LeishMANIAdb
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Membrane-bound acid phosphatase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound acid phosphatase 2
Gene product:
membrane-bound acid phosphatase 2
Species:
Leishmania infantum
UniProt:
A4I0H5_LEIIN
TriTrypDb:
LINF_230020800
Length:
532

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Annotations by Jardim et al.

Phosphatase, Membrane-bound acid phosphatase 2 MBAP2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 34, no: 4
NetGPI no yes: 0, no: 38
Cellular components
Term Name Level Count
GO:0016020 membrane 2 27
GO:0110165 cellular anatomical entity 1 27

Expansion

Sequence features

A4I0H5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0H5

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0003993 acid phosphatase activity 6 2
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016791 phosphatase activity 5 7
GO:0042578 phosphoric ester hydrolase activity 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 325 329 PF00656 0.382
CLV_C14_Caspase3-7 415 419 PF00656 0.451
CLV_NRD_NRD_1 200 202 PF00675 0.534
CLV_NRD_NRD_1 430 432 PF00675 0.516
CLV_NRD_NRD_1 522 524 PF00675 0.439
CLV_PCSK_KEX2_1 200 202 PF00082 0.502
CLV_PCSK_KEX2_1 432 434 PF00082 0.583
CLV_PCSK_PC1ET2_1 432 434 PF00082 0.425
CLV_PCSK_SKI1_1 121 125 PF00082 0.493
CLV_PCSK_SKI1_1 2 6 PF00082 0.608
DEG_APCC_DBOX_1 1 9 PF00400 0.507
DEG_APCC_DBOX_1 230 238 PF00400 0.288
DEG_Nend_UBRbox_1 1 4 PF02207 0.589
DEG_SPOP_SBC_1 461 465 PF00917 0.457
DOC_ANK_TNKS_1 406 413 PF00023 0.271
DOC_CDC14_PxL_1 221 229 PF14671 0.378
DOC_CYCLIN_yCln2_LP_2 15 21 PF00134 0.635
DOC_CYCLIN_yCln2_LP_2 310 313 PF00134 0.201
DOC_MAPK_gen_1 521 529 PF00069 0.669
DOC_MAPK_MEF2A_6 2 9 PF00069 0.543
DOC_MAPK_NFAT4_5 2 10 PF00069 0.322
DOC_PP1_RVXF_1 380 387 PF00149 0.401
DOC_PP2B_LxvP_1 15 18 PF13499 0.604
DOC_PP2B_LxvP_1 310 313 PF13499 0.201
DOC_USP7_MATH_1 278 282 PF00917 0.349
DOC_USP7_MATH_1 390 394 PF00917 0.425
DOC_USP7_MATH_1 422 426 PF00917 0.304
DOC_USP7_MATH_1 43 47 PF00917 0.341
DOC_USP7_MATH_1 461 465 PF00917 0.454
DOC_USP7_MATH_1 484 488 PF00917 0.553
DOC_WW_Pin1_4 340 345 PF00397 0.314
DOC_WW_Pin1_4 359 364 PF00397 0.322
DOC_WW_Pin1_4 471 476 PF00397 0.569
DOC_WW_Pin1_4 522 527 PF00397 0.718
DOC_WW_Pin1_4 53 58 PF00397 0.407
LIG_14-3-3_CanoR_1 105 113 PF00244 0.284
LIG_14-3-3_CanoR_1 200 208 PF00244 0.313
LIG_14-3-3_CanoR_1 297 303 PF00244 0.201
LIG_14-3-3_CanoR_1 374 378 PF00244 0.329
LIG_14-3-3_CanoR_1 79 87 PF00244 0.353
LIG_deltaCOP1_diTrp_1 349 356 PF00928 0.296
LIG_EH1_1 501 509 PF00400 0.363
LIG_FHA_1 105 111 PF00498 0.309
LIG_FHA_1 145 151 PF00498 0.284
LIG_FHA_1 20 26 PF00498 0.382
LIG_FHA_1 315 321 PF00498 0.316
LIG_FHA_1 379 385 PF00498 0.360
LIG_FHA_1 492 498 PF00498 0.270
LIG_FHA_1 499 505 PF00498 0.344
LIG_FHA_1 511 517 PF00498 0.454
LIG_FHA_2 134 140 PF00498 0.325
LIG_FHA_2 205 211 PF00498 0.273
LIG_FHA_2 227 233 PF00498 0.352
LIG_FHA_2 303 309 PF00498 0.305
LIG_GBD_Chelix_1 318 326 PF00786 0.401
LIG_LIR_Gen_1 178 186 PF02991 0.335
LIG_LIR_Gen_1 203 213 PF02991 0.276
LIG_LIR_Gen_1 379 388 PF02991 0.289
LIG_LIR_Gen_1 393 403 PF02991 0.410
LIG_LIR_Gen_1 418 424 PF02991 0.458
LIG_LIR_Nem_3 128 134 PF02991 0.278
LIG_LIR_Nem_3 141 146 PF02991 0.287
LIG_LIR_Nem_3 173 179 PF02991 0.321
LIG_LIR_Nem_3 203 209 PF02991 0.233
LIG_LIR_Nem_3 222 227 PF02991 0.278
LIG_LIR_Nem_3 280 286 PF02991 0.292
LIG_LIR_Nem_3 379 383 PF02991 0.299
LIG_LIR_Nem_3 393 399 PF02991 0.314
LIG_LIR_Nem_3 400 406 PF02991 0.272
LIG_LIR_Nem_3 418 423 PF02991 0.331
LIG_LIR_Nem_3 62 66 PF02991 0.253
LIG_LYPXL_S_1 130 134 PF13949 0.496
LIG_LYPXL_yS_3 131 134 PF13949 0.278
LIG_LYPXL_yS_3 224 227 PF13949 0.387
LIG_NRBOX 4 10 PF00104 0.380
LIG_PCNA_yPIPBox_3 263 271 PF02747 0.259
LIG_PDZ_Class_1 527 532 PF00595 0.554
LIG_Pex14_2 119 123 PF04695 0.367
LIG_Pex14_2 153 157 PF04695 0.330
LIG_Pex14_2 348 352 PF04695 0.402
LIG_SH2_CRK 403 407 PF00017 0.324
LIG_SH2_GRB2like 146 149 PF00017 0.356
LIG_SH2_STAP1 146 150 PF00017 0.318
LIG_SH2_STAP1 437 441 PF00017 0.423
LIG_SH2_STAP1 97 101 PF00017 0.309
LIG_SH2_STAT3 149 152 PF00017 0.374
LIG_SH2_STAT5 143 146 PF00017 0.321
LIG_SH2_STAT5 149 152 PF00017 0.300
LIG_SH2_STAT5 194 197 PF00017 0.296
LIG_SH2_STAT5 246 249 PF00017 0.321
LIG_SH2_STAT5 396 399 PF00017 0.296
LIG_SH2_STAT5 60 63 PF00017 0.295
LIG_SH3_3 14 20 PF00018 0.361
LIG_SH3_3 164 170 PF00018 0.288
LIG_SH3_3 465 471 PF00018 0.550
LIG_SH3_3 84 90 PF00018 0.318
LIG_SH3_5 93 97 PF00018 0.238
LIG_SUMO_SIM_par_1 316 321 PF11976 0.326
LIG_UBA3_1 208 215 PF00899 0.372
LIG_WRC_WIRS_1 499 504 PF05994 0.363
MOD_CK1_1 104 110 PF00069 0.343
MOD_CK1_1 115 121 PF00069 0.349
MOD_CK1_1 196 202 PF00069 0.320
MOD_CK1_1 327 333 PF00069 0.279
MOD_CK1_1 343 349 PF00069 0.385
MOD_CK1_1 487 493 PF00069 0.512
MOD_CK1_1 85 91 PF00069 0.352
MOD_CK2_1 133 139 PF00069 0.385
MOD_CK2_1 343 349 PF00069 0.398
MOD_CK2_1 61 67 PF00069 0.187
MOD_GlcNHglycan 114 117 PF01048 0.478
MOD_GlcNHglycan 260 263 PF01048 0.547
MOD_GlcNHglycan 288 291 PF01048 0.507
MOD_GlcNHglycan 345 348 PF01048 0.609
MOD_GlcNHglycan 363 366 PF01048 0.496
MOD_GlcNHglycan 370 373 PF01048 0.557
MOD_GlcNHglycan 424 427 PF01048 0.561
MOD_GlcNHglycan 486 489 PF01048 0.728
MOD_GlcNHglycan 63 66 PF01048 0.549
MOD_GSK3_1 286 293 PF00069 0.284
MOD_GSK3_1 298 305 PF00069 0.265
MOD_GSK3_1 322 329 PF00069 0.311
MOD_GSK3_1 39 46 PF00069 0.365
MOD_GSK3_1 455 462 PF00069 0.384
MOD_GSK3_1 487 494 PF00069 0.516
MOD_GSK3_1 75 82 PF00069 0.354
MOD_N-GLC_1 125 130 PF02516 0.501
MOD_N-GLC_1 248 253 PF02516 0.491
MOD_N-GLC_1 368 373 PF02516 0.520
MOD_N-GLC_1 47 52 PF02516 0.563
MOD_N-GLC_1 479 484 PF02516 0.621
MOD_N-GLC_2 373 375 PF02516 0.525
MOD_NEK2_1 277 282 PF00069 0.320
MOD_NEK2_1 314 319 PF00069 0.308
MOD_NEK2_1 322 327 PF00069 0.316
MOD_NEK2_1 444 449 PF00069 0.361
MOD_NEK2_1 61 66 PF00069 0.307
MOD_NEK2_1 69 74 PF00069 0.305
MOD_NEK2_1 75 80 PF00069 0.327
MOD_NEK2_2 204 209 PF00069 0.331
MOD_OFUCOSY 434 439 PF10250 0.529
MOD_OFUCOSY 452 459 PF10250 0.636
MOD_PIKK_1 232 238 PF00454 0.286
MOD_PIKK_1 47 53 PF00454 0.341
MOD_PKA_2 104 110 PF00069 0.285
MOD_PKA_2 199 205 PF00069 0.328
MOD_PKA_2 232 238 PF00069 0.299
MOD_PKA_2 373 379 PF00069 0.357
MOD_PKB_1 431 439 PF00069 0.232
MOD_PKB_1 77 85 PF00069 0.378
MOD_Plk_1 125 131 PF00069 0.343
MOD_Plk_1 291 297 PF00069 0.287
MOD_Plk_1 327 333 PF00069 0.201
MOD_Plk_1 378 384 PF00069 0.333
MOD_Plk_1 47 53 PF00069 0.350
MOD_Plk_1 479 485 PF00069 0.403
MOD_Plk_1 82 88 PF00069 0.308
MOD_Plk_4 115 121 PF00069 0.381
MOD_Plk_4 126 132 PF00069 0.355
MOD_Plk_4 314 320 PF00069 0.299
MOD_Plk_4 82 88 PF00069 0.322
MOD_ProDKin_1 340 346 PF00069 0.316
MOD_ProDKin_1 359 365 PF00069 0.325
MOD_ProDKin_1 471 477 PF00069 0.569
MOD_ProDKin_1 522 528 PF00069 0.718
MOD_ProDKin_1 53 59 PF00069 0.401
TRG_ENDOCYTIC_2 131 134 PF00928 0.307
TRG_ENDOCYTIC_2 156 159 PF00928 0.261
TRG_ENDOCYTIC_2 224 227 PF00928 0.363
TRG_ENDOCYTIC_2 396 399 PF00928 0.323
TRG_ENDOCYTIC_2 403 406 PF00928 0.313
TRG_ER_diArg_1 430 433 PF00400 0.338
TRG_ER_diArg_1 76 79 PF00400 0.337
TRG_NES_CRM1_1 308 321 PF08389 0.287
TRG_NLS_MonoExtC_3 430 435 PF00514 0.222

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 45% 93%
A0A0N1I756 Leptomonas seymouri 38% 100%
A0A0N1PEH4 Leptomonas seymouri 37% 100%
A0A0S4IRF5 Bodo saltans 23% 80%
A0A0S4IUV8 Bodo saltans 22% 100%
A0A0S4IV77 Bodo saltans 35% 100%
A0A0S4IXN9 Bodo saltans 24% 100%
A0A0S4JEA9 Bodo saltans 27% 100%
A0A0S4JJK3 Bodo saltans 27% 100%
A0A0S4JW09 Bodo saltans 27% 100%
A0A1X0NNY4 Trypanosomatidae 36% 96%
A0A1X0NQL4 Trypanosomatidae 28% 97%
A0A1X0NY34 Trypanosomatidae 25% 100%
A0A1X0P7V5 Trypanosomatidae 46% 100%
A0A3Q8IR23 Leishmania donovani 50% 93%
A0A3R7KSH4 Trypanosoma rangeli 25% 100%
A0A3R7MEN7 Trypanosoma rangeli 43% 100%
A0A3R7MHJ7 Trypanosoma rangeli 28% 100%
A0A3S5H827 Leishmania donovani 39% 100%
A0A3S7WXU0 Leishmania donovani 99% 100%
A0A3S7X1W4 Leishmania donovani 44% 97%
A4HCZ0 Leishmania braziliensis 85% 100%
A4HGW8 Leishmania braziliensis 43% 100%
A4HPC1 Leishmania braziliensis 39% 100%
A4HPC5 Leishmania braziliensis 50% 100%
A4HQG6 Leishmania braziliensis 35% 100%
A4HQG9 Leishmania braziliensis 35% 100%
A4I3Z8 Leishmania infantum 44% 97%
A4ICA5 Leishmania infantum 36% 80%
A4ICG3 Leishmania infantum 39% 100%
A4ICG5 Leishmania infantum 51% 93%
B1H1P9 Xenopus laevis 27% 100%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
P11117 Homo sapiens 27% 100%
P24638 Mus musculus 26% 100%
Q0P5F0 Bos taurus 26% 100%
Q4Q0A9 Leishmania major 30% 99%
Q4Q1G2 Leishmania major 51% 100%
Q4Q1G4 Leishmania major 38% 100%
Q4Q7Z7 Leishmania major 44% 100%
Q4QB35 Leishmania major 95% 100%
Q4R5N9 Macaca fascicularis 27% 100%
Q5NVF6 Pongo abelii 27% 100%
V5BCI2 Trypanosoma cruzi 26% 100%
V5BK91 Trypanosoma cruzi 42% 100%
V5BL75 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS