LeishMANIAdb
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Putative mitochondrial DNA primase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial DNA primase
Gene product:
mitochondrial DNA primase - putative
Species:
Leishmania infantum
UniProt:
A4I0B9_LEIIN
TriTrypDb:
LINF_230014500 *
Length:
684

Annotations

Annotations by Jardim et al.

Polymerase, mitochondrial DNA primase PRI1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005759 mitochondrial matrix 5 1
GO:0020023 kinetoplast 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I0B9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0B9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006260 DNA replication 5 1
GO:0006261 DNA-templated DNA replication 6 1
GO:0006264 mitochondrial DNA replication 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0032042 mitochondrial DNA metabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5
GO:0016779 nucleotidyltransferase activity 4 5
GO:0016787 hydrolase activity 2 7
GO:0016817 hydrolase activity, acting on acid anhydrides 3 7
GO:0034062 5'-3' RNA polymerase activity 5 5
GO:0097747 RNA polymerase activity 4 5
GO:0140098 catalytic activity, acting on RNA 3 5
GO:0140640 catalytic activity, acting on a nucleic acid 2 5
GO:0003896 DNA primase activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 271 275 PF00656 0.474
CLV_C14_Caspase3-7 572 576 PF00656 0.310
CLV_NRD_NRD_1 101 103 PF00675 0.537
CLV_NRD_NRD_1 147 149 PF00675 0.604
CLV_NRD_NRD_1 156 158 PF00675 0.572
CLV_NRD_NRD_1 252 254 PF00675 0.658
CLV_NRD_NRD_1 279 281 PF00675 0.405
CLV_NRD_NRD_1 348 350 PF00675 0.379
CLV_NRD_NRD_1 581 583 PF00675 0.310
CLV_NRD_NRD_1 671 673 PF00675 0.577
CLV_NRD_NRD_1 682 684 PF00675 0.587
CLV_NRD_NRD_1 90 92 PF00675 0.531
CLV_NRD_NRD_1 97 99 PF00675 0.527
CLV_PCSK_KEX2_1 101 103 PF00082 0.518
CLV_PCSK_KEX2_1 147 149 PF00082 0.529
CLV_PCSK_KEX2_1 19 21 PF00082 0.660
CLV_PCSK_KEX2_1 279 281 PF00082 0.405
CLV_PCSK_KEX2_1 616 618 PF00082 0.471
CLV_PCSK_KEX2_1 682 684 PF00082 0.606
CLV_PCSK_KEX2_1 97 99 PF00082 0.514
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.518
CLV_PCSK_PC1ET2_1 19 21 PF00082 0.571
CLV_PCSK_PC1ET2_1 616 618 PF00082 0.471
CLV_PCSK_PC7_1 97 103 PF00082 0.514
CLV_PCSK_SKI1_1 349 353 PF00082 0.368
CLV_PCSK_SKI1_1 479 483 PF00082 0.433
CLV_PCSK_SKI1_1 532 536 PF00082 0.383
CLV_PCSK_SKI1_1 672 676 PF00082 0.579
CLV_PCSK_SKI1_1 678 682 PF00082 0.585
CLV_PCSK_SKI1_1 8 12 PF00082 0.550
CLV_PCSK_SKI1_1 98 102 PF00082 0.510
DEG_APCC_DBOX_1 146 154 PF00400 0.527
DEG_APCC_DBOX_1 348 356 PF00400 0.362
DEG_APCC_KENBOX_2 434 438 PF00400 0.421
DEG_Nend_UBRbox_3 1 3 PF02207 0.527
DEG_SCF_FBW7_2 355 361 PF00400 0.419
DEG_SIAH_1 72 80 PF03145 0.520
DOC_ANK_TNKS_1 156 163 PF00023 0.603
DOC_CKS1_1 292 297 PF01111 0.394
DOC_CKS1_1 355 360 PF01111 0.415
DOC_CYCLIN_RxL_1 476 484 PF00134 0.405
DOC_CYCLIN_yCln2_LP_2 565 571 PF00134 0.358
DOC_MAPK_DCC_7 409 419 PF00069 0.382
DOC_MAPK_gen_1 435 445 PF00069 0.467
DOC_MAPK_gen_1 529 539 PF00069 0.310
DOC_MAPK_gen_1 582 588 PF00069 0.383
DOC_MAPK_gen_1 616 623 PF00069 0.485
DOC_MAPK_HePTP_8 316 328 PF00069 0.359
DOC_MAPK_MEF2A_6 319 328 PF00069 0.361
DOC_MAPK_MEF2A_6 413 421 PF00069 0.455
DOC_MAPK_MEF2A_6 543 550 PF00069 0.310
DOC_MAPK_MEF2A_6 616 625 PF00069 0.497
DOC_MAPK_NFAT4_5 543 551 PF00069 0.310
DOC_PP1_RVXF_1 477 484 PF00149 0.408
DOC_PP2B_LxvP_1 509 512 PF13499 0.591
DOC_PP2B_LxvP_1 621 624 PF13499 0.512
DOC_PP2B_LxvP_1 69 72 PF13499 0.558
DOC_PP4_FxxP_1 289 292 PF00568 0.370
DOC_PP4_FxxP_1 445 448 PF00568 0.361
DOC_PP4_FxxP_1 483 486 PF00568 0.434
DOC_PP4_MxPP_1 47 50 PF00568 0.557
DOC_USP7_MATH_1 130 134 PF00917 0.563
DOC_USP7_MATH_1 160 164 PF00917 0.618
DOC_USP7_MATH_1 217 221 PF00917 0.572
DOC_USP7_MATH_1 234 238 PF00917 0.571
DOC_USP7_MATH_1 268 272 PF00917 0.495
DOC_USP7_MATH_1 297 301 PF00917 0.436
DOC_USP7_MATH_1 30 34 PF00917 0.557
DOC_USP7_MATH_1 302 306 PF00917 0.455
DOC_USP7_MATH_1 465 469 PF00917 0.386
DOC_USP7_MATH_1 59 63 PF00917 0.619
DOC_USP7_MATH_1 663 667 PF00917 0.602
DOC_USP7_MATH_1 73 77 PF00917 0.500
DOC_USP7_UBL2_3 583 587 PF12436 0.310
DOC_USP7_UBL2_3 675 679 PF12436 0.577
DOC_WW_Pin1_4 178 183 PF00397 0.594
DOC_WW_Pin1_4 291 296 PF00397 0.412
DOC_WW_Pin1_4 319 324 PF00397 0.412
DOC_WW_Pin1_4 354 359 PF00397 0.412
DOC_WW_Pin1_4 375 380 PF00397 0.370
DOC_WW_Pin1_4 45 50 PF00397 0.593
LIG_14-3-3_CanoR_1 102 112 PF00244 0.513
LIG_14-3-3_CanoR_1 253 261 PF00244 0.501
LIG_14-3-3_CanoR_1 3 10 PF00244 0.535
LIG_14-3-3_CanoR_1 438 445 PF00244 0.454
LIG_14-3-3_CanoR_1 479 484 PF00244 0.414
LIG_14-3-3_CanoR_1 532 539 PF00244 0.460
LIG_14-3-3_CanoR_1 65 70 PF00244 0.547
LIG_Actin_WH2_2 367 384 PF00022 0.383
LIG_APCC_ABBA_1 442 447 PF00400 0.371
LIG_deltaCOP1_diTrp_1 446 454 PF00928 0.389
LIG_deltaCOP1_diTrp_1 541 545 PF00928 0.351
LIG_deltaCOP1_diTrp_1 594 600 PF00928 0.310
LIG_FHA_1 253 259 PF00498 0.478
LIG_FHA_1 370 376 PF00498 0.368
LIG_FHA_1 437 443 PF00498 0.396
LIG_FHA_2 320 326 PF00498 0.438
LIG_FHA_2 517 523 PF00498 0.422
LIG_FHA_2 533 539 PF00498 0.383
LIG_LIR_Apic_2 482 486 PF02991 0.439
LIG_LIR_Gen_1 238 245 PF02991 0.560
LIG_LIR_Gen_1 394 403 PF02991 0.357
LIG_LIR_Gen_1 475 485 PF02991 0.479
LIG_LIR_Gen_1 594 605 PF02991 0.310
LIG_LIR_Nem_3 238 244 PF02991 0.557
LIG_LIR_Nem_3 394 400 PF02991 0.373
LIG_LIR_Nem_3 475 480 PF02991 0.475
LIG_LIR_Nem_3 544 548 PF02991 0.310
LIG_LIR_Nem_3 594 600 PF02991 0.310
LIG_LIR_Nem_3 609 615 PF02991 0.310
LIG_LRP6_Inhibitor_1 151 157 PF00058 0.510
LIG_MAD2 350 358 PF02301 0.438
LIG_OCRL_FandH_1 399 411 PF00620 0.334
LIG_Pex14_1 450 454 PF04695 0.375
LIG_Pex14_1 611 615 PF04695 0.310
LIG_Pex14_2 10 14 PF04695 0.557
LIG_Pex14_2 406 410 PF04695 0.354
LIG_SH2_CRK 241 245 PF00017 0.542
LIG_SH2_CRK 615 619 PF00017 0.456
LIG_SH2_NCK_1 241 245 PF00017 0.542
LIG_SH2_STAP1 241 245 PF00017 0.559
LIG_SH2_STAP1 608 612 PF00017 0.258
LIG_SH3_3 120 126 PF00018 0.647
LIG_SH3_3 129 135 PF00018 0.553
LIG_SH3_3 289 295 PF00018 0.385
LIG_SH3_3 301 307 PF00018 0.482
LIG_SH3_3 352 358 PF00018 0.437
LIG_SH3_3 468 474 PF00018 0.436
LIG_SH3_3 511 517 PF00018 0.532
LIG_SH3_3 649 655 PF00018 0.584
LIG_SH3_3 67 73 PF00018 0.564
LIG_SUMO_SIM_anti_2 322 329 PF11976 0.348
LIG_TRAF2_1 163 166 PF00917 0.766
LIG_UBA3_1 152 158 PF00899 0.578
LIG_UBA3_1 427 435 PF00899 0.370
LIG_UBA3_1 95 104 PF00899 0.515
LIG_WRC_WIRS_1 480 485 PF05994 0.486
LIG_WW_3 144 148 PF00397 0.548
MOD_CDK_SPxK_1 178 184 PF00069 0.587
MOD_CDK_SPxK_1 354 360 PF00069 0.419
MOD_CDK_SPxxK_3 375 382 PF00069 0.381
MOD_CK1_1 176 182 PF00069 0.671
MOD_CK1_1 197 203 PF00069 0.752
MOD_CK1_1 252 258 PF00069 0.516
MOD_CK1_1 45 51 PF00069 0.564
MOD_CK1_1 475 481 PF00069 0.475
MOD_CK1_1 666 672 PF00069 0.653
MOD_CK2_1 160 166 PF00069 0.624
MOD_CK2_1 222 228 PF00069 0.732
MOD_CK2_1 516 522 PF00069 0.453
MOD_CK2_1 532 538 PF00069 0.310
MOD_CMANNOS 542 545 PF00535 0.310
MOD_DYRK1A_RPxSP_1 319 323 PF00069 0.450
MOD_GlcNHglycan 105 108 PF01048 0.562
MOD_GlcNHglycan 225 228 PF01048 0.777
MOD_GlcNHglycan 24 27 PF01048 0.497
MOD_GlcNHglycan 282 285 PF01048 0.459
MOD_GlcNHglycan 300 303 PF01048 0.463
MOD_GlcNHglycan 439 442 PF01048 0.379
MOD_GlcNHglycan 5 8 PF01048 0.531
MOD_GlcNHglycan 589 592 PF01048 0.345
MOD_GlcNHglycan 612 615 PF01048 0.345
MOD_GlcNHglycan 65 68 PF01048 0.587
MOD_GlcNHglycan 668 671 PF01048 0.614
MOD_GlcNHglycan 73 76 PF01048 0.522
MOD_GlcNHglycan 79 82 PF01048 0.521
MOD_GSK3_1 169 176 PF00069 0.684
MOD_GSK3_1 18 25 PF00069 0.515
MOD_GSK3_1 211 218 PF00069 0.702
MOD_GSK3_1 248 255 PF00069 0.629
MOD_GSK3_1 298 305 PF00069 0.425
MOD_GSK3_1 475 482 PF00069 0.444
MOD_GSK3_1 59 66 PF00069 0.566
MOD_GSK3_1 606 613 PF00069 0.345
MOD_GSK3_1 73 80 PF00069 0.505
MOD_N-GLC_1 22 27 PF02516 0.560
MOD_N-GLC_1 246 251 PF02516 0.655
MOD_N-GLC_1 436 441 PF02516 0.415
MOD_N-GLC_1 525 530 PF02516 0.261
MOD_NEK2_1 63 68 PF00069 0.602
MOD_PIKK_1 121 127 PF00454 0.783
MOD_PIKK_1 194 200 PF00454 0.641
MOD_PIKK_1 369 375 PF00454 0.379
MOD_PKA_1 103 109 PF00069 0.551
MOD_PKA_1 19 25 PF00069 0.553
MOD_PKA_1 382 388 PF00069 0.363
MOD_PKA_2 19 25 PF00069 0.540
MOD_PKA_2 2 8 PF00069 0.519
MOD_PKA_2 252 258 PF00069 0.531
MOD_PKA_2 437 443 PF00069 0.469
MOD_Plk_1 525 531 PF00069 0.261
MOD_Plk_2-3 173 179 PF00069 0.710
MOD_Plk_4 65 71 PF00069 0.544
MOD_ProDKin_1 178 184 PF00069 0.594
MOD_ProDKin_1 291 297 PF00069 0.415
MOD_ProDKin_1 319 325 PF00069 0.410
MOD_ProDKin_1 354 360 PF00069 0.419
MOD_ProDKin_1 375 381 PF00069 0.376
MOD_ProDKin_1 45 51 PF00069 0.594
MOD_SUMO_for_1 359 362 PF00179 0.382
MOD_SUMO_rev_2 161 168 PF00179 0.603
TRG_ENDOCYTIC_2 241 244 PF00928 0.569
TRG_ENDOCYTIC_2 338 341 PF00928 0.408
TRG_ENDOCYTIC_2 615 618 PF00928 0.386
TRG_ER_diArg_1 146 148 PF00400 0.539
TRG_ER_diArg_1 279 281 PF00400 0.405
TRG_ER_diArg_1 681 683 PF00400 0.657
TRG_ER_diArg_1 96 98 PF00400 0.517
TRG_NES_CRM1_1 364 377 PF08389 0.387
TRG_NLS_Bipartite_1 91 106 PF00514 0.520
TRG_NLS_MonoCore_2 100 105 PF00514 0.541
TRG_NLS_MonoCore_2 90 95 PF00514 0.519
TRG_NLS_MonoExtN_4 88 95 PF00514 0.539
TRG_NLS_MonoExtN_4 98 105 PF00514 0.505
TRG_Pf-PMV_PEXEL_1 479 484 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 529 533 PF00026 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0R5 Leptomonas seymouri 60% 98%
A0A3S7WXR7 Leishmania donovani 100% 100%
A4HCT9 Leishmania braziliensis 82% 100%
E9AW83 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QB95 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS