Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4I0D5_LEIIN

TriTrypDb:

LINF_230016200

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 0
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I0D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0D5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.643
CLV_NRD_NRD_1	224	226	PF00675	0.609
CLV_PCSK_KEX2_1	224	226	PF00082	0.609
CLV_PCSK_KEX2_1	409	411	PF00082	0.509
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.457
CLV_PCSK_SKI1_1	109	113	PF00082	0.688
CLV_PCSK_SKI1_1	13	17	PF00082	0.620
CLV_PCSK_SKI1_1	188	192	PF00082	0.544
CLV_Separin_Metazoa	153	157	PF03568	0.464
DEG_APCC_DBOX_1	12	20	PF00400	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DEG_SPOP_SBC_1	91	95	PF00917	0.456
DOC_CKS1_1	227	232	PF01111	0.416
DOC_CYCLIN_RxL_1	185	195	PF00134	0.353
DOC_CYCLIN_RxL_1	277	288	PF00134	0.341
DOC_MAPK_DCC_7	109	118	PF00069	0.463
DOC_MAPK_FxFP_2	370	373	PF00069	0.665
DOC_MAPK_gen_1	204	213	PF00069	0.432
DOC_MAPK_HePTP_8	10	22	PF00069	0.460
DOC_MAPK_HePTP_8	106	118	PF00069	0.464
DOC_MAPK_MEF2A_6	109	118	PF00069	0.463
DOC_MAPK_MEF2A_6	13	22	PF00069	0.504
DOC_MAPK_MEF2A_6	204	213	PF00069	0.381
DOC_MAPK_NFAT4_5	13	21	PF00069	0.505
DOC_PP1_RVXF_1	186	192	PF00149	0.346
DOC_PP1_RVXF_1	278	285	PF00149	0.341
DOC_PP2B_PxIxI_1	113	119	PF00149	0.456
DOC_PP4_FxxP_1	191	194	PF00568	0.355
DOC_PP4_FxxP_1	370	373	PF00568	0.665
DOC_PP4_FxxP_1	414	417	PF00568	0.658
DOC_USP7_MATH_1	137	141	PF00917	0.485
DOC_USP7_MATH_1	373	377	PF00917	0.683
DOC_USP7_MATH_1	380	384	PF00917	0.620
DOC_USP7_MATH_1	50	54	PF00917	0.505
DOC_WW_Pin1_4	116	121	PF00397	0.448
DOC_WW_Pin1_4	226	231	PF00397	0.484
DOC_WW_Pin1_4	25	30	PF00397	0.534
DOC_WW_Pin1_4	40	45	PF00397	0.532
LIG_14-3-3_CanoR_1	197	203	PF00244	0.438
LIG_14-3-3_CanoR_1	299	307	PF00244	0.438
LIG_14-3-3_CanoR_1	410	415	PF00244	0.653
LIG_Actin_WH2_2	231	247	PF00022	0.416
LIG_APCC_ABBA_1	392	397	PF00400	0.642
LIG_BRCT_BRCA1_1	366	370	PF00533	0.657
LIG_BRCT_BRCA1_1	400	404	PF00533	0.653
LIG_eIF4E_1	11	17	PF01652	0.661
LIG_eIF4E_1	185	191	PF01652	0.389
LIG_FHA_1	1	7	PF00498	0.615
LIG_FHA_1	172	178	PF00498	0.432
LIG_FHA_1	182	188	PF00498	0.385
LIG_FHA_1	227	233	PF00498	0.441
LIG_FHA_1	285	291	PF00498	0.419
LIG_FHA_1	306	312	PF00498	0.444
LIG_FHA_1	64	70	PF00498	0.518
LIG_FHA_1	73	79	PF00498	0.590
LIG_FHA_1	94	100	PF00498	0.558
LIG_FHA_2	366	372	PF00498	0.707
LIG_LIR_Apic_2	36	42	PF02991	0.576
LIG_LIR_Apic_2	367	373	PF02991	0.660
LIG_LIR_Apic_2	411	417	PF02991	0.655
LIG_LIR_Gen_1	163	172	PF02991	0.448
LIG_LIR_Gen_1	305	311	PF02991	0.457
LIG_LIR_Gen_1	401	412	PF02991	0.762
LIG_LIR_Gen_1	54	65	PF02991	0.434
LIG_LIR_Nem_3	163	169	PF02991	0.453
LIG_LIR_Nem_3	401	407	PF02991	0.762
LIG_MLH1_MIPbox_1	400	404	PF16413	0.653
LIG_NRBOX	15	21	PF00104	0.503
LIG_PCNA_yPIPBox_3	266	280	PF02747	0.439
LIG_PCNA_yPIPBox_3	4	13	PF02747	0.481
LIG_PTB_Apo_2	179	186	PF02174	0.413
LIG_PTB_Phospho_1	179	185	PF10480	0.412
LIG_SH2_CRK	158	162	PF00017	0.444
LIG_SH2_CRK	166	170	PF00017	0.447
LIG_SH2_CRK	39	43	PF00017	0.578
LIG_SH2_NCK_1	11	15	PF00017	0.462
LIG_SH2_NCK_1	166	170	PF00017	0.447
LIG_SH2_NCK_1	39	43	PF00017	0.578
LIG_SH2_STAP1	11	15	PF00017	0.510
LIG_SH2_STAP1	278	282	PF00017	0.383
LIG_SH2_STAP1	307	311	PF00017	0.410
LIG_SH2_STAT3	395	398	PF00017	0.646
LIG_SH2_STAT5	178	181	PF00017	0.388
LIG_SH2_STAT5	307	310	PF00017	0.525
LIG_SH2_STAT5	354	357	PF00017	0.633
LIG_SH2_STAT5	403	406	PF00017	0.770
LIG_SH3_3	108	114	PF00018	0.466
LIG_SH3_3	166	172	PF00018	0.460
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.365
LIG_SUMO_SIM_par_1	15	21	PF11976	0.501
LIG_SUMO_SIM_par_1	254	259	PF11976	0.380
LIG_TRAF2_1	119	122	PF00917	0.478
MOD_CK1_1	138	144	PF00069	0.513
MOD_CK1_1	192	198	PF00069	0.425
MOD_CK1_1	25	31	PF00069	0.545
MOD_CK1_1	297	303	PF00069	0.437
MOD_CK1_1	51	57	PF00069	0.451
MOD_CK1_1	95	101	PF00069	0.458
MOD_CK2_1	116	122	PF00069	0.486
MOD_GlcNHglycan	101	104	PF01048	0.739
MOD_GlcNHglycan	169	172	PF01048	0.718
MOD_GlcNHglycan	191	194	PF01048	0.600
MOD_GlcNHglycan	50	53	PF01048	0.706
MOD_GSK3_1	128	135	PF00069	0.478
MOD_GSK3_1	137	144	PF00069	0.467
MOD_GSK3_1	167	174	PF00069	0.443
MOD_GSK3_1	18	25	PF00069	0.545
MOD_GSK3_1	192	199	PF00069	0.435
MOD_GSK3_1	284	291	PF00069	0.388
MOD_GSK3_1	294	301	PF00069	0.378
MOD_GSK3_1	360	367	PF00069	0.731
MOD_GSK3_1	408	415	PF00069	0.667
MOD_GSK3_1	90	97	PF00069	0.571
MOD_N-GLC_1	181	186	PF02516	0.633
MOD_N-GLC_1	207	212	PF02516	0.595
MOD_N-GLC_1	285	290	PF02516	0.621
MOD_N-GLC_1	295	300	PF02516	0.581
MOD_N-GLC_1	361	366	PF02516	0.473
MOD_N-GLC_1	398	403	PF02516	0.453
MOD_NEK2_1	165	170	PF00069	0.489
MOD_NEK2_1	18	23	PF00069	0.580
MOD_NEK2_1	220	225	PF00069	0.401
MOD_NEK2_1	284	289	PF00069	0.430
MOD_NEK2_1	294	299	PF00069	0.380
MOD_NEK2_1	412	417	PF00069	0.657
MOD_NEK2_1	74	79	PF00069	0.497
MOD_NEK2_1	99	104	PF00069	0.497
MOD_PIKK_1	141	147	PF00454	0.501
MOD_PKA_2	196	202	PF00069	0.473
MOD_PKA_2	298	304	PF00069	0.401
MOD_Plk_1	135	141	PF00069	0.556
MOD_Plk_1	181	187	PF00069	0.405
MOD_Plk_1	207	213	PF00069	0.429
MOD_Plk_1	256	262	PF00069	0.482
MOD_Plk_1	314	320	PF00069	0.403
MOD_Plk_1	365	371	PF00069	0.669
MOD_Plk_1	380	386	PF00069	0.631
MOD_Plk_1	398	404	PF00069	0.654
MOD_Plk_4	18	24	PF00069	0.622
MOD_Plk_4	209	215	PF00069	0.399
MOD_Plk_4	306	312	PF00069	0.410
MOD_Plk_4	314	320	PF00069	0.372
MOD_ProDKin_1	116	122	PF00069	0.446
MOD_ProDKin_1	226	232	PF00069	0.483
MOD_ProDKin_1	25	31	PF00069	0.538
MOD_ProDKin_1	40	46	PF00069	0.530
MOD_SUMO_rev_2	239	247	PF00179	0.442
TRG_DiLeu_BaEn_2	174	180	PF01217	0.411
TRG_ENDOCYTIC_2	166	169	PF00928	0.453
TRG_ENDOCYTIC_2	307	310	PF00928	0.417
TRG_ER_diArg_1	224	226	PF00400	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IM39	Leishmania donovani	99%	100%
A4HCV4	Leishmania braziliensis	44%	100%