Metallo-beta-lactamase family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase family protein-like protein

Species:

Leishmania infantum

UniProt:

A4I0A3_LEIIN

TriTrypDb:

LINF_230012900

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	351	353	PF00675	0.394
CLV_NRD_NRD_1	363	365	PF00675	0.406
CLV_NRD_NRD_1	62	64	PF00675	0.512
CLV_NRD_NRD_1	99	101	PF00675	0.473
CLV_PCSK_FUR_1	349	353	PF00082	0.395
CLV_PCSK_KEX2_1	351	353	PF00082	0.412
CLV_PCSK_KEX2_1	363	365	PF00082	0.423
CLV_PCSK_KEX2_1	62	64	PF00082	0.486
CLV_PCSK_SKI1_1	295	299	PF00082	0.266
CLV_PCSK_SKI1_1	6	10	PF00082	0.515
DEG_APCC_DBOX_1	186	194	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DEG_SCF_FBW7_1	277	283	PF00400	0.360
DOC_CKS1_1	277	282	PF01111	0.360
DOC_CYCLIN_RxL_1	292	301	PF00134	0.286
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.496
DOC_MAPK_DCC_7	62	70	PF00069	0.334
DOC_MAPK_gen_1	62	70	PF00069	0.570
DOC_MAPK_gen_1	98	106	PF00069	0.311
DOC_PP1_RVXF_1	293	299	PF00149	0.266
DOC_PP2B_LxvP_1	289	292	PF13499	0.266
DOC_USP7_MATH_1	165	169	PF00917	0.410
DOC_USP7_MATH_1	314	318	PF00917	0.411
DOC_USP7_MATH_1	58	62	PF00917	0.431
DOC_USP7_UBL2_3	47	51	PF12436	0.499
DOC_WW_Pin1_4	236	241	PF00397	0.620
DOC_WW_Pin1_4	276	281	PF00397	0.266
DOC_WW_Pin1_4	71	76	PF00397	0.358
LIG_14-3-3_CanoR_1	235	240	PF00244	0.790
LIG_14-3-3_CanoR_1	249	255	PF00244	0.410
LIG_14-3-3_CanoR_1	25	29	PF00244	0.413
LIG_14-3-3_CanoR_1	261	266	PF00244	0.310
LIG_14-3-3_CanoR_1	343	348	PF00244	0.360
LIG_Actin_WH2_2	113	128	PF00022	0.463
LIG_Actin_WH2_2	32	49	PF00022	0.444
LIG_Actin_WH2_2	4	21	PF00022	0.443
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.441
LIG_BRCT_BRCA1_1	261	265	PF00533	0.466
LIG_Clathr_ClatBox_1	325	329	PF01394	0.411
LIG_DCNL_PONY_1	1	4	PF03556	0.543
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.306
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.308
LIG_FHA_1	120	126	PF00498	0.396
LIG_FHA_1	19	25	PF00498	0.518
LIG_FHA_1	297	303	PF00498	0.322
LIG_FHA_1	333	339	PF00498	0.266
LIG_FHA_1	34	40	PF00498	0.369
LIG_FHA_1	72	78	PF00498	0.424
LIG_LIR_Gen_1	114	121	PF02991	0.317
LIG_LIR_Gen_1	166	176	PF02991	0.491
LIG_LIR_Gen_1	43	53	PF02991	0.537
LIG_LIR_Nem_3	114	119	PF02991	0.319
LIG_LIR_Nem_3	166	172	PF02991	0.419
LIG_LIR_Nem_3	178	183	PF02991	0.310
LIG_LIR_Nem_3	196	201	PF02991	0.535
LIG_LIR_Nem_3	262	268	PF02991	0.356
LIG_LIR_Nem_3	43	48	PF02991	0.529
LIG_PCNA_PIPBox_1	194	203	PF02747	0.393
LIG_PCNA_yPIPBox_3	349	361	PF02747	0.428
LIG_Pex14_1	169	173	PF04695	0.311
LIG_PTB_Apo_2	192	199	PF02174	0.496
LIG_PTB_Phospho_1	192	198	PF10480	0.498
LIG_SH2_CRK	305	309	PF00017	0.300
LIG_SH2_GRB2like	84	87	PF00017	0.457
LIG_SH2_NCK_1	305	309	PF00017	0.262
LIG_SH2_SRC	84	87	PF00017	0.457
LIG_SH2_STAP1	203	207	PF00017	0.548
LIG_SH2_STAP1	361	365	PF00017	0.522
LIG_SH2_STAT3	203	206	PF00017	0.477
LIG_SH2_STAT5	201	204	PF00017	0.423
LIG_SH2_STAT5	276	279	PF00017	0.281
LIG_SH3_2	240	245	PF14604	0.563
LIG_SH3_3	237	243	PF00018	0.616
LIG_SH3_3	274	280	PF00018	0.411
LIG_SH3_3	308	314	PF00018	0.298
LIG_SH3_3	333	339	PF00018	0.275
LIG_SH3_CIN85_PxpxPR_1	240	245	PF14604	0.563
LIG_SUMO_SIM_par_1	323	329	PF11976	0.411
LIG_TYR_ITIM	303	308	PF00017	0.300
LIG_WW_3	242	246	PF00397	0.537
MOD_CDK_SPK_2	236	241	PF00069	0.587
MOD_CK1_1	196	202	PF00069	0.468
MOD_CK1_1	256	262	PF00069	0.380
MOD_CK1_1	324	330	PF00069	0.411
MOD_GlcNHglycan	122	125	PF01048	0.432
MOD_GlcNHglycan	256	259	PF01048	0.457
MOD_GlcNHglycan	316	319	PF01048	0.399
MOD_GSK3_1	115	122	PF00069	0.355
MOD_GSK3_1	256	263	PF00069	0.376
MOD_GSK3_1	276	283	PF00069	0.302
MOD_LATS_1	341	347	PF00433	0.357
MOD_N-GLC_1	259	264	PF02516	0.512
MOD_N-GLC_1	30	35	PF02516	0.376
MOD_NEK2_1	119	124	PF00069	0.342
MOD_NEK2_1	130	135	PF00069	0.262
MOD_NEK2_1	193	198	PF00069	0.441
MOD_NEK2_1	254	259	PF00069	0.389
MOD_NEK2_1	321	326	PF00069	0.271
MOD_PK_1	66	72	PF00069	0.374
MOD_PKA_2	125	131	PF00069	0.387
MOD_PKA_2	18	24	PF00069	0.483
MOD_PKA_2	234	240	PF00069	0.577
MOD_PKA_2	248	254	PF00069	0.355
MOD_PKA_2	260	266	PF00069	0.310
MOD_PKA_2	342	348	PF00069	0.357
MOD_PKA_2	58	64	PF00069	0.440
MOD_Plk_1	165	171	PF00069	0.456
MOD_Plk_1	30	36	PF00069	0.378
MOD_Plk_1	332	338	PF00069	0.266
MOD_Plk_4	115	121	PF00069	0.458
MOD_Plk_4	165	171	PF00069	0.456
MOD_Plk_4	193	199	PF00069	0.529
MOD_Plk_4	261	267	PF00069	0.367
MOD_Plk_4	269	275	PF00069	0.339
MOD_Plk_4	321	327	PF00069	0.318
MOD_Plk_4	332	338	PF00069	0.218
MOD_ProDKin_1	236	242	PF00069	0.615
MOD_ProDKin_1	276	282	PF00069	0.266
MOD_ProDKin_1	71	77	PF00069	0.350
TRG_DiLeu_BaEn_1	73	78	PF01217	0.474
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.411
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.711
TRG_ENDOCYTIC_2	180	183	PF00928	0.342
TRG_ENDOCYTIC_2	305	308	PF00928	0.300
TRG_ER_diArg_1	210	213	PF00400	0.531
TRG_NES_CRM1_1	138	151	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I936	Leptomonas seymouri	79%	98%
A0A0S4IRF9	Bodo saltans	43%	100%
A0A1X0NXH8	Trypanosomatidae	49%	100%
A0A3Q8ICH4	Leishmania donovani	100%	100%
A0A422MYI7	Trypanosoma rangeli	50%	100%
A4HCS9	Leishmania braziliensis	87%	99%
C9ZV29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AW68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QBB0	Leishmania major	98%	100%
V5BFN3	Trypanosoma cruzi	51%	100%