Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein - putative

Species:

Leishmania infantum

UniProt:

A4I0C4_LEIIN

TriTrypDb:

LINF_230015000

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0C4

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.536
CLV_C14_Caspase3-7	233	237	PF00656	0.652
CLV_C14_Caspase3-7	320	324	PF00656	0.630
CLV_NRD_NRD_1	128	130	PF00675	0.419
CLV_NRD_NRD_1	234	236	PF00675	0.698
CLV_NRD_NRD_1	242	244	PF00675	0.605
CLV_NRD_NRD_1	248	250	PF00675	0.542
CLV_NRD_NRD_1	254	256	PF00675	0.560
CLV_PCSK_FUR_1	232	236	PF00082	0.686
CLV_PCSK_FUR_1	240	244	PF00082	0.607
CLV_PCSK_KEX2_1	128	130	PF00082	0.419
CLV_PCSK_KEX2_1	234	236	PF00082	0.684
CLV_PCSK_KEX2_1	242	244	PF00082	0.698
CLV_PCSK_KEX2_1	248	250	PF00082	0.572
CLV_PCSK_KEX2_1	254	256	PF00082	0.526
DEG_SCF_FBW7_1	363	368	PF00400	0.623
DEG_SCF_FBW7_2	113	118	PF00400	0.606
DEG_SPOP_SBC_1	316	320	PF00917	0.592
DOC_MAPK_FxFP_2	440	443	PF00069	0.648
DOC_PP2B_LxvP_1	225	228	PF13499	0.658
DOC_PP2B_LxvP_1	392	395	PF13499	0.572
DOC_PP4_FxxP_1	303	306	PF00568	0.576
DOC_PP4_FxxP_1	440	443	PF00568	0.648
DOC_USP7_MATH_1	26	30	PF00917	0.636
DOC_USP7_MATH_1	286	290	PF00917	0.619
DOC_USP7_MATH_1	365	369	PF00917	0.643
DOC_USP7_MATH_1	395	399	PF00917	0.536
DOC_USP7_MATH_1	452	456	PF00917	0.600
DOC_USP7_MATH_1	46	50	PF00917	0.601
DOC_USP7_MATH_1	516	520	PF00917	0.710
DOC_USP7_MATH_1	547	551	PF00917	0.600
DOC_USP7_MATH_1	95	99	PF00917	0.572
DOC_USP7_UBL2_3	89	93	PF12436	0.622
DOC_WW_Pin1_4	1	6	PF00397	0.719
DOC_WW_Pin1_4	103	108	PF00397	0.592
DOC_WW_Pin1_4	111	116	PF00397	0.610
DOC_WW_Pin1_4	207	212	PF00397	0.520
DOC_WW_Pin1_4	328	333	PF00397	0.673
DOC_WW_Pin1_4	337	342	PF00397	0.616
DOC_WW_Pin1_4	354	359	PF00397	0.722
DOC_WW_Pin1_4	361	366	PF00397	0.616
DOC_WW_Pin1_4	383	388	PF00397	0.580
DOC_WW_Pin1_4	390	395	PF00397	0.572
DOC_WW_Pin1_4	435	440	PF00397	0.575
DOC_WW_Pin1_4	512	517	PF00397	0.667
DOC_WW_Pin1_4	80	85	PF00397	0.596
LIG_14-3-3_CanoR_1	97	102	PF00244	0.642
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_4	425	429	PF00653	0.677
LIG_BRCT_BRCA1_1	141	145	PF00533	0.475
LIG_BRCT_BRCA1_1	18	22	PF00533	0.616
LIG_BRCT_BRCA1_1	332	336	PF00533	0.620
LIG_FHA_1	312	318	PF00498	0.627
LIG_FHA_1	45	51	PF00498	0.650
LIG_FHA_1	460	466	PF00498	0.610
LIG_FHA_2	470	476	PF00498	0.616
LIG_LIR_Apic_2	438	443	PF02991	0.644
LIG_LIR_Apic_2	473	479	PF02991	0.604
LIG_LIR_Gen_1	52	61	PF02991	0.605
LIG_LIR_Gen_1	535	546	PF02991	0.497
LIG_LIR_Nem_3	142	148	PF02991	0.475
LIG_LIR_Nem_3	298	303	PF02991	0.513
LIG_LIR_Nem_3	333	339	PF02991	0.713
LIG_LIR_Nem_3	483	489	PF02991	0.544
LIG_LIR_Nem_3	493	499	PF02991	0.552
LIG_LIR_Nem_3	52	56	PF02991	0.709
LIG_LIR_Nem_3	535	541	PF02991	0.519
LIG_MYND_1	556	560	PF01753	0.643
LIG_Pex14_2	18	22	PF04695	0.671
LIG_Pex14_2	440	444	PF04695	0.649
LIG_PTAP_UEV_1	562	567	PF05743	0.634
LIG_SH2_SRC	561	564	PF00017	0.661
LIG_SH2_STAT5	132	135	PF00017	0.475
LIG_SH2_STAT5	300	303	PF00017	0.651
LIG_SH2_STAT5	540	543	PF00017	0.597
LIG_SH2_STAT5	561	564	PF00017	0.782
LIG_SH3_1	81	87	PF00018	0.716
LIG_SH3_2	116	121	PF14604	0.592
LIG_SH3_2	84	89	PF14604	0.601
LIG_SH3_3	110	116	PF00018	0.628
LIG_SH3_3	274	280	PF00018	0.648
LIG_SH3_3	433	439	PF00018	0.660
LIG_SH3_3	446	452	PF00018	0.681
LIG_SH3_3	484	490	PF00018	0.527
LIG_SH3_3	510	516	PF00018	0.585
LIG_SH3_3	553	559	PF00018	0.569
LIG_SH3_3	560	566	PF00018	0.596
LIG_SH3_3	81	87	PF00018	0.718
LIG_SxIP_EBH_1	254	268	PF03271	0.539
LIG_WRC_WIRS_1	50	55	PF05994	0.598
LIG_WW_1	137	140	PF00397	0.475
MOD_CDK_SPK_2	342	347	PF00069	0.583
MOD_CK1_1	179	185	PF00069	0.500
MOD_CK1_1	207	213	PF00069	0.523
MOD_CK1_1	21	27	PF00069	0.602
MOD_CK1_1	241	247	PF00069	0.688
MOD_CK1_1	33	39	PF00069	0.637
MOD_CK1_1	331	337	PF00069	0.669
MOD_CK1_1	345	351	PF00069	0.586
MOD_CK1_1	383	389	PF00069	0.605
MOD_CK1_1	398	404	PF00069	0.630
MOD_CK1_1	407	413	PF00069	0.619
MOD_CK1_1	49	55	PF00069	0.618
MOD_CK1_1	550	556	PF00069	0.624
MOD_CK2_1	11	17	PF00069	0.622
MOD_CK2_1	26	32	PF00069	0.555
MOD_CK2_1	469	475	PF00069	0.615
MOD_Cter_Amidation	252	255	PF01082	0.684
MOD_GlcNHglycan	1	4	PF01048	0.571
MOD_GlcNHglycan	133	136	PF01048	0.291
MOD_GlcNHglycan	180	184	PF01048	0.302
MOD_GlcNHglycan	243	246	PF01048	0.654
MOD_GlcNHglycan	26	29	PF01048	0.626
MOD_GlcNHglycan	269	272	PF01048	0.573
MOD_GlcNHglycan	288	291	PF01048	0.638
MOD_GlcNHglycan	319	322	PF01048	0.683
MOD_GlcNHglycan	32	35	PF01048	0.636
MOD_GlcNHglycan	367	370	PF01048	0.605
MOD_GlcNHglycan	382	385	PF01048	0.559
MOD_GlcNHglycan	409	412	PF01048	0.647
MOD_GlcNHglycan	454	457	PF01048	0.572
MOD_GlcNHglycan	509	512	PF01048	0.709
MOD_GlcNHglycan	518	521	PF01048	0.615
MOD_GlcNHglycan	563	566	PF01048	0.609
MOD_GlcNHglycan	577	580	PF01048	0.515
MOD_GlcNHglycan	97	100	PF01048	0.662
MOD_GSK3_1	12	19	PF00069	0.767
MOD_GSK3_1	24	31	PF00069	0.576
MOD_GSK3_1	244	251	PF00069	0.748
MOD_GSK3_1	311	318	PF00069	0.631
MOD_GSK3_1	327	334	PF00069	0.590
MOD_GSK3_1	361	368	PF00069	0.600
MOD_GSK3_1	386	393	PF00069	0.591
MOD_GSK3_1	395	402	PF00069	0.628
MOD_GSK3_1	403	410	PF00069	0.699
MOD_GSK3_1	45	52	PF00069	0.697
MOD_GSK3_1	498	505	PF00069	0.593
MOD_GSK3_1	512	519	PF00069	0.696
MOD_GSK3_1	532	539	PF00069	0.605
MOD_GSK3_1	95	102	PF00069	0.630
MOD_N-GLC_1	11	16	PF02516	0.734
MOD_N-GLC_1	190	195	PF02516	0.275
MOD_N-GLC_1	221	226	PF02516	0.605
MOD_N-GLC_1	238	243	PF02516	0.717
MOD_N-GLC_1	257	262	PF02516	0.621
MOD_N-GLC_1	328	333	PF02516	0.669
MOD_N-GLC_1	532	537	PF02516	0.595
MOD_N-GLC_1	548	553	PF02516	0.637
MOD_N-GLC_1	567	572	PF02516	0.625
MOD_NEK2_1	18	23	PF00069	0.634
MOD_NEK2_1	190	195	PF00069	0.475
MOD_NEK2_1	204	209	PF00069	0.490
MOD_NEK2_1	317	322	PF00069	0.652
MOD_NEK2_1	39	44	PF00069	0.601
MOD_NEK2_1	45	50	PF00069	0.549
MOD_NEK2_1	459	464	PF00069	0.608
MOD_NEK2_1	548	553	PF00069	0.669
MOD_NEK2_2	332	337	PF00069	0.539
MOD_NEK2_2	395	400	PF00069	0.650
MOD_PIKK_1	248	254	PF00454	0.634
MOD_PIKK_1	26	32	PF00454	0.641
MOD_PIKK_1	295	301	PF00454	0.657
MOD_PIKK_1	33	39	PF00454	0.577
MOD_PIKK_1	430	436	PF00454	0.735
MOD_PIKK_1	64	70	PF00454	0.669
MOD_PKA_1	248	254	PF00069	0.685
MOD_PKA_2	241	247	PF00069	0.663
MOD_PKA_2	248	254	PF00069	0.584
MOD_Plk_1	16	22	PF00069	0.670
MOD_Plk_1	221	227	PF00069	0.582
MOD_Plk_1	257	263	PF00069	0.597
MOD_Plk_4	190	196	PF00069	0.475
MOD_Plk_4	332	338	PF00069	0.540
MOD_Plk_4	46	52	PF00069	0.595
MOD_Plk_4	580	586	PF00069	0.576
MOD_ProDKin_1	1	7	PF00069	0.718
MOD_ProDKin_1	103	109	PF00069	0.590
MOD_ProDKin_1	111	117	PF00069	0.611
MOD_ProDKin_1	207	213	PF00069	0.523
MOD_ProDKin_1	328	334	PF00069	0.671
MOD_ProDKin_1	337	343	PF00069	0.613
MOD_ProDKin_1	354	360	PF00069	0.721
MOD_ProDKin_1	361	367	PF00069	0.620
MOD_ProDKin_1	383	389	PF00069	0.578
MOD_ProDKin_1	390	396	PF00069	0.574
MOD_ProDKin_1	435	441	PF00069	0.577
MOD_ProDKin_1	512	518	PF00069	0.663
MOD_ProDKin_1	80	86	PF00069	0.594
TRG_ENDOCYTIC_2	300	303	PF00928	0.575
TRG_ENDOCYTIC_2	488	491	PF00928	0.572
TRG_ENDOCYTIC_2	496	499	PF00928	0.600
TRG_ENDOCYTIC_2	540	543	PF00928	0.559
TRG_ER_diArg_1	127	129	PF00400	0.438
TRG_ER_diArg_1	240	243	PF00400	0.686
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P747	Leptomonas seymouri	39%	99%
A0A3Q8ICI4	Leishmania donovani	99%	100%
A4HCU3	Leishmania braziliensis	74%	100%
E9AW88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QB90	Leishmania major	93%	100%