Hydrophilic acylated surface protein a

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0F1_LEIIN

TriTrypDb:

LINF_230018500

Length:

131

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 30, 40
Promastigote/Amastigote: 94

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I0F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0F1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.702
CLV_PCSK_KEX2_1	104	106	PF00082	0.569
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.569
LIG_BIR_III_2	9	13	PF00653	0.690
LIG_WRC_WIRS_1	1	6	PF05994	0.684
MOD_N-GLC_1	91	96	PF02516	0.634
MOD_NMyristoyl	1	7	PF02799	0.750
MOD_Plk_1	27	33	PF00069	0.704
MOD_SUMO_for_1	90	93	PF00179	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICK5	Leishmania donovani	90%	100%
A4HCX1	Leishmania braziliensis	35%	87%
E9AWB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QB61	Leishmania major	76%	99%