LeishMANIAdb
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Putative mitochondrial RNA binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial RNA binding protein
Gene product:
mitochondrial RNA binding protein - putative
Species:
Leishmania infantum
UniProt:
A4I0C7_LEIIN
TriTrypDb:
LINF_230015400
Length:
348

Annotations

Annotations by Jardim et al.

Nucleic acid binding, mitochondrial RNA binding RBP38

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I0C7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0C7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003677 DNA binding 4 2
GO:0003697 single-stranded DNA binding 5 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 293 297 PF00656 0.250
CLV_MEL_PAP_1 10 16 PF00089 0.456
CLV_NRD_NRD_1 104 106 PF00675 0.395
CLV_NRD_NRD_1 182 184 PF00675 0.404
CLV_NRD_NRD_1 212 214 PF00675 0.438
CLV_NRD_NRD_1 279 281 PF00675 0.456
CLV_NRD_NRD_1 3 5 PF00675 0.534
CLV_NRD_NRD_1 310 312 PF00675 0.391
CLV_PCSK_KEX2_1 182 184 PF00082 0.495
CLV_PCSK_KEX2_1 212 214 PF00082 0.447
CLV_PCSK_KEX2_1 3 5 PF00082 0.534
CLV_PCSK_KEX2_1 309 311 PF00082 0.346
CLV_PCSK_PC1ET2_1 309 311 PF00082 0.317
DEG_APCC_DBOX_1 3 11 PF00400 0.586
DEG_APCC_KENBOX_2 137 141 PF00400 0.504
DEG_Nend_Nbox_1 1 3 PF02207 0.571
DOC_MAPK_gen_1 309 315 PF00069 0.285
DOC_PP1_RVXF_1 109 115 PF00149 0.386
DOC_PP2B_LxvP_1 87 90 PF13499 0.256
DOC_USP7_MATH_1 147 151 PF00917 0.376
DOC_USP7_MATH_1 273 277 PF00917 0.557
DOC_USP7_MATH_1 97 101 PF00917 0.372
DOC_USP7_UBL2_3 155 159 PF12436 0.424
DOC_USP7_UBL2_3 305 309 PF12436 0.245
DOC_WW_Pin1_4 43 48 PF00397 0.266
LIG_14-3-3_CanoR_1 122 126 PF00244 0.463
LIG_14-3-3_CanoR_1 13 20 PF00244 0.541
LIG_14-3-3_CanoR_1 3 8 PF00244 0.595
LIG_BRCT_BRCA1_1 200 204 PF00533 0.552
LIG_Clathr_ClatBox_1 327 331 PF01394 0.344
LIG_Clathr_ClatBox_1 81 85 PF01394 0.285
LIG_DLG_GKlike_1 3 10 PF00625 0.586
LIG_FHA_1 24 30 PF00498 0.468
LIG_FHA_1 264 270 PF00498 0.425
LIG_FHA_1 69 75 PF00498 0.260
LIG_FHA_2 232 238 PF00498 0.487
LIG_FHA_2 291 297 PF00498 0.391
LIG_LIR_Apic_2 298 303 PF02991 0.292
LIG_LIR_Gen_1 190 199 PF02991 0.340
LIG_LIR_Nem_3 190 195 PF02991 0.351
LIG_LIR_Nem_3 216 220 PF02991 0.350
LIG_Pex14_2 282 286 PF04695 0.519
LIG_REV1ctd_RIR_1 215 221 PF16727 0.335
LIG_SH2_STAT5 209 212 PF00017 0.365
LIG_SH3_3 259 265 PF00018 0.395
LIG_SUMO_SIM_par_1 25 31 PF11976 0.272
LIG_TRFH_1 218 222 PF08558 0.428
LIG_WRC_WIRS_1 264 269 PF05994 0.392
MOD_CK1_1 100 106 PF00069 0.386
MOD_CK1_1 124 130 PF00069 0.469
MOD_CK1_1 164 170 PF00069 0.497
MOD_CK1_1 178 184 PF00069 0.380
MOD_CK1_1 276 282 PF00069 0.561
MOD_CK1_1 316 322 PF00069 0.419
MOD_CK2_1 164 170 PF00069 0.507
MOD_GlcNHglycan 14 17 PF01048 0.655
MOD_GlcNHglycan 166 169 PF01048 0.431
MOD_GlcNHglycan 177 180 PF01048 0.359
MOD_GlcNHglycan 205 208 PF01048 0.361
MOD_GlcNHglycan 269 272 PF01048 0.417
MOD_GlcNHglycan 319 322 PF01048 0.325
MOD_GlcNHglycan 7 10 PF01048 0.635
MOD_GSK3_1 147 154 PF00069 0.346
MOD_GSK3_1 160 167 PF00069 0.331
MOD_GSK3_1 19 26 PF00069 0.617
MOD_GSK3_1 263 270 PF00069 0.455
MOD_GSK3_1 313 320 PF00069 0.399
MOD_GSK3_1 97 104 PF00069 0.358
MOD_NEK2_1 153 158 PF00069 0.403
MOD_NEK2_1 160 165 PF00069 0.322
MOD_NEK2_1 208 213 PF00069 0.323
MOD_PIKK_1 153 159 PF00454 0.433
MOD_PIKK_1 161 167 PF00454 0.312
MOD_PIKK_1 28 34 PF00454 0.268
MOD_PIKK_1 68 74 PF00454 0.266
MOD_PKA_1 3 9 PF00069 0.583
MOD_PKA_2 12 18 PF00069 0.538
MOD_PKA_2 121 127 PF00069 0.503
MOD_PKA_2 147 153 PF00069 0.345
MOD_PKA_2 3 9 PF00069 0.583
MOD_Plk_4 147 153 PF00069 0.345
MOD_Plk_4 263 269 PF00069 0.385
MOD_ProDKin_1 43 49 PF00069 0.266
MOD_SUMO_for_1 62 65 PF00179 0.391
TRG_DiLeu_BaEn_1 190 195 PF01217 0.386
TRG_ENDOCYTIC_2 325 328 PF00928 0.409
TRG_ER_diArg_1 182 184 PF00400 0.495
TRG_ER_diArg_1 2 4 PF00400 0.536

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8F7 Leptomonas seymouri 82% 100%
A0A0S4IYJ9 Bodo saltans 44% 100%
A0A1X0NXK3 Trypanosomatidae 70% 100%
A0A3Q8IB02 Leishmania donovani 100% 100%
A0A3R7MG63 Trypanosoma rangeli 72% 100%
A4HCU6 Leishmania braziliensis 93% 100%
C9ZV43 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9AW91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QB87 Leishmania major 98% 100%
V5BBM3 Trypanosoma cruzi 71% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS