Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0E6_LEIIN

TriTrypDb:

LINF_230018000

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.583
CLV_C14_Caspase3-7	173	177	PF00656	0.563
CLV_C14_Caspase3-7	182	186	PF00656	0.493
CLV_C14_Caspase3-7	332	336	PF00656	0.619
CLV_NRD_NRD_1	288	290	PF00675	0.478
CLV_NRD_NRD_1	291	293	PF00675	0.497
CLV_NRD_NRD_1	339	341	PF00675	0.662
CLV_NRD_NRD_1	374	376	PF00675	0.582
CLV_PCSK_FUR_1	289	293	PF00082	0.465
CLV_PCSK_KEX2_1	290	292	PF00082	0.490
CLV_PCSK_KEX2_1	306	308	PF00082	0.603
CLV_PCSK_KEX2_1	339	341	PF00082	0.676
CLV_PCSK_KEX2_1	374	376	PF00082	0.582
CLV_PCSK_KEX2_1	383	385	PF00082	0.603
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.465
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.603
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.637
CLV_PCSK_SKI1_1	258	262	PF00082	0.413
CLV_PCSK_SKI1_1	278	282	PF00082	0.416
CLV_PCSK_SKI1_1	291	295	PF00082	0.511
CLV_PCSK_SKI1_1	370	374	PF00082	0.502
CLV_PCSK_SKI1_1	46	50	PF00082	0.356
CLV_Separin_Fungi	326	332	PF03568	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DOC_MAPK_gen_1	254	261	PF00069	0.402
DOC_MAPK_gen_1	289	296	PF00069	0.481
DOC_PP2B_LxvP_1	71	74	PF13499	0.463
DOC_USP7_MATH_1	202	206	PF00917	0.578
DOC_USP7_MATH_1	216	220	PF00917	0.374
DOC_USP7_MATH_1	228	232	PF00917	0.374
DOC_USP7_MATH_1	271	275	PF00917	0.458
DOC_USP7_MATH_1	321	325	PF00917	0.684
DOC_USP7_MATH_1	378	382	PF00917	0.586
DOC_WW_Pin1_4	11	16	PF00397	0.588
DOC_WW_Pin1_4	144	149	PF00397	0.602
DOC_WW_Pin1_4	301	306	PF00397	0.591
LIG_14-3-3_CanoR_1	171	175	PF00244	0.576
LIG_14-3-3_CanoR_1	377	385	PF00244	0.602
LIG_14-3-3_CanoR_1	6	16	PF00244	0.532
LIG_BIR_III_2	92	96	PF00653	0.408
LIG_BIR_III_4	335	339	PF00653	0.614
LIG_DCNL_PONY_1	1	4	PF03556	0.652
LIG_deltaCOP1_diTrp_1	308	315	PF00928	0.618
LIG_eIF4E_1	44	50	PF01652	0.374
LIG_FHA_1	12	18	PF00498	0.572
LIG_FHA_1	45	51	PF00498	0.381
LIG_FHA_2	106	112	PF00498	0.601
LIG_FHA_2	349	355	PF00498	0.519
LIG_FHA_2	81	87	PF00498	0.430
LIG_Integrin_RGD_1	345	347	PF01839	0.612
LIG_LIR_Gen_1	39	50	PF02991	0.418
LIG_LIR_Nem_3	10	16	PF02991	0.489
LIG_LIR_Nem_3	309	315	PF02991	0.621
LIG_LIR_Nem_3	382	388	PF02991	0.592
LIG_LIR_Nem_3	39	45	PF02991	0.441
LIG_LYPXL_SIV_4	41	49	PF13949	0.374
LIG_NRBOX	67	73	PF00104	0.419
LIG_SH2_CRK	13	17	PF00017	0.540
LIG_SH2_CRK	239	243	PF00017	0.366
LIG_SH2_CRK	38	42	PF00017	0.474
LIG_SH2_NCK_1	38	42	PF00017	0.434
LIG_SH2_PTP2	42	45	PF00017	0.378
LIG_SH2_SRC	42	45	PF00017	0.378
LIG_SH2_SRC	64	67	PF00017	0.378
LIG_SH2_STAP1	31	35	PF00017	0.470
LIG_SH2_STAT5	13	16	PF00017	0.616
LIG_SH2_STAT5	143	146	PF00017	0.543
LIG_SH2_STAT5	42	45	PF00017	0.410
LIG_SH2_STAT5	64	67	PF00017	0.429
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.400
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.410
LIG_TRAF2_1	280	283	PF00917	0.414
LIG_TRAF2_1	359	362	PF00917	0.566
LIG_TYR_ITIM	237	242	PF00017	0.354
LIG_UBA3_1	295	303	PF00899	0.531
LIG_WRC_WIRS_1	220	225	PF05994	0.418
MOD_CDK_SPK_2	301	306	PF00069	0.522
MOD_CDK_SPxK_1	301	307	PF00069	0.597
MOD_CK1_1	131	137	PF00069	0.564
MOD_CK1_1	146	152	PF00069	0.583
MOD_CK1_1	166	172	PF00069	0.598
MOD_CK1_1	219	225	PF00069	0.463
MOD_CK1_1	29	35	PF00069	0.496
MOD_CK1_1	5	11	PF00069	0.543
MOD_CK1_1	75	81	PF00069	0.508
MOD_CK2_1	105	111	PF00069	0.623
MOD_CK2_1	202	208	PF00069	0.502
MOD_CK2_1	249	255	PF00069	0.388
MOD_CK2_1	271	277	PF00069	0.343
MOD_CK2_1	348	354	PF00069	0.526
MOD_CK2_1	80	86	PF00069	0.439
MOD_Cter_Amidation	337	340	PF01082	0.675
MOD_GlcNHglycan	100	103	PF01048	0.754
MOD_GlcNHglycan	224	227	PF01048	0.513
MOD_GlcNHglycan	251	254	PF01048	0.423
MOD_GlcNHglycan	269	272	PF01048	0.488
MOD_GlcNHglycan	31	34	PF01048	0.484
MOD_GlcNHglycan	319	322	PF01048	0.774
MOD_GlcNHglycan	331	334	PF01048	0.609
MOD_GSK3_1	127	134	PF00069	0.623
MOD_GSK3_1	166	173	PF00069	0.577
MOD_GSK3_1	22	29	PF00069	0.453
MOD_GSK3_1	224	231	PF00069	0.470
MOD_GSK3_1	267	274	PF00069	0.352
MOD_GSK3_1	313	320	PF00069	0.657
MOD_GSK3_1	7	14	PF00069	0.619
MOD_N-GLC_1	301	306	PF02516	0.667
MOD_N-GLC_1	80	85	PF02516	0.430
MOD_NEK2_1	2	7	PF00069	0.568
MOD_NEK2_1	22	27	PF00069	0.407
MOD_NEK2_1	261	266	PF00069	0.405
MOD_NEK2_1	50	55	PF00069	0.384
MOD_PIKK_1	271	277	PF00454	0.343
MOD_PIKK_1	75	81	PF00454	0.470
MOD_PK_1	284	290	PF00069	0.435
MOD_PKA_2	170	176	PF00069	0.646
MOD_PKA_2	379	385	PF00069	0.595
MOD_PKA_2	5	11	PF00069	0.535
MOD_Plk_2-3	128	134	PF00069	0.592
MOD_Plk_4	216	222	PF00069	0.487
MOD_Plk_4	22	28	PF00069	0.480
MOD_Plk_4	368	374	PF00069	0.562
MOD_Plk_4	44	50	PF00069	0.358
MOD_ProDKin_1	11	17	PF00069	0.580
MOD_ProDKin_1	144	150	PF00069	0.606
MOD_ProDKin_1	301	307	PF00069	0.593
TRG_DiLeu_BaEn_1	257	262	PF01217	0.397
TRG_DiLeu_BaEn_2	85	91	PF01217	0.399
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.544
TRG_ENDOCYTIC_2	13	16	PF00928	0.497
TRG_ENDOCYTIC_2	239	242	PF00928	0.359
TRG_ENDOCYTIC_2	385	388	PF00928	0.660
TRG_ENDOCYTIC_2	42	45	PF00928	0.378
TRG_ER_diArg_1	288	291	PF00400	0.452
TRG_ER_diArg_1	373	375	PF00400	0.490
TRG_NLS_MonoCore_2	288	293	PF00514	0.459
TRG_NLS_MonoExtN_4	289	294	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP9	Leptomonas seymouri	52%	100%
A0A3S5H7C1	Leishmania donovani	98%	99%
A4HCW6	Leishmania braziliensis	71%	99%
E9AWA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QB66	Leishmania major	90%	100%