LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Coronin

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Coronin
Gene product:
coronin - putative
Species:
Leishmania infantum
UniProt:
A4I0H2_LEIIN
TriTrypDb:
LINF_230020500
Length:
510

Annotations

Annotations by Jardim et al.

Structural Proteins, Coronin CRN12

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 11
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 11
GO:0005815 microtubule organizing center 2 1
GO:0020016 ciliary pocket 2 1
GO:0036064 ciliary basal body 3 1
GO:0000139 Golgi membrane 5 1
GO:0005829 cytosol 2 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0098588 bounding membrane of organelle 4 1

Phosphorylation

Promastigote: 399

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I0H2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0H2

PDB structure(s): 6icr_A , 6icr_B , 6icr_C , 6icr_D

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007015 actin filament organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0003779 actin binding 4 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0019894 kinesin binding 4 1
GO:0044877 protein-containing complex binding 2 1
GO:0051015 actin filament binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 221 223 PF00675 0.340
CLV_NRD_NRD_1 244 246 PF00675 0.416
CLV_NRD_NRD_1 319 321 PF00675 0.433
CLV_NRD_NRD_1 343 345 PF00675 0.287
CLV_NRD_NRD_1 470 472 PF00675 0.573
CLV_NRD_NRD_1 489 491 PF00675 0.437
CLV_PCSK_KEX2_1 221 223 PF00082 0.346
CLV_PCSK_KEX2_1 470 472 PF00082 0.595
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.389
CLV_PCSK_SKI1_1 18 22 PF00082 0.349
CLV_PCSK_SKI1_1 237 241 PF00082 0.417
CLV_PCSK_SKI1_1 414 418 PF00082 0.742
CLV_PCSK_SKI1_1 463 467 PF00082 0.492
CLV_PCSK_SKI1_1 490 494 PF00082 0.545
CLV_PCSK_SKI1_1 90 94 PF00082 0.352
DEG_APCC_DBOX_1 178 186 PF00400 0.384
DEG_SPOP_SBC_1 23 27 PF00917 0.397
DOC_CYCLIN_RxL_1 12 25 PF00134 0.391
DOC_MAPK_gen_1 126 133 PF00069 0.431
DOC_MAPK_gen_1 15 23 PF00069 0.391
DOC_MAPK_gen_1 221 229 PF00069 0.345
DOC_MAPK_gen_1 428 435 PF00069 0.679
DOC_MAPK_MEF2A_6 63 72 PF00069 0.422
DOC_MAPK_MEF2A_6 75 83 PF00069 0.381
DOC_USP7_MATH_1 361 365 PF00917 0.426
DOC_USP7_MATH_1 436 440 PF00917 0.650
DOC_USP7_UBL2_3 122 126 PF12436 0.512
DOC_USP7_UBL2_3 417 421 PF12436 0.624
DOC_WW_Pin1_4 113 118 PF00397 0.522
DOC_WW_Pin1_4 389 394 PF00397 0.537
DOC_WW_Pin1_4 397 402 PF00397 0.613
LIG_14-3-3_CanoR_1 249 254 PF00244 0.367
LIG_14-3-3_CanoR_1 344 351 PF00244 0.358
LIG_14-3-3_CanoR_1 5 13 PF00244 0.331
LIG_Actin_WH2_2 178 195 PF00022 0.389
LIG_AP2alpha_2 84 86 PF02296 0.448
LIG_APCC_ABBA_1 264 269 PF00400 0.351
LIG_BIR_II_1 1 5 PF00653 0.329
LIG_BRCT_BRCA1_1 259 263 PF00533 0.423
LIG_BRCT_BRCA1_1 384 388 PF00533 0.526
LIG_Clathr_ClatBox_1 335 339 PF01394 0.427
LIG_deltaCOP1_diTrp_1 175 183 PF00928 0.432
LIG_EH1_1 335 343 PF00400 0.383
LIG_eIF4E_1 382 388 PF01652 0.462
LIG_FHA_1 189 195 PF00498 0.446
LIG_FHA_1 8 14 PF00498 0.310
LIG_FHA_2 170 176 PF00498 0.380
LIG_FHA_2 252 258 PF00498 0.514
LIG_FHA_2 357 363 PF00498 0.319
LIG_FHA_2 459 465 PF00498 0.598
LIG_FHA_2 91 97 PF00498 0.325
LIG_LIR_Gen_1 323 332 PF02991 0.434
LIG_LIR_Gen_1 40 50 PF02991 0.287
LIG_LIR_Nem_3 260 266 PF02991 0.453
LIG_LIR_Nem_3 323 327 PF02991 0.433
LIG_LIR_Nem_3 331 335 PF02991 0.417
LIG_LIR_Nem_3 40 45 PF02991 0.287
LIG_LIR_Nem_3 59 64 PF02991 0.328
LIG_LIR_Nem_3 80 86 PF02991 0.329
LIG_Pex14_2 356 360 PF04695 0.358
LIG_Rb_pABgroove_1 382 390 PF01858 0.437
LIG_SH2_CRK 332 336 PF00017 0.445
LIG_SH2_STAP1 267 271 PF00017 0.382
LIG_SH3_1 63 69 PF00018 0.469
LIG_SH3_3 10 16 PF00018 0.397
LIG_SH3_3 191 197 PF00018 0.388
LIG_SH3_3 430 436 PF00018 0.718
LIG_SH3_3 63 69 PF00018 0.471
LIG_SUMO_SIM_par_1 272 278 PF11976 0.374
LIG_TRAF2_1 492 495 PF00917 0.559
LIG_TYR_ITIM 330 335 PF00017 0.438
LIG_UBA3_1 182 190 PF00899 0.251
LIG_UBA3_1 226 233 PF00899 0.441
LIG_UBA3_1 273 279 PF00899 0.421
LIG_WRC_WIRS_1 130 135 PF05994 0.446
MOD_CDC14_SPxK_1 402 405 PF00782 0.648
MOD_CDK_SPK_2 389 394 PF00069 0.518
MOD_CDK_SPxK_1 399 405 PF00069 0.649
MOD_CK1_1 112 118 PF00069 0.427
MOD_CK1_1 165 171 PF00069 0.509
MOD_CK1_1 205 211 PF00069 0.414
MOD_CK1_1 334 340 PF00069 0.409
MOD_CK1_1 364 370 PF00069 0.430
MOD_CK1_1 373 379 PF00069 0.281
MOD_CK1_1 399 405 PF00069 0.713
MOD_CK1_1 431 437 PF00069 0.702
MOD_CK1_1 439 445 PF00069 0.688
MOD_CK2_1 169 175 PF00069 0.434
MOD_CK2_1 201 207 PF00069 0.496
MOD_CK2_1 249 255 PF00069 0.446
MOD_CK2_1 275 281 PF00069 0.364
MOD_CK2_1 344 350 PF00069 0.359
MOD_CK2_1 364 370 PF00069 0.358
MOD_CK2_1 458 464 PF00069 0.574
MOD_CK2_1 90 96 PF00069 0.323
MOD_GlcNHglycan 135 138 PF01048 0.236
MOD_GlcNHglycan 142 145 PF01048 0.225
MOD_GlcNHglycan 210 213 PF01048 0.382
MOD_GlcNHglycan 259 262 PF01048 0.493
MOD_GlcNHglycan 362 366 PF01048 0.420
MOD_GlcNHglycan 372 375 PF01048 0.187
MOD_GlcNHglycan 383 387 PF01048 0.481
MOD_GlcNHglycan 442 445 PF01048 0.657
MOD_GlcNHglycan 485 489 PF01048 0.576
MOD_GSK3_1 109 116 PF00069 0.259
MOD_GSK3_1 129 136 PF00069 0.299
MOD_GSK3_1 156 163 PF00069 0.448
MOD_GSK3_1 165 172 PF00069 0.382
MOD_GSK3_1 184 191 PF00069 0.161
MOD_GSK3_1 198 205 PF00069 0.416
MOD_GSK3_1 225 232 PF00069 0.402
MOD_GSK3_1 30 37 PF00069 0.397
MOD_GSK3_1 431 438 PF00069 0.647
MOD_GSK3_1 46 53 PF00069 0.397
MOD_GSK3_1 92 99 PF00069 0.349
MOD_N-GLC_1 112 117 PF02516 0.389
MOD_N-GLC_1 165 170 PF02516 0.444
MOD_N-GLC_1 21 26 PF02516 0.328
MOD_NEK2_1 1 6 PF00069 0.286
MOD_NEK2_1 178 183 PF00069 0.313
MOD_NEK2_1 21 26 PF00069 0.099
MOD_NEK2_1 229 234 PF00069 0.365
MOD_NEK2_1 241 246 PF00069 0.385
MOD_NEK2_1 256 261 PF00069 0.420
MOD_NEK2_1 396 401 PF00069 0.644
MOD_NEK2_1 50 55 PF00069 0.328
MOD_NEK2_2 129 134 PF00069 0.446
MOD_PIKK_1 211 217 PF00454 0.446
MOD_PIKK_1 231 237 PF00454 0.174
MOD_PIKK_1 458 464 PF00454 0.561
MOD_PK_1 249 255 PF00069 0.388
MOD_PKA_1 222 228 PF00069 0.472
MOD_PKA_1 344 350 PF00069 0.397
MOD_PKA_2 156 162 PF00069 0.440
MOD_PKA_2 178 184 PF00069 0.411
MOD_PKA_2 6 12 PF00069 0.285
MOD_PKB_1 5 13 PF00069 0.397
MOD_Plk_1 188 194 PF00069 0.437
MOD_Plk_1 198 204 PF00069 0.402
MOD_Plk_1 322 328 PF00069 0.381
MOD_Plk_1 361 367 PF00069 0.429
MOD_Plk_1 428 434 PF00069 0.753
MOD_Plk_1 484 490 PF00069 0.503
MOD_Plk_4 178 184 PF00069 0.322
MOD_Plk_4 198 204 PF00069 0.198
MOD_Plk_4 222 228 PF00069 0.477
MOD_Plk_4 331 337 PF00069 0.326
MOD_Plk_4 96 102 PF00069 0.339
MOD_ProDKin_1 113 119 PF00069 0.518
MOD_ProDKin_1 389 395 PF00069 0.534
MOD_ProDKin_1 397 403 PF00069 0.613
MOD_SUMO_for_1 420 423 PF00179 0.743
TRG_DiLeu_BaEn_1 269 274 PF01217 0.421
TRG_ENDOCYTIC_2 332 335 PF00928 0.453
TRG_ER_diArg_1 470 472 PF00400 0.597
TRG_Pf-PMV_PEXEL_1 414 418 PF00026 0.652
TRG_Pf-PMV_PEXEL_1 463 467 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 470 474 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGC0 Leptomonas seymouri 62% 99%
A0A0S4IT51 Bodo saltans 50% 100%
A0A1X0NWV5 Trypanosomatidae 41% 96%
A0A3Q8IEM1 Leishmania donovani 100% 100%
A0A3R7K7Y6 Trypanosoma rangeli 48% 100%
A4HCY7 Leishmania braziliensis 79% 100%
A8WGE3 Xenopus tropicalis 33% 100%
B0R0D7 Danio rerio 35% 100%
C9ZV95 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 98%
E9AWD4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O13923 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 85%
O89046 Rattus norvegicus 36% 100%
O89053 Mus musculus 37% 100%
P27133 Dictyostelium discoideum 35% 100%
P31146 Homo sapiens 36% 100%
Q06440 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 78%
Q21624 Caenorhabditis elegans 32% 84%
Q32LP9 Bos taurus 33% 97%
Q4QB38 Leishmania major 94% 100%
Q4R4J2 Macaca fascicularis 37% 100%
Q5NVK4 Pongo abelii 37% 100%
Q6DJD8 Xenopus laevis 34% 100%
Q6QEF8 Homo sapiens 36% 100%
Q8BH44 Mus musculus 33% 100%
Q8C0P5 Mus musculus 31% 97%
Q91ZN1 Rattus norvegicus 37% 100%
Q920J3 Rattus norvegicus 36% 100%
Q920M5 Mus musculus 35% 100%
Q92176 Bos taurus 37% 100%
Q92828 Homo sapiens 34% 97%
Q9BR76 Homo sapiens 37% 100%
Q9ULV4 Homo sapiens 36% 100%
Q9UQ03 Homo sapiens 34% 100%
Q9WUM3 Mus musculus 36% 100%
Q9WUM4 Mus musculus 35% 100%
Q9XS70 Oryctolagus cuniculus 36% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS