LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I0B0_LEIIN
TriTrypDb:
LINF_230013500
Length:
410

Annotations

LeishMANIAdb annotations

Unique kinetoplastid membrane protein. Protein duplicated in Leishmanniids as well as in T. rangeli.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5
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Expansion

Sequence features

A4I0B0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0B0

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 271 275 PF00656 0.828
CLV_NRD_NRD_1 118 120 PF00675 0.485
CLV_NRD_NRD_1 132 134 PF00675 0.486
CLV_NRD_NRD_1 182 184 PF00675 0.458
CLV_NRD_NRD_1 384 386 PF00675 0.492
CLV_NRD_NRD_1 79 81 PF00675 0.412
CLV_NRD_NRD_1 90 92 PF00675 0.365
CLV_PCSK_KEX2_1 118 120 PF00082 0.489
CLV_PCSK_KEX2_1 122 124 PF00082 0.477
CLV_PCSK_KEX2_1 132 134 PF00082 0.479
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HZ47 Leptomonas seymouri 36% 96%
A0A3Q8IEI6 Leishmania donovani 100% 100%
A4H6H5 Leishmania braziliensis 64% 99%
E9AW74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q9NF81 Leishmania major 90% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS