Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0B7_LEIIN

TriTrypDb:

LINF_230014300

Length:

885

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.631
CLV_C14_Caspase3-7	441	445	PF00656	0.569
CLV_C14_Caspase3-7	75	79	PF00656	0.583
CLV_C14_Caspase3-7	852	856	PF00656	0.643
CLV_NRD_NRD_1	140	142	PF00675	0.545
CLV_NRD_NRD_1	374	376	PF00675	0.765
CLV_NRD_NRD_1	385	387	PF00675	0.402
CLV_NRD_NRD_1	392	394	PF00675	0.584
CLV_NRD_NRD_1	577	579	PF00675	0.525
CLV_NRD_NRD_1	753	755	PF00675	0.573
CLV_NRD_NRD_1	829	831	PF00675	0.640
CLV_PCSK_FUR_1	751	755	PF00082	0.546
CLV_PCSK_FUR_1	827	831	PF00082	0.638
CLV_PCSK_KEX2_1	363	365	PF00082	0.600
CLV_PCSK_KEX2_1	374	376	PF00082	0.531
CLV_PCSK_KEX2_1	392	394	PF00082	0.651
CLV_PCSK_KEX2_1	471	473	PF00082	0.518
CLV_PCSK_KEX2_1	577	579	PF00082	0.525
CLV_PCSK_KEX2_1	753	755	PF00082	0.573
CLV_PCSK_KEX2_1	829	831	PF00082	0.640
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.600
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.518
CLV_PCSK_SKI1_1	124	128	PF00082	0.567
CLV_PCSK_SKI1_1	321	325	PF00082	0.459
CLV_PCSK_SKI1_1	363	367	PF00082	0.538
CLV_PCSK_SKI1_1	392	396	PF00082	0.612
CLV_PCSK_SKI1_1	410	414	PF00082	0.537
CLV_PCSK_SKI1_1	416	420	PF00082	0.694
CLV_PCSK_SKI1_1	472	476	PF00082	0.510
CLV_PCSK_SKI1_1	646	650	PF00082	0.549
CLV_PCSK_SKI1_1	659	663	PF00082	0.461
CLV_PCSK_SKI1_1	738	742	PF00082	0.623
DEG_APCC_DBOX_1	320	328	PF00400	0.451
DEG_SCF_FBW7_1	285	292	PF00400	0.600
DEG_SCF_FBW7_1	474	481	PF00400	0.669
DEG_SCF_FBW7_2	489	496	PF00400	0.626
DEG_SPOP_SBC_1	209	213	PF00917	0.641
DEG_SPOP_SBC_1	263	267	PF00917	0.647
DEG_SPOP_SBC_1	693	697	PF00917	0.572
DOC_AGCK_PIF_2	437	442	PF00069	0.527
DOC_ANK_TNKS_1	179	186	PF00023	0.583
DOC_CYCLIN_yCln2_LP_2	668	674	PF00134	0.566
DOC_MAPK_DCC_7	578	588	PF00069	0.534
DOC_MAPK_gen_1	751	760	PF00069	0.591
DOC_MAPK_JIP1_4	618	624	PF00069	0.449
DOC_MAPK_MEF2A_6	174	181	PF00069	0.618
DOC_MAPK_MEF2A_6	618	626	PF00069	0.439
DOC_PP1_RVXF_1	152	159	PF00149	0.534
DOC_PP2B_LxvP_1	486	489	PF13499	0.644
DOC_USP7_MATH_1	120	124	PF00917	0.663
DOC_USP7_MATH_1	164	168	PF00917	0.559
DOC_USP7_MATH_1	216	220	PF00917	0.550
DOC_USP7_MATH_1	263	267	PF00917	0.660
DOC_USP7_MATH_1	277	281	PF00917	0.577
DOC_USP7_MATH_1	291	295	PF00917	0.595
DOC_USP7_MATH_1	403	407	PF00917	0.543
DOC_USP7_MATH_1	430	434	PF00917	0.588
DOC_USP7_MATH_1	470	474	PF00917	0.572
DOC_USP7_MATH_1	513	517	PF00917	0.531
DOC_USP7_MATH_1	541	545	PF00917	0.543
DOC_USP7_MATH_1	617	621	PF00917	0.538
DOC_USP7_MATH_1	672	676	PF00917	0.655
DOC_USP7_MATH_1	679	683	PF00917	0.605
DOC_USP7_MATH_1	692	696	PF00917	0.509
DOC_USP7_MATH_1	707	711	PF00917	0.612
DOC_USP7_MATH_1	731	735	PF00917	0.621
DOC_USP7_MATH_1	842	846	PF00917	0.588
DOC_USP7_MATH_1	881	885	PF00917	0.537
DOC_USP7_UBL2_3	359	363	PF12436	0.591
DOC_USP7_UBL2_3	397	401	PF12436	0.618
DOC_USP7_UBL2_3	494	498	PF12436	0.637
DOC_WW_Pin1_4	285	290	PF00397	0.653
DOC_WW_Pin1_4	404	409	PF00397	0.656
DOC_WW_Pin1_4	474	479	PF00397	0.671
DOC_WW_Pin1_4	489	494	PF00397	0.548
DOC_WW_Pin1_4	530	535	PF00397	0.557
DOC_WW_Pin1_4	670	675	PF00397	0.723
DOC_WW_Pin1_4	677	682	PF00397	0.639
DOC_WW_Pin1_4	705	710	PF00397	0.666
DOC_WW_Pin1_4	742	747	PF00397	0.583
DOC_WW_Pin1_4	784	789	PF00397	0.619
DOC_WW_Pin1_4	80	85	PF00397	0.621
LIG_14-3-3_CanoR_1	108	112	PF00244	0.544
LIG_14-3-3_CanoR_1	16	24	PF00244	0.579
LIG_14-3-3_CanoR_1	261	270	PF00244	0.584
LIG_14-3-3_CanoR_1	31	40	PF00244	0.562
LIG_14-3-3_CanoR_1	374	382	PF00244	0.535
LIG_14-3-3_CanoR_1	386	390	PF00244	0.405
LIG_14-3-3_CanoR_1	466	474	PF00244	0.584
LIG_14-3-3_CanoR_1	738	746	PF00244	0.611
LIG_14-3-3_CanoR_1	807	812	PF00244	0.530
LIG_14-3-3_CanoR_1	827	837	PF00244	0.638
LIG_Actin_WH2_2	436	454	PF00022	0.644
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BIR_III_4	453	457	PF00653	0.695
LIG_BRCT_BRCA1_1	18	22	PF00533	0.595
LIG_BRCT_BRCA1_1	237	241	PF00533	0.526
LIG_FHA_1	204	210	PF00498	0.695
LIG_FHA_1	483	489	PF00498	0.581
LIG_FHA_1	656	662	PF00498	0.681
LIG_FHA_1	794	800	PF00498	0.679
LIG_FHA_1	81	87	PF00498	0.562
LIG_FHA_2	485	491	PF00498	0.640
LIG_FHA_2	564	570	PF00498	0.493
LIG_FHA_2	597	603	PF00498	0.593
LIG_FHA_2	637	643	PF00498	0.600
LIG_LIR_Apic_2	564	568	PF02991	0.496
LIG_LIR_Gen_1	235	245	PF02991	0.536
LIG_LIR_Gen_1	417	427	PF02991	0.759
LIG_LIR_Gen_1	434	443	PF02991	0.544
LIG_LIR_Gen_1	550	560	PF02991	0.451
LIG_LIR_Gen_1	620	629	PF02991	0.461
LIG_LIR_Gen_1	771	779	PF02991	0.607
LIG_LIR_Nem_3	2	6	PF02991	0.532
LIG_LIR_Nem_3	235	240	PF02991	0.528
LIG_LIR_Nem_3	417	422	PF02991	0.757
LIG_LIR_Nem_3	434	440	PF02991	0.548
LIG_LIR_Nem_3	48	53	PF02991	0.611
LIG_LIR_Nem_3	550	556	PF02991	0.454
LIG_LIR_Nem_3	591	596	PF02991	0.542
LIG_LIR_Nem_3	620	624	PF02991	0.468
LIG_LIR_Nem_3	771	775	PF02991	0.624
LIG_LIR_Nem_3	796	800	PF02991	0.670
LIG_MLH1_MIPbox_1	237	241	PF16413	0.526
LIG_NRBOX	323	329	PF00104	0.516
LIG_PALB2_WD40_1	235	243	PF16756	0.554
LIG_Pex14_1	237	241	PF04695	0.549
LIG_Pex14_2	96	100	PF04695	0.454
LIG_PTAP_UEV_1	500	505	PF05743	0.582
LIG_PTAP_UEV_1	727	732	PF05743	0.614
LIG_PTB_Apo_2	798	805	PF02174	0.612
LIG_PTB_Phospho_1	798	804	PF10480	0.614
LIG_SH2_CRK	159	163	PF00017	0.541
LIG_SH2_CRK	53	57	PF00017	0.535
LIG_SH2_GRB2like	804	807	PF00017	0.657
LIG_SH2_STAT5	307	310	PF00017	0.581
LIG_SH2_STAT5	621	624	PF00017	0.444
LIG_SH3_1	498	504	PF00018	0.621
LIG_SH3_1	613	619	PF00018	0.490
LIG_SH3_3	178	184	PF00018	0.599
LIG_SH3_3	402	408	PF00018	0.542
LIG_SH3_3	498	504	PF00018	0.610
LIG_SH3_3	613	619	PF00018	0.485
LIG_SH3_3	661	667	PF00018	0.503
LIG_SH3_3	703	709	PF00018	0.614
LIG_SH3_3	725	731	PF00018	0.582
LIG_SH3_4	359	366	PF00018	0.591
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.493
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.514
LIG_SUMO_SIM_par_1	484	490	PF11976	0.563
LIG_SUMO_SIM_par_1	525	530	PF11976	0.457
LIG_SUMO_SIM_par_1	660	665	PF11976	0.479
LIG_TRAF2_1	224	227	PF00917	0.588
LIG_TRFH_1	241	245	PF08558	0.520
LIG_UBA3_1	324	332	PF00899	0.632
MOD_CDC14_SPxK_1	407	410	PF00782	0.621
MOD_CDK_SPK_2	489	494	PF00069	0.624
MOD_CDK_SPK_2	784	789	PF00069	0.634
MOD_CDK_SPK_2	80	85	PF00069	0.621
MOD_CDK_SPxK_1	404	410	PF00069	0.622
MOD_CK1_1	200	206	PF00069	0.628
MOD_CK1_1	219	225	PF00069	0.635
MOD_CK1_1	246	252	PF00069	0.716
MOD_CK1_1	284	290	PF00069	0.646
MOD_CK1_1	295	301	PF00069	0.609
MOD_CK1_1	34	40	PF00069	0.618
MOD_CK1_1	341	347	PF00069	0.441
MOD_CK1_1	404	410	PF00069	0.637
MOD_CK1_1	417	423	PF00069	0.795
MOD_CK1_1	533	539	PF00069	0.691
MOD_CK1_1	673	679	PF00069	0.661
MOD_CK1_1	697	703	PF00069	0.640
MOD_CK1_1	705	711	PF00069	0.610
MOD_CK1_1	714	720	PF00069	0.557
MOD_CK1_1	745	751	PF00069	0.662
MOD_CK1_1	787	793	PF00069	0.640
MOD_CK1_1	845	851	PF00069	0.640
MOD_CK2_1	484	490	PF00069	0.563
MOD_CK2_1	596	602	PF00069	0.579
MOD_Cter_Amidation	827	830	PF01082	0.638
MOD_GlcNHglycan	13	16	PF01048	0.537
MOD_GlcNHglycan	143	146	PF01048	0.466
MOD_GlcNHglycan	166	169	PF01048	0.591
MOD_GlcNHglycan	206	209	PF01048	0.644
MOD_GlcNHglycan	216	219	PF01048	0.539
MOD_GlcNHglycan	245	248	PF01048	0.643
MOD_GlcNHglycan	257	260	PF01048	0.664
MOD_GlcNHglycan	266	269	PF01048	0.561
MOD_GlcNHglycan	279	282	PF01048	0.670
MOD_GlcNHglycan	293	297	PF01048	0.546
MOD_GlcNHglycan	340	343	PF01048	0.523
MOD_GlcNHglycan	36	39	PF01048	0.629
MOD_GlcNHglycan	416	419	PF01048	0.581
MOD_GlcNHglycan	457	460	PF01048	0.820
MOD_GlcNHglycan	501	504	PF01048	0.691
MOD_GlcNHglycan	56	59	PF01048	0.585
MOD_GlcNHglycan	6	9	PF01048	0.602
MOD_GlcNHglycan	608	611	PF01048	0.645
MOD_GlcNHglycan	681	684	PF01048	0.614
MOD_GlcNHglycan	721	724	PF01048	0.640
MOD_GlcNHglycan	74	77	PF01048	0.720
MOD_GlcNHglycan	747	750	PF01048	0.663
MOD_GlcNHglycan	761	764	PF01048	0.519
MOD_GlcNHglycan	784	787	PF01048	0.628
MOD_GlcNHglycan	789	792	PF01048	0.597
MOD_GlcNHglycan	816	819	PF01048	0.572
MOD_GlcNHglycan	844	847	PF01048	0.613
MOD_GlcNHglycan	857	860	PF01048	0.486
MOD_GlcNHglycan	878	881	PF01048	0.487
MOD_GSK3_1	16	23	PF00069	0.623
MOD_GSK3_1	197	204	PF00069	0.801
MOD_GSK3_1	210	217	PF00069	0.735
MOD_GSK3_1	235	242	PF00069	0.632
MOD_GSK3_1	26	33	PF00069	0.763
MOD_GSK3_1	264	271	PF00069	0.690
MOD_GSK3_1	277	284	PF00069	0.580
MOD_GSK3_1	285	292	PF00069	0.685
MOD_GSK3_1	404	411	PF00069	0.653
MOD_GSK3_1	414	421	PF00069	0.577
MOD_GSK3_1	466	473	PF00069	0.645
MOD_GSK3_1	474	481	PF00069	0.573
MOD_GSK3_1	627	634	PF00069	0.488
MOD_GSK3_1	673	680	PF00069	0.641
MOD_GSK3_1	693	700	PF00069	0.553
MOD_GSK3_1	701	708	PF00069	0.731
MOD_GSK3_1	710	717	PF00069	0.559
MOD_GSK3_1	738	745	PF00069	0.581
MOD_GSK3_1	872	879	PF00069	0.450
MOD_N-GLC_1	164	169	PF02516	0.605
MOD_N-GLC_1	779	784	PF02516	0.673
MOD_NEK2_1	107	112	PF00069	0.496
MOD_NEK2_1	11	16	PF00069	0.527
MOD_NEK2_1	127	132	PF00069	0.457
MOD_NEK2_1	264	269	PF00069	0.651
MOD_NEK2_1	385	390	PF00069	0.588
MOD_NEK2_1	442	447	PF00069	0.569
MOD_NEK2_1	563	568	PF00069	0.486
MOD_NEK2_1	622	627	PF00069	0.501
MOD_NEK2_1	649	654	PF00069	0.543
MOD_NEK2_1	699	704	PF00069	0.606
MOD_NEK2_1	779	784	PF00069	0.605
MOD_NEK2_1	799	804	PF00069	0.613
MOD_NEK2_2	435	440	PF00069	0.623
MOD_NEK2_2	631	636	PF00069	0.479
MOD_PIKK_1	31	37	PF00454	0.619
MOD_PIKK_1	380	386	PF00454	0.531
MOD_PIKK_1	738	744	PF00454	0.563
MOD_PIKK_1	774	780	PF00454	0.637
MOD_PK_1	401	407	PF00069	0.544
MOD_PK_1	807	813	PF00069	0.531
MOD_PKA_1	141	147	PF00069	0.532
MOD_PKA_1	201	207	PF00069	0.621
MOD_PKA_1	392	398	PF00069	0.655
MOD_PKA_2	107	113	PF00069	0.544
MOD_PKA_2	127	133	PF00069	0.453
MOD_PKA_2	26	32	PF00069	0.629
MOD_PKA_2	385	391	PF00069	0.559
MOD_PKA_2	392	398	PF00069	0.555
MOD_PKA_2	617	623	PF00069	0.459
MOD_PKA_2	823	829	PF00069	0.663
MOD_Plk_1	756	762	PF00069	0.584
MOD_Plk_4	107	113	PF00069	0.423
MOD_Plk_4	210	216	PF00069	0.645
MOD_Plk_4	295	301	PF00069	0.635
MOD_Plk_4	513	519	PF00069	0.597
MOD_Plk_4	617	623	PF00069	0.516
MOD_Plk_4	694	700	PF00069	0.630
MOD_Plk_4	872	878	PF00069	0.476
MOD_Plk_4	91	97	PF00069	0.599
MOD_ProDKin_1	285	291	PF00069	0.653
MOD_ProDKin_1	404	410	PF00069	0.658
MOD_ProDKin_1	474	480	PF00069	0.668
MOD_ProDKin_1	489	495	PF00069	0.548
MOD_ProDKin_1	530	536	PF00069	0.561
MOD_ProDKin_1	670	676	PF00069	0.724
MOD_ProDKin_1	677	683	PF00069	0.640
MOD_ProDKin_1	705	711	PF00069	0.667
MOD_ProDKin_1	742	748	PF00069	0.580
MOD_ProDKin_1	784	790	PF00069	0.618
MOD_ProDKin_1	80	86	PF00069	0.614
MOD_SUMO_for_1	493	496	PF00179	0.654
MOD_SUMO_rev_2	116	121	PF00179	0.607
MOD_SUMO_rev_2	138	144	PF00179	0.497
MOD_SUMO_rev_2	198	203	PF00179	0.613
MOD_SUMO_rev_2	602	609	PF00179	0.618
TRG_DiLeu_BaEn_1	304	309	PF01217	0.543
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.550
TRG_ENDOCYTIC_2	53	56	PF00928	0.536
TRG_ENDOCYTIC_2	593	596	PF00928	0.486
TRG_ENDOCYTIC_2	621	624	PF00928	0.444
TRG_ER_diArg_1	24	27	PF00400	0.614
TRG_ER_diArg_1	391	393	PF00400	0.640
TRG_ER_diArg_1	576	578	PF00400	0.512
TRG_ER_diArg_1	827	830	PF00400	0.679
TRG_PTS1	882	885	PF00515	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I942	Leptomonas seymouri	41%	97%
A0A3S7WXM2	Leishmania donovani	99%	100%
A4HCT7	Leishmania braziliensis	71%	99%
E9AW81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q9U0V6	Leishmania major	91%	100%