LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I0B5_LEIIN
TriTrypDb:
LINF_230014100
Length:
556

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 0
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 4

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I0B5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0B5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006887 exocytosis 4 1
GO:0009987 cellular process 1 1
GO:0016192 vesicle-mediated transport 4 1
GO:0032940 secretion by cell 3 1
GO:0045055 regulated exocytosis 5 1
GO:0046903 secretion 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0140352 export from cell 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 5
GO:0005515 protein binding 2 5
GO:0019899 enzyme binding 3 5
GO:0031267 small GTPase binding 5 5
GO:0051020 GTPase binding 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 38 42 PF00656 0.376
CLV_C14_Caspase3-7 467 471 PF00656 0.302
CLV_C14_Caspase3-7 530 534 PF00656 0.557
CLV_NRD_NRD_1 10 12 PF00675 0.518
CLV_NRD_NRD_1 101 103 PF00675 0.583
CLV_NRD_NRD_1 118 120 PF00675 0.520
CLV_NRD_NRD_1 128 130 PF00675 0.459
CLV_NRD_NRD_1 136 138 PF00675 0.506
CLV_NRD_NRD_1 148 150 PF00675 0.452
CLV_NRD_NRD_1 156 158 PF00675 0.462
CLV_NRD_NRD_1 168 170 PF00675 0.482
CLV_NRD_NRD_1 176 178 PF00675 0.461
CLV_NRD_NRD_1 186 188 PF00675 0.536
CLV_NRD_NRD_1 196 198 PF00675 0.499
CLV_NRD_NRD_1 89 91 PF00675 0.592
CLV_PCSK_FUR_1 146 150 PF00082 0.477
CLV_PCSK_FUR_1 166 170 PF00082 0.444
CLV_PCSK_FUR_1 193 197 PF00082 0.617
CLV_PCSK_FUR_1 99 103 PF00082 0.490
CLV_PCSK_KEX2_1 101 103 PF00082 0.580
CLV_PCSK_KEX2_1 117 119 PF00082 0.516
CLV_PCSK_KEX2_1 128 130 PF00082 0.455
CLV_PCSK_KEX2_1 135 137 PF00082 0.495
CLV_PCSK_KEX2_1 148 150 PF00082 0.455
CLV_PCSK_KEX2_1 155 157 PF00082 0.578
CLV_PCSK_KEX2_1 168 170 PF00082 0.532
CLV_PCSK_KEX2_1 175 177 PF00082 0.597
CLV_PCSK_KEX2_1 185 187 PF00082 0.523
CLV_PCSK_KEX2_1 195 197 PF00082 0.595
CLV_PCSK_KEX2_1 260 262 PF00082 0.517
CLV_PCSK_KEX2_1 372 374 PF00082 0.505
CLV_PCSK_KEX2_1 519 521 PF00082 0.403
CLV_PCSK_KEX2_1 89 91 PF00082 0.592
CLV_PCSK_KEX2_1 9 11 PF00082 0.533
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.517
CLV_PCSK_PC1ET2_1 195 197 PF00082 0.631
CLV_PCSK_PC1ET2_1 260 262 PF00082 0.517
CLV_PCSK_PC1ET2_1 372 374 PF00082 0.499
CLV_PCSK_PC1ET2_1 519 521 PF00082 0.403
CLV_PCSK_SKI1_1 11 15 PF00082 0.567
CLV_PCSK_SKI1_1 519 523 PF00082 0.327
DEG_APCC_DBOX_1 9 17 PF00400 0.382
DEG_Nend_UBRbox_1 1 4 PF02207 0.535
DOC_CYCLIN_RxL_1 321 329 PF00134 0.316
DOC_MAPK_gen_1 117 126 PF00069 0.271
DOC_MAPK_gen_1 383 389 PF00069 0.244
DOC_MAPK_gen_1 9 18 PF00069 0.385
DOC_MAPK_MEF2A_6 425 432 PF00069 0.288
DOC_MAPK_MEF2A_6 9 18 PF00069 0.357
DOC_MAPK_NFAT4_5 425 433 PF00069 0.236
DOC_PP1_RVXF_1 309 316 PF00149 0.265
DOC_USP7_MATH_1 300 304 PF00917 0.444
DOC_USP7_MATH_1 448 452 PF00917 0.300
DOC_USP7_MATH_1 527 531 PF00917 0.697
DOC_USP7_MATH_1 62 66 PF00917 0.475
DOC_USP7_UBL2_3 346 350 PF12436 0.275
DOC_WW_Pin1_4 339 344 PF00397 0.305
DOC_WW_Pin1_4 519 524 PF00397 0.527
LIG_14-3-3_CanoR_1 205 212 PF00244 0.319
LIG_14-3-3_CanoR_1 230 237 PF00244 0.422
LIG_14-3-3_CanoR_1 317 327 PF00244 0.296
LIG_14-3-3_CanoR_1 63 69 PF00244 0.471
LIG_14-3-3_CanoR_1 9 14 PF00244 0.471
LIG_Actin_WH2_2 442 459 PF00022 0.275
LIG_BIR_III_2 297 301 PF00653 0.257
LIG_BIR_III_4 41 45 PF00653 0.371
LIG_FHA_1 340 346 PF00498 0.349
LIG_FHA_1 347 353 PF00498 0.282
LIG_FHA_1 64 70 PF00498 0.431
LIG_FHA_2 36 42 PF00498 0.399
LIG_FHA_2 55 61 PF00498 0.596
LIG_LIR_Gen_1 360 369 PF02991 0.310
LIG_LIR_Gen_1 460 469 PF02991 0.294
LIG_LIR_Gen_1 502 508 PF02991 0.282
LIG_LIR_Nem_3 339 344 PF02991 0.305
LIG_LIR_Nem_3 360 366 PF02991 0.301
LIG_LIR_Nem_3 429 434 PF02991 0.249
LIG_LIR_Nem_3 460 464 PF02991 0.292
LIG_LIR_Nem_3 481 487 PF02991 0.333
LIG_LIR_Nem_3 502 506 PF02991 0.282
LIG_PCNA_TLS_4 425 432 PF02747 0.236
LIG_Pex14_1 427 431 PF04695 0.240
LIG_Pex14_2 503 507 PF04695 0.288
LIG_REV1ctd_RIR_1 313 321 PF16727 0.265
LIG_SH2_CRK 341 345 PF00017 0.312
LIG_SH2_CRK 391 395 PF00017 0.262
LIG_SH2_CRK 484 488 PF00017 0.244
LIG_SH2_NCK_1 391 395 PF00017 0.236
LIG_SH2_SRC 420 423 PF00017 0.229
LIG_SH2_STAP1 348 352 PF00017 0.265
LIG_SH2_STAP1 363 367 PF00017 0.311
LIG_SH2_STAP1 420 424 PF00017 0.288
LIG_SH2_STAT3 272 275 PF00017 0.238
LIG_SH2_STAT5 222 225 PF00017 0.309
LIG_SH2_STAT5 314 317 PF00017 0.318
LIG_SH2_STAT5 327 330 PF00017 0.178
LIG_SH2_STAT5 341 344 PF00017 0.353
LIG_SH2_STAT5 348 351 PF00017 0.305
LIG_SH2_STAT5 355 358 PF00017 0.295
LIG_SH2_STAT5 422 425 PF00017 0.310
LIG_SH2_STAT5 435 438 PF00017 0.313
LIG_SH2_STAT5 491 494 PF00017 0.239
LIG_SH3_3 246 252 PF00018 0.305
LIG_SH3_3 371 377 PF00018 0.256
LIG_SH3_3 406 412 PF00018 0.224
LIG_SH3_3 473 479 PF00018 0.254
LIG_SH3_4 45 52 PF00018 0.443
LIG_Sin3_3 406 413 PF02671 0.330
LIG_SUMO_SIM_anti_2 495 500 PF11976 0.236
LIG_TRAF2_1 207 210 PF00917 0.309
LIG_TRAF2_1 57 60 PF00917 0.434
LIG_TYR_ITIM 389 394 PF00017 0.236
LIG_TYR_ITIM 418 423 PF00017 0.213
LIG_UBA3_1 378 384 PF00899 0.381
MOD_CDK_SPxxK_3 339 346 PF00069 0.326
MOD_CK1_1 303 309 PF00069 0.362
MOD_CK1_1 52 58 PF00069 0.682
MOD_CK2_1 204 210 PF00069 0.380
MOD_CK2_1 301 307 PF00069 0.464
MOD_CK2_1 54 60 PF00069 0.588
MOD_Cter_Amidation 370 373 PF01082 0.371
MOD_Cter_Amidation 516 519 PF01082 0.487
MOD_GlcNHglycan 206 209 PF01048 0.394
MOD_GlcNHglycan 359 362 PF01048 0.387
MOD_GlcNHglycan 369 372 PF01048 0.542
MOD_GlcNHglycan 529 532 PF01048 0.556
MOD_GSK3_1 280 287 PF00069 0.349
MOD_GSK3_1 344 351 PF00069 0.367
MOD_GSK3_1 444 451 PF00069 0.397
MOD_GSK3_1 460 467 PF00069 0.278
MOD_GSK3_1 48 55 PF00069 0.714
MOD_GSK3_1 5 12 PF00069 0.469
MOD_GSK3_1 527 534 PF00069 0.538
MOD_NEK2_1 316 321 PF00069 0.448
MOD_NEK2_1 326 331 PF00069 0.409
MOD_NEK2_1 337 342 PF00069 0.392
MOD_NEK2_1 492 497 PF00069 0.338
MOD_NEK2_1 506 511 PF00069 0.391
MOD_OFUCOSY 505 510 PF10250 0.236
MOD_PK_1 197 203 PF00069 0.437
MOD_PKA_1 9 15 PF00069 0.443
MOD_PKA_2 204 210 PF00069 0.380
MOD_PKA_2 316 322 PF00069 0.300
MOD_PKA_2 62 68 PF00069 0.518
MOD_PKA_2 9 15 PF00069 0.443
MOD_Plk_1 300 306 PF00069 0.366
MOD_Plk_2-3 301 307 PF00069 0.363
MOD_Plk_4 25 31 PF00069 0.489
MOD_Plk_4 464 470 PF00069 0.368
MOD_Plk_4 499 505 PF00069 0.320
MOD_ProDKin_1 339 345 PF00069 0.376
MOD_ProDKin_1 519 525 PF00069 0.407
TRG_DiLeu_BaEn_4 121 127 PF01217 0.379
TRG_DiLeu_BaEn_4 179 185 PF01217 0.354
TRG_DiLeu_BaEn_4 91 97 PF01217 0.434
TRG_ENDOCYTIC_2 341 344 PF00928 0.362
TRG_ENDOCYTIC_2 363 366 PF00928 0.386
TRG_ENDOCYTIC_2 391 394 PF00928 0.213
TRG_ENDOCYTIC_2 420 423 PF00928 0.282
TRG_ENDOCYTIC_2 484 487 PF00928 0.374
TRG_ER_diArg_1 116 119 PF00400 0.399
TRG_ER_diArg_1 135 137 PF00400 0.388
TRG_ER_diArg_1 146 149 PF00400 0.343
TRG_ER_diArg_1 155 157 PF00400 0.287
TRG_ER_diArg_1 166 169 PF00400 0.317
TRG_ER_diArg_1 175 177 PF00400 0.354
TRG_ER_diArg_1 196 198 PF00400 0.580
TRG_ER_diArg_1 9 11 PF00400 0.413
TRG_ER_diArg_1 99 102 PF00400 0.419
TRG_ER_diLys_1 553 556 PF00400 0.512
TRG_NLS_Bipartite_1 168 189 PF00514 0.313
TRG_NLS_MonoExtC_3 184 190 PF00514 0.317
TRG_NLS_MonoExtN_4 516 522 PF00514 0.418
TRG_Pf-PMV_PEXEL_1 80 85 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD68 Leptomonas seymouri 45% 100%
A0A3Q8ICI9 Leishmania donovani 98% 100%
A4H6H3 Leishmania braziliensis 66% 100%
Q9U0V4 Leishmania major 80% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS