRG_ENDOCYTIC_2	274	277	PF00928	0.450
TRG_ER_diArg_1	136	139	PF00400	0.502
TRG_ER_diArg_1	289	292	PF00400	0.463
TRG_ER_diArg_1	472	474	PF00400	0.534
TRG_ER_diArg_1	77	80	PF00400	0.588
TRG_NES_CRM1_1	346	361	PF08389	0.460
TRG_NLS_Bipartite_1	59	81	PF00514	0.583
TRG_NLS_MonoCore_2	134	139	PF00514	0.513
TRG_NLS_MonoCore_2	76	81	PF00514	0.523
TRG_NLS_MonoExtN_4	132	139	PF00514	0.523
TRG_NLS_MonoExtN_4	74	81	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB41	Leptomonas seymouri	72%	98%
A0A0S4J2S9	Bodo saltans	42%	100%
A0A1X0NY59	Trypanosomatidae	59%	100%
A0A3Q8IM97	Leishmania donovani	99%	100%
A0A3R7KU88	Trypanosoma rangeli	61%	100%
A4HCZ1	Leishmania braziliensis	86%	100%
B9JY62	Agrobacterium vitis (strain S4 / ATCC BAA-846)	26%	100%
C9ZVA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AWD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QB34	Leishmania major	96%	100%
V5BEN6	Trypanosoma cruzi	62%	100%