Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0D7_LEIIN

TriTrypDb:

LINF_230016750

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.436
CLV_C14_Caspase3-7	566	570	PF00656	0.460
CLV_NRD_NRD_1	187	189	PF00675	0.417
CLV_NRD_NRD_1	313	315	PF00675	0.700
CLV_NRD_NRD_1	422	424	PF00675	0.411
CLV_NRD_NRD_1	536	538	PF00675	0.579
CLV_NRD_NRD_1	592	594	PF00675	0.586
CLV_NRD_NRD_1	633	635	PF00675	0.558
CLV_PCSK_KEX2_1	187	189	PF00082	0.417
CLV_PCSK_KEX2_1	313	315	PF00082	0.700
CLV_PCSK_KEX2_1	422	424	PF00082	0.433
CLV_PCSK_KEX2_1	536	538	PF00082	0.579
CLV_PCSK_KEX2_1	592	594	PF00082	0.586
CLV_PCSK_KEX2_1	622	624	PF00082	0.616
CLV_PCSK_KEX2_1	633	635	PF00082	0.396
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.616
CLV_PCSK_SKI1_1	179	183	PF00082	0.521
CLV_PCSK_SKI1_1	22	26	PF00082	0.523
CLV_PCSK_SKI1_1	231	235	PF00082	0.408
CLV_PCSK_SKI1_1	573	577	PF00082	0.425
CLV_PCSK_SKI1_1	711	715	PF00082	0.645
CLV_PCSK_SKI1_1	761	765	PF00082	0.651
CLV_PCSK_SKI1_1	87	91	PF00082	0.490
CLV_Separin_Metazoa	762	766	PF03568	0.637
DEG_APCC_DBOX_1	230	238	PF00400	0.403
DEG_APCC_DBOX_1	760	768	PF00400	0.646
DEG_SCF_FBW7_1	315	320	PF00400	0.634
DEG_SIAH_1	269	277	PF03145	0.647
DOC_CKS1_1	112	117	PF01111	0.642
DOC_CYCLIN_RxL_1	176	185	PF00134	0.524
DOC_CYCLIN_RxL_1	19	29	PF00134	0.528
DOC_CYCLIN_RxL_1	228	235	PF00134	0.410
DOC_MAPK_gen_1	403	411	PF00069	0.428
DOC_MAPK_gen_1	735	744	PF00069	0.756
DOC_MAPK_MEF2A_6	405	413	PF00069	0.391
DOC_MAPK_RevD_3	173	188	PF00069	0.398
DOC_MAPK_RevD_3	407	423	PF00069	0.388
DOC_PP2B_PxIxI_1	227	233	PF00149	0.413
DOC_SPAK_OSR1_1	357	361	PF12202	0.427
DOC_USP7_MATH_1	212	216	PF00917	0.408
DOC_USP7_MATH_1	253	257	PF00917	0.593
DOC_USP7_MATH_1	279	283	PF00917	0.744
DOC_USP7_MATH_1	293	297	PF00917	0.649
DOC_USP7_MATH_1	445	449	PF00917	0.540
DOC_USP7_MATH_1	468	472	PF00917	0.429
DOC_USP7_MATH_1	479	483	PF00917	0.517
DOC_USP7_MATH_1	552	556	PF00917	0.663
DOC_USP7_UBL2_3	239	243	PF12436	0.466
DOC_USP7_UBL2_3	618	622	PF12436	0.614
DOC_WW_Pin1_4	111	116	PF00397	0.725
DOC_WW_Pin1_4	133	138	PF00397	0.644
DOC_WW_Pin1_4	272	277	PF00397	0.779
DOC_WW_Pin1_4	282	287	PF00397	0.643
DOC_WW_Pin1_4	289	294	PF00397	0.744
DOC_WW_Pin1_4	295	300	PF00397	0.559
DOC_WW_Pin1_4	313	318	PF00397	0.625
DOC_WW_Pin1_4	398	403	PF00397	0.459
DOC_WW_Pin1_4	584	589	PF00397	0.585
DOC_WW_Pin1_4	696	701	PF00397	0.528
LIG_14-3-3_CanoR_1	467	477	PF00244	0.438
LIG_14-3-3_CanoR_1	486	490	PF00244	0.592
LIG_14-3-3_CanoR_1	521	529	PF00244	0.612
LIG_14-3-3_CanoR_1	557	561	PF00244	0.683
LIG_14-3-3_CanoR_1	623	630	PF00244	0.618
LIG_14-3-3_CanoR_1	644	650	PF00244	0.405
LIG_14-3-3_CanoR_1	670	675	PF00244	0.571
LIG_Actin_WH2_1	433	449	PF00022	0.530
LIG_Actin_WH2_2	432	449	PF00022	0.530
LIG_APCC_ABBA_1	614	619	PF00400	0.448
LIG_BRCT_BRCA1_1	355	359	PF00533	0.410
LIG_BRCT_BRCA1_1	430	434	PF00533	0.524
LIG_EH1_1	640	648	PF00400	0.552
LIG_FHA_1	124	130	PF00498	0.555
LIG_FHA_1	170	176	PF00498	0.559
LIG_FHA_1	35	41	PF00498	0.455
LIG_FHA_1	404	410	PF00498	0.385
LIG_FHA_1	511	517	PF00498	0.671
LIG_FHA_1	609	615	PF00498	0.419
LIG_FHA_1	83	89	PF00498	0.635
LIG_FHA_2	169	175	PF00498	0.448
LIG_FHA_2	206	212	PF00498	0.433
LIG_FHA_2	219	225	PF00498	0.450
LIG_FHA_2	51	57	PF00498	0.609
LIG_FHA_2	686	692	PF00498	0.472
LIG_GBD_Chelix_1	330	338	PF00786	0.532
LIG_LIR_Apic_2	724	729	PF02991	0.572
LIG_LIR_Gen_1	316	327	PF02991	0.577
LIG_LIR_Gen_1	431	442	PF02991	0.530
LIG_LIR_Gen_1	574	584	PF02991	0.415
LIG_LIR_Nem_3	114	120	PF02991	0.687
LIG_LIR_Nem_3	185	189	PF02991	0.553
LIG_LIR_Nem_3	218	223	PF02991	0.513
LIG_LIR_Nem_3	29	35	PF02991	0.513
LIG_LIR_Nem_3	316	322	PF02991	0.639
LIG_LIR_Nem_3	380	386	PF02991	0.381
LIG_LIR_Nem_3	431	437	PF02991	0.429
LIG_LIR_Nem_3	574	580	PF02991	0.416
LIG_MLH1_MIPbox_1	355	359	PF16413	0.410
LIG_NRBOX	67	73	PF00104	0.575
LIG_NRP_CendR_1	773	776	PF00754	0.705
LIG_Pex14_2	391	395	PF04695	0.491
LIG_SH2_CRK	117	121	PF00017	0.506
LIG_SH2_CRK	200	204	PF00017	0.510
LIG_SH2_CRK	319	323	PF00017	0.619
LIG_SH2_CRK	35	39	PF00017	0.466
LIG_SH2_CRK	4	8	PF00017	0.548
LIG_SH2_CRK	726	730	PF00017	0.595
LIG_SH2_NCK_1	241	245	PF00017	0.393
LIG_SH2_NCK_1	4	8	PF00017	0.548
LIG_SH2_STAP1	200	204	PF00017	0.562
LIG_SH2_STAP1	241	245	PF00017	0.443
LIG_SH2_STAP1	374	378	PF00017	0.529
LIG_SH2_STAT3	148	151	PF00017	0.559
LIG_SH2_STAT5	148	151	PF00017	0.560
LIG_SH2_STAT5	180	183	PF00017	0.385
LIG_SH2_STAT5	220	223	PF00017	0.529
LIG_SH2_STAT5	236	239	PF00017	0.544
LIG_SH2_STAT5	241	244	PF00017	0.510
LIG_SH2_STAT5	319	322	PF00017	0.762
LIG_SH2_STAT5	35	38	PF00017	0.462
LIG_SH2_STAT5	579	582	PF00017	0.412
LIG_SH3_1	134	140	PF00018	0.775
LIG_SH3_1	283	289	PF00018	0.602
LIG_SH3_3	106	112	PF00018	0.650
LIG_SH3_3	134	140	PF00018	0.775
LIG_SH3_3	283	289	PF00018	0.639
LIG_SH3_3	76	82	PF00018	0.507
LIG_Sin3_3	525	532	PF02671	0.691
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.421
LIG_SUMO_SIM_par_1	214	221	PF11976	0.552
LIG_TRAF2_1	244	247	PF00917	0.534
LIG_TYR_ITIM	184	189	PF00017	0.538
LIG_UBA3_1	233	239	PF00899	0.432
LIG_UBA3_1	64	73	PF00899	0.388
MOD_CDK_SPK_2	398	403	PF00069	0.433
MOD_CDK_SPxxK_3	111	118	PF00069	0.714
MOD_CDK_SPxxK_3	398	405	PF00069	0.444
MOD_CK1_1	282	288	PF00069	0.788
MOD_CK1_1	291	297	PF00069	0.647
MOD_CK1_1	333	339	PF00069	0.511
MOD_CK1_1	481	487	PF00069	0.553
MOD_CK1_1	488	494	PF00069	0.597
MOD_CK1_1	49	55	PF00069	0.576
MOD_CK1_1	499	505	PF00069	0.709
MOD_CK1_1	556	562	PF00069	0.756
MOD_CK2_1	212	218	PF00069	0.412
MOD_CK2_1	346	352	PF00069	0.447
MOD_CK2_1	685	691	PF00069	0.473
MOD_Cter_Amidation	590	593	PF01082	0.580
MOD_GlcNHglycan	253	256	PF01048	0.579
MOD_GlcNHglycan	396	399	PF01048	0.543
MOD_GlcNHglycan	443	446	PF01048	0.488
MOD_GlcNHglycan	447	450	PF01048	0.535
MOD_GlcNHglycan	470	473	PF01048	0.324
MOD_GlcNHglycan	487	490	PF01048	0.681
MOD_GlcNHglycan	501	504	PF01048	0.645
MOD_GlcNHglycan	66	71	PF01048	0.450
MOD_GSK3_1	165	172	PF00069	0.620
MOD_GSK3_1	287	294	PF00069	0.631
MOD_GSK3_1	302	309	PF00069	0.730
MOD_GSK3_1	313	320	PF00069	0.699
MOD_GSK3_1	394	401	PF00069	0.603
MOD_GSK3_1	403	410	PF00069	0.434
MOD_GSK3_1	441	448	PF00069	0.523
MOD_GSK3_1	46	53	PF00069	0.641
MOD_GSK3_1	477	484	PF00069	0.518
MOD_GSK3_1	485	492	PF00069	0.569
MOD_GSK3_1	499	506	PF00069	0.605
MOD_GSK3_1	552	559	PF00069	0.703
MOD_N-GLC_1	468	473	PF02516	0.562
MOD_N-GLC_1	623	628	PF02516	0.513
MOD_NEK2_1	182	187	PF00069	0.527
MOD_NEK2_1	407	412	PF00069	0.517
MOD_NEK2_1	43	48	PF00069	0.539
MOD_NEK2_1	485	490	PF00069	0.564
MOD_NEK2_1	501	506	PF00069	0.744
MOD_NEK2_1	685	690	PF00069	0.469
MOD_NEK2_2	34	39	PF00069	0.467
MOD_PIKK_1	147	153	PF00454	0.550
MOD_PIKK_1	50	56	PF00454	0.626
MOD_PIKK_1	82	88	PF00454	0.646
MOD_PK_1	3	9	PF00069	0.691
MOD_PKA_2	485	491	PF00069	0.600
MOD_PKA_2	506	512	PF00069	0.617
MOD_PKA_2	520	526	PF00069	0.530
MOD_PKA_2	556	562	PF00069	0.682
MOD_PKB_1	668	676	PF00069	0.574
MOD_Plk_1	165	171	PF00069	0.488
MOD_Plk_1	429	435	PF00069	0.493
MOD_Plk_1	553	559	PF00069	0.688
MOD_Plk_1	66	72	PF00069	0.497
MOD_Plk_2-3	678	684	PF00069	0.477
MOD_Plk_4	165	171	PF00069	0.658
MOD_Plk_4	212	218	PF00069	0.412
MOD_Plk_4	330	336	PF00069	0.555
MOD_Plk_4	407	413	PF00069	0.514
MOD_Plk_4	43	49	PF00069	0.471
MOD_Plk_4	496	502	PF00069	0.625
MOD_Plk_4	670	676	PF00069	0.576
MOD_ProDKin_1	111	117	PF00069	0.719
MOD_ProDKin_1	133	139	PF00069	0.644
MOD_ProDKin_1	272	278	PF00069	0.780
MOD_ProDKin_1	282	288	PF00069	0.644
MOD_ProDKin_1	289	295	PF00069	0.743
MOD_ProDKin_1	313	319	PF00069	0.763
MOD_ProDKin_1	398	404	PF00069	0.451
MOD_ProDKin_1	584	590	PF00069	0.582
MOD_ProDKin_1	696	702	PF00069	0.536
TRG_DiLeu_BaEn_1	524	529	PF01217	0.690
TRG_DiLeu_BaEn_1	610	615	PF01217	0.419
TRG_DiLeu_BaEn_1	67	72	PF01217	0.603
TRG_DiLeu_BaEn_1	701	706	PF01217	0.570
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.452
TRG_ENDOCYTIC_2	117	120	PF00928	0.503
TRG_ENDOCYTIC_2	186	189	PF00928	0.507
TRG_ENDOCYTIC_2	200	203	PF00928	0.335
TRG_ENDOCYTIC_2	220	223	PF00928	0.308
TRG_ENDOCYTIC_2	319	322	PF00928	0.627
TRG_ENDOCYTIC_2	35	38	PF00928	0.476
TRG_ENDOCYTIC_2	4	7	PF00928	0.560
TRG_ENDOCYTIC_2	669	672	PF00928	0.426
TRG_ER_diArg_1	186	188	PF00400	0.415
TRG_ER_diArg_1	228	231	PF00400	0.414
TRG_ER_diArg_1	313	315	PF00400	0.626
TRG_ER_diArg_1	422	424	PF00400	0.433
TRG_ER_diArg_1	474	477	PF00400	0.455
TRG_ER_diArg_1	592	594	PF00400	0.586
TRG_NES_CRM1_1	62	78	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	761	766	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B3	Leptomonas seymouri	57%	88%
A0A3Q8ICJ7	Leishmania donovani	99%	100%
A4HCV7	Leishmania braziliensis	80%	100%
E9AWA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QB78	Leishmania major	95%	100%