LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I0E9_LEIIN
TriTrypDb:
LINF_230018300
Length:
232

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0E9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0E9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 203 205 PF00675 0.460
CLV_NRD_NRD_1 28 30 PF00675 0.538
CLV_PCSK_KEX2_1 148 150 PF00082 0.574
CLV_PCSK_KEX2_1 203 205 PF00082 0.459
CLV_PCSK_PC1ET2_1 148 150 PF00082 0.574
CLV_PCSK_SKI1_1 125 129 PF00082 0.522
CLV_PCSK_SKI1_1 15 19 PF00082 0.560
CLV_PCSK_SKI1_1 158 162 PF00082 0.619
DEG_APCC_DBOX_1 148 156 PF00400 0.423
DEG_APCC_DBOX_1 28 36 PF00400 0.463
DOC_MAPK_gen_1 191 200 PF00069 0.622
DOC_MAPK_gen_1 203 211 PF00069 0.406
DOC_MAPK_MEF2A_6 179 186 PF00069 0.554
DOC_USP7_MATH_1 108 112 PF00917 0.483
DOC_USP7_MATH_1 20 24 PF00917 0.550
DOC_USP7_MATH_1 37 41 PF00917 0.327
DOC_USP7_MATH_1 77 81 PF00917 0.618
DOC_USP7_UBL2_3 11 15 PF12436 0.554
DOC_USP7_UBL2_3 125 129 PF12436 0.483
DOC_USP7_UBL2_3 133 137 PF12436 0.492
DOC_USP7_UBL2_3 144 148 PF12436 0.482
DOC_USP7_UBL2_3 158 162 PF12436 0.424
DOC_USP7_UBL2_3 171 175 PF12436 0.508
DOC_WW_Pin1_4 2 7 PF00397 0.801
LIG_14-3-3_CanoR_1 203 209 PF00244 0.564
LIG_14-3-3_CanoR_1 213 223 PF00244 0.495
LIG_14-3-3_CanoR_1 67 73 PF00244 0.523
LIG_14-3-3_CanoR_1 92 99 PF00244 0.730
LIG_Actin_WH2_2 110 127 PF00022 0.534
LIG_APCC_Cbox_2 73 79 PF00515 0.595
LIG_BRCT_BRCA1_1 95 99 PF00533 0.632
LIG_Dynein_DLC8_1 201 207 PF01221 0.394
LIG_FHA_1 112 118 PF00498 0.449
LIG_FHA_1 203 209 PF00498 0.568
LIG_FHA_1 88 94 PF00498 0.600
LIG_FHA_2 68 74 PF00498 0.583
LIG_LIR_Gen_1 196 201 PF02991 0.624
LIG_LIR_Gen_1 220 230 PF02991 0.580
LIG_LIR_Nem_3 103 109 PF02991 0.528
LIG_LIR_Nem_3 196 200 PF02991 0.565
LIG_LIR_Nem_3 220 226 PF02991 0.525
LIG_SH2_NCK_1 24 28 PF00017 0.494
LIG_SH2_STAP1 172 176 PF00017 0.553
LIG_SH2_STAP1 24 28 PF00017 0.481
LIG_SH2_STAT5 31 34 PF00017 0.455
LIG_SUMO_SIM_par_1 59 66 PF11976 0.427
LIG_UBA3_1 127 133 PF00899 0.467
MOD_CK1_1 111 117 PF00069 0.571
MOD_CK1_1 224 230 PF00069 0.570
MOD_CK1_1 23 29 PF00069 0.614
MOD_CK1_1 85 91 PF00069 0.617
MOD_CK2_1 164 170 PF00069 0.506
MOD_CK2_1 37 43 PF00069 0.531
MOD_CK2_1 50 56 PF00069 0.557
MOD_GlcNHglycan 118 121 PF01048 0.507
MOD_GlcNHglycan 25 28 PF01048 0.475
MOD_GlcNHglycan 79 82 PF01048 0.724
MOD_GlcNHglycan 84 87 PF01048 0.792
MOD_GlcNHglycan 95 98 PF01048 0.701
MOD_GSK3_1 111 118 PF00069 0.533
MOD_GSK3_1 147 154 PF00069 0.600
MOD_GSK3_1 217 224 PF00069 0.550
MOD_GSK3_1 77 84 PF00069 0.705
MOD_GSK3_1 87 94 PF00069 0.580
MOD_NEK2_1 76 81 PF00069 0.614
MOD_NEK2_1 93 98 PF00069 0.684
MOD_PIKK_1 202 208 PF00454 0.522
MOD_PIKK_1 50 56 PF00454 0.605
MOD_PKA_1 147 153 PF00069 0.562
MOD_PKA_1 15 21 PF00069 0.509
MOD_PKA_2 178 184 PF00069 0.546
MOD_PKA_2 202 208 PF00069 0.510
MOD_PKA_2 91 97 PF00069 0.685
MOD_Plk_1 38 44 PF00069 0.529
MOD_Plk_2-3 151 157 PF00069 0.508
MOD_Plk_4 204 210 PF00069 0.498
MOD_ProDKin_1 2 8 PF00069 0.784
MOD_SUMO_rev_2 118 127 PF00179 0.537
MOD_SUMO_rev_2 150 160 PF00179 0.595
MOD_SUMO_rev_2 4 13 PF00179 0.676
TRG_DiLeu_BaEn_1 196 201 PF01217 0.575
TRG_DiLeu_BaEn_1 9 14 PF01217 0.591
TRG_ENDOCYTIC_2 223 226 PF00928 0.573
TRG_Pf-PMV_PEXEL_1 191 196 PF00026 0.502
TRG_Pf-PMV_PEXEL_1 50 54 PF00026 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCG3 Leptomonas seymouri 48% 99%
A0A1X0NYD1 Trypanosomatidae 28% 90%
A0A3Q8ICK8 Leishmania donovani 100% 100%
A0A3R7KGK2 Trypanosoma rangeli 25% 100%
A4HCW9 Leishmania braziliensis 59% 100%
E9AWB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4QB63 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS