LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative 3-ketoacyl-CoA thiolase

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 3-ketoacyl-CoA thiolase
Gene product:
3-ketoacyl-CoA thiolase - putative
Species:
Leishmania infantum
UniProt:
A4I0C0_LEIIN
TriTrypDb:
LINF_230014600
Length:
441

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, 3-ketoacyl-CoA thiolase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 229

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I0C0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0C0

PDB structure(s): 3zbg_A , 3zbg_B , 3zbk_A , 3zbk_B , 3zbl_A , 3zbl_B , 3zbn_A , 3zbn_B , 3zbn_C , 3zbn_D , 5lnq_A , 5lnq_B , 5lnq_C , 5lnq_D , 5lot_A , 5lot_B , 5lot_C , 5lot_D

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0003988 acetyl-CoA C-acyltransferase activity 6 7
GO:0016408 C-acyltransferase activity 5 7
GO:0016740 transferase activity 2 11
GO:0016746 acyltransferase activity 3 11
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 174 176 PF00675 0.372
CLV_NRD_NRD_1 225 227 PF00675 0.250
CLV_PCSK_KEX2_1 188 190 PF00082 0.273
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.267
CLV_PCSK_SKI1_1 188 192 PF00082 0.241
CLV_PCSK_SKI1_1 403 407 PF00082 0.267
DEG_APCC_DBOX_1 216 224 PF00400 0.241
DEG_Nend_Nbox_1 1 3 PF02207 0.535
DOC_CDC14_PxL_1 414 422 PF14671 0.317
DOC_CYCLIN_RxL_1 222 231 PF00134 0.252
DOC_MAPK_FxFP_2 180 183 PF00069 0.231
DOC_MAPK_gen_1 43 49 PF00069 0.321
DOC_MAPK_JIP1_4 328 334 PF00069 0.250
DOC_MAPK_MEF2A_6 9 17 PF00069 0.416
DOC_PP1_RVXF_1 224 231 PF00149 0.268
DOC_PP4_FxxP_1 180 183 PF00568 0.231
DOC_PP4_FxxP_1 386 389 PF00568 0.231
DOC_USP7_MATH_1 122 126 PF00917 0.259
DOC_USP7_MATH_1 283 287 PF00917 0.427
DOC_USP7_MATH_1 96 100 PF00917 0.269
DOC_WW_Pin1_4 20 25 PF00397 0.274
DOC_WW_Pin1_4 279 284 PF00397 0.413
LIG_14-3-3_CanoR_1 226 231 PF00244 0.251
LIG_14-3-3_CanoR_1 254 261 PF00244 0.268
LIG_14-3-3_CanoR_1 3 13 PF00244 0.476
LIG_Actin_WH2_2 124 140 PF00022 0.360
LIG_BRCT_BRCA1_1 29 33 PF00533 0.284
LIG_EH1_1 340 348 PF00400 0.231
LIG_FHA_1 132 138 PF00498 0.253
LIG_FHA_1 155 161 PF00498 0.268
LIG_FHA_1 202 208 PF00498 0.259
LIG_FHA_1 21 27 PF00498 0.294
LIG_FHA_1 223 229 PF00498 0.252
LIG_FHA_2 198 204 PF00498 0.231
LIG_FHA_2 246 252 PF00498 0.321
LIG_FHA_2 340 346 PF00498 0.311
LIG_FHA_2 367 373 PF00498 0.231
LIG_FHA_2 46 52 PF00498 0.253
LIG_LIR_Apic_2 178 183 PF02991 0.231
LIG_LIR_Apic_2 299 305 PF02991 0.445
LIG_LIR_Apic_2 385 389 PF02991 0.287
LIG_LIR_Gen_1 251 257 PF02991 0.321
LIG_LIR_Nem_3 179 185 PF02991 0.231
LIG_LIR_Nem_3 247 252 PF02991 0.231
LIG_PCNA_PIPBox_1 75 84 PF02747 0.343
LIG_PCNA_yPIPBox_3 69 82 PF02747 0.343
LIG_Pex14_2 182 186 PF04695 0.231
LIG_PTB_Apo_2 243 250 PF02174 0.302
LIG_PTB_Phospho_1 243 249 PF10480 0.231
LIG_RPA_C_Fungi 310 322 PF08784 0.250
LIG_SH2_GRB2like 212 215 PF00017 0.231
LIG_SH2_NCK_1 302 306 PF00017 0.340
LIG_SH2_SRC 212 215 PF00017 0.231
LIG_SH2_SRC 302 305 PF00017 0.311
LIG_SH2_STAT3 171 174 PF00017 0.231
LIG_SH2_STAT5 164 167 PF00017 0.231
LIG_SH2_STAT5 192 195 PF00017 0.360
LIG_SH2_STAT5 252 255 PF00017 0.360
LIG_SUMO_SIM_par_1 285 293 PF11976 0.338
LIG_TRAF2_1 271 274 PF00917 0.250
LIG_TRAF2_1 48 51 PF00917 0.259
LIG_TYR_ITIM 347 352 PF00017 0.231
LIG_WRC_WIRS_1 383 388 PF05994 0.287
MOD_CK1_1 259 265 PF00069 0.228
MOD_CK1_1 4 10 PF00069 0.546
MOD_CK2_1 245 251 PF00069 0.321
MOD_CK2_1 339 345 PF00069 0.233
MOD_CK2_1 366 372 PF00069 0.275
MOD_CK2_1 45 51 PF00069 0.273
MOD_Cter_Amidation 41 44 PF01082 0.231
MOD_GlcNHglycan 124 127 PF01048 0.246
MOD_GlcNHglycan 131 134 PF01048 0.340
MOD_GlcNHglycan 140 143 PF01048 0.311
MOD_GlcNHglycan 434 437 PF01048 0.379
MOD_GSK3_1 197 204 PF00069 0.234
MOD_GSK3_1 222 229 PF00069 0.275
MOD_GSK3_1 279 286 PF00069 0.365
MOD_GSK3_1 53 60 PF00069 0.327
MOD_LATS_1 224 230 PF00433 0.310
MOD_N-GLC_1 245 250 PF02516 0.309
MOD_N-GLC_1 283 288 PF02516 0.370
MOD_N-GLC_1 45 50 PF02516 0.231
MOD_NEK2_1 1 6 PF00069 0.534
MOD_NEK2_1 201 206 PF00069 0.231
MOD_NEK2_1 311 316 PF00069 0.267
MOD_NEK2_1 420 425 PF00069 0.273
MOD_NEK2_1 53 58 PF00069 0.247
MOD_NEK2_1 85 90 PF00069 0.227
MOD_PIKK_1 256 262 PF00454 0.231
MOD_PIKK_1 85 91 PF00454 0.227
MOD_PKA_1 226 232 PF00069 0.293
MOD_PKA_2 2 8 PF00069 0.553
MOD_PKA_2 253 259 PF00069 0.268
MOD_Plk_1 178 184 PF00069 0.231
MOD_Plk_1 245 251 PF00069 0.243
MOD_Plk_1 256 262 PF00069 0.205
MOD_Plk_1 283 289 PF00069 0.389
MOD_Plk_1 367 373 PF00069 0.310
MOD_Plk_1 429 435 PF00069 0.271
MOD_Plk_1 45 51 PF00069 0.231
MOD_Plk_2-3 339 345 PF00069 0.231
MOD_ProDKin_1 20 26 PF00069 0.275
MOD_ProDKin_1 279 285 PF00069 0.408
MOD_SUMO_rev_2 285 294 PF00179 0.292
MOD_SUMO_rev_2 30 39 PF00179 0.356
TRG_ENDOCYTIC_2 252 255 PF00928 0.275
TRG_ENDOCYTIC_2 349 352 PF00928 0.231
TRG_ENDOCYTIC_2 402 405 PF00928 0.231
TRG_NLS_Bipartite_1 175 192 PF00514 0.324
TRG_Pf-PMV_PEXEL_1 175 179 PF00026 0.231
TRG_Pf-PMV_PEXEL_1 226 231 PF00026 0.252
TRG_PTS2 1 22 PF00400 0.352

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFA5 Leptomonas seymouri 82% 100%
A0A0S4IUN8 Bodo saltans 65% 100%
A0A1X0NX18 Trypanosomatidae 75% 100%
A0A3R7K9N6 Trypanosoma rangeli 74% 100%
A0A3S7WXL6 Leishmania donovani 100% 100%
A0KK76 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) 26% 100%
A0KV75 Shewanella sp. (strain ANA-3) 23% 100%
A1ADI9 Escherichia coli O1:K1 / APEC 22% 100%
A1JK23 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 22% 100%
A1RI91 Shewanella sp. (strain W3-18-1) 24% 100%
A3D685 Shewanella baltica (strain OS155 / ATCC BAA-1091) 23% 100%
A4HCU5 Leishmania braziliensis 91% 100%
A4SMT9 Aeromonas salmonicida (strain A449) 26% 100%
A4WCW7 Enterobacter sp. (strain 638) 22% 100%
A4Y898 Shewanella putrefaciens (strain CN-32 / ATCC BAA-453) 24% 100%
A5F2P1 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) 23% 100%
A6TC20 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 21% 100%
A6WQ26 Shewanella baltica (strain OS185) 23% 100%
A7ZPF9 Escherichia coli O139:H28 (strain E24377A / ETEC) 21% 100%
A8A2L1 Escherichia coli O9:H4 (strain HS) 21% 100%
A8FTR6 Shewanella sediminis (strain HAW-EB3) 24% 100%
A8GH87 Serratia proteamaculans (strain 568) 22% 100%
A8H5T2 Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) 25% 100%
A9KTW7 Shewanella baltica (strain OS195) 23% 100%
A9MJ36 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 24% 100%
A9N452 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 23% 100%
B0TL22 Shewanella halifaxensis (strain HAW-EB4) 25% 100%
B0YA65 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 23% 100%
B1IXA4 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 21% 100%
B1KKT1 Shewanella woodyi (strain ATCC 51908 / MS32) 23% 100%
B1LME8 Escherichia coli (strain SMS-3-5 / SECEC) 23% 100%
B1X9L5 Escherichia coli (strain K12 / DH10B) 21% 100%
B2TWV5 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 21% 100%
B4RTU9 Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype) 25% 100%
B4SZR1 Salmonella newport (strain SL254) 23% 100%
B4TCA9 Salmonella heidelberg (strain SL476) 23% 100%
B4TQC3 Salmonella schwarzengrund (strain CVM19633) 23% 100%
B5BBA0 Salmonella paratyphi A (strain AKU_12601) 23% 100%
B5EZS0 Salmonella agona (strain SL483) 23% 100%
B5FGB5 Aliivibrio fischeri (strain MJ11) 23% 100%
B5FPN2 Salmonella dublin (strain CT_02021853) 23% 100%
B5R3S0 Salmonella enteritidis PT4 (strain P125109) 23% 100%
B5XVW1 Klebsiella pneumoniae (strain 342) 22% 100%
B5YXY5 Escherichia coli O157:H7 (strain EC4115 / EHEC) 22% 100%
B6I6Q5 Escherichia coli (strain SE11) 21% 100%
B7LBJ6 Escherichia coli (strain 55989 / EAEC) 21% 100%
B7LLC9 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 22% 100%
B7M6M3 Escherichia coli O8 (strain IAI1) 21% 100%
B7MGV8 Escherichia coli O45:K1 (strain S88 / ExPEC) 22% 100%
B7MY17 Escherichia coli O81 (strain ED1a) 22% 100%
B7N5V3 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 22% 100%
B7NP25 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 21% 100%
B7UFZ9 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 23% 100%
B8CPY7 Shewanella piezotolerans (strain WP3 / JCM 13877) 24% 100%
B8EE97 Shewanella baltica (strain OS223) 23% 100%
C0PZX5 Salmonella paratyphi C (strain RKS4594) 24% 100%
C4ZVN3 Escherichia coli (strain K12 / MC4100 / BW2952) 21% 100%
C6DAL8 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 24% 100%
E9AW84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
G5EDP2 Caenorhabditis elegans 25% 100%
I6XHJ3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 24% 100%
O26884 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 33% 100%
O32177 Bacillus subtilis (strain 168) 25% 100%
O46629 Bos taurus 23% 93%
O62742 Oryctolagus cuniculus 26% 81%
P07857 Bos taurus 25% 81%
P11915 Rattus norvegicus 26% 81%
P14611 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 25% 100%
P22307 Homo sapiens 26% 81%
P27796 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P32020 Mus musculus 26% 81%
P34255 Caenorhabditis elegans 21% 98%
P45369 Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) 24% 100%
P76503 Escherichia coli (strain K12) 21% 100%
Q07598 Gallus gallus 28% 81%
Q07ZP7 Shewanella frigidimarina (strain NCIMB 400) 22% 100%
Q0HKD2 Shewanella sp. (strain MR-4) 23% 100%
Q0HWN4 Shewanella sp. (strain MR-7) 23% 100%
Q0T2E5 Shigella flexneri serotype 5b (strain 8401) 21% 100%
Q0TFA5 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 22% 100%
Q12P12 Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) 23% 100%
Q15VA3 Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) 23% 100%
Q1R971 Escherichia coli (strain UTI89 / UPEC) 22% 100%
Q31YB6 Shigella boydii serotype 4 (strain Sb227) 22% 100%
Q32DJ3 Shigella dysenteriae serotype 1 (strain Sd197) 22% 100%
Q3YZM1 Shigella sonnei (strain Ss046) 21% 100%
Q47ZB6 Colwellia psychrerythraea (strain 34H / ATCC BAA-681) 22% 100%
Q4WCL5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 100%
Q51956 Pseudomonas putida 24% 100%
Q57LW5 Salmonella choleraesuis (strain SC-B67) 23% 100%
Q58944 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 31% 100%
Q5PCX7 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 23% 100%
Q60587 Rattus norvegicus 24% 93%
Q6D2L6 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 23% 100%
Q7N287 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 23% 100%
Q83K95 Shigella flexneri 21% 100%
Q8FFG3 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 23% 100%
Q8S4Y1 Arabidopsis thaliana 24% 100%
Q8VPF1 Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13) 25% 100%
Q8XCN9 Escherichia coli O157:H7 22% 100%
Q8Z4Y9 Salmonella typhi 23% 100%
Q8ZNA6 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 23% 100%
Q99JY0 Mus musculus 24% 93%
Q9KT59 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 23% 100%
Q9U0V9 Leishmania major 99% 100%
V5ARP0 Trypanosoma cruzi 73% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS