Coronin

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Coronin

Gene product:

coronin - putative

Species:

Leishmania infantum

UniProt:

A4I0H2_LEIIN

TriTrypDb:

LINF_230020500

Length:

510

Annotations

Annotations by Jardim et al.

Structural Proteins, Coronin CRN12

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0005815	microtubule organizing center	2	1
GO:0005829	cytosol	2	1
GO:0005840	ribosome	5	11
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0031090	organelle membrane	3	1
GO:0032991	protein-containing complex	1	11
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	11

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Phosphorylation

Promastigote: 399

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I0H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0H2

PDB structure(s): 6icr_A , 6icr_B , 6icr_C , 6icr_D

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007015	actin filament organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0019894	kinesin binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.340
CLV_NRD_NRD_1	244	246	PF00675	0.416
CLV_NRD_NRD_1	319	321	PF00675	0.433
CLV_NRD_NRD_1	343	345	PF00675	0.287
CLV_NRD_NRD_1	470	472	PF00675	0.573
CLV_NRD_NRD_1	489	491	PF00675	0.437
CLV_PCSK_KEX2_1	221	223	PF00082	0.346
CLV_PCSK_KEX2_1	470	472	PF00082	0.595
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.389
CLV_PCSK_SKI1_1	18	22	PF00082	0.349

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGC0	Leptomonas seymouri	62%	99%
A0A0S4IT51	Bodo saltans	50%	100%
A0A1X0NWV5	Trypanosomatidae	41%	96%
A0A3Q8IEM1	Leishmania donovani	100%	100%
A0A3R7K7Y6	Trypanosoma rangeli	48%	100%
A4HCY7	Leishmania braziliensis	79%	100%
A8WGE3	Xenopus tropicalis	33%	100%
B0R0D7	Danio rerio	35%	100%
C9ZV95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AWD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%

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