LeishMANIAdb
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Kinesin-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin-like protein
Gene product:
kinesin - putative
Species:
Leishmania infantum
UniProt:
A4I0A6_LEIIN
TriTrypDb:
LINF_230013200
Length:
656

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 13
GO:0099080 supramolecular complex 2 13
GO:0099081 supramolecular polymer 3 13
GO:0099512 supramolecular fiber 4 13
GO:0099513 polymeric cytoskeletal fiber 5 13
GO:0110165 cellular anatomical entity 1 13
GO:0005871 kinesin complex 3 1
GO:0005875 microtubule associated complex 2 1
GO:0032991 protein-containing complex 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I0A6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0A6

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 13
GO:0007018 microtubule-based movement 3 13
GO:0009987 cellular process 1 13
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0000902 cell morphogenesis 3 1
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0009653 anatomical structure morphogenesis 2 1
GO:0016043 cellular component organization 3 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0030865 cortical cytoskeleton organization 6 1
GO:0031122 cytoplasmic microtubule organization 4 1
GO:0032502 developmental process 1 1
GO:0043622 cortical microtubule organization 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003774 cytoskeletal motor activity 1 13
GO:0003777 microtubule motor activity 2 13
GO:0003824 catalytic activity 1 6
GO:0005488 binding 1 13
GO:0005515 protein binding 2 13
GO:0005524 ATP binding 5 13
GO:0008017 microtubule binding 5 13
GO:0008092 cytoskeletal protein binding 3 13
GO:0015631 tubulin binding 4 13
GO:0016787 hydrolase activity 2 6
GO:0017076 purine nucleotide binding 4 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:0140657 ATP-dependent activity 1 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0016462 pyrophosphatase activity 5 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 117 123 PF00089 0.337
CLV_NRD_NRD_1 296 298 PF00675 0.322
CLV_NRD_NRD_1 501 503 PF00675 0.553
CLV_NRD_NRD_1 544 546 PF00675 0.630
CLV_NRD_NRD_1 550 552 PF00675 0.626
CLV_NRD_NRD_1 571 573 PF00675 0.549
CLV_NRD_NRD_1 6 8 PF00675 0.472
CLV_NRD_NRD_1 612 614 PF00675 0.595
CLV_NRD_NRD_1 625 627 PF00675 0.392
CLV_NRD_NRD_1 635 637 PF00675 0.444
CLV_PCSK_FUR_1 626 630 PF00082 0.572
CLV_PCSK_FUR_1 633 637 PF00082 0.566
CLV_PCSK_KEX2_1 296 298 PF00082 0.322
CLV_PCSK_KEX2_1 543 545 PF00082 0.634
CLV_PCSK_KEX2_1 550 552 PF00082 0.576
CLV_PCSK_KEX2_1 570 572 PF00082 0.556
CLV_PCSK_KEX2_1 6 8 PF00082 0.485
CLV_PCSK_KEX2_1 612 614 PF00082 0.554
CLV_PCSK_KEX2_1 628 630 PF00082 0.356
CLV_PCSK_KEX2_1 635 637 PF00082 0.482
CLV_PCSK_PC1ET2_1 570 572 PF00082 0.606
CLV_PCSK_PC1ET2_1 612 614 PF00082 0.589
CLV_PCSK_PC1ET2_1 628 630 PF00082 0.407
CLV_PCSK_PC7_1 540 546 PF00082 0.624
CLV_PCSK_SKI1_1 16 20 PF00082 0.479
CLV_PCSK_SKI1_1 163 167 PF00082 0.314
CLV_PCSK_SKI1_1 252 256 PF00082 0.414
CLV_PCSK_SKI1_1 436 440 PF00082 0.528
CLV_PCSK_SKI1_1 450 454 PF00082 0.450
CLV_PCSK_SKI1_1 456 460 PF00082 0.357
CLV_PCSK_SKI1_1 467 471 PF00082 0.425
CLV_PCSK_SKI1_1 513 517 PF00082 0.561
CLV_PCSK_SKI1_1 652 656 PF00082 0.640
CLV_Separin_Metazoa 562 566 PF03568 0.626
CLV_Separin_Metazoa 623 627 PF03568 0.528
CLV_Separin_Metazoa 638 642 PF03568 0.436
DEG_APCC_DBOX_1 263 271 PF00400 0.309
DEG_APCC_DBOX_1 410 418 PF00400 0.616
DEG_Nend_UBRbox_2 1 3 PF02207 0.626
DOC_MAPK_gen_1 143 152 PF00069 0.335
DOC_MAPK_gen_1 376 383 PF00069 0.425
DOC_MAPK_gen_1 550 557 PF00069 0.445
DOC_MAPK_gen_1 586 593 PF00069 0.449
DOC_MAPK_gen_1 594 602 PF00069 0.331
DOC_MAPK_MEF2A_6 120 129 PF00069 0.350
DOC_MAPK_MEF2A_6 145 154 PF00069 0.315
DOC_MAPK_MEF2A_6 325 332 PF00069 0.322
DOC_USP7_MATH_1 105 109 PF00917 0.377
DOC_USP7_MATH_1 119 123 PF00917 0.334
DOC_USP7_MATH_1 577 581 PF00917 0.559
DOC_USP7_UBL2_3 436 440 PF12436 0.542
DOC_USP7_UBL2_3 513 517 PF12436 0.560
DOC_USP7_UBL2_3 651 655 PF12436 0.544
DOC_WW_Pin1_4 355 360 PF00397 0.309
LIG_14-3-3_CanoR_1 219 226 PF00244 0.316
LIG_14-3-3_CanoR_1 350 354 PF00244 0.322
LIG_14-3-3_CanoR_1 378 384 PF00244 0.430
LIG_14-3-3_CanoR_1 418 422 PF00244 0.571
LIG_14-3-3_CanoR_1 46 52 PF00244 0.522
LIG_14-3-3_CanoR_1 6 10 PF00244 0.478
LIG_Actin_WH2_2 155 173 PF00022 0.322
LIG_APCC_ABBA_1 155 160 PF00400 0.309
LIG_BRCT_BRCA1_1 189 193 PF00533 0.337
LIG_deltaCOP1_diTrp_1 24 32 PF00928 0.424
LIG_FHA_1 13 19 PF00498 0.434
LIG_FHA_1 288 294 PF00498 0.351
LIG_FHA_1 336 342 PF00498 0.309
LIG_FHA_1 349 355 PF00498 0.309
LIG_FHA_1 42 48 PF00498 0.550
LIG_FHA_1 433 439 PF00498 0.577
LIG_FHA_2 196 202 PF00498 0.457
LIG_FHA_2 208 214 PF00498 0.259
LIG_FHA_2 48 54 PF00498 0.495
LIG_FHA_2 59 65 PF00498 0.322
LIG_LIR_Apic_2 187 192 PF02991 0.337
LIG_LIR_Apic_2 37 42 PF02991 0.408
LIG_LIR_Gen_1 124 133 PF02991 0.322
LIG_LIR_Gen_1 151 162 PF02991 0.309
LIG_LIR_Gen_1 497 505 PF02991 0.686
LIG_LIR_Gen_1 634 645 PF02991 0.597
LIG_LIR_Gen_1 64 74 PF02991 0.337
LIG_LIR_Gen_1 96 105 PF02991 0.322
LIG_LIR_Nem_3 124 129 PF02991 0.309
LIG_LIR_Nem_3 151 157 PF02991 0.309
LIG_LIR_Nem_3 497 501 PF02991 0.705
LIG_LIR_Nem_3 634 640 PF02991 0.597
LIG_LIR_Nem_3 64 69 PF02991 0.330
LIG_NRBOX 336 342 PF00104 0.309
LIG_PCNA_yPIPBox_3 55 69 PF02747 0.344
LIG_PTB_Apo_2 120 127 PF02174 0.322
LIG_Rb_pABgroove_1 97 105 PF01858 0.436
LIG_SH2_CRK 189 193 PF00017 0.337
LIG_SH2_CRK 253 257 PF00017 0.337
LIG_SH2_CRK 498 502 PF00017 0.668
LIG_SH2_CRK 66 70 PF00017 0.377
LIG_SH2_NCK_1 253 257 PF00017 0.356
LIG_SH2_NCK_1 66 70 PF00017 0.309
LIG_SH2_STAP1 364 368 PF00017 0.425
LIG_SH2_STAT3 59 62 PF00017 0.356
LIG_SH2_STAT5 281 284 PF00017 0.322
LIG_SH2_STAT5 97 100 PF00017 0.322
LIG_SH3_1 325 331 PF00018 0.322
LIG_SH3_2 328 333 PF14604 0.322
LIG_SH3_3 325 331 PF00018 0.322
LIG_SUMO_SIM_par_1 15 21 PF11976 0.408
LIG_TRAF2_1 423 426 PF00917 0.632
LIG_UBA3_1 125 130 PF00899 0.323
LIG_UBA3_1 599 607 PF00899 0.605
LIG_UBA3_1 621 628 PF00899 0.580
LIG_WRC_WIRS_1 48 53 PF05994 0.517
LIG_WW_3 140 144 PF00397 0.380
MOD_CDK_SPxxK_3 355 362 PF00069 0.322
MOD_CK1_1 230 236 PF00069 0.309
MOD_CK1_1 335 341 PF00069 0.309
MOD_CK1_1 37 43 PF00069 0.418
MOD_CK1_1 93 99 PF00069 0.309
MOD_CK2_1 150 156 PF00069 0.333
MOD_CK2_1 195 201 PF00069 0.457
MOD_CK2_1 207 213 PF00069 0.259
MOD_CK2_1 420 426 PF00069 0.550
MOD_CK2_1 5 11 PF00069 0.454
MOD_CK2_1 532 538 PF00069 0.536
MOD_GlcNHglycan 189 192 PF01048 0.337
MOD_GlcNHglycan 284 287 PF01048 0.322
MOD_GlcNHglycan 489 492 PF01048 0.702
MOD_GlcNHglycan 92 95 PF01048 0.309
MOD_GSK3_1 10 17 PF00069 0.405
MOD_GSK3_1 213 220 PF00069 0.302
MOD_GSK3_1 335 342 PF00069 0.322
MOD_GSK3_1 349 356 PF00069 0.322
MOD_GSK3_1 367 374 PF00069 0.322
MOD_GSK3_1 37 44 PF00069 0.460
MOD_GSK3_1 413 420 PF00069 0.556
MOD_GSK3_1 438 445 PF00069 0.524
MOD_GSK3_1 47 54 PF00069 0.445
MOD_GSK3_1 80 87 PF00069 0.333
MOD_N-GLC_1 105 110 PF02516 0.377
MOD_N-GLC_1 227 232 PF02516 0.322
MOD_N-GLC_1 288 293 PF02516 0.309
MOD_N-GLC_1 300 305 PF02516 0.309
MOD_N-GLC_1 487 492 PF02516 0.705
MOD_N-GLC_2 82 84 PF02516 0.309
MOD_NEK2_1 12 17 PF00069 0.552
MOD_NEK2_1 170 175 PF00069 0.337
MOD_NEK2_1 237 242 PF00069 0.377
MOD_NEK2_1 332 337 PF00069 0.314
MOD_NEK2_1 34 39 PF00069 0.396
MOD_NEK2_1 341 346 PF00069 0.299
MOD_NEK2_1 353 358 PF00069 0.309
MOD_NEK2_1 371 376 PF00069 0.322
MOD_NEK2_1 417 422 PF00069 0.540
MOD_NEK2_1 438 443 PF00069 0.589
MOD_NEK2_1 51 56 PF00069 0.490
MOD_PIKK_1 213 219 PF00454 0.427
MOD_PIKK_1 257 263 PF00454 0.430
MOD_PIKK_1 58 64 PF00454 0.320
MOD_PKA_2 119 125 PF00069 0.323
MOD_PKA_2 170 176 PF00069 0.377
MOD_PKA_2 213 219 PF00069 0.318
MOD_PKA_2 332 338 PF00069 0.309
MOD_PKA_2 349 355 PF00069 0.309
MOD_PKA_2 417 423 PF00069 0.578
MOD_PKA_2 432 438 PF00069 0.395
MOD_PKA_2 5 11 PF00069 0.470
MOD_Plk_1 150 156 PF00069 0.337
MOD_Plk_1 288 294 PF00069 0.309
MOD_Plk_1 34 40 PF00069 0.427
MOD_Plk_2-3 5 11 PF00069 0.470
MOD_Plk_2-3 520 526 PF00069 0.630
MOD_Plk_4 14 20 PF00069 0.419
MOD_Plk_4 150 156 PF00069 0.337
MOD_Plk_4 207 213 PF00069 0.413
MOD_Plk_4 237 243 PF00069 0.352
MOD_Plk_4 288 294 PF00069 0.337
MOD_Plk_4 332 338 PF00069 0.324
MOD_Plk_4 34 40 PF00069 0.401
MOD_Plk_4 349 355 PF00069 0.297
MOD_Plk_4 379 385 PF00069 0.431
MOD_Plk_4 95 101 PF00069 0.309
MOD_ProDKin_1 355 361 PF00069 0.309
MOD_SUMO_for_1 516 519 PF00179 0.591
MOD_SUMO_rev_2 131 139 PF00179 0.347
MOD_SUMO_rev_2 432 441 PF00179 0.614
MOD_SUMO_rev_2 519 528 PF00179 0.594
MOD_SUMO_rev_2 616 622 PF00179 0.570
TRG_DiLeu_BaEn_3 616 622 PF01217 0.514
TRG_ENDOCYTIC_2 498 501 PF00928 0.673
TRG_ENDOCYTIC_2 637 640 PF00928 0.594
TRG_ENDOCYTIC_2 66 69 PF00928 0.309
TRG_ENDOCYTIC_2 97 100 PF00928 0.309
TRG_ER_diArg_1 295 297 PF00400 0.322
TRG_ER_diArg_1 542 545 PF00400 0.639
TRG_ER_diArg_1 550 553 PF00400 0.624
TRG_ER_diArg_1 632 635 PF00400 0.511
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.322
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.322
TRG_Pf-PMV_PEXEL_1 450 454 PF00026 0.620

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD6 Leptomonas seymouri 79% 86%
A0A0S4IP49 Bodo saltans 28% 81%
A0A0S4IR67 Bodo saltans 63% 84%
A0A0S4J2K1 Bodo saltans 30% 69%
A0A0S4JRN9 Bodo saltans 34% 100%
A0A0S4KL43 Bodo saltans 27% 100%
A0A1X0NQ03 Trypanosomatidae 27% 79%
A0A1X0NWZ8 Trypanosomatidae 62% 88%
A0A3Q8IAZ2 Leishmania donovani 100% 100%
A0A3Q8IEL2 Leishmania donovani 31% 100%
A0A3R7KHX7 Trypanosoma rangeli 30% 89%
A0A3S7X9Y1 Leishmania donovani 27% 100%
A0A422NEQ8 Trypanosoma rangeli 61% 87%
A0A422NMD1 Trypanosoma rangeli 24% 100%
A4HAQ7 Leishmania braziliensis 32% 100%
A4HCT2 Leishmania braziliensis 82% 100%
A4HND6 Leishmania braziliensis 26% 100%
A4HSA6 Leishmania infantum 30% 100%
A4I4V3 Leishmania infantum 31% 100%
A4IC09 Leishmania infantum 27% 100%
C9ZV26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 87%
D0A8T5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9AFU7 Leishmania major 27% 100%
E9AW71 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9B6Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P28743 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 93%
Q4KLL9 Rattus norvegicus 31% 79%
Q6PFD6 Mus musculus 32% 79%
Q8LNZ2 Arabidopsis thaliana 30% 70%
Q8S905 Arabidopsis thaliana 26% 67%
Q9NF78 Leishmania major 97% 100%
V5B6Q5 Trypanosoma cruzi 23% 100%
V5D733 Trypanosoma cruzi 62% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS