LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I0H0_LEIIN
TriTrypDb:
LINF_230020300
Length:
466

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0H0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0H0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 358 362 PF00656 0.484
CLV_NRD_NRD_1 203 205 PF00675 0.606
CLV_NRD_NRD_1 263 265 PF00675 0.534
CLV_NRD_NRD_1 324 326 PF00675 0.488
CLV_NRD_NRD_1 84 86 PF00675 0.411
CLV_PCSK_FUR_1 458 462 PF00082 0.519
CLV_PCSK_FUR_1 82 86 PF00082 0.392
CLV_PCSK_KEX2_1 162 164 PF00082 0.622
CLV_PCSK_KEX2_1 205 207 PF00082 0.677
CLV_PCSK_KEX2_1 30 32 PF00082 0.626
CLV_PCSK_KEX2_1 460 462 PF00082 0.548
CLV_PCSK_KEX2_1 84 86 PF00082 0.501
CLV_PCSK_KEX2_1 91 93 PF00082 0.522
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.622
CLV_PCSK_PC1ET2_1 205 207 PF00082 0.645
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.626
CLV_PCSK_PC1ET2_1 460 462 PF00082 0.548
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.557
CLV_PCSK_SKI1_1 198 202 PF00082 0.580
CLV_PCSK_SKI1_1 208 212 PF00082 0.471
CLV_PCSK_SKI1_1 428 432 PF00082 0.577
CLV_PCSK_SKI1_1 442 446 PF00082 0.679
CLV_PCSK_SKI1_1 64 68 PF00082 0.521
CLV_PCSK_SKI1_1 92 96 PF00082 0.485
CLV_Separin_Metazoa 61 65 PF03568 0.507
DEG_APCC_DBOX_1 17 25 PF00400 0.412
DEG_APCC_KENBOX_2 356 360 PF00400 0.485
DOC_CYCLIN_yClb1_LxF_4 448 454 PF00134 0.593
DOC_MAPK_gen_1 144 152 PF00069 0.534
DOC_MAPK_gen_1 262 270 PF00069 0.561
DOC_MAPK_MEF2A_6 241 249 PF00069 0.378
DOC_MAPK_MEF2A_6 385 393 PF00069 0.565
DOC_PP4_FxxP_1 165 168 PF00568 0.539
DOC_USP7_MATH_1 184 188 PF00917 0.520
DOC_USP7_MATH_1 29 33 PF00917 0.557
DOC_USP7_MATH_1 371 375 PF00917 0.511
DOC_USP7_MATH_1 65 69 PF00917 0.566
DOC_USP7_UBL2_3 456 460 PF12436 0.530
DOC_WW_Pin1_4 222 227 PF00397 0.629
LIG_14-3-3_CanoR_1 144 150 PF00244 0.519
LIG_14-3-3_CanoR_1 18 22 PF00244 0.418
LIG_14-3-3_CanoR_1 190 194 PF00244 0.566
LIG_14-3-3_CanoR_1 208 217 PF00244 0.379
LIG_14-3-3_CanoR_1 218 226 PF00244 0.582
LIG_14-3-3_CanoR_1 292 296 PF00244 0.516
LIG_14-3-3_CanoR_1 31 39 PF00244 0.514
LIG_14-3-3_CanoR_1 433 440 PF00244 0.567
LIG_14-3-3_CanoR_1 92 98 PF00244 0.495
LIG_CaM_IQ_9 77 93 PF13499 0.429
LIG_FHA_1 232 238 PF00498 0.604
LIG_FHA_2 120 126 PF00498 0.726
LIG_FHA_2 190 196 PF00498 0.591
LIG_FHA_2 379 385 PF00498 0.421
LIG_FHA_2 56 62 PF00498 0.576
LIG_FHA_2 93 99 PF00498 0.544
LIG_GBD_Chelix_1 245 253 PF00786 0.581
LIG_LIR_Gen_1 12 21 PF02991 0.432
LIG_LIR_Gen_1 369 376 PF02991 0.585
LIG_LIR_LC3C_4 242 247 PF02991 0.370
LIG_LIR_Nem_3 12 17 PF02991 0.427
LIG_LIR_Nem_3 343 347 PF02991 0.423
LIG_LIR_Nem_3 369 375 PF02991 0.586
LIG_NRBOX 346 352 PF00104 0.566
LIG_SH2_CRK 344 348 PF00017 0.501
LIG_SH2_CRK 372 376 PF00017 0.578
LIG_SH2_STAT5 416 419 PF00017 0.515
LIG_SH2_STAT5 450 453 PF00017 0.668
LIG_SH3_2 2 7 PF14604 0.481
LIG_SH3_3 115 121 PF00018 0.597
LIG_SH3_3 418 424 PF00018 0.540
LIG_SUMO_SIM_par_1 242 248 PF11976 0.412
LIG_TRAF2_1 177 180 PF00917 0.531
LIG_TRAF2_1 319 322 PF00917 0.551
LIG_TRAF2_1 32 35 PF00917 0.545
LIG_TRAF2_1 381 384 PF00917 0.438
LIG_TRAF2_1 434 437 PF00917 0.619
LIG_TRAF2_1 69 72 PF00917 0.592
LIG_UBA3_1 199 205 PF00899 0.508
MOD_CK1_1 283 289 PF00069 0.507
MOD_CK1_1 299 305 PF00069 0.419
MOD_CK1_1 311 317 PF00069 0.437
MOD_CK1_1 374 380 PF00069 0.660
MOD_CK1_1 41 47 PF00069 0.604
MOD_CK1_1 422 428 PF00069 0.630
MOD_CK2_1 173 179 PF00069 0.567
MOD_CK2_1 29 35 PF00069 0.546
MOD_CK2_1 357 363 PF00069 0.576
MOD_CK2_1 378 384 PF00069 0.489
MOD_CK2_1 460 466 PF00069 0.571
MOD_CK2_1 55 61 PF00069 0.585
MOD_CK2_1 65 71 PF00069 0.468
MOD_CK2_1 9 15 PF00069 0.528
MOD_CK2_1 92 98 PF00069 0.546
MOD_GlcNHglycan 108 111 PF01048 0.513
MOD_GlcNHglycan 122 125 PF01048 0.537
MOD_GlcNHglycan 175 178 PF01048 0.570
MOD_GlcNHglycan 186 189 PF01048 0.541
MOD_GlcNHglycan 26 30 PF01048 0.587
MOD_GlcNHglycan 313 316 PF01048 0.566
MOD_GlcNHglycan 43 46 PF01048 0.401
MOD_GlcNHglycan 52 55 PF01048 0.472
MOD_GlcNHglycan 67 70 PF01048 0.512
MOD_GSK3_1 102 109 PF00069 0.524
MOD_GSK3_1 189 196 PF00069 0.552
MOD_GSK3_1 227 234 PF00069 0.638
MOD_GSK3_1 25 32 PF00069 0.580
MOD_GSK3_1 37 44 PF00069 0.462
MOD_GSK3_1 374 381 PF00069 0.442
MOD_GSK3_1 415 422 PF00069 0.622
MOD_GSK3_1 9 16 PF00069 0.545
MOD_N-GLC_2 133 135 PF02516 0.641
MOD_NEK2_1 145 150 PF00069 0.603
MOD_NEK2_1 189 194 PF00069 0.578
MOD_NEK2_1 245 250 PF00069 0.604
MOD_NEK2_1 38 43 PF00069 0.588
MOD_PIKK_1 247 253 PF00454 0.567
MOD_PIKK_1 283 289 PF00454 0.542
MOD_PIKK_1 296 302 PF00454 0.448
MOD_PIKK_1 30 36 PF00454 0.548
MOD_PIKK_1 378 384 PF00454 0.516
MOD_PIKK_1 395 401 PF00454 0.388
MOD_PK_1 401 407 PF00069 0.410
MOD_PKA_1 30 36 PF00069 0.581
MOD_PKA_1 460 466 PF00069 0.549
MOD_PKA_2 17 23 PF00069 0.411
MOD_PKA_2 173 179 PF00069 0.520
MOD_PKA_2 184 190 PF00069 0.515
MOD_PKA_2 217 223 PF00069 0.584
MOD_PKA_2 291 297 PF00069 0.535
MOD_PKA_2 30 36 PF00069 0.485
MOD_PKA_2 432 438 PF00069 0.568
MOD_PKA_2 460 466 PF00069 0.585
MOD_PKB_1 206 214 PF00069 0.582
MOD_Plk_1 179 185 PF00069 0.579
MOD_Plk_1 231 237 PF00069 0.623
MOD_Plk_1 401 407 PF00069 0.431
MOD_Plk_1 442 448 PF00069 0.573
MOD_Plk_2-3 9 15 PF00069 0.504
MOD_Plk_4 156 162 PF00069 0.589
MOD_Plk_4 308 314 PF00069 0.560
MOD_Plk_4 371 377 PF00069 0.580
MOD_Plk_4 422 428 PF00069 0.681
MOD_Plk_4 9 15 PF00069 0.438
MOD_ProDKin_1 222 228 PF00069 0.633
MOD_SUMO_for_1 6 9 PF00179 0.552
TRG_DiLeu_BaEn_1 232 237 PF01217 0.603
TRG_ENDOCYTIC_2 14 17 PF00928 0.428
TRG_ENDOCYTIC_2 344 347 PF00928 0.448
TRG_ENDOCYTIC_2 372 375 PF00928 0.579
TRG_ENDOCYTIC_2 450 453 PF00928 0.648
TRG_ENDOCYTIC_2 83 86 PF00928 0.539
TRG_ER_diArg_1 203 206 PF00400 0.542
TRG_ER_diArg_1 83 85 PF00400 0.399
TRG_NLS_MonoCore_2 263 268 PF00514 0.549
TRG_NLS_MonoExtC_3 203 208 PF00514 0.508
TRG_NLS_MonoExtN_4 204 209 PF00514 0.446
TRG_NLS_MonoExtN_4 262 269 PF00514 0.599
TRG_Pf-PMV_PEXEL_1 208 213 PF00026 0.578
TRG_Pf-PMV_PEXEL_1 282 287 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.615

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9S1 Leptomonas seymouri 24% 100%
A0A3Q8IFW4 Leishmania donovani 98% 100%
A4HCY5 Leishmania braziliensis 68% 100%
E9AWD2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QB40 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS