LeishMANIAdb
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Probable methyltransferase BMT2 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable methyltransferase BMT2 homolog
Gene product:
Probable methyltransferase BTM2 homolog
Species:
Leishmania infantum
UniProt:
A4I0G2_LEIIN
TriTrypDb:
LINF_230019500
Length:
672

Annotations

LeishMANIAdb annotations

Homologous to S-adenosylmethionine sensor upstream of mTORC1. Does not appear to be membrane-associated.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0G2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0G2

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 9
GO:0032259 methylation 2 9
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0032006 regulation of TOR signaling 6 1
GO:0032007 negative regulation of TOR signaling 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
GO:1903432 regulation of TORC1 signaling 7 1
GO:1904262 negative regulation of TORC1 signaling 8 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0008168 methyltransferase activity 4 9
GO:0016740 transferase activity 2 10
GO:0016741 transferase activity, transferring one-carbon groups 3 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 180 184 PF00656 0.589
CLV_C14_Caspase3-7 207 211 PF00656 0.440
CLV_C14_Caspase3-7 338 342 PF00656 0.547
CLV_C14_Caspase3-7 359 363 PF00656 0.403
CLV_C14_Caspase3-7 506 510 PF00656 0.540
CLV_C14_Caspase3-7 520 524 PF00656 0.553
CLV_C14_Caspase3-7 525 529 PF00656 0.545
CLV_NRD_NRD_1 174 176 PF00675 0.747
CLV_NRD_NRD_1 290 292 PF00675 0.543
CLV_NRD_NRD_1 373 375 PF00675 0.695
CLV_NRD_NRD_1 591 593 PF00675 0.427
CLV_NRD_NRD_1 633 635 PF00675 0.470
CLV_PCSK_KEX2_1 174 176 PF00082 0.806
CLV_PCSK_KEX2_1 290 292 PF00082 0.545
CLV_PCSK_KEX2_1 373 375 PF00082 0.695
CLV_PCSK_KEX2_1 590 592 PF00082 0.440
CLV_PCSK_KEX2_1 633 635 PF00082 0.476
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.806
CLV_PCSK_PC7_1 170 176 PF00082 0.773
CLV_PCSK_SKI1_1 160 164 PF00082 0.671
CLV_PCSK_SKI1_1 284 288 PF00082 0.563
CLV_PCSK_SKI1_1 290 294 PF00082 0.551
CLV_PCSK_SKI1_1 299 303 PF00082 0.518
DEG_ODPH_VHL_1 425 437 PF01847 0.452
DEG_SPOP_SBC_1 258 262 PF00917 0.445
DEG_SPOP_SBC_1 34 38 PF00917 0.534
DOC_CKS1_1 185 190 PF01111 0.508
DOC_CKS1_1 556 561 PF01111 0.378
DOC_MAPK_DCC_7 421 430 PF00069 0.442
DOC_MAPK_gen_1 284 294 PF00069 0.430
DOC_MAPK_MEF2A_6 574 582 PF00069 0.344
DOC_PP1_RVXF_1 288 295 PF00149 0.442
DOC_PP1_RVXF_1 558 564 PF00149 0.405
DOC_USP7_MATH_1 161 165 PF00917 0.508
DOC_USP7_MATH_1 204 208 PF00917 0.543
DOC_USP7_MATH_1 257 261 PF00917 0.543
DOC_USP7_MATH_1 325 329 PF00917 0.520
DOC_USP7_MATH_1 34 38 PF00917 0.606
DOC_USP7_MATH_1 485 489 PF00917 0.520
DOC_USP7_MATH_1 503 507 PF00917 0.511
DOC_USP7_MATH_1 518 522 PF00917 0.550
DOC_USP7_MATH_1 529 533 PF00917 0.482
DOC_USP7_MATH_1 65 69 PF00917 0.422
DOC_WW_Pin1_4 132 137 PF00397 0.568
DOC_WW_Pin1_4 184 189 PF00397 0.511
DOC_WW_Pin1_4 25 30 PF00397 0.612
DOC_WW_Pin1_4 311 316 PF00397 0.418
DOC_WW_Pin1_4 391 396 PF00397 0.553
DOC_WW_Pin1_4 452 457 PF00397 0.468
DOC_WW_Pin1_4 555 560 PF00397 0.382
DOC_WW_Pin1_4 624 629 PF00397 0.618
LIG_14-3-3_CanoR_1 103 107 PF00244 0.473
LIG_14-3-3_CanoR_1 114 122 PF00244 0.326
LIG_14-3-3_CanoR_1 160 169 PF00244 0.508
LIG_14-3-3_CanoR_1 175 185 PF00244 0.553
LIG_14-3-3_CanoR_1 212 220 PF00244 0.425
LIG_14-3-3_CanoR_1 299 306 PF00244 0.356
LIG_14-3-3_CanoR_1 502 508 PF00244 0.554
LIG_14-3-3_CanoR_1 592 602 PF00244 0.588
LIG_14-3-3_CanoR_1 633 637 PF00244 0.666
LIG_BIR_II_1 1 5 PF00653 0.557
LIG_BRCT_BRCA1_1 603 607 PF00533 0.630
LIG_deltaCOP1_diTrp_1 462 469 PF00928 0.332
LIG_FHA_1 338 344 PF00498 0.475
LIG_FHA_1 345 351 PF00498 0.409
LIG_FHA_1 402 408 PF00498 0.398
LIG_FHA_1 420 426 PF00498 0.276
LIG_FHA_1 44 50 PF00498 0.498
LIG_FHA_1 556 562 PF00498 0.377
LIG_FHA_1 597 603 PF00498 0.636
LIG_FHA_2 140 146 PF00498 0.535
LIG_FHA_2 203 209 PF00498 0.559
LIG_FHA_2 300 306 PF00498 0.369
LIG_FHA_2 431 437 PF00498 0.343
LIG_FHA_2 488 494 PF00498 0.403
LIG_FHA_2 660 666 PF00498 0.604
LIG_LIR_Apic_2 127 132 PF02991 0.453
LIG_LIR_Gen_1 189 198 PF02991 0.440
LIG_LIR_Gen_1 462 470 PF02991 0.334
LIG_LIR_Gen_1 542 552 PF02991 0.375
LIG_LIR_Gen_1 604 614 PF02991 0.612
LIG_LIR_Gen_1 622 630 PF02991 0.541
LIG_LIR_Nem_3 189 194 PF02991 0.441
LIG_LIR_Nem_3 273 278 PF02991 0.368
LIG_LIR_Nem_3 409 414 PF02991 0.333
LIG_LIR_Nem_3 542 547 PF02991 0.302
LIG_LIR_Nem_3 604 610 PF02991 0.607
LIG_LIR_Nem_3 622 626 PF02991 0.518
LIG_LYPXL_SIV_4 117 125 PF13949 0.451
LIG_REV1ctd_RIR_1 291 300 PF16727 0.427
LIG_REV1ctd_RIR_1 412 421 PF16727 0.381
LIG_SH2_CRK 544 548 PF00017 0.335
LIG_SH2_GRB2like 129 132 PF00017 0.528
LIG_SH2_NCK_1 544 548 PF00017 0.335
LIG_SH2_SRC 118 121 PF00017 0.446
LIG_SH2_STAP1 118 122 PF00017 0.362
LIG_SH2_STAP1 214 218 PF00017 0.433
LIG_SH2_STAP1 544 548 PF00017 0.335
LIG_SH2_STAT3 220 223 PF00017 0.365
LIG_SH2_STAT3 498 501 PF00017 0.505
LIG_SH2_STAT5 220 223 PF00017 0.374
LIG_SH2_STAT5 229 232 PF00017 0.316
LIG_SH2_STAT5 386 389 PF00017 0.482
LIG_SH2_STAT5 555 558 PF00017 0.330
LIG_SH2_STAT5 84 87 PF00017 0.440
LIG_SH3_1 421 427 PF00018 0.460
LIG_SH3_3 182 188 PF00018 0.543
LIG_SH3_3 23 29 PF00018 0.598
LIG_SH3_3 282 288 PF00018 0.414
LIG_SH3_3 421 427 PF00018 0.460
LIG_SUMO_SIM_par_1 403 409 PF11976 0.304
LIG_SUMO_SIM_par_1 577 584 PF11976 0.344
LIG_SxIP_EBH_1 549 562 PF03271 0.354
LIG_TRAF2_1 490 493 PF00917 0.429
LIG_TRAF2_1 613 616 PF00917 0.624
LIG_WW_1 92 95 PF00397 0.429
MOD_CDK_SPK_2 555 560 PF00069 0.382
MOD_CDK_SPxK_1 311 317 PF00069 0.454
MOD_CDK_SPxxK_3 555 562 PF00069 0.378
MOD_CK1_1 164 170 PF00069 0.631
MOD_CK1_1 178 184 PF00069 0.533
MOD_CK1_1 224 230 PF00069 0.407
MOD_CK1_1 3 9 PF00069 0.478
MOD_CK1_1 311 317 PF00069 0.391
MOD_CK1_1 334 340 PF00069 0.520
MOD_CK1_1 344 350 PF00069 0.452
MOD_CK1_1 505 511 PF00069 0.558
MOD_CK1_1 583 589 PF00069 0.581
MOD_CK1_1 596 602 PF00069 0.538
MOD_CK1_1 635 641 PF00069 0.580
MOD_CK1_1 68 74 PF00069 0.493
MOD_CK2_1 299 305 PF00069 0.359
MOD_CK2_1 343 349 PF00069 0.516
MOD_CK2_1 36 42 PF00069 0.582
MOD_CK2_1 487 493 PF00069 0.451
MOD_CK2_1 610 616 PF00069 0.588
MOD_CK2_1 91 97 PF00069 0.468
MOD_GlcNHglycan 115 118 PF01048 0.660
MOD_GlcNHglycan 198 201 PF01048 0.718
MOD_GlcNHglycan 2 5 PF01048 0.740
MOD_GlcNHglycan 244 247 PF01048 0.772
MOD_GlcNHglycan 310 313 PF01048 0.587
MOD_GlcNHglycan 343 346 PF01048 0.656
MOD_GlcNHglycan 396 399 PF01048 0.681
MOD_GlcNHglycan 487 490 PF01048 0.629
MOD_GlcNHglycan 513 516 PF01048 0.791
MOD_GlcNHglycan 523 527 PF01048 0.755
MOD_GlcNHglycan 628 631 PF01048 0.460
MOD_GlcNHglycan 652 655 PF01048 0.433
MOD_GlcNHglycan 67 70 PF01048 0.673
MOD_GlcNHglycan 72 75 PF01048 0.726
MOD_GlcNHglycan 88 91 PF01048 0.759
MOD_GSK3_1 160 167 PF00069 0.537
MOD_GSK3_1 196 203 PF00069 0.581
MOD_GSK3_1 204 211 PF00069 0.553
MOD_GSK3_1 313 320 PF00069 0.462
MOD_GSK3_1 331 338 PF00069 0.389
MOD_GSK3_1 339 346 PF00069 0.433
MOD_GSK3_1 375 382 PF00069 0.422
MOD_GSK3_1 481 488 PF00069 0.496
MOD_GSK3_1 518 525 PF00069 0.552
MOD_GSK3_1 530 537 PF00069 0.282
MOD_GSK3_1 551 558 PF00069 0.372
MOD_GSK3_1 593 600 PF00069 0.602
MOD_GSK3_1 645 652 PF00069 0.636
MOD_GSK3_1 68 75 PF00069 0.505
MOD_GSK3_1 80 87 PF00069 0.581
MOD_N-GLC_1 447 452 PF02516 0.625
MOD_NEK2_1 198 203 PF00069 0.584
MOD_NEK2_1 35 40 PF00069 0.596
MOD_NEK2_1 384 389 PF00069 0.390
MOD_NEK2_1 419 424 PF00069 0.380
MOD_NEK2_1 430 435 PF00069 0.301
MOD_NEK2_1 534 539 PF00069 0.422
MOD_NEK2_1 551 556 PF00069 0.216
MOD_NEK2_1 649 654 PF00069 0.636
MOD_NEK2_1 80 85 PF00069 0.519
MOD_NEK2_1 86 91 PF00069 0.520
MOD_PIKK_1 27 33 PF00454 0.577
MOD_PIKK_1 3 9 PF00454 0.478
MOD_PIKK_1 36 42 PF00454 0.534
MOD_PIKK_1 583 589 PF00454 0.581
MOD_PKA_1 175 181 PF00069 0.538
MOD_PKA_2 102 108 PF00069 0.471
MOD_PKA_2 113 119 PF00069 0.334
MOD_PKA_2 176 182 PF00069 0.605
MOD_PKA_2 479 485 PF00069 0.489
MOD_PKA_2 632 638 PF00069 0.635
MOD_PKA_2 659 665 PF00069 0.655
MOD_PKB_1 500 508 PF00069 0.488
MOD_Plk_1 270 276 PF00069 0.399
MOD_Plk_1 367 373 PF00069 0.472
MOD_Plk_1 375 381 PF00069 0.442
MOD_Plk_4 124 130 PF00069 0.480
MOD_Plk_4 187 193 PF00069 0.525
MOD_Plk_4 224 230 PF00069 0.417
MOD_Plk_4 50 56 PF00069 0.482
MOD_Plk_4 551 557 PF00069 0.349
MOD_Plk_4 645 651 PF00069 0.607
MOD_Plk_4 72 78 PF00069 0.417
MOD_ProDKin_1 132 138 PF00069 0.570
MOD_ProDKin_1 184 190 PF00069 0.510
MOD_ProDKin_1 25 31 PF00069 0.613
MOD_ProDKin_1 311 317 PF00069 0.428
MOD_ProDKin_1 391 397 PF00069 0.550
MOD_ProDKin_1 452 458 PF00069 0.456
MOD_ProDKin_1 555 561 PF00069 0.380
MOD_ProDKin_1 624 630 PF00069 0.624
MOD_SUMO_rev_2 94 101 PF00179 0.468
TRG_DiLeu_BaEn_1 305 310 PF01217 0.409
TRG_DiLeu_BaEn_1 575 580 PF01217 0.401
TRG_ENDOCYTIC_2 297 300 PF00928 0.394
TRG_ENDOCYTIC_2 411 414 PF00928 0.324
TRG_ENDOCYTIC_2 544 547 PF00928 0.335
TRG_ER_diArg_1 289 291 PF00400 0.339
TRG_ER_diArg_1 372 374 PF00400 0.498
TRG_ER_diArg_1 495 498 PF00400 0.463
TRG_ER_diArg_1 500 503 PF00400 0.488
TRG_ER_diArg_1 559 562 PF00400 0.291
TRG_ER_diArg_1 589 592 PF00400 0.697
TRG_ER_diArg_1 632 634 PF00400 0.672
TRG_NLS_MonoExtC_3 174 180 PF00514 0.612
TRG_NLS_MonoExtN_4 174 179 PF00514 0.614
TRG_Pf-PMV_PEXEL_1 290 295 PF00026 0.647
TRG_Pf-PMV_PEXEL_1 354 358 PF00026 0.650
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.622

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHP2 Leptomonas seymouri 47% 100%
A0A1X0NWU4 Trypanosomatidae 29% 100%
A0A3Q8IM81 Leishmania donovani 99% 100%
A4HCX9 Leishmania braziliensis 74% 98%
C9ZV78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AWC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QB47 Leishmania major 89% 100%
V5BEP9 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS