Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0D1_LEIIN

TriTrypDb:

LINF_230015800

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0D1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.836
CLV_NRD_NRD_1	19	21	PF00675	0.624
CLV_NRD_NRD_1	24	26	PF00675	0.622
CLV_NRD_NRD_1	247	249	PF00675	0.440
CLV_NRD_NRD_1	37	39	PF00675	0.606
CLV_PCSK_FUR_1	22	26	PF00082	0.541
CLV_PCSK_KEX2_1	21	23	PF00082	0.638
CLV_PCSK_KEX2_1	225	227	PF00082	0.579
CLV_PCSK_KEX2_1	24	26	PF00082	0.633
CLV_PCSK_KEX2_1	247	249	PF00082	0.440
CLV_PCSK_KEX2_1	326	328	PF00082	0.619
CLV_PCSK_KEX2_1	37	39	PF00082	0.613
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.543
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.579
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.717
CLV_PCSK_PC7_1	20	26	PF00082	0.541
CLV_PCSK_SKI1_1	338	342	PF00082	0.679
CLV_PCSK_SKI1_1	48	52	PF00082	0.613
DEG_SCF_FBW7_1	29	35	PF00400	0.836
DEG_SCF_FBW7_1	64	71	PF00400	0.753
DEG_SPOP_SBC_1	119	123	PF00917	0.837
DOC_CKS1_1	29	34	PF01111	0.837
DOC_MAPK_gen_1	28	36	PF00069	0.726
DOC_MAPK_gen_1	48	57	PF00069	0.816
DOC_MAPK_MEF2A_6	28	36	PF00069	0.770
DOC_PP2B_LxvP_1	257	260	PF13499	0.369
DOC_PP4_FxxP_1	341	344	PF00568	0.544
DOC_USP7_MATH_1	111	115	PF00917	0.827
DOC_USP7_MATH_1	119	123	PF00917	0.748
DOC_USP7_MATH_1	124	128	PF00917	0.842
DOC_USP7_MATH_1	152	156	PF00917	0.729
DOC_USP7_MATH_1	175	179	PF00917	0.842
DOC_USP7_MATH_1	68	72	PF00917	0.837
DOC_USP7_MATH_1	91	95	PF00917	0.827
DOC_USP7_UBL2_3	202	206	PF12436	0.804
DOC_WW_Pin1_4	120	125	PF00397	0.840
DOC_WW_Pin1_4	28	33	PF00397	0.840
DOC_WW_Pin1_4	293	298	PF00397	0.564
DOC_WW_Pin1_4	50	55	PF00397	0.810
DOC_WW_Pin1_4	64	69	PF00397	0.646
LIG_14-3-3_CanoR_1	151	161	PF00244	0.737
LIG_14-3-3_CanoR_1	252	260	PF00244	0.622
LIG_14-3-3_CanoR_1	318	325	PF00244	0.489
LIG_14-3-3_CanoR_1	335	344	PF00244	0.490
LIG_14-3-3_CanoR_1	37	44	PF00244	0.735
LIG_14-3-3_CanoR_1	56	64	PF00244	0.832
LIG_14-3-3_CanoR_1	90	100	PF00244	0.744
LIG_Actin_WH2_2	345	361	PF00022	0.414
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BRCT_BRCA1_1	320	324	PF00533	0.436
LIG_BRCT_BRCA1_2	320	326	PF00533	0.436
LIG_Clathr_ClatBox_1	351	355	PF01394	0.522
LIG_FHA_1	252	258	PF00498	0.517
LIG_FHA_1	29	35	PF00498	0.836
LIG_FHA_1	307	313	PF00498	0.549
LIG_FHA_1	344	350	PF00498	0.519
LIG_FHA_2	105	111	PF00498	0.834
LIG_LIR_Apic_2	339	344	PF02991	0.546
LIG_LIR_Gen_1	254	264	PF02991	0.510
LIG_LIR_Nem_3	254	259	PF02991	0.510
LIG_NRBOX	282	288	PF00104	0.520
LIG_PCNA_yPIPBox_3	276	287	PF02747	0.433
LIG_Pex14_1	325	329	PF04695	0.515
LIG_SH2_STAP1	253	257	PF00017	0.510
LIG_SH2_STAP1	302	306	PF00017	0.499
LIG_SH2_STAP1	329	333	PF00017	0.503
LIG_SH2_STAT5	250	253	PF00017	0.720
LIG_SxIP_EBH_1	56	67	PF03271	0.833
LIG_UBA3_1	351	359	PF00899	0.470
MOD_CDK_SPK_2	293	298	PF00069	0.564
MOD_CDK_SPxK_1	50	56	PF00069	0.812
MOD_CDK_SPxxK_3	293	300	PF00069	0.565
MOD_CK1_1	123	129	PF00069	0.857
MOD_CK1_1	146	152	PF00069	0.725
MOD_CK1_1	176	182	PF00069	0.762
MOD_CK1_1	296	302	PF00069	0.578
MOD_CK1_1	75	81	PF00069	0.810
MOD_CK1_1	93	99	PF00069	0.824
MOD_CK2_1	156	162	PF00069	0.746
MOD_CK2_1	214	220	PF00069	0.775
MOD_CK2_1	336	342	PF00069	0.564
MOD_CK2_1	358	364	PF00069	0.510
MOD_GlcNHglycan	126	129	PF01048	0.592
MOD_GlcNHglycan	154	157	PF01048	0.550
MOD_GlcNHglycan	158	161	PF01048	0.550
MOD_GlcNHglycan	170	173	PF01048	0.537
MOD_GlcNHglycan	185	188	PF01048	0.457
MOD_GlcNHglycan	338	341	PF01048	0.664
MOD_GlcNHglycan	40	43	PF01048	0.589
MOD_GlcNHglycan	70	73	PF01048	0.642
MOD_GlcNHglycan	80	83	PF01048	0.582
MOD_GlcNHglycan	95	98	PF01048	0.528
MOD_GSK3_1	119	126	PF00069	0.789
MOD_GSK3_1	152	159	PF00069	0.735
MOD_GSK3_1	251	258	PF00069	0.636
MOD_GSK3_1	28	35	PF00069	0.838
MOD_GSK3_1	292	299	PF00069	0.559
MOD_GSK3_1	358	365	PF00069	0.551
MOD_GSK3_1	6	13	PF00069	0.701
MOD_GSK3_1	64	71	PF00069	0.778
MOD_GSK3_1	78	85	PF00069	0.724
MOD_GSK3_1	98	105	PF00069	0.826
MOD_N-GLC_1	68	73	PF02516	0.638
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	100	105	PF00069	0.724
MOD_NEK2_1	143	148	PF00069	0.737
MOD_NEK2_1	214	219	PF00069	0.771
MOD_NEK2_1	264	269	PF00069	0.408
MOD_NEK2_1	334	339	PF00069	0.461
MOD_NEK2_1	57	62	PF00069	0.833
MOD_NEK2_2	32	37	PF00069	0.832
MOD_PIKK_1	62	68	PF00454	0.833
MOD_PIKK_1	91	97	PF00454	0.827
MOD_PKA_1	37	43	PF00069	0.820
MOD_PKA_2	166	172	PF00069	0.819
MOD_PKA_2	173	179	PF00069	0.795
MOD_PKA_2	214	220	PF00069	0.775
MOD_PKA_2	251	257	PF00069	0.517
MOD_PKA_2	334	340	PF00069	0.484
MOD_PKA_2	342	348	PF00069	0.516
MOD_PKA_2	37	43	PF00069	0.820
MOD_PKB_1	28	36	PF00069	0.754
MOD_Plk_1	161	167	PF00069	0.759
MOD_Plk_2-3	216	222	PF00069	0.786
MOD_Plk_4	1	7	PF00069	0.699
MOD_Plk_4	266	272	PF00069	0.509
MOD_Plk_4	75	81	PF00069	0.823
MOD_ProDKin_1	120	126	PF00069	0.840
MOD_ProDKin_1	28	34	PF00069	0.839
MOD_ProDKin_1	293	299	PF00069	0.560
MOD_ProDKin_1	50	56	PF00069	0.812
MOD_ProDKin_1	64	70	PF00069	0.646
MOD_SUMO_rev_2	199	203	PF00179	0.805
MOD_SUMO_rev_2	353	361	PF00179	0.448
TRG_ENDOCYTIC_2	253	256	PF00928	0.378
TRG_ER_diArg_1	20	23	PF00400	0.837
TRG_ER_diArg_1	24	26	PF00400	0.822
TRG_ER_diArg_1	246	248	PF00400	0.653
TRG_ER_diArg_1	317	320	PF00400	0.533
TRG_ER_diArg_1	36	38	PF00400	0.671
TRG_NES_CRM1_1	282	294	PF08389	0.528
TRG_NLS_MonoExtC_3	20	25	PF00514	0.742
TRG_NLS_MonoExtC_3	203	208	PF00514	0.796
TRG_NLS_MonoExtN_4	18	25	PF00514	0.742
TRG_NLS_MonoExtN_4	202	208	PF00514	0.797
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBI6	Leishmania donovani	97%	82%