Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0G9_LEIIN

TriTrypDb:

LINF_230020200

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005814	centriole	5	2
GO:0005874	microtubule	6	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I0G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0G9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.527
CLV_C14_Caspase3-7	253	257	PF00656	0.509
CLV_C14_Caspase3-7	31	35	PF00656	0.646
CLV_C14_Caspase3-7	474	478	PF00656	0.505
CLV_NRD_NRD_1	103	105	PF00675	0.539
CLV_NRD_NRD_1	193	195	PF00675	0.567
CLV_NRD_NRD_1	268	270	PF00675	0.618
CLV_NRD_NRD_1	382	384	PF00675	0.496
CLV_NRD_NRD_1	6	8	PF00675	0.585
CLV_PCSK_FUR_1	134	138	PF00082	0.426
CLV_PCSK_FUR_1	380	384	PF00082	0.434
CLV_PCSK_KEX2_1	136	138	PF00082	0.519
CLV_PCSK_KEX2_1	192	194	PF00082	0.571
CLV_PCSK_KEX2_1	343	345	PF00082	0.576
CLV_PCSK_KEX2_1	380	382	PF00082	0.527
CLV_PCSK_KEX2_1	55	57	PF00082	0.640
CLV_PCSK_KEX2_1	580	582	PF00082	0.441
CLV_PCSK_KEX2_1	6	8	PF00082	0.561
CLV_PCSK_KEX2_1	606	608	PF00082	0.539
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.458
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.571
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.576
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.640
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.501
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.539
CLV_PCSK_SKI1_1	129	133	PF00082	0.502
CLV_PCSK_SKI1_1	194	198	PF00082	0.556
CLV_PCSK_SKI1_1	333	337	PF00082	0.538
CLV_PCSK_SKI1_1	415	419	PF00082	0.677
CLV_PCSK_SKI1_1	468	472	PF00082	0.423
DEG_APCC_DBOX_1	5	13	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DOC_CYCLIN_RxL_1	327	340	PF00134	0.540
DOC_MAPK_gen_1	192	199	PF00069	0.520
DOC_MAPK_gen_1	320	330	PF00069	0.531
DOC_MAPK_gen_1	588	598	PF00069	0.463
DOC_MAPK_gen_1	606	612	PF00069	0.338
DOC_MAPK_MEF2A_6	6	13	PF00069	0.563
DOC_PP1_RVXF_1	555	561	PF00149	0.467
DOC_PP2B_LxvP_1	371	374	PF13499	0.642
DOC_SPAK_OSR1_1	607	611	PF12202	0.530
DOC_USP7_MATH_1	147	151	PF00917	0.632
DOC_USP7_MATH_1	16	20	PF00917	0.644
DOC_USP7_MATH_1	160	164	PF00917	0.417
DOC_USP7_MATH_1	168	172	PF00917	0.530
DOC_USP7_MATH_1	22	26	PF00917	0.592
DOC_USP7_MATH_1	257	261	PF00917	0.564
DOC_USP7_MATH_1	40	44	PF00917	0.639
DOC_USP7_MATH_1	401	405	PF00917	0.660
DOC_USP7_MATH_1	406	410	PF00917	0.721
DOC_USP7_MATH_1	440	444	PF00917	0.503
DOC_USP7_UBL2_3	568	572	PF12436	0.559
DOC_WW_Pin1_4	14	19	PF00397	0.573
DOC_WW_Pin1_4	209	214	PF00397	0.683
LIG_14-3-3_CanoR_1	10	16	PF00244	0.713
LIG_14-3-3_CanoR_1	162	166	PF00244	0.438
LIG_14-3-3_CanoR_1	359	367	PF00244	0.564
LIG_14-3-3_CanoR_1	382	388	PF00244	0.558
LIG_14-3-3_CanoR_1	468	473	PF00244	0.525
LIG_14-3-3_CanoR_1	56	62	PF00244	0.628
LIG_Actin_WH2_2	42	57	PF00022	0.533
LIG_FAT_LD_1	612	620	PF03623	0.406
LIG_FHA_1	18	24	PF00498	0.650
LIG_FHA_1	210	216	PF00498	0.650
LIG_FHA_1	351	357	PF00498	0.486
LIG_FHA_1	571	577	PF00498	0.557
LIG_FHA_1	592	598	PF00498	0.511
LIG_FHA_2	165	171	PF00498	0.560
LIG_FHA_2	184	190	PF00498	0.614
LIG_FHA_2	261	267	PF00498	0.515
LIG_FHA_2	361	367	PF00498	0.607
LIG_LIR_Gen_1	139	147	PF02991	0.551
LIG_LIR_Nem_3	133	138	PF02991	0.591
LIG_LIR_Nem_3	139	145	PF02991	0.542
LIG_MAD2	10	18	PF02301	0.537
LIG_NRBOX	611	617	PF00104	0.408
LIG_PCNA_yPIPBox_3	606	616	PF02747	0.527
LIG_PTB_Apo_2	85	92	PF02174	0.563
LIG_SH2_STAP1	547	551	PF00017	0.553
LIG_SH2_STAT5	565	568	PF00017	0.453
LIG_SH2_STAT5	90	93	PF00017	0.619
LIG_SH3_4	432	439	PF00018	0.733
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.651
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.647
LIG_SUMO_SIM_par_1	28	35	PF11976	0.647
LIG_SUMO_SIM_par_1	550	556	PF11976	0.533
LIG_TRAF2_1	345	348	PF00917	0.573
LIG_UBA3_1	29	38	PF00899	0.643
LIG_UBA3_1	576	580	PF00899	0.530
MOD_CK1_1	164	170	PF00069	0.535
MOD_CK1_1	17	23	PF00069	0.663
MOD_CK1_1	260	266	PF00069	0.567
MOD_CK1_1	285	291	PF00069	0.557
MOD_CK1_1	41	47	PF00069	0.604
MOD_CK1_1	515	521	PF00069	0.608
MOD_CK1_1	524	530	PF00069	0.565
MOD_CK1_1	533	539	PF00069	0.575
MOD_CK1_1	72	78	PF00069	0.605
MOD_CK1_1	89	95	PF00069	0.475
MOD_CK2_1	183	189	PF00069	0.616
MOD_CK2_1	22	28	PF00069	0.702
MOD_CK2_1	260	266	PF00069	0.515
MOD_CK2_1	300	306	PF00069	0.536
MOD_CK2_1	360	366	PF00069	0.606
MOD_CK2_1	382	388	PF00069	0.551
MOD_CK2_1	450	456	PF00069	0.515
MOD_CK2_1	507	513	PF00069	0.611
MOD_GlcNHglycan	153	156	PF01048	0.599
MOD_GlcNHglycan	170	173	PF01048	0.487
MOD_GlcNHglycan	217	220	PF01048	0.703
MOD_GlcNHglycan	294	297	PF01048	0.485
MOD_GlcNHglycan	314	317	PF01048	0.605
MOD_GlcNHglycan	40	43	PF01048	0.754
MOD_GlcNHglycan	408	411	PF01048	0.653
MOD_GlcNHglycan	48	52	PF01048	0.620
MOD_GlcNHglycan	502	505	PF01048	0.606
MOD_GlcNHglycan	63	66	PF01048	0.497
MOD_GlcNHglycan	71	74	PF01048	0.759
MOD_GlcNHglycan	92	95	PF01048	0.515
MOD_GSK3_1	147	154	PF00069	0.484
MOD_GSK3_1	160	167	PF00069	0.536
MOD_GSK3_1	183	190	PF00069	0.588
MOD_GSK3_1	205	212	PF00069	0.609
MOD_GSK3_1	215	222	PF00069	0.687
MOD_GSK3_1	246	253	PF00069	0.529
MOD_GSK3_1	260	267	PF00069	0.369
MOD_GSK3_1	40	47	PF00069	0.683
MOD_GSK3_1	446	453	PF00069	0.544
MOD_GSK3_1	471	478	PF00069	0.505
MOD_GSK3_1	86	93	PF00069	0.751
MOD_N-GLC_1	120	125	PF02516	0.520
MOD_N-GLC_1	168	173	PF02516	0.577
MOD_N-GLC_1	38	43	PF02516	0.707
MOD_N-GLC_1	427	432	PF02516	0.573
MOD_N-GLC_1	468	473	PF02516	0.473
MOD_NEK2_1	151	156	PF00069	0.525
MOD_NEK2_1	205	210	PF00069	0.653
MOD_NEK2_1	241	246	PF00069	0.567
MOD_NEK2_1	307	312	PF00069	0.519
MOD_NEK2_1	446	451	PF00069	0.524
MOD_NEK2_1	512	517	PF00069	0.580
MOD_NEK2_1	86	91	PF00069	0.624
MOD_NEK2_2	161	166	PF00069	0.433
MOD_PIKK_1	106	112	PF00454	0.523
MOD_PIKK_1	241	247	PF00454	0.499
MOD_PIKK_1	285	291	PF00454	0.509
MOD_PIKK_1	515	521	PF00454	0.574
MOD_PIKK_1	600	606	PF00454	0.537
MOD_PK_1	246	252	PF00069	0.567
MOD_PK_1	300	306	PF00069	0.497
MOD_PK_1	475	481	PF00069	0.558
MOD_PKA_1	269	275	PF00069	0.551
MOD_PKA_1	300	306	PF00069	0.497
MOD_PKA_1	382	388	PF00069	0.551
MOD_PKA_1	55	61	PF00069	0.633
MOD_PKA_2	161	167	PF00069	0.443
MOD_PKA_2	241	247	PF00069	0.580
MOD_PKA_2	382	388	PF00069	0.551
MOD_PKA_2	530	536	PF00069	0.441
MOD_PKA_2	55	61	PF00069	0.639
MOD_PKB_1	380	388	PF00069	0.501
MOD_Plk_1	120	126	PF00069	0.520
MOD_Plk_1	260	266	PF00069	0.628
MOD_Plk_1	446	452	PF00069	0.573
MOD_Plk_1	468	474	PF00069	0.472
MOD_Plk_1	507	513	PF00069	0.595
MOD_Plk_1	547	553	PF00069	0.541
MOD_Plk_1	86	92	PF00069	0.642
MOD_Plk_4	120	126	PF00069	0.520
MOD_Plk_4	147	153	PF00069	0.534
MOD_Plk_4	211	217	PF00069	0.651
MOD_Plk_4	450	456	PF00069	0.513
MOD_Plk_4	547	553	PF00069	0.594
MOD_Plk_4	617	623	PF00069	0.525
MOD_Plk_4	86	92	PF00069	0.642
MOD_ProDKin_1	14	20	PF00069	0.574
MOD_ProDKin_1	209	215	PF00069	0.685
MOD_SUMO_rev_2	122	131	PF00179	0.504
MOD_SUMO_rev_2	141	150	PF00179	0.334
MOD_SUMO_rev_2	266	272	PF00179	0.531
MOD_SUMO_rev_2	347	356	PF00179	0.638
MOD_SUMO_rev_2	484	492	PF00179	0.562
MOD_SUMO_rev_2	569	573	PF00179	0.537
MOD_SUMO_rev_2	575	582	PF00179	0.490
MOD_SUMO_rev_2	584	589	PF00179	0.566
MOD_SUMO_rev_2	595	603	PF00179	0.408
TRG_DiLeu_BaEn_1	592	597	PF01217	0.563
TRG_DiLeu_BaEn_2	555	561	PF01217	0.467
TRG_DiLeu_BaEn_4	507	513	PF01217	0.555
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.520
TRG_ER_diArg_1	327	330	PF00400	0.521
TRG_ER_diArg_1	367	370	PF00400	0.586
TRG_ER_diArg_1	380	383	PF00400	0.419
TRG_ER_diArg_1	5	7	PF00400	0.530
TRG_NES_CRM1_1	578	590	PF08389	0.481
TRG_NLS_MonoExtN_4	6	11	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB33	Leishmania donovani	100%	100%
A0A422NPG5	Trypanosoma rangeli	25%	83%
A4HCY4	Leishmania braziliensis	80%	100%
C9ZV65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	72%
E9AWD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QB41	Leishmania major	93%	100%