Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0E8_LEIIN

TriTrypDb:

LINF_230018200

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.869
CLV_C14_Caspase3-7	462	466	PF00656	0.666
CLV_NRD_NRD_1	156	158	PF00675	0.580
CLV_NRD_NRD_1	161	163	PF00675	0.589
CLV_NRD_NRD_1	168	170	PF00675	0.631
CLV_NRD_NRD_1	187	189	PF00675	0.450
CLV_NRD_NRD_1	323	325	PF00675	0.765
CLV_NRD_NRD_1	459	461	PF00675	0.786
CLV_NRD_NRD_1	550	552	PF00675	0.777
CLV_NRD_NRD_1	573	575	PF00675	0.778
CLV_NRD_NRD_1	597	599	PF00675	0.809
CLV_PCSK_FUR_1	595	599	PF00082	0.809
CLV_PCSK_KEX2_1	292	294	PF00082	0.866
CLV_PCSK_KEX2_1	323	325	PF00082	0.672
CLV_PCSK_KEX2_1	459	461	PF00082	0.786
CLV_PCSK_KEX2_1	550	552	PF00082	0.777
CLV_PCSK_KEX2_1	597	599	PF00082	0.808
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.788
CLV_PCSK_SKI1_1	151	155	PF00082	0.619
CLV_PCSK_SKI1_1	163	167	PF00082	0.483
CLV_PCSK_SKI1_1	172	176	PF00082	0.535
CLV_PCSK_SKI1_1	28	32	PF00082	0.510
CLV_PCSK_SKI1_1	464	468	PF00082	0.711
DEG_APCC_DBOX_1	550	558	PF00400	0.738
DEG_Nend_Nbox_1	1	3	PF02207	0.767
DEG_SCF_TRCP1_1	254	260	PF00400	0.693
DEG_SCF_TRCP1_1	343	348	PF00400	0.702
DEG_SPOP_SBC_1	431	435	PF00917	0.740
DEG_SPOP_SBC_1	582	586	PF00917	0.770
DOC_CDC14_PxL_1	497	505	PF14671	0.653
DOC_MAPK_DCC_7	558	567	PF00069	0.748
DOC_MAPK_gen_1	274	282	PF00069	0.684
DOC_MAPK_gen_1	28	37	PF00069	0.541
DOC_MAPK_gen_1	323	330	PF00069	0.707
DOC_MAPK_gen_1	550	557	PF00069	0.763
DOC_USP7_MATH_1	304	308	PF00917	0.718
DOC_USP7_MATH_1	578	582	PF00917	0.826
DOC_USP7_MATH_1	583	587	PF00917	0.736
DOC_USP7_MATH_1	641	645	PF00917	0.849
DOC_USP7_MATH_1	9	13	PF00917	0.646
DOC_USP7_UBL2_3	147	151	PF12436	0.624
DOC_USP7_UBL2_3	166	170	PF12436	0.428
DOC_USP7_UBL2_3	178	182	PF12436	0.492
DOC_USP7_UBL2_3	602	606	PF12436	0.764
DOC_WW_Pin1_4	286	291	PF00397	0.722
DOC_WW_Pin1_4	295	300	PF00397	0.696
DOC_WW_Pin1_4	3	8	PF00397	0.717
DOC_WW_Pin1_4	354	359	PF00397	0.802
DOC_WW_Pin1_4	364	369	PF00397	0.801
DOC_WW_Pin1_4	392	397	PF00397	0.754
DOC_WW_Pin1_4	427	432	PF00397	0.736
DOC_WW_Pin1_4	720	725	PF00397	0.782
DOC_WW_Pin1_4	744	749	PF00397	0.710
LIG_14-3-3_CanoR_1	172	181	PF00244	0.702
LIG_14-3-3_CanoR_1	370	374	PF00244	0.751
LIG_14-3-3_CanoR_1	384	391	PF00244	0.625
LIG_14-3-3_CanoR_1	39	47	PF00244	0.662
LIG_14-3-3_CanoR_1	550	555	PF00244	0.823
LIG_14-3-3_CanoR_1	579	587	PF00244	0.844
LIG_14-3-3_CanoR_1	632	642	PF00244	0.819
LIG_Actin_WH2_2	118	136	PF00022	0.664
LIG_BIR_III_2	410	414	PF00653	0.761
LIG_BRCT_BRCA1_1	312	316	PF00533	0.712
LIG_BRCT_BRCA1_1	398	402	PF00533	0.653
LIG_Clathr_ClatBox_1	562	566	PF01394	0.837
LIG_CtBP_PxDLS_1	675	679	PF00389	0.742
LIG_DLG_GKlike_1	550	557	PF00625	0.646
LIG_FHA_1	137	143	PF00498	0.554
LIG_FHA_1	226	232	PF00498	0.536
LIG_FHA_1	470	476	PF00498	0.755
LIG_FHA_1	550	556	PF00498	0.768
LIG_FHA_1	582	588	PF00498	0.773
LIG_FHA_1	671	677	PF00498	0.653
LIG_FHA_1	703	709	PF00498	0.685
LIG_FHA_2	201	207	PF00498	0.584
LIG_FHA_2	217	223	PF00498	0.361
LIG_FHA_2	431	437	PF00498	0.863
LIG_FHA_2	469	475	PF00498	0.765
LIG_LIR_Gen_1	202	213	PF02991	0.558
LIG_LIR_Gen_1	221	231	PF02991	0.348
LIG_LIR_Gen_1	348	358	PF02991	0.714
LIG_LIR_Gen_1	57	65	PF02991	0.597
LIG_LIR_Gen_1	77	87	PF02991	0.424
LIG_LIR_Nem_3	112	117	PF02991	0.521
LIG_LIR_Nem_3	154	159	PF02991	0.507
LIG_LIR_Nem_3	202	208	PF02991	0.560
LIG_LIR_Nem_3	313	319	PF02991	0.685
LIG_LIR_Nem_3	348	354	PF02991	0.714
LIG_LIR_Nem_3	57	61	PF02991	0.589
LIG_LIR_Nem_3	77	82	PF02991	0.445
LIG_NRBOX	258	264	PF00104	0.717
LIG_PDZ_Class_1	744	749	PF00595	0.738
LIG_SH2_CRK	351	355	PF00017	0.718
LIG_SH2_GRB2like	320	323	PF00017	0.752
LIG_SH2_NCK_1	386	390	PF00017	0.781
LIG_SH2_SRC	329	332	PF00017	0.718
LIG_SH2_STAP1	14	18	PF00017	0.598
LIG_SH2_STAP1	194	198	PF00017	0.543
LIG_SH2_STAP1	205	209	PF00017	0.446
LIG_SH2_STAT3	180	183	PF00017	0.603
LIG_SH2_STAT3	416	419	PF00017	0.668
LIG_SH2_STAT5	167	170	PF00017	0.629
LIG_SH2_STAT5	180	183	PF00017	0.544
LIG_SH2_STAT5	214	217	PF00017	0.550
LIG_SH2_STAT5	230	233	PF00017	0.427
LIG_SH2_STAT5	329	332	PF00017	0.745
LIG_SH2_STAT5	36	39	PF00017	0.627
LIG_SH2_STAT5	416	419	PF00017	0.765
LIG_SH2_STAT5	79	82	PF00017	0.765
LIG_SH3_3	388	394	PF00018	0.758
LIG_SH3_3	397	403	PF00018	0.746
LIG_SH3_3	486	492	PF00018	0.750
LIG_SH3_3	496	502	PF00018	0.743
LIG_SH3_3	584	590	PF00018	0.776
LIG_SH3_CIN85_PxpxPR_1	403	408	PF14604	0.646
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.558
LIG_SUMO_SIM_par_1	563	571	PF11976	0.796
LIG_UBA3_1	105	109	PF00899	0.572
LIG_UBA3_1	554	558	PF00899	0.717
LIG_WRC_WIRS_1	198	203	PF05994	0.562
LIG_WRC_WIRS_1	79	84	PF05994	0.755
MOD_CDC14_SPxK_1	303	306	PF00782	0.640
MOD_CDK_SPxK_1	286	292	PF00069	0.785
MOD_CDK_SPxK_1	295	301	PF00069	0.715
MOD_CDK_SPxK_1	354	360	PF00069	0.891
MOD_CDK_SPxK_1	364	370	PF00069	0.710
MOD_CDK_SPxxK_3	286	293	PF00069	0.848
MOD_CK1_1	286	292	PF00069	0.767
MOD_CK1_1	344	350	PF00069	0.804
MOD_CK1_1	364	370	PF00069	0.876
MOD_CK1_1	427	433	PF00069	0.768
MOD_CK1_1	49	55	PF00069	0.613
MOD_CK1_1	553	559	PF00069	0.742
MOD_CK1_1	568	574	PF00069	0.707
MOD_CK1_1	581	587	PF00069	0.785
MOD_CK1_1	631	637	PF00069	0.799
MOD_CK1_1	709	715	PF00069	0.883
MOD_CK2_1	158	164	PF00069	0.638
MOD_CK2_1	200	206	PF00069	0.542
MOD_CK2_1	384	390	PF00069	0.855
MOD_CK2_1	468	474	PF00069	0.767
MOD_CK2_1	54	60	PF00069	0.551
MOD_Cter_Amidation	457	460	PF01082	0.788
MOD_DYRK1A_RPxSP_1	744	748	PF00069	0.649
MOD_GlcNHglycan	101	104	PF01048	0.590
MOD_GlcNHglycan	254	257	PF01048	0.765
MOD_GlcNHglycan	343	346	PF01048	0.839
MOD_GlcNHglycan	354	357	PF01048	0.582
MOD_GlcNHglycan	374	377	PF01048	0.725
MOD_GlcNHglycan	386	389	PF01048	0.648
MOD_GlcNHglycan	455	459	PF01048	0.650
MOD_GlcNHglycan	461	464	PF01048	0.623
MOD_GlcNHglycan	535	538	PF01048	0.718
MOD_GlcNHglycan	580	583	PF01048	0.775
MOD_GlcNHglycan	621	624	PF01048	0.888
MOD_GlcNHglycan	688	691	PF01048	0.772
MOD_GlcNHglycan	708	711	PF01048	0.548
MOD_GlcNHglycan	71	74	PF01048	0.696
MOD_GSK3_1	113	120	PF00069	0.591
MOD_GSK3_1	200	207	PF00069	0.577
MOD_GSK3_1	225	232	PF00069	0.592
MOD_GSK3_1	282	289	PF00069	0.723
MOD_GSK3_1	3	10	PF00069	0.704
MOD_GSK3_1	300	307	PF00069	0.632
MOD_GSK3_1	310	317	PF00069	0.773
MOD_GSK3_1	341	348	PF00069	0.830
MOD_GSK3_1	350	357	PF00069	0.768
MOD_GSK3_1	380	387	PF00069	0.736
MOD_GSK3_1	392	399	PF00069	0.626
MOD_GSK3_1	427	434	PF00069	0.822
MOD_GSK3_1	464	471	PF00069	0.868
MOD_GSK3_1	545	552	PF00069	0.742
MOD_GSK3_1	577	584	PF00069	0.817
MOD_GSK3_1	585	592	PF00069	0.700
MOD_GSK3_1	626	633	PF00069	0.793
MOD_GSK3_1	65	72	PF00069	0.617
MOD_GSK3_1	670	677	PF00069	0.852
MOD_GSK3_1	702	709	PF00069	0.739
MOD_GSK3_1	720	727	PF00069	0.853
MOD_GSK3_1	738	745	PF00069	0.555
MOD_N-GLC_1	117	122	PF02516	0.661
MOD_N-GLC_1	283	288	PF02516	0.736
MOD_N-GLC_1	314	319	PF02516	0.782
MOD_N-GLC_1	364	369	PF02516	0.876
MOD_N-GLC_1	65	70	PF02516	0.587
MOD_NEK2_1	174	179	PF00069	0.609
MOD_NEK2_1	283	288	PF00069	0.749
MOD_NEK2_1	424	429	PF00069	0.799
MOD_NEK2_1	630	635	PF00069	0.770
MOD_NEK2_1	642	647	PF00069	0.788
MOD_NEK2_1	683	688	PF00069	0.779
MOD_NEK2_1	715	720	PF00069	0.799
MOD_NEK2_1	86	91	PF00069	0.632
MOD_NEK2_2	117	122	PF00069	0.661
MOD_PIKK_1	38	44	PF00454	0.659
MOD_PIKK_1	589	595	PF00454	0.778
MOD_PIKK_1	633	639	PF00454	0.886
MOD_PIKK_1	709	715	PF00454	0.766
MOD_PIKK_1	738	744	PF00454	0.852
MOD_PKA_1	151	157	PF00069	0.599
MOD_PKA_1	459	465	PF00069	0.796
MOD_PKA_1	550	556	PF00069	0.765
MOD_PKA_2	369	375	PF00069	0.778
MOD_PKA_2	38	44	PF00069	0.659
MOD_PKA_2	459	465	PF00069	0.831
MOD_PKA_2	469	475	PF00069	0.737
MOD_PKA_2	549	555	PF00069	0.743
MOD_PKA_2	578	584	PF00069	0.825
MOD_PKA_2	631	637	PF00069	0.785
MOD_Plk_1	117	123	PF00069	0.590
MOD_Plk_1	314	320	PF00069	0.652
MOD_Plk_1	473	479	PF00069	0.759
MOD_Plk_1	568	574	PF00069	0.803
MOD_Plk_1	626	632	PF00069	0.796
MOD_Plk_1	642	648	PF00069	0.788
MOD_Plk_1	738	744	PF00069	0.852
MOD_Plk_4	204	210	PF00069	0.668
MOD_Plk_4	225	231	PF00069	0.496
MOD_Plk_4	315	321	PF00069	0.642
MOD_Plk_4	49	55	PF00069	0.554
MOD_Plk_4	550	556	PF00069	0.777
MOD_Plk_4	96	102	PF00069	0.575
MOD_ProDKin_1	286	292	PF00069	0.725
MOD_ProDKin_1	295	301	PF00069	0.695
MOD_ProDKin_1	3	9	PF00069	0.713
MOD_ProDKin_1	354	360	PF00069	0.801
MOD_ProDKin_1	364	370	PF00069	0.800
MOD_ProDKin_1	392	398	PF00069	0.756
MOD_ProDKin_1	427	433	PF00069	0.737
MOD_ProDKin_1	720	726	PF00069	0.781
MOD_SUMO_for_1	146	149	PF00179	0.590
MOD_SUMO_rev_2	141	148	PF00179	0.681
MOD_SUMO_rev_2	161	168	PF00179	0.361
MOD_SUMO_rev_2	191	198	PF00179	0.572
TRG_DiLeu_BaEn_1	204	209	PF01217	0.549
TRG_DiLeu_BaEn_1	21	26	PF01217	0.641
TRG_ENDOCYTIC_2	205	208	PF00928	0.465
TRG_ENDOCYTIC_2	351	354	PF00928	0.721
TRG_ENDOCYTIC_2	58	61	PF00928	0.534
TRG_ENDOCYTIC_2	79	82	PF00928	0.765
TRG_ER_diArg_1	595	598	PF00400	0.779
TRG_NLS_Bipartite_1	151	173	PF00514	0.613
TRG_NLS_MonoExtC_3	168	173	PF00514	0.602
TRG_NLS_MonoExtN_4	166	173	PF00514	0.606
TRG_NLS_MonoExtN_4	598	605	PF00514	0.864
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.788
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R4	Leptomonas seymouri	40%	99%
A0A3Q8ICQ5	Leishmania donovani	99%	100%
A4HCW8	Leishmania braziliensis	60%	100%
E9AWB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QB64	Leishmania major	93%	100%