LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Scavenger mRNA decapping enzyme C-term binding/HIT domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I0G0_LEIIN
TriTrypDb:
LINF_230019300
Length:
351

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0G0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0G0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0047710 bis(5'-adenosyl)-triphosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.625
CLV_NRD_NRD_1 250 252 PF00675 0.381
CLV_NRD_NRD_1 3 5 PF00675 0.601
CLV_NRD_NRD_1 316 318 PF00675 0.577
CLV_PCSK_KEX2_1 250 252 PF00082 0.324
CLV_PCSK_KEX2_1 3 5 PF00082 0.601
CLV_PCSK_KEX2_1 315 317 PF00082 0.587
CLV_PCSK_SKI1_1 3 7 PF00082 0.535
CLV_PCSK_SKI1_1 333 337 PF00082 0.538
DEG_COP1_1 81 91 PF00400 0.661
DEG_SCF_FBW7_2 169 174 PF00400 0.499
DEG_SPOP_SBC_1 162 166 PF00917 0.508
DEG_SPOP_SBC_1 343 347 PF00917 0.551
DEG_SPOP_SBC_1 74 78 PF00917 0.746
DOC_CKS1_1 319 324 PF01111 0.618
DOC_CYCLIN_RxL_1 330 340 PF00134 0.524
DOC_PP1_RVXF_1 235 241 PF00149 0.443
DOC_PP4_FxxP_1 14 17 PF00568 0.597
DOC_USP7_MATH_1 135 139 PF00917 0.526
DOC_USP7_MATH_1 157 161 PF00917 0.550
DOC_USP7_MATH_1 188 192 PF00917 0.379
DOC_USP7_MATH_1 193 197 PF00917 0.324
DOC_USP7_MATH_1 259 263 PF00917 0.523
DOC_USP7_MATH_1 342 346 PF00917 0.605
DOC_USP7_MATH_1 73 77 PF00917 0.776
DOC_USP7_MATH_1 8 12 PF00917 0.507
DOC_WW_Pin1_4 103 108 PF00397 0.647
DOC_WW_Pin1_4 13 18 PF00397 0.508
DOC_WW_Pin1_4 167 172 PF00397 0.682
DOC_WW_Pin1_4 261 266 PF00397 0.562
DOC_WW_Pin1_4 318 323 PF00397 0.626
DOC_WW_Pin1_4 54 59 PF00397 0.607
LIG_14-3-3_CanoR_1 178 182 PF00244 0.466
LIG_14-3-3_CanoR_1 219 227 PF00244 0.517
LIG_14-3-3_CanoR_1 3 8 PF00244 0.533
LIG_AP2alpha_2 90 92 PF02296 0.481
LIG_BIR_II_1 1 5 PF00653 0.645
LIG_BRCT_BRCA1_1 10 14 PF00533 0.573
LIG_BRCT_BRCA1_1 195 199 PF00533 0.490
LIG_deltaCOP1_diTrp_1 233 240 PF00928 0.443
LIG_FHA_1 168 174 PF00498 0.504
LIG_FHA_1 18 24 PF00498 0.693
LIG_FHA_1 240 246 PF00498 0.484
LIG_FHA_1 262 268 PF00498 0.590
LIG_FHA_1 319 325 PF00498 0.515
LIG_FHA_1 327 333 PF00498 0.445
LIG_FHA_1 91 97 PF00498 0.594
LIG_FHA_2 114 120 PF00498 0.632
LIG_FHA_2 124 130 PF00498 0.560
LIG_FHA_2 226 232 PF00498 0.530
LIG_FHA_2 24 30 PF00498 0.794
LIG_FHA_2 76 82 PF00498 0.757
LIG_LIR_Apic_2 11 17 PF02991 0.472
LIG_LIR_Apic_2 180 185 PF02991 0.397
LIG_LIR_Gen_1 196 207 PF02991 0.490
LIG_LIR_Gen_1 90 99 PF02991 0.596
LIG_LIR_Nem_3 180 184 PF02991 0.419
LIG_LIR_Nem_3 196 202 PF02991 0.449
LIG_LIR_Nem_3 233 238 PF02991 0.504
LIG_LIR_Nem_3 90 95 PF02991 0.595
LIG_SH2_CRK 63 67 PF00017 0.584
LIG_SH2_NCK_1 156 160 PF00017 0.583
LIG_SH2_NCK_1 339 343 PF00017 0.607
LIG_SH2_SRC 45 48 PF00017 0.580
LIG_SH2_STAP1 273 277 PF00017 0.561
LIG_SH2_STAP1 339 343 PF00017 0.607
LIG_SH2_STAT3 194 197 PF00017 0.590
LIG_SH2_STAT5 194 197 PF00017 0.536
LIG_SH2_STAT5 339 342 PF00017 0.574
LIG_SH2_STAT5 45 48 PF00017 0.642
LIG_SH3_1 316 322 PF00018 0.631
LIG_SH3_3 187 193 PF00018 0.500
LIG_SH3_3 204 210 PF00018 0.355
LIG_SH3_3 262 268 PF00018 0.546
LIG_SH3_3 293 299 PF00018 0.490
LIG_SH3_3 316 322 PF00018 0.631
LIG_SH3_3 85 91 PF00018 0.693
LIG_SH3_4 139 146 PF00018 0.611
LIG_TRAF2_1 106 109 PF00917 0.706
LIG_TRAF2_1 228 231 PF00917 0.530
LIG_TRFH_1 69 73 PF08558 0.718
LIG_WW_3 317 321 PF00397 0.580
MOD_CK1_1 167 173 PF00069 0.636
MOD_CK1_1 261 267 PF00069 0.567
MOD_CK2_1 103 109 PF00069 0.691
MOD_CK2_1 123 129 PF00069 0.570
MOD_CK2_1 225 231 PF00069 0.490
MOD_CK2_1 30 36 PF00069 0.752
MOD_CK2_1 75 81 PF00069 0.761
MOD_GlcNHglycan 108 113 PF01048 0.666
MOD_GlcNHglycan 186 189 PF01048 0.492
MOD_GlcNHglycan 261 264 PF01048 0.347
MOD_GlcNHglycan 32 35 PF01048 0.821
MOD_GlcNHglycan 346 349 PF01048 0.479
MOD_GSK3_1 113 120 PF00069 0.632
MOD_GSK3_1 157 164 PF00069 0.556
MOD_GSK3_1 184 191 PF00069 0.505
MOD_GSK3_1 23 30 PF00069 0.728
MOD_GSK3_1 8 15 PF00069 0.506
MOD_GSK3_1 90 97 PF00069 0.617
MOD_N-GLC_1 12 17 PF02516 0.539
MOD_N-GLC_1 162 167 PF02516 0.645
MOD_N-GLC_1 271 276 PF02516 0.361
MOD_NEK2_1 12 17 PF00069 0.477
MOD_NEK2_1 23 28 PF00069 0.609
MOD_NEK2_1 239 244 PF00069 0.492
MOD_NEK2_2 177 182 PF00069 0.431
MOD_NEK2_2 220 225 PF00069 0.508
MOD_PIKK_1 193 199 PF00454 0.484
MOD_PKA_1 3 9 PF00069 0.590
MOD_PKA_2 177 183 PF00069 0.543
MOD_PKA_2 23 29 PF00069 0.674
MOD_PKA_2 252 258 PF00069 0.561
MOD_PKA_2 3 9 PF00069 0.587
MOD_Plk_1 117 123 PF00069 0.638
MOD_Plk_1 271 277 PF00069 0.561
MOD_Plk_4 320 326 PF00069 0.436
MOD_ProDKin_1 103 109 PF00069 0.647
MOD_ProDKin_1 13 19 PF00069 0.515
MOD_ProDKin_1 167 173 PF00069 0.667
MOD_ProDKin_1 261 267 PF00069 0.562
MOD_ProDKin_1 318 324 PF00069 0.624
MOD_ProDKin_1 54 60 PF00069 0.600
TRG_ENDOCYTIC_2 45 48 PF00928 0.676
TRG_ENDOCYTIC_2 63 66 PF00928 0.333
TRG_ER_diArg_1 249 251 PF00400 0.581
TRG_ER_diArg_1 3 5 PF00400 0.601
TRG_ER_diArg_1 315 317 PF00400 0.620
TRG_Pf-PMV_PEXEL_1 333 338 PF00026 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P352 Leptomonas seymouri 57% 81%
A0A1X0NWV2 Trypanosomatidae 39% 77%
A0A3S7WXW4 Leishmania donovani 100% 100%
A4HCX7 Leishmania braziliensis 83% 100%
C9ZV80 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 84%
E9AWC3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QB49 Leishmania major 93% 100%
V5BJC2 Trypanosoma cruzi 45% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS