Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I0D0_LEIIN

TriTrypDb:

LINF_230015700

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0D0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.739
CLV_C14_Caspase3-7	493	497	PF00656	0.459
CLV_C14_Caspase3-7	551	555	PF00656	0.548
CLV_C14_Caspase3-7	621	625	PF00656	0.499
CLV_NRD_NRD_1	206	208	PF00675	0.606
CLV_NRD_NRD_1	218	220	PF00675	0.515
CLV_NRD_NRD_1	22	24	PF00675	0.478
CLV_NRD_NRD_1	245	247	PF00675	0.474
CLV_NRD_NRD_1	251	253	PF00675	0.502
CLV_NRD_NRD_1	261	263	PF00675	0.631
CLV_NRD_NRD_1	502	504	PF00675	0.497
CLV_NRD_NRD_1	736	738	PF00675	0.361
CLV_NRD_NRD_1	76	78	PF00675	0.572
CLV_PCSK_FUR_1	249	253	PF00082	0.467
CLV_PCSK_KEX2_1	22	24	PF00082	0.478
CLV_PCSK_KEX2_1	244	246	PF00082	0.477
CLV_PCSK_KEX2_1	249	251	PF00082	0.497
CLV_PCSK_KEX2_1	261	263	PF00082	0.612
CLV_PCSK_KEX2_1	502	504	PF00082	0.497
CLV_PCSK_KEX2_1	601	603	PF00082	0.261
CLV_PCSK_KEX2_1	735	737	PF00082	0.347
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.324
CLV_PCSK_PC7_1	245	251	PF00082	0.470
CLV_PCSK_PC7_1	597	603	PF00082	0.242
CLV_PCSK_SKI1_1	207	211	PF00082	0.600
CLV_PCSK_SKI1_1	601	605	PF00082	0.248
CLV_PCSK_SKI1_1	616	620	PF00082	0.324
CLV_PCSK_SKI1_1	737	741	PF00082	0.351
DEG_APCC_DBOX_1	152	160	PF00400	0.525
DEG_Nend_UBRbox_2	1	3	PF02207	0.496
DEG_SCF_FBW7_1	822	829	PF00400	0.585
DEG_SPOP_SBC_1	268	272	PF00917	0.498
DEG_SPOP_SBC_1	334	338	PF00917	0.592
DEG_SPOP_SBC_1	359	363	PF00917	0.534
DEG_SPOP_SBC_1	459	463	PF00917	0.715
DOC_ANK_TNKS_1	513	520	PF00023	0.565
DOC_CKS1_1	265	270	PF01111	0.467
DOC_CYCLIN_RxL_1	227	240	PF00134	0.463
DOC_CYCLIN_RxL_1	734	742	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	437	440	PF00134	0.558
DOC_MAPK_gen_1	219	226	PF00069	0.507
DOC_MAPK_gen_1	249	259	PF00069	0.500
DOC_MAPK_MEF2A_6	755	763	PF00069	0.370
DOC_PP1_RVXF_1	364	371	PF00149	0.501
DOC_PP2B_LxvP_1	437	440	PF13499	0.558
DOC_PP2B_LxvP_1	806	809	PF13499	0.552
DOC_PP2B_PxIxI_1	758	764	PF00149	0.382
DOC_PP4_FxxP_1	787	790	PF00568	0.586
DOC_USP7_MATH_1	212	216	PF00917	0.552
DOC_USP7_MATH_1	268	272	PF00917	0.517
DOC_USP7_MATH_1	283	287	PF00917	0.328
DOC_USP7_MATH_1	335	339	PF00917	0.529
DOC_USP7_MATH_1	400	404	PF00917	0.501
DOC_USP7_MATH_1	412	416	PF00917	0.634
DOC_USP7_MATH_1	466	470	PF00917	0.496
DOC_USP7_MATH_1	521	525	PF00917	0.720
DOC_USP7_MATH_1	62	66	PF00917	0.582
DOC_USP7_MATH_1	682	686	PF00917	0.429
DOC_USP7_MATH_1	795	799	PF00917	0.575
DOC_USP7_MATH_1	815	819	PF00917	0.642
DOC_USP7_MATH_1	93	97	PF00917	0.736
DOC_USP7_MATH_1	98	102	PF00917	0.734
DOC_USP7_MATH_2	473	479	PF00917	0.401
DOC_USP7_UBL2_3	210	214	PF12436	0.568
DOC_USP7_UBL2_3	485	489	PF12436	0.420
DOC_WW_Pin1_4	119	124	PF00397	0.613
DOC_WW_Pin1_4	130	135	PF00397	0.472
DOC_WW_Pin1_4	23	28	PF00397	0.448
DOC_WW_Pin1_4	264	269	PF00397	0.471
DOC_WW_Pin1_4	439	444	PF00397	0.807
DOC_WW_Pin1_4	451	456	PF00397	0.731
DOC_WW_Pin1_4	524	529	PF00397	0.675
DOC_WW_Pin1_4	565	570	PF00397	0.526
DOC_WW_Pin1_4	780	785	PF00397	0.505
DOC_WW_Pin1_4	811	816	PF00397	0.587
DOC_WW_Pin1_4	822	827	PF00397	0.519
LIG_14-3-3_CanoR_1	128	134	PF00244	0.538
LIG_14-3-3_CanoR_1	360	365	PF00244	0.546
LIG_14-3-3_CanoR_1	391	401	PF00244	0.452
LIG_14-3-3_CanoR_1	514	521	PF00244	0.813
LIG_14-3-3_CanoR_1	536	543	PF00244	0.674
LIG_14-3-3_CanoR_1	589	593	PF00244	0.456
LIG_14-3-3_CanoR_1	616	621	PF00244	0.586
LIG_14-3-3_CanoR_1	836	841	PF00244	0.449
LIG_14-3-3_CanoR_1	88	95	PF00244	0.532
LIG_Actin_WH2_2	475	491	PF00022	0.394
LIG_APCC_ABBA_1	678	683	PF00400	0.442
LIG_BIR_III_2	496	500	PF00653	0.473
LIG_BRCT_BRCA1_1	137	141	PF00533	0.384
LIG_BRCT_BRCA1_1	270	274	PF00533	0.567
LIG_BRCT_BRCA1_1	371	375	PF00533	0.389
LIG_EVH1_2	807	811	PF00568	0.423
LIG_FHA_1	106	112	PF00498	0.524
LIG_FHA_1	329	335	PF00498	0.572
LIG_FHA_1	428	434	PF00498	0.705
LIG_FHA_1	489	495	PF00498	0.608
LIG_FHA_1	641	647	PF00498	0.483
LIG_FHA_2	393	399	PF00498	0.654
LIG_FHA_2	430	436	PF00498	0.801
LIG_FHA_2	549	555	PF00498	0.549
LIG_FHA_2	723	729	PF00498	0.650
LIG_FHA_2	827	833	PF00498	0.526
LIG_GSK3_LRP6_1	439	444	PF00069	0.557
LIG_Integrin_RGD_1	449	451	PF01839	0.562
LIG_LIR_Apic_2	263	268	PF02991	0.438
LIG_LIR_Gen_1	133	144	PF02991	0.530
LIG_LIR_Gen_1	369	378	PF02991	0.353
LIG_LIR_Gen_1	568	577	PF02991	0.535
LIG_LIR_Gen_1	651	661	PF02991	0.430
LIG_LIR_Gen_1	721	730	PF02991	0.509
LIG_LIR_Nem_3	133	139	PF02991	0.487
LIG_LIR_Nem_3	320	325	PF02991	0.391
LIG_LIR_Nem_3	369	373	PF02991	0.366
LIG_LIR_Nem_3	568	574	PF02991	0.536
LIG_LIR_Nem_3	590	595	PF02991	0.446
LIG_LIR_Nem_3	651	657	PF02991	0.430
LIG_LIR_Nem_3	665	669	PF02991	0.457
LIG_LIR_Nem_3	721	727	PF02991	0.429
LIG_LIR_Nem_3	742	746	PF02991	0.342
LIG_LYPXL_S_1	321	325	PF13949	0.322
LIG_LYPXL_yS_3	322	325	PF13949	0.325
LIG_NRBOX	606	612	PF00104	0.474
LIG_SH2_GRB2like	686	689	PF00017	0.429
LIG_SH2_NCK_1	280	284	PF00017	0.413
LIG_SH2_NCK_1	724	728	PF00017	0.451
LIG_SH2_SRC	280	283	PF00017	0.441
LIG_SH2_STAP1	107	111	PF00017	0.521
LIG_SH2_STAP1	571	575	PF00017	0.501
LIG_SH2_STAP1	709	713	PF00017	0.474
LIG_SH2_STAT3	669	672	PF00017	0.474
LIG_SH2_STAT5	107	110	PF00017	0.663
LIG_SH2_STAT5	130	133	PF00017	0.446
LIG_SH2_STAT5	330	333	PF00017	0.576
LIG_SH2_STAT5	653	656	PF00017	0.524
LIG_SH2_STAT5	686	689	PF00017	0.429
LIG_SH2_STAT5	724	727	PF00017	0.380
LIG_SH2_STAT5	802	805	PF00017	0.360
LIG_SH3_1	802	808	PF00018	0.394
LIG_SH3_3	345	351	PF00018	0.650
LIG_SH3_3	37	43	PF00018	0.437
LIG_SH3_3	408	414	PF00018	0.609
LIG_SH3_3	437	443	PF00018	0.628
LIG_SH3_3	467	473	PF00018	0.616
LIG_SH3_3	505	511	PF00018	0.685
LIG_SH3_3	713	719	PF00018	0.498
LIG_SH3_3	769	775	PF00018	0.690
LIG_SH3_3	802	808	PF00018	0.417
LIG_SH3_CIN85_PxpxPR_1	528	533	PF14604	0.559
LIG_SUMO_SIM_anti_2	491	496	PF11976	0.465
LIG_SUMO_SIM_anti_2	578	585	PF11976	0.432
LIG_SUMO_SIM_par_1	490	496	PF11976	0.495
LIG_TRAF2_1	11	14	PF00917	0.571
LIG_TRAF2_1	279	282	PF00917	0.467
LIG_TRAF2_1	715	718	PF00917	0.474
LIG_TRAF2_1	829	832	PF00917	0.615
LIG_TYR_ITIM	722	727	PF00017	0.363
MOD_CDC14_SPxK_1	814	817	PF00782	0.584
MOD_CDK_SPK_2	565	570	PF00069	0.522
MOD_CDK_SPxK_1	811	817	PF00069	0.579
MOD_CK1_1	105	111	PF00069	0.703
MOD_CK1_1	122	128	PF00069	0.635
MOD_CK1_1	213	219	PF00069	0.634
MOD_CK1_1	270	276	PF00069	0.695
MOD_CK1_1	286	292	PF00069	0.309
MOD_CK1_1	3	9	PF00069	0.444
MOD_CK1_1	337	343	PF00069	0.613
MOD_CK1_1	454	460	PF00069	0.749
MOD_CK1_1	461	467	PF00069	0.757
MOD_CK1_1	524	530	PF00069	0.731
MOD_CK1_1	54	60	PF00069	0.606
MOD_CK1_1	545	551	PF00069	0.755
MOD_CK1_1	65	71	PF00069	0.595
MOD_CK1_1	824	830	PF00069	0.651
MOD_CK2_1	152	158	PF00069	0.501
MOD_CK2_1	23	29	PF00069	0.307
MOD_CK2_1	358	364	PF00069	0.512
MOD_CK2_1	429	435	PF00069	0.764
MOD_CK2_1	475	481	PF00069	0.497
MOD_CK2_1	512	518	PF00069	0.749
MOD_CK2_1	7	13	PF00069	0.559
MOD_CK2_1	722	728	PF00069	0.406
MOD_CK2_1	826	832	PF00069	0.545
MOD_DYRK1A_RPxSP_1	565	569	PF00069	0.421
MOD_GlcNHglycan	100	103	PF01048	0.683
MOD_GlcNHglycan	198	201	PF01048	0.657
MOD_GlcNHglycan	215	218	PF01048	0.515
MOD_GlcNHglycan	285	288	PF01048	0.388
MOD_GlcNHglycan	310	314	PF01048	0.417
MOD_GlcNHglycan	337	340	PF01048	0.624
MOD_GlcNHglycan	375	378	PF01048	0.517
MOD_GlcNHglycan	414	417	PF01048	0.655
MOD_GlcNHglycan	420	423	PF01048	0.669
MOD_GlcNHglycan	443	446	PF01048	0.689
MOD_GlcNHglycan	47	50	PF01048	0.363
MOD_GlcNHglycan	507	511	PF01048	0.645
MOD_GlcNHglycan	515	518	PF01048	0.728
MOD_GlcNHglycan	64	67	PF01048	0.684
MOD_GlcNHglycan	731	734	PF01048	0.509
MOD_GlcNHglycan	752	755	PF01048	0.445
MOD_GlcNHglycan	772	775	PF01048	0.684
MOD_GlcNHglycan	776	779	PF01048	0.509
MOD_GlcNHglycan	819	822	PF01048	0.618
MOD_GlcNHglycan	90	93	PF01048	0.683
MOD_GlcNHglycan	95	98	PF01048	0.696
MOD_GSK3_1	124	131	PF00069	0.526
MOD_GSK3_1	264	271	PF00069	0.642
MOD_GSK3_1	3	10	PF00069	0.516
MOD_GSK3_1	333	340	PF00069	0.634
MOD_GSK3_1	369	376	PF00069	0.453
MOD_GSK3_1	425	432	PF00069	0.747
MOD_GSK3_1	454	461	PF00069	0.710
MOD_GSK3_1	50	57	PF00069	0.454
MOD_GSK3_1	544	551	PF00069	0.672
MOD_GSK3_1	61	68	PF00069	0.654
MOD_GSK3_1	616	623	PF00069	0.433
MOD_GSK3_1	624	631	PF00069	0.360
MOD_GSK3_1	718	725	PF00069	0.442
MOD_GSK3_1	770	777	PF00069	0.645
MOD_GSK3_1	811	818	PF00069	0.682
MOD_GSK3_1	822	829	PF00069	0.565
MOD_GSK3_1	836	843	PF00069	0.366
MOD_GSK3_1	98	105	PF00069	0.758
MOD_N-GLC_1	187	192	PF02516	0.708
MOD_N-GLC_1	549	554	PF02516	0.681
MOD_N-GLC_1	579	584	PF02516	0.264
MOD_N-GLC_1	687	692	PF02516	0.264
MOD_N-GLC_2	44	46	PF02516	0.425
MOD_N-GLC_2	694	696	PF02516	0.264
MOD_NEK2_1	170	175	PF00069	0.439
MOD_NEK2_1	317	322	PF00069	0.488
MOD_NEK2_1	373	378	PF00069	0.493
MOD_NEK2_1	458	463	PF00069	0.670
MOD_NEK2_1	50	55	PF00069	0.512
MOD_NEK2_1	687	692	PF00069	0.294
MOD_NEK2_1	7	12	PF00069	0.578
MOD_NEK2_1	739	744	PF00069	0.352
MOD_NEK2_1	810	815	PF00069	0.742
MOD_NEK2_2	795	800	PF00069	0.395
MOD_PIKK_1	425	431	PF00454	0.657
MOD_PIKK_1	668	674	PF00454	0.326
MOD_PKA_1	210	216	PF00069	0.644
MOD_PKA_2	152	158	PF00069	0.501
MOD_PKA_2	359	365	PF00069	0.460
MOD_PKA_2	513	519	PF00069	0.565
MOD_PKA_2	535	541	PF00069	0.729
MOD_PKA_2	588	594	PF00069	0.298
MOD_PKA_2	750	756	PF00069	0.449
MOD_PKA_2	768	774	PF00069	0.598
MOD_PKB_1	542	550	PF00069	0.538
MOD_Plk_1	170	176	PF00069	0.444
MOD_Plk_1	579	585	PF00069	0.280
MOD_Plk_1	682	688	PF00069	0.264
MOD_Plk_1	795	801	PF00069	0.572
MOD_Plk_2-3	475	481	PF00069	0.398
MOD_Plk_4	344	350	PF00069	0.758
MOD_Plk_4	369	375	PF00069	0.357
MOD_Plk_4	454	460	PF00069	0.767
MOD_Plk_4	466	472	PF00069	0.607
MOD_Plk_4	579	585	PF00069	0.288
MOD_Plk_4	682	688	PF00069	0.269
MOD_ProDKin_1	119	125	PF00069	0.611
MOD_ProDKin_1	130	136	PF00069	0.463
MOD_ProDKin_1	23	29	PF00069	0.447
MOD_ProDKin_1	264	270	PF00069	0.475
MOD_ProDKin_1	439	445	PF00069	0.808
MOD_ProDKin_1	451	457	PF00069	0.728
MOD_ProDKin_1	524	530	PF00069	0.675
MOD_ProDKin_1	565	571	PF00069	0.517
MOD_ProDKin_1	780	786	PF00069	0.507
MOD_ProDKin_1	811	817	PF00069	0.591
MOD_ProDKin_1	822	828	PF00069	0.506
MOD_SUMO_rev_2	421	428	PF00179	0.575
TRG_DiLeu_BaEn_1	369	374	PF01217	0.315
TRG_DiLeu_BaEn_1	788	793	PF01217	0.525
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.537
TRG_ENDOCYTIC_2	322	325	PF00928	0.307
TRG_ENDOCYTIC_2	329	332	PF00928	0.403
TRG_ENDOCYTIC_2	571	574	PF00928	0.517
TRG_ENDOCYTIC_2	596	599	PF00928	0.264
TRG_ENDOCYTIC_2	724	727	PF00928	0.380
TRG_ENDOCYTIC_2	743	746	PF00928	0.334
TRG_ER_diArg_1	243	246	PF00400	0.542
TRG_ER_diArg_1	249	252	PF00400	0.542
TRG_ER_diArg_1	260	262	PF00400	0.600
TRG_ER_diArg_1	501	503	PF00400	0.648
TRG_ER_diArg_1	564	567	PF00400	0.579
TRG_ER_diArg_1	735	737	PF00400	0.347
TRG_ER_diArg_1	842	845	PF00400	0.447
TRG_NLS_Bipartite_1	207	223	PF00514	0.463
TRG_NLS_MonoExtC_3	206	211	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ6	Leptomonas seymouri	49%	100%
A0A1X0NYH3	Trypanosomatidae	30%	100%
A0A3R7KV16	Trypanosoma rangeli	30%	100%
A0A3S7WXM7	Leishmania donovani	100%	100%
C9ZV40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AW94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QB84	Leishmania major	87%	100%
V5ARQ1	Trypanosoma cruzi	29%	100%