Cadherin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Chitobiase/beta-hexosaminidase C-terminal domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I0E5_LEIIN

TriTrypDb:

LINF_230017900

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I0E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.602
CLV_C14_Caspase3-7	50	54	PF00656	0.672
CLV_C14_Caspase3-7	650	654	PF00656	0.651
CLV_NRD_NRD_1	244	246	PF00675	0.554
CLV_NRD_NRD_1	350	352	PF00675	0.457
CLV_NRD_NRD_1	37	39	PF00675	0.395
CLV_NRD_NRD_1	44	46	PF00675	0.445
CLV_NRD_NRD_1	445	447	PF00675	0.480
CLV_NRD_NRD_1	521	523	PF00675	0.489
CLV_PCSK_FUR_1	35	39	PF00082	0.448
CLV_PCSK_FUR_1	41	45	PF00082	0.480
CLV_PCSK_KEX2_1	244	246	PF00082	0.531
CLV_PCSK_KEX2_1	35	37	PF00082	0.394
CLV_PCSK_KEX2_1	350	352	PF00082	0.425
CLV_PCSK_KEX2_1	43	45	PF00082	0.434
CLV_PCSK_KEX2_1	445	447	PF00082	0.474
CLV_PCSK_KEX2_1	520	522	PF00082	0.497
CLV_PCSK_SKI1_1	390	394	PF00082	0.448
CLV_PCSK_SKI1_1	446	450	PF00082	0.484
CLV_PCSK_SKI1_1	49	53	PF00082	0.496
CLV_PCSK_SKI1_1	510	514	PF00082	0.483
CLV_PCSK_SKI1_1	547	551	PF00082	0.409
CLV_PCSK_SKI1_1	643	647	PF00082	0.360
DEG_COP1_1	401	410	PF00400	0.643
DEG_SIAH_1	271	279	PF03145	0.730
DEG_SPOP_SBC_1	299	303	PF00917	0.651
DOC_CKS1_1	110	115	PF01111	0.631
DOC_CKS1_1	306	311	PF01111	0.698
DOC_CKS1_1	407	412	PF01111	0.660
DOC_CYCLIN_RxL_1	38	52	PF00134	0.657
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.720
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	533	536	PF00134	0.634
DOC_MAPK_gen_1	36	48	PF00069	0.648
DOC_MAPK_MEF2A_6	6	14	PF00069	0.364
DOC_MAPK_RevD_3	22	36	PF00069	0.394
DOC_PP1_RVXF_1	444	451	PF00149	0.687
DOC_PP1_RVXF_1	545	551	PF00149	0.574
DOC_PP2B_LxvP_1	211	214	PF13499	0.748
DOC_PP2B_LxvP_1	338	341	PF13499	0.597
DOC_PP2B_LxvP_1	533	536	PF13499	0.567
DOC_PP2B_PxIxI_1	536	542	PF00149	0.542
DOC_PP4_FxxP_1	110	113	PF00568	0.623
DOC_PP4_FxxP_1	172	175	PF00568	0.547
DOC_PP4_FxxP_1	550	553	PF00568	0.548
DOC_USP7_MATH_1	105	109	PF00917	0.644
DOC_USP7_MATH_1	226	230	PF00917	0.819
DOC_USP7_MATH_1	408	412	PF00917	0.601
DOC_WW_Pin1_4	100	105	PF00397	0.557
DOC_WW_Pin1_4	109	114	PF00397	0.566
DOC_WW_Pin1_4	209	214	PF00397	0.783
DOC_WW_Pin1_4	261	266	PF00397	0.794
DOC_WW_Pin1_4	290	295	PF00397	0.622
DOC_WW_Pin1_4	305	310	PF00397	0.541
DOC_WW_Pin1_4	312	317	PF00397	0.620
DOC_WW_Pin1_4	406	411	PF00397	0.645
DOC_WW_Pin1_4	571	576	PF00397	0.667
DOC_WW_Pin1_4	605	610	PF00397	0.769
LIG_14-3-3_CanoR_1	320	324	PF00244	0.566
LIG_14-3-3_CanoR_1	337	341	PF00244	0.649
LIG_14-3-3_CanoR_1	384	388	PF00244	0.654
LIG_14-3-3_CanoR_1	413	423	PF00244	0.597
LIG_14-3-3_CanoR_1	498	503	PF00244	0.574
LIG_14-3-3_CanoR_1	510	518	PF00244	0.598
LIG_14-3-3_CanoR_1	558	564	PF00244	0.618
LIG_BIR_III_4	281	285	PF00653	0.659
LIG_BIR_III_4	62	66	PF00653	0.726
LIG_CaM_IQ_9	30	46	PF13499	0.442
LIG_Clathr_ClatBox_1	133	137	PF01394	0.586
LIG_Clathr_ClatBox_1	438	442	PF01394	0.609
LIG_eIF4E_1	159	165	PF01652	0.597
LIG_FHA_1	110	116	PF00498	0.588
LIG_FHA_1	165	171	PF00498	0.580
LIG_FHA_1	210	216	PF00498	0.792
LIG_FHA_1	233	239	PF00498	0.779
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_1	258	264	PF00498	0.768
LIG_FHA_1	301	307	PF00498	0.572
LIG_FHA_1	430	436	PF00498	0.557
LIG_FHA_1	464	470	PF00498	0.671
LIG_FHA_1	633	639	PF00498	0.585
LIG_FHA_2	222	228	PF00498	0.803
LIG_FHA_2	299	305	PF00498	0.624
LIG_FHA_2	306	312	PF00498	0.588
LIG_FHA_2	432	438	PF00498	0.622
LIG_FHA_2	560	566	PF00498	0.647
LIG_FHA_2	629	635	PF00498	0.688
LIG_GBD_Chelix_1	22	30	PF00786	0.394
LIG_Integrin_isoDGR_2	488	490	PF01839	0.427
LIG_Integrin_isoDGR_2	556	558	PF01839	0.421
LIG_LIR_Apic_2	108	113	PF02991	0.630
LIG_LIR_Apic_2	171	175	PF02991	0.587
LIG_LIR_Apic_2	329	335	PF02991	0.574
LIG_LIR_Apic_2	401	405	PF02991	0.569
LIG_LIR_Gen_1	434	444	PF02991	0.588
LIG_LIR_LC3C_4	112	116	PF02991	0.601
LIG_LIR_Nem_3	161	166	PF02991	0.556
LIG_LIR_Nem_3	27	32	PF02991	0.454
LIG_LIR_Nem_3	324	330	PF02991	0.581
LIG_LIR_Nem_3	434	439	PF02991	0.573
LIG_LYPXL_yS_3	327	330	PF13949	0.609
LIG_MYND_1	213	217	PF01753	0.719
LIG_Pex14_2	645	649	PF04695	0.598
LIG_Pex14_2	682	686	PF04695	0.539
LIG_Pex14_2	86	90	PF04695	0.622
LIG_PTB_Apo_2	152	159	PF02174	0.688
LIG_PTB_Phospho_1	152	158	PF10480	0.694
LIG_RPA_C_Fungi	239	251	PF08784	0.674
LIG_RPA_C_Fungi	31	43	PF08784	0.530
LIG_SH2_CRK	166	170	PF00017	0.531
LIG_SH2_CRK	332	336	PF00017	0.439
LIG_SH2_CRK	678	682	PF00017	0.533
LIG_SH2_GRB2like	58	61	PF00017	0.613
LIG_SH2_GRB2like	687	690	PF00017	0.599
LIG_SH2_NCK_1	332	336	PF00017	0.591
LIG_SH2_NCK_1	436	440	PF00017	0.528
LIG_SH2_SRC	225	228	PF00017	0.726
LIG_SH2_SRC	622	625	PF00017	0.566
LIG_SH2_STAP1	436	440	PF00017	0.524
LIG_SH2_STAT3	178	181	PF00017	0.550
LIG_SH2_STAT3	620	623	PF00017	0.491
LIG_SH2_STAT5	117	120	PF00017	0.479
LIG_SH2_STAT5	126	129	PF00017	0.558
LIG_SH2_STAT5	166	169	PF00017	0.442
LIG_SH2_STAT5	200	203	PF00017	0.486
LIG_SH2_STAT5	332	335	PF00017	0.441
LIG_SH2_STAT5	402	405	PF00017	0.533
LIG_SH2_STAT5	422	425	PF00017	0.453
LIG_SH2_STAT5	47	50	PF00017	0.675
LIG_SH2_STAT5	561	564	PF00017	0.435
LIG_SH2_STAT5	620	623	PF00017	0.536
LIG_SH2_STAT5	639	642	PF00017	0.419
LIG_SH2_STAT5	687	690	PF00017	0.599
LIG_SH3_1	402	408	PF00018	0.595
LIG_SH3_3	210	216	PF00018	0.750
LIG_SH3_3	260	266	PF00018	0.769
LIG_SH3_3	283	289	PF00018	0.549
LIG_SH3_3	303	309	PF00018	0.299
LIG_SH3_3	402	408	PF00018	0.453
LIG_SH3_3	570	576	PF00018	0.482
LIG_SH3_3	641	647	PF00018	0.431
LIG_SH3_3	69	75	PF00018	0.671
LIG_Sin3_3	391	398	PF02671	0.486
LIG_SUMO_SIM_par_1	131	137	PF11976	0.481
LIG_SUMO_SIM_par_1	20	25	PF11976	0.473
LIG_SUMO_SIM_par_1	461	467	PF11976	0.572
LIG_TRAF2_1	94	97	PF00917	0.555
LIG_TYR_ITIM	115	120	PF00017	0.471
LIG_TYR_ITSM	432	439	PF00017	0.529
LIG_WRC_WIRS_1	48	53	PF05994	0.603
LIG_WW_2	213	216	PF00397	0.665
MOD_CDK_SPxxK_3	406	413	PF00069	0.563
MOD_CK1_1	103	109	PF00069	0.566
MOD_CK1_1	142	148	PF00069	0.651
MOD_CK1_1	209	215	PF00069	0.741
MOD_CK1_1	326	332	PF00069	0.457
MOD_CK1_1	375	381	PF00069	0.657
MOD_CK1_1	386	392	PF00069	0.411
MOD_CK2_1	221	227	PF00069	0.786
MOD_CK2_1	290	296	PF00069	0.585
MOD_CK2_1	298	304	PF00069	0.543
MOD_CK2_1	305	311	PF00069	0.507
MOD_CK2_1	431	437	PF00069	0.509
MOD_CK2_1	539	545	PF00069	0.500
MOD_CK2_1	628	634	PF00069	0.607
MOD_DYRK1A_RPxSP_1	406	410	PF00069	0.381
MOD_GlcNHglycan	105	108	PF01048	0.613
MOD_GlcNHglycan	208	211	PF01048	0.708
MOD_GlcNHglycan	229	232	PF01048	0.721
MOD_GlcNHglycan	272	275	PF01048	0.781
MOD_GlcNHglycan	277	281	PF01048	0.736
MOD_GlcNHglycan	369	373	PF01048	0.689
MOD_GlcNHglycan	374	377	PF01048	0.656
MOD_GlcNHglycan	381	384	PF01048	0.553
MOD_GlcNHglycan	417	420	PF01048	0.396
MOD_GlcNHglycan	479	482	PF01048	0.595
MOD_GlcNHglycan	669	672	PF01048	0.645
MOD_GlcNHglycan	80	83	PF01048	0.651
MOD_GSK3_1	105	112	PF00069	0.529
MOD_GSK3_1	142	149	PF00069	0.610
MOD_GSK3_1	205	212	PF00069	0.656
MOD_GSK3_1	257	264	PF00069	0.759
MOD_GSK3_1	272	279	PF00069	0.737
MOD_GSK3_1	319	326	PF00069	0.466
MOD_GSK3_1	341	348	PF00069	0.629
MOD_GSK3_1	368	375	PF00069	0.690
MOD_GSK3_1	379	386	PF00069	0.556
MOD_GSK3_1	473	480	PF00069	0.541
MOD_GSK3_1	506	513	PF00069	0.556
MOD_GSK3_1	559	566	PF00069	0.429
MOD_GSK3_1	628	635	PF00069	0.486
MOD_GSK3_1	63	70	PF00069	0.742
MOD_GSK3_1	663	670	PF00069	0.680
MOD_N-GLC_1	232	237	PF02516	0.741
MOD_N-GLC_1	563	568	PF02516	0.543
MOD_NEK2_1	139	144	PF00069	0.645
MOD_NEK2_1	164	169	PF00069	0.491
MOD_NEK2_1	257	262	PF00069	0.815
MOD_NEK2_1	323	328	PF00069	0.467
MOD_NEK2_1	330	335	PF00069	0.428
MOD_NEK2_1	336	341	PF00069	0.431
MOD_NEK2_1	414	419	PF00069	0.510
MOD_NEK2_1	632	637	PF00069	0.627
MOD_NEK2_1	78	83	PF00069	0.696
MOD_PIKK_1	147	153	PF00454	0.484
MOD_PIKK_1	345	351	PF00454	0.606
MOD_PIKK_1	429	435	PF00454	0.507
MOD_PIKK_1	632	638	PF00454	0.605
MOD_PK_1	498	504	PF00069	0.565
MOD_PKA_2	139	145	PF00069	0.669
MOD_PKA_2	319	325	PF00069	0.449
MOD_PKA_2	336	342	PF00069	0.607
MOD_PKA_2	383	389	PF00069	0.581
MOD_PKA_2	414	420	PF00069	0.607
MOD_PKB_1	413	421	PF00069	0.392
MOD_Plk_1	233	239	PF00069	0.736
MOD_Plk_4	24	30	PF00069	0.422
MOD_Plk_4	326	332	PF00069	0.432
MOD_Plk_4	341	347	PF00069	0.529
MOD_Plk_4	383	389	PF00069	0.484
MOD_Plk_4	398	404	PF00069	0.435
MOD_Plk_4	417	423	PF00069	0.536
MOD_Plk_4	431	437	PF00069	0.479
MOD_Plk_4	616	622	PF00069	0.454
MOD_Plk_4	628	634	PF00069	0.454
MOD_Plk_4	68	74	PF00069	0.650
MOD_ProDKin_1	100	106	PF00069	0.446
MOD_ProDKin_1	109	115	PF00069	0.453
MOD_ProDKin_1	209	215	PF00069	0.758
MOD_ProDKin_1	261	267	PF00069	0.771
MOD_ProDKin_1	290	296	PF00069	0.537
MOD_ProDKin_1	305	311	PF00069	0.428
MOD_ProDKin_1	312	318	PF00069	0.522
MOD_ProDKin_1	406	412	PF00069	0.558
MOD_ProDKin_1	571	577	PF00069	0.584
MOD_ProDKin_1	605	611	PF00069	0.725
MOD_SUMO_rev_2	542	549	PF00179	0.485
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.791
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.539
TRG_ENDOCYTIC_2	117	120	PF00928	0.522
TRG_ENDOCYTIC_2	327	330	PF00928	0.483
TRG_ENDOCYTIC_2	436	439	PF00928	0.411
TRG_ENDOCYTIC_2	678	681	PF00928	0.513
TRG_ENDOCYTIC_2	87	90	PF00928	0.480
TRG_ER_diArg_1	118	121	PF00400	0.527
TRG_ER_diArg_1	35	38	PF00400	0.514
TRG_ER_diArg_1	41	44	PF00400	0.547
TRG_ER_diArg_1	412	415	PF00400	0.531
TRG_ER_diArg_1	520	522	PF00400	0.654
TRG_NLS_MonoExtN_4	445	450	PF00514	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q7	Leptomonas seymouri	54%	100%
A0A1X0NWT3	Trypanosomatidae	33%	100%
A0A3Q8IM61	Leishmania donovani	100%	100%
A0A3R7NT57	Trypanosoma rangeli	34%	100%
A4HCW5	Leishmania braziliensis	73%	98%
C9ZV90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AWA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QB67	Leishmania major	92%	100%
V5BEP2	Trypanosoma cruzi	34%	100%