LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I0D6_LEIIN
TriTrypDb:
LINF_230016400
Length:
527

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I0D6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0D6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 205 209 PF00656 0.380
CLV_NRD_NRD_1 361 363 PF00675 0.670
CLV_NRD_NRD_1 514 516 PF00675 0.570
CLV_NRD_NRD_1 6 8 PF00675 0.749
CLV_PCSK_KEX2_1 361 363 PF00082 0.668
CLV_PCSK_KEX2_1 437 439 PF00082 0.708
CLV_PCSK_KEX2_1 516 518 PF00082 0.571
CLV_PCSK_KEX2_1 6 8 PF00082 0.749
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.708
CLV_PCSK_PC1ET2_1 516 518 PF00082 0.573
CLV_PCSK_SKI1_1 362 366 PF00082 0.755
CLV_PCSK_SKI1_1 517 521 PF00082 0.508
CLV_PCSK_SKI1_1 96 100 PF00082 0.657
DEG_APCC_DBOX_1 63 71 PF00400 0.377
DEG_Nend_UBRbox_1 1 4 PF02207 0.742
DEG_SIAH_1 242 250 PF03145 0.497
DOC_CDC14_PxL_1 275 283 PF14671 0.472
DOC_CKS1_1 249 254 PF01111 0.497
DOC_CKS1_1 97 102 PF01111 0.429
DOC_CYCLIN_yCln2_LP_2 49 55 PF00134 0.403
DOC_MAPK_FxFP_2 198 201 PF00069 0.425
DOC_MAPK_gen_1 472 482 PF00069 0.372
DOC_MAPK_HePTP_8 19 31 PF00069 0.551
DOC_MAPK_MEF2A_6 14 23 PF00069 0.556
DOC_MAPK_MEF2A_6 475 482 PF00069 0.393
DOC_PP1_RVXF_1 85 92 PF00149 0.368
DOC_PP2B_LxvP_1 49 52 PF13499 0.446
DOC_PP4_FxxP_1 198 201 PF00568 0.466
DOC_USP7_MATH_1 103 107 PF00917 0.433
DOC_USP7_MATH_1 130 134 PF00917 0.459
DOC_USP7_MATH_1 209 213 PF00917 0.410
DOC_USP7_MATH_1 259 263 PF00917 0.514
DOC_USP7_MATH_1 377 381 PF00917 0.510
DOC_USP7_MATH_1 441 445 PF00917 0.564
DOC_USP7_MATH_1 461 465 PF00917 0.587
DOC_USP7_MATH_1 83 87 PF00917 0.485
DOC_WW_Pin1_4 219 224 PF00397 0.501
DOC_WW_Pin1_4 245 250 PF00397 0.484
DOC_WW_Pin1_4 293 298 PF00397 0.496
DOC_WW_Pin1_4 402 407 PF00397 0.527
DOC_WW_Pin1_4 453 458 PF00397 0.539
DOC_WW_Pin1_4 96 101 PF00397 0.449
LIG_14-3-3_CanoR_1 132 139 PF00244 0.389
LIG_14-3-3_CanoR_1 269 275 PF00244 0.403
LIG_14-3-3_CanoR_1 361 365 PF00244 0.503
LIG_14-3-3_CanoR_1 367 377 PF00244 0.481
LIG_14-3-3_CanoR_1 438 448 PF00244 0.503
LIG_14-3-3_CanoR_1 517 527 PF00244 0.766
LIG_Actin_WH2_2 124 139 PF00022 0.481
LIG_BRCT_BRCA1_1 144 148 PF00533 0.448
LIG_BRCT_BRCA1_1 175 179 PF00533 0.479
LIG_CSL_BTD_1 403 406 PF09270 0.441
LIG_deltaCOP1_diTrp_1 334 340 PF00928 0.460
LIG_EH_1 300 304 PF12763 0.615
LIG_EH1_1 475 483 PF00400 0.320
LIG_FHA_1 223 229 PF00498 0.516
LIG_FHA_1 294 300 PF00498 0.539
LIG_FHA_1 419 425 PF00498 0.430
LIG_FHA_1 460 466 PF00498 0.505
LIG_FHA_2 249 255 PF00498 0.524
LIG_FHA_2 271 277 PF00498 0.485
LIG_LIR_Apic_2 196 201 PF02991 0.474
LIG_LIR_Gen_1 177 188 PF02991 0.535
LIG_LIR_Gen_1 312 319 PF02991 0.566
LIG_LIR_Gen_1 322 333 PF02991 0.426
LIG_LIR_Gen_1 54 63 PF02991 0.403
LIG_LIR_Nem_3 176 182 PF02991 0.436
LIG_LIR_Nem_3 231 237 PF02991 0.410
LIG_LIR_Nem_3 276 281 PF02991 0.478
LIG_LIR_Nem_3 312 318 PF02991 0.619
LIG_LIR_Nem_3 322 328 PF02991 0.430
LIG_LIR_Nem_3 334 339 PF02991 0.397
LIG_LIR_Nem_3 54 59 PF02991 0.395
LIG_LYPXL_yS_3 278 281 PF13949 0.504
LIG_MLH1_MIPbox_1 175 179 PF16413 0.479
LIG_MYND_1 168 172 PF01753 0.455
LIG_PAM2_1 47 59 PF00658 0.386
LIG_PCNA_PIPBox_1 17 26 PF02747 0.562
LIG_PCNA_yPIPBox_3 14 24 PF02747 0.578
LIG_Pex14_1 233 237 PF04695 0.430
LIG_PTB_Apo_2 363 370 PF02174 0.466
LIG_SH2_GRB2like 270 273 PF00017 0.384
LIG_SH2_SRC 476 479 PF00017 0.377
LIG_SH2_STAP1 284 288 PF00017 0.445
LIG_SH2_STAP1 467 471 PF00017 0.519
LIG_SH2_STAT3 200 203 PF00017 0.423
LIG_SH2_STAT5 217 220 PF00017 0.386
LIG_SH2_STAT5 234 237 PF00017 0.499
LIG_SH2_STAT5 325 328 PF00017 0.430
LIG_SH2_STAT5 425 428 PF00017 0.469
LIG_SH2_STAT5 435 438 PF00017 0.504
LIG_SH2_STAT5 476 479 PF00017 0.366
LIG_SH3_2 97 102 PF14604 0.429
LIG_SH3_3 10 16 PF00018 0.693
LIG_SH3_3 166 172 PF00018 0.460
LIG_SH3_3 246 252 PF00018 0.522
LIG_SH3_3 400 406 PF00018 0.486
LIG_SH3_3 57 63 PF00018 0.435
LIG_SH3_3 94 100 PF00018 0.391
LIG_SUMO_SIM_anti_2 484 489 PF11976 0.485
LIG_SUMO_SIM_anti_2 491 498 PF11976 0.439
LIG_SUMO_SIM_par_1 495 500 PF11976 0.447
LIG_TRAF2_1 123 126 PF00917 0.388
LIG_TRAF2_1 350 353 PF00917 0.473
LIG_TRAF2_1 405 408 PF00917 0.531
MOD_CDK_SPxK_1 96 102 PF00069 0.492
MOD_CK1_1 174 180 PF00069 0.549
MOD_CK1_1 250 256 PF00069 0.604
MOD_CK1_1 372 378 PF00069 0.631
MOD_CK1_1 456 462 PF00069 0.588
MOD_CK1_1 518 524 PF00069 0.686
MOD_CK1_1 54 60 PF00069 0.444
MOD_CK2_1 120 126 PF00069 0.422
MOD_CK2_1 347 353 PF00069 0.637
MOD_CK2_1 402 408 PF00069 0.638
MOD_GlcNHglycan 105 108 PF01048 0.484
MOD_GlcNHglycan 173 176 PF01048 0.569
MOD_GlcNHglycan 329 332 PF01048 0.548
MOD_GlcNHglycan 371 374 PF01048 0.513
MOD_GlcNHglycan 418 421 PF01048 0.584
MOD_GlcNHglycan 426 429 PF01048 0.522
MOD_GlcNHglycan 49 52 PF01048 0.411
MOD_GlcNHglycan 517 520 PF01048 0.625
MOD_GlcNHglycan 78 81 PF01048 0.470
MOD_GSK3_1 131 138 PF00069 0.474
MOD_GSK3_1 229 236 PF00069 0.575
MOD_GSK3_1 270 277 PF00069 0.568
MOD_GSK3_1 368 375 PF00069 0.562
MOD_GSK3_1 439 446 PF00069 0.787
MOD_GSK3_1 449 456 PF00069 0.661
MOD_GSK3_1 459 466 PF00069 0.529
MOD_GSK3_1 47 54 PF00069 0.450
MOD_GSK3_1 58 65 PF00069 0.550
MOD_N-GLC_1 228 233 PF02516 0.516
MOD_N-GLC_1 319 324 PF02516 0.669
MOD_N-GLC_1 377 382 PF02516 0.581
MOD_N-GLC_1 416 421 PF02516 0.576
MOD_NEK2_1 183 188 PF00069 0.528
MOD_NEK2_1 369 374 PF00069 0.546
MOD_NEK2_1 424 429 PF00069 0.691
MOD_NEK2_1 449 454 PF00069 0.638
MOD_NEK2_1 91 96 PF00069 0.461
MOD_PIKK_1 186 192 PF00454 0.512
MOD_PIKK_1 418 424 PF00454 0.483
MOD_PIKK_1 441 447 PF00454 0.696
MOD_PKA_1 515 521 PF00069 0.699
MOD_PKA_2 103 109 PF00069 0.475
MOD_PKA_2 120 126 PF00069 0.495
MOD_PKA_2 131 137 PF00069 0.444
MOD_PKA_2 360 366 PF00069 0.547
MOD_Plk_1 210 216 PF00069 0.575
MOD_Plk_1 228 234 PF00069 0.392
MOD_Plk_1 377 383 PF00069 0.584
MOD_Plk_4 174 180 PF00069 0.497
MOD_Plk_4 183 189 PF00069 0.589
MOD_Plk_4 229 235 PF00069 0.481
MOD_Plk_4 270 276 PF00069 0.518
MOD_Plk_4 443 449 PF00069 0.632
MOD_Plk_4 481 487 PF00069 0.469
MOD_Plk_4 488 494 PF00069 0.381
MOD_Plk_4 51 57 PF00069 0.466
MOD_ProDKin_1 219 225 PF00069 0.602
MOD_ProDKin_1 245 251 PF00069 0.571
MOD_ProDKin_1 293 299 PF00069 0.610
MOD_ProDKin_1 402 408 PF00069 0.638
MOD_ProDKin_1 453 459 PF00069 0.645
MOD_ProDKin_1 96 102 PF00069 0.541
MOD_SUMO_rev_2 79 89 PF00179 0.415
TRG_DiLeu_LyEn_5 408 413 PF01217 0.557
TRG_ENDOCYTIC_2 113 116 PF00928 0.454
TRG_ENDOCYTIC_2 278 281 PF00928 0.499
TRG_ENDOCYTIC_2 284 287 PF00928 0.536
TRG_ENDOCYTIC_2 325 328 PF00928 0.588
TRG_ER_diArg_1 119 122 PF00400 0.433
TRG_ER_diArg_1 469 472 PF00400 0.637

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4Q7 Leptomonas seymouri 33% 95%
A0A3S5H7C0 Leishmania donovani 99% 100%
A4HCV5 Leishmania braziliensis 53% 99%
E9AW99 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4QB79 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS