Hydrophilic acylated surface protein b

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrophilic acylated surface protein b

Species:

Leishmania infantum

UniProt:

A4I0F4_LEIIN

TriTrypDb:

LINF_230018700

Length:

247

Annotations

Annotations by Jardim et al.

Plasma membrane, Hydrophilic acylated surface b HASPB

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I0F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	15	17	PF00082	0.691
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.691
DOC_USP7_UBL2_3	7	11	PF12436	0.770
LIG_SH2_STAT5	4	7	PF00017	0.567
MOD_CK2_1	6	12	PF00069	0.745
MOD_GlcNHglycan	45	48	PF01048	0.642
MOD_GlcNHglycan	8	11	PF01048	0.673
MOD_N-GLC_1	43	48	PF02516	0.604
MOD_NEK2_1	43	48	PF00069	0.604
MOD_NMyristoyl	1	7	PF02799	0.765
MOD_PIKK_1	107	113	PF00454	0.557
MOD_PIKK_1	121	127	PF00454	0.550
MOD_PIKK_1	135	141	PF00454	0.544
MOD_PIKK_1	149	155	PF00454	0.551
MOD_PIKK_1	163	169	PF00454	0.543
MOD_PIKK_1	177	183	PF00454	0.543
MOD_PIKK_1	191	197	PF00454	0.579
MOD_PIKK_1	51	57	PF00454	0.623
MOD_PIKK_1	65	71	PF00454	0.561
MOD_PIKK_1	79	85	PF00454	0.580
MOD_PIKK_1	93	99	PF00454	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB23	Leishmania donovani	85%	90%
A0A3Q8IFV6	Leishmania donovani	62%	100%
E9AWB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	82%
Q4QB56	Leishmania major	61%	100%