G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase/Dynamin family - putative

Species:

Leishmania infantum

UniProt:

A4I0C5_LEIIN

TriTrypDb:

LINF_230015100

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0C5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.493
CLV_C14_Caspase3-7	540	544	PF00656	0.640
CLV_C14_Caspase3-7	601	605	PF00656	0.333
CLV_C14_Caspase3-7	73	77	PF00656	0.462
CLV_MEL_PAP_1	126	132	PF00089	0.417
CLV_NRD_NRD_1	212	214	PF00675	0.643
CLV_NRD_NRD_1	258	260	PF00675	0.450
CLV_NRD_NRD_1	309	311	PF00675	0.452
CLV_NRD_NRD_1	312	314	PF00675	0.456
CLV_NRD_NRD_1	511	513	PF00675	0.590
CLV_NRD_NRD_1	79	81	PF00675	0.585
CLV_PCSK_KEX2_1	212	214	PF00082	0.560
CLV_PCSK_KEX2_1	309	311	PF00082	0.443
CLV_PCSK_KEX2_1	316	318	PF00082	0.471
CLV_PCSK_KEX2_1	384	386	PF00082	0.701
CLV_PCSK_KEX2_1	511	513	PF00082	0.587
CLV_PCSK_KEX2_1	567	569	PF00082	0.330
CLV_PCSK_KEX2_1	78	80	PF00082	0.588
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.504
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.743
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.325
CLV_PCSK_SKI1_1	14	18	PF00082	0.450
CLV_PCSK_SKI1_1	167	171	PF00082	0.577
CLV_PCSK_SKI1_1	25	29	PF00082	0.395
CLV_PCSK_SKI1_1	296	300	PF00082	0.453
CLV_PCSK_SKI1_1	313	317	PF00082	0.452
CLV_PCSK_SKI1_1	355	359	PF00082	0.468
CLV_PCSK_SKI1_1	37	41	PF00082	0.389
CLV_PCSK_SKI1_1	387	391	PF00082	0.583
CLV_PCSK_SKI1_1	462	466	PF00082	0.212
CLV_PCSK_SKI1_1	564	568	PF00082	0.336
DEG_APCC_DBOX_1	295	303	PF00400	0.452
DEG_SCF_FBW7_1	372	379	PF00400	0.552
DEG_SPOP_SBC_1	191	195	PF00917	0.710
DEG_SPOP_SBC_1	198	202	PF00917	0.751
DEG_SPOP_SBC_1	280	284	PF00917	0.641
DOC_CKS1_1	148	153	PF01111	0.638
DOC_CKS1_1	440	445	PF01111	0.467
DOC_CKS1_1	477	482	PF01111	0.428
DOC_CKS1_1	7	12	PF01111	0.457
DOC_CKS1_1	88	93	PF01111	0.437
DOC_CYCLIN_RxL_1	229	237	PF00134	0.388
DOC_CYCLIN_yClb1_LxF_4	451	457	PF00134	0.429
DOC_MAPK_DCC_7	412	421	PF00069	0.517
DOC_MAPK_DCC_7	47	57	PF00069	0.401
DOC_MAPK_gen_1	109	119	PF00069	0.438
DOC_MAPK_gen_1	511	519	PF00069	0.461
DOC_MAPK_HePTP_8	28	40	PF00069	0.410
DOC_MAPK_MEF2A_6	31	40	PF00069	0.405
DOC_MAPK_MEF2A_6	412	421	PF00069	0.413
DOC_MAPK_RevD_3	63	79	PF00069	0.443
DOC_PP1_RVXF_1	315	322	PF00149	0.460
DOC_PP1_RVXF_1	35	41	PF00149	0.407
DOC_PP2B_LxvP_1	102	105	PF13499	0.645
DOC_PP4_FxxP_1	101	104	PF00568	0.425
DOC_USP7_MATH_1	187	191	PF00917	0.668
DOC_USP7_MATH_1	198	202	PF00917	0.619
DOC_USP7_MATH_1	223	227	PF00917	0.556
DOC_USP7_MATH_1	411	415	PF00917	0.540
DOC_USP7_UBL2_3	390	394	PF12436	0.587
DOC_WW_Pin1_4	1	6	PF00397	0.446
DOC_WW_Pin1_4	100	105	PF00397	0.396
DOC_WW_Pin1_4	147	152	PF00397	0.677
DOC_WW_Pin1_4	194	199	PF00397	0.626
DOC_WW_Pin1_4	372	377	PF00397	0.684
DOC_WW_Pin1_4	439	444	PF00397	0.536
DOC_WW_Pin1_4	476	481	PF00397	0.439
DOC_WW_Pin1_4	520	525	PF00397	0.562
DOC_WW_Pin1_4	64	69	PF00397	0.543
DOC_WW_Pin1_4	660	665	PF00397	0.477
DOC_WW_Pin1_4	87	92	PF00397	0.440
LIG_14-3-3_CanoR_1	112	119	PF00244	0.435
LIG_14-3-3_CanoR_1	164	170	PF00244	0.565
LIG_14-3-3_CanoR_1	212	222	PF00244	0.595
LIG_14-3-3_CanoR_1	31	36	PF00244	0.400
LIG_14-3-3_CanoR_1	317	322	PF00244	0.523
LIG_14-3-3_CanoR_1	355	360	PF00244	0.510
LIG_14-3-3_CanoR_1	412	416	PF00244	0.515
LIG_14-3-3_CanoR_1	424	432	PF00244	0.388
LIG_14-3-3_CanoR_1	512	518	PF00244	0.589
LIG_14-3-3_CanoR_1	624	632	PF00244	0.409
LIG_14-3-3_CanoR_1	66	72	PF00244	0.439
LIG_14-3-3_CanoR_1	78	84	PF00244	0.478
LIG_Actin_WH2_2	151	166	PF00022	0.513
LIG_Actin_WH2_2	433	450	PF00022	0.467
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BIR_III_2	604	608	PF00653	0.375
LIG_BRCT_BRCA1_1	452	456	PF00533	0.478
LIG_Clathr_ClatBox_1	463	467	PF01394	0.507
LIG_eIF4E_1	583	589	PF01652	0.418
LIG_eIF4E_1	617	623	PF01652	0.403
LIG_FHA_1	329	335	PF00498	0.523
LIG_FHA_1	449	455	PF00498	0.431
LIG_FHA_1	477	483	PF00498	0.400
LIG_FHA_1	553	559	PF00498	0.572
LIG_FHA_1	632	638	PF00498	0.344
LIG_FHA_2	324	330	PF00498	0.483
LIG_FHA_2	544	550	PF00498	0.718
LIG_FHA_2	599	605	PF00498	0.307
LIG_FHA_2	71	77	PF00498	0.454
LIG_GBD_Chelix_1	432	440	PF00786	0.324
LIG_GSK3_LRP6_1	87	92	PF00069	0.440
LIG_LIR_Apic_2	590	595	PF02991	0.482
LIG_LIR_Gen_1	582	592	PF02991	0.357
LIG_LIR_Gen_1	663	670	PF02991	0.423
LIG_LIR_Nem_3	301	306	PF02991	0.447
LIG_LIR_Nem_3	33	38	PF02991	0.401
LIG_LIR_Nem_3	442	447	PF02991	0.478
LIG_LIR_Nem_3	453	459	PF02991	0.433
LIG_LIR_Nem_3	582	588	PF02991	0.286
LIG_LIR_Nem_3	663	669	PF02991	0.453
LIG_PCNA_yPIPBox_3	429	441	PF02747	0.431
LIG_PDZ_Class_1	665	670	PF00595	0.472
LIG_RPA_C_Fungi	74	86	PF08784	0.474
LIG_SH2_CRK	592	596	PF00017	0.366
LIG_SH2_NCK_1	457	461	PF00017	0.255
LIG_SH2_PTP2	54	57	PF00017	0.404
LIG_SH2_PTP2	62	65	PF00017	0.403
LIG_SH2_SRC	54	57	PF00017	0.404
LIG_SH2_SRC	62	65	PF00017	0.403
LIG_SH2_STAT5	118	121	PF00017	0.409
LIG_SH2_STAT5	29	32	PF00017	0.418
LIG_SH2_STAT5	303	306	PF00017	0.584
LIG_SH2_STAT5	48	51	PF00017	0.361
LIG_SH2_STAT5	494	497	PF00017	0.334
LIG_SH2_STAT5	54	57	PF00017	0.392
LIG_SH2_STAT5	585	588	PF00017	0.297
LIG_SH2_STAT5	617	620	PF00017	0.536
LIG_SH2_STAT5	62	65	PF00017	0.390
LIG_SH2_STAT5	625	628	PF00017	0.376
LIG_SH3_3	176	182	PF00018	0.593
LIG_SH3_3	2	8	PF00018	0.442
LIG_SH3_3	217	223	PF00018	0.448
LIG_SH3_3	463	469	PF00018	0.261
LIG_SH3_3	50	56	PF00018	0.401
LIG_SH3_3	514	520	PF00018	0.592
LIG_SH3_3	85	91	PF00018	0.451
LIG_TRFH_1	100	104	PF08558	0.426
LIG_TYR_ITIM	46	51	PF00017	0.399
LIG_TYR_ITIM	52	57	PF00017	0.389
LIG_WRC_WIRS_1	649	654	PF05994	0.481
LIG_WW_2	5	8	PF00397	0.421
MOD_CDC14_SPxK_1	202	205	PF00782	0.651
MOD_CDK_SPK_2	6	11	PF00069	0.451
MOD_CDK_SPK_2	64	69	PF00069	0.422
MOD_CDK_SPxK_1	199	205	PF00069	0.657
MOD_CDK_SPxxK_3	147	154	PF00069	0.523
MOD_CDK_SPxxK_3	520	527	PF00069	0.519
MOD_CK1_1	103	109	PF00069	0.535
MOD_CK1_1	120	126	PF00069	0.379
MOD_CK1_1	165	171	PF00069	0.510
MOD_CK1_1	190	196	PF00069	0.639
MOD_CK1_1	197	203	PF00069	0.621
MOD_CK1_1	281	287	PF00069	0.644
MOD_CK1_1	427	433	PF00069	0.255
MOD_CK1_1	67	73	PF00069	0.501
MOD_CK2_1	223	229	PF00069	0.592
MOD_CK2_1	281	287	PF00069	0.644
MOD_CMANNOS	321	324	PF00535	0.464
MOD_Cter_Amidation	307	310	PF01082	0.445
MOD_Cter_Amidation	382	385	PF01082	0.709
MOD_GlcNHglycan	105	108	PF01048	0.554
MOD_GlcNHglycan	183	186	PF01048	0.744
MOD_GlcNHglycan	189	192	PF01048	0.647
MOD_GlcNHglycan	215	218	PF01048	0.556
MOD_GlcNHglycan	225	228	PF01048	0.420
MOD_GlcNHglycan	381	384	PF01048	0.682
MOD_GlcNHglycan	426	429	PF01048	0.318
MOD_GlcNHglycan	527	530	PF01048	0.723
MOD_GlcNHglycan	573	576	PF01048	0.404
MOD_GSK3_1	187	194	PF00069	0.592
MOD_GSK3_1	274	281	PF00069	0.560
MOD_GSK3_1	372	379	PF00069	0.693
MOD_GSK3_1	423	430	PF00069	0.256
MOD_GSK3_1	660	667	PF00069	0.450
MOD_GSK3_1	67	74	PF00069	0.499
MOD_LATS_1	211	217	PF00433	0.498
MOD_LATS_1	446	452	PF00433	0.321
MOD_LATS_1	550	556	PF00433	0.718
MOD_N-GLC_1	335	340	PF02516	0.578
MOD_N-GLC_1	543	548	PF02516	0.760
MOD_NEK2_1	162	167	PF00069	0.558
MOD_NEK2_1	335	340	PF00069	0.559
MOD_NEK2_1	447	452	PF00069	0.294
MOD_NEK2_1	571	576	PF00069	0.368
MOD_NEK2_1	632	637	PF00069	0.318
MOD_NEK2_1	648	653	PF00069	0.339
MOD_PIKK_1	118	124	PF00454	0.458
MOD_PIKK_1	617	623	PF00454	0.482
MOD_PK_1	79	85	PF00069	0.477
MOD_PKA_1	212	218	PF00069	0.442
MOD_PKA_1	79	85	PF00069	0.477
MOD_PKA_2	111	117	PF00069	0.442
MOD_PKA_2	163	169	PF00069	0.573
MOD_PKA_2	212	218	PF00069	0.543
MOD_PKA_2	251	257	PF00069	0.488
MOD_PKA_2	274	280	PF00069	0.516
MOD_PKA_2	30	36	PF00069	0.403
MOD_PKA_2	411	417	PF00069	0.507
MOD_PKA_2	423	429	PF00069	0.225
MOD_PKA_2	447	453	PF00069	0.458
MOD_PKA_2	612	618	PF00069	0.470
MOD_PKA_2	623	629	PF00069	0.325
MOD_PKA_2	79	85	PF00069	0.477
MOD_Plk_1	243	249	PF00069	0.509
MOD_Plk_1	664	670	PF00069	0.418
MOD_Plk_2-3	543	549	PF00069	0.507
MOD_Plk_4	411	417	PF00069	0.491
MOD_Plk_4	428	434	PF00069	0.180
MOD_ProDKin_1	1	7	PF00069	0.449
MOD_ProDKin_1	100	106	PF00069	0.395
MOD_ProDKin_1	147	153	PF00069	0.674
MOD_ProDKin_1	194	200	PF00069	0.626
MOD_ProDKin_1	372	378	PF00069	0.687
MOD_ProDKin_1	439	445	PF00069	0.418
MOD_ProDKin_1	476	482	PF00069	0.442
MOD_ProDKin_1	520	526	PF00069	0.562
MOD_ProDKin_1	64	70	PF00069	0.544
MOD_ProDKin_1	660	666	PF00069	0.464
MOD_ProDKin_1	87	93	PF00069	0.439
MOD_SUMO_for_1	135	138	PF00179	0.456
MOD_SUMO_rev_2	248	256	PF00179	0.503
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.418
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.380
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.622
TRG_ENDOCYTIC_2	303	306	PF00928	0.439
TRG_ENDOCYTIC_2	444	447	PF00928	0.255
TRG_ENDOCYTIC_2	474	477	PF00928	0.375
TRG_ENDOCYTIC_2	48	51	PF00928	0.399
TRG_ENDOCYTIC_2	54	57	PF00928	0.392
TRG_ENDOCYTIC_2	585	588	PF00928	0.390
TRG_ENDOCYTIC_2	62	65	PF00928	0.390
TRG_ER_diArg_1	212	214	PF00400	0.672
TRG_ER_diArg_1	289	292	PF00400	0.515
TRG_ER_diArg_1	309	311	PF00400	0.320
TRG_ER_diArg_1	511	513	PF00400	0.482
TRG_ER_diArg_1	78	80	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I045	Leptomonas seymouri	62%	100%
A0A0S4IVC3	Bodo saltans	45%	100%
A0A1X0NWZ9	Trypanosomatidae	52%	100%
A0A3S7WXN4	Leishmania donovani	100%	100%
A0A422MX57	Trypanosoma rangeli	53%	100%
A4HCU4	Leishmania braziliensis	83%	100%
C9ZV46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
V5ARP5	Trypanosoma cruzi	53%	100%