Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I098_LEIIN

TriTrypDb:

LINF_230011300

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I098

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I098

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.520
CLV_NRD_NRD_1	217	219	PF00675	0.511
CLV_NRD_NRD_1	308	310	PF00675	0.613
CLV_NRD_NRD_1	448	450	PF00675	0.553
CLV_PCSK_KEX2_1	217	219	PF00082	0.472
CLV_PCSK_KEX2_1	310	312	PF00082	0.588
CLV_PCSK_KEX2_1	435	437	PF00082	0.565
CLV_PCSK_KEX2_1	448	450	PF00082	0.377
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.568
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.551
CLV_PCSK_SKI1_1	14	18	PF00082	0.431
CLV_PCSK_SKI1_1	448	452	PF00082	0.477
DEG_ODPH_VHL_1	116	127	PF01847	0.471
DEG_SCF_FBW7_1	245	250	PF00400	0.595
DEG_SPOP_SBC_1	376	380	PF00917	0.622
DOC_ANK_TNKS_1	317	324	PF00023	0.641
DOC_CKS1_1	141	146	PF01111	0.571
DOC_CKS1_1	253	258	PF01111	0.554
DOC_CYCLIN_RxL_1	296	308	PF00134	0.596
DOC_CYCLIN_RxL_1	392	403	PF00134	0.565
DOC_CYCLIN_RxL_1	446	456	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.326
DOC_PP1_RVXF_1	195	202	PF00149	0.483
DOC_PP1_RVXF_1	393	400	PF00149	0.600
DOC_PP1_RVXF_1	446	453	PF00149	0.447
DOC_PP2B_LxvP_1	367	370	PF13499	0.537
DOC_PP2B_LxvP_1	56	59	PF13499	0.328
DOC_PP4_FxxP_1	201	204	PF00568	0.458
DOC_USP7_MATH_1	118	122	PF00917	0.585
DOC_USP7_MATH_1	18	22	PF00917	0.408
DOC_USP7_MATH_1	224	228	PF00917	0.547
DOC_USP7_MATH_1	304	308	PF00917	0.621
DOC_USP7_MATH_1	321	325	PF00917	0.509
DOC_USP7_MATH_1	370	374	PF00917	0.552
DOC_USP7_MATH_1	393	397	PF00917	0.630
DOC_USP7_MATH_2	312	318	PF00917	0.658
DOC_USP7_UBL2_3	234	238	PF12436	0.555
DOC_WW_Pin1_4	140	145	PF00397	0.583
DOC_WW_Pin1_4	200	205	PF00397	0.463
DOC_WW_Pin1_4	243	248	PF00397	0.585
DOC_WW_Pin1_4	252	257	PF00397	0.646
DOC_WW_Pin1_4	276	281	PF00397	0.583
LIG_14-3-3_CanoR_1	14	23	PF00244	0.419
LIG_14-3-3_CanoR_1	449	457	PF00244	0.568
LIG_Actin_WH2_2	97	112	PF00022	0.445
LIG_APCC_ABBA_1	399	404	PF00400	0.478
LIG_BIR_III_4	189	193	PF00653	0.436
LIG_BRCT_BRCA1_1	158	162	PF00533	0.506
LIG_BRCT_BRCA1_1	18	22	PF00533	0.386
LIG_BRCT_BRCA1_1	395	399	PF00533	0.524
LIG_BRCT_BRCA1_1	6	10	PF00533	0.302
LIG_Clathr_ClatBox_1	8	12	PF01394	0.320
LIG_FHA_1	101	107	PF00498	0.437
LIG_FHA_1	149	155	PF00498	0.433
LIG_FHA_1	253	259	PF00498	0.538
LIG_FHA_1	3	9	PF00498	0.332
LIG_FHA_1	439	445	PF00498	0.464
LIG_FHA_1	452	458	PF00498	0.518
LIG_FHA_2	170	176	PF00498	0.383
LIG_FHA_2	317	323	PF00498	0.616
LIG_FHA_2	380	386	PF00498	0.613
LIG_FHA_2	403	409	PF00498	0.532
LIG_FHA_2	413	419	PF00498	0.426
LIG_FHA_2	426	432	PF00498	0.341
LIG_FHA_2	451	457	PF00498	0.567
LIG_LIR_Gen_1	227	236	PF02991	0.747
LIG_LIR_Gen_1	40	47	PF02991	0.300
LIG_LIR_Gen_1	410	419	PF02991	0.446
LIG_LIR_Nem_3	159	165	PF02991	0.476
LIG_LIR_Nem_3	227	231	PF02991	0.732
LIG_LIR_Nem_3	38	42	PF02991	0.324
LIG_LIR_Nem_3	396	402	PF02991	0.521
LIG_LIR_Nem_3	410	416	PF02991	0.543
LIG_MLH1_MIPbox_1	19	23	PF16413	0.407
LIG_SH2_CRK	273	277	PF00017	0.523
LIG_SH2_NCK_1	273	277	PF00017	0.523
LIG_SH2_PTP2	413	416	PF00017	0.444
LIG_SH2_PTP2	42	45	PF00017	0.301
LIG_SH2_SRC	42	45	PF00017	0.301
LIG_SH2_STAP1	39	43	PF00017	0.319
LIG_SH2_STAT5	214	217	PF00017	0.416
LIG_SH2_STAT5	228	231	PF00017	0.541
LIG_SH2_STAT5	413	416	PF00017	0.444
LIG_SH2_STAT5	42	45	PF00017	0.301
LIG_SH3_3	141	147	PF00018	0.629
LIG_SH3_3	242	248	PF00018	0.533
LIG_SH3_3	279	285	PF00018	0.535
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.440
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.316
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.300
LIG_TRAF2_1	427	430	PF00917	0.539
LIG_WRC_WIRS_1	228	233	PF05994	0.622
MOD_CK1_1	129	135	PF00069	0.619
MOD_CK1_1	169	175	PF00069	0.394
MOD_CK1_1	227	233	PF00069	0.544
MOD_CK1_1	297	303	PF00069	0.638
MOD_CK1_1	317	323	PF00069	0.635
MOD_CK1_1	324	330	PF00069	0.619
MOD_CK1_1	345	351	PF00069	0.664
MOD_CK1_1	379	385	PF00069	0.688
MOD_CK1_1	4	10	PF00069	0.316
MOD_CK1_1	407	413	PF00069	0.547
MOD_CK1_1	51	57	PF00069	0.358
MOD_CK2_1	181	187	PF00069	0.387
MOD_CK2_1	316	322	PF00069	0.573
MOD_CK2_1	375	381	PF00069	0.611
MOD_CK2_1	385	391	PF00069	0.569
MOD_CK2_1	425	431	PF00069	0.465
MOD_CK2_1	450	456	PF00069	0.556
MOD_GlcNHglycan	120	123	PF01048	0.566
MOD_GlcNHglycan	128	131	PF01048	0.605
MOD_GlcNHglycan	209	212	PF01048	0.443
MOD_GlcNHglycan	264	267	PF01048	0.641
MOD_GlcNHglycan	273	276	PF01048	0.671
MOD_GlcNHglycan	319	322	PF01048	0.636
MOD_GlcNHglycan	323	326	PF01048	0.611
MOD_GlcNHglycan	345	348	PF01048	0.622
MOD_GlcNHglycan	445	448	PF01048	0.633
MOD_GlcNHglycan	92	95	PF01048	0.379
MOD_GSK3_1	136	143	PF00069	0.616
MOD_GSK3_1	14	21	PF00069	0.420
MOD_GSK3_1	243	250	PF00069	0.589
MOD_GSK3_1	317	324	PF00069	0.576
MOD_GSK3_1	345	352	PF00069	0.577
MOD_GSK3_1	371	378	PF00069	0.710
MOD_GSK3_1	400	407	PF00069	0.516
MOD_GSK3_1	47	54	PF00069	0.328
MOD_GSK3_1	86	93	PF00069	0.339
MOD_N-GLC_1	135	140	PF02516	0.572
MOD_N-GLC_1	180	185	PF02516	0.369
MOD_NEK2_1	1	6	PF00069	0.380
MOD_NEK2_1	16	21	PF00069	0.393
MOD_NEK2_1	180	185	PF00069	0.398
MOD_NEK2_1	37	42	PF00069	0.335
MOD_NEK2_1	402	407	PF00069	0.667
MOD_NEK2_1	47	52	PF00069	0.296
MOD_NEK2_2	18	23	PF00069	0.411
MOD_NEK2_2	393	398	PF00069	0.613
MOD_NEK2_2	86	91	PF00069	0.323
MOD_NEK2_2	97	102	PF00069	0.418
MOD_PIKK_1	331	337	PF00454	0.653
MOD_PIKK_1	425	431	PF00454	0.536
MOD_PK_1	110	116	PF00069	0.452
MOD_PKA_2	295	301	PF00069	0.647
MOD_PKA_2	317	323	PF00069	0.592
MOD_Plk_1	135	141	PF00069	0.601
MOD_Plk_1	180	186	PF00069	0.388
MOD_Plk_1	294	300	PF00069	0.570
MOD_Plk_1	385	391	PF00069	0.706
MOD_Plk_2-3	385	391	PF00069	0.587
MOD_Plk_4	110	116	PF00069	0.476
MOD_Plk_4	136	142	PF00069	0.643
MOD_Plk_4	148	154	PF00069	0.359
MOD_Plk_4	18	24	PF00069	0.383
MOD_Plk_4	181	187	PF00069	0.402
MOD_Plk_4	224	230	PF00069	0.617
MOD_Plk_4	351	357	PF00069	0.580
MOD_Plk_4	38	44	PF00069	0.287
MOD_Plk_4	4	10	PF00069	0.316
MOD_Plk_4	409	415	PF00069	0.482
MOD_ProDKin_1	140	146	PF00069	0.576
MOD_ProDKin_1	200	206	PF00069	0.457
MOD_ProDKin_1	243	249	PF00069	0.588
MOD_ProDKin_1	252	258	PF00069	0.643
MOD_ProDKin_1	276	282	PF00069	0.583
MOD_SUMO_rev_2	306	312	PF00179	0.658
TRG_ENDOCYTIC_2	228	231	PF00928	0.732
TRG_ENDOCYTIC_2	413	416	PF00928	0.444
TRG_ENDOCYTIC_2	42	45	PF00928	0.301
TRG_ER_diArg_1	309	312	PF00400	0.704
TRG_ER_diArg_1	448	450	PF00400	0.447
TRG_ER_diArg_1	72	75	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE95	Leptomonas seymouri	48%	100%
A0A3S5H7B8	Leishmania donovani	99%	100%
A4HCS4	Leishmania braziliensis	74%	100%
E9AW63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBB5	Leishmania major	87%	100%