LeishMANIAdb
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C2 NT-type domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2 NT-type domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I096_LEIIN
TriTrypDb:
LINF_230011000
Length:
882

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 151

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I096
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I096

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 51 55 PF00656 0.473
CLV_MEL_PAP_1 116 122 PF00089 0.499
CLV_NRD_NRD_1 29 31 PF00675 0.477
CLV_NRD_NRD_1 72 74 PF00675 0.481
CLV_NRD_NRD_1 752 754 PF00675 0.711
CLV_NRD_NRD_1 84 86 PF00675 0.526
CLV_PCSK_KEX2_1 72 74 PF00082 0.476
CLV_PCSK_KEX2_1 752 754 PF00082 0.711
CLV_PCSK_SKI1_1 166 170 PF00082 0.571
CLV_PCSK_SKI1_1 241 245 PF00082 0.517
CLV_PCSK_SKI1_1 338 342 PF00082 0.488
CLV_PCSK_SKI1_1 72 76 PF00082 0.525
DEG_SCF_FBW7_1 570 576 PF00400 0.624
DEG_SPOP_SBC_1 528 532 PF00917 0.749
DOC_AGCK_PIF_2 77 82 PF00069 0.425
DOC_CKS1_1 136 141 PF01111 0.531
DOC_CKS1_1 440 445 PF01111 0.639
DOC_CKS1_1 515 520 PF01111 0.679
DOC_CKS1_1 570 575 PF01111 0.625
DOC_CKS1_1 581 586 PF01111 0.542
DOC_CKS1_1 668 673 PF01111 0.614
DOC_CKS1_1 683 688 PF01111 0.514
DOC_CYCLIN_yClb3_PxF_3 745 753 PF00134 0.678
DOC_CYCLIN_yCln2_LP_2 683 689 PF00134 0.620
DOC_MAPK_gen_1 70 77 PF00069 0.461
DOC_MAPK_JIP1_4 60 66 PF00069 0.499
DOC_MAPK_MEF2A_6 19 27 PF00069 0.422
DOC_MAPK_MEF2A_6 773 781 PF00069 0.588
DOC_MAPK_MEF2A_6 855 864 PF00069 0.569
DOC_PP1_RVXF_1 112 119 PF00149 0.488
DOC_PP1_RVXF_1 429 436 PF00149 0.670
DOC_PP1_RVXF_1 71 78 PF00149 0.457
DOC_PP2B_LxvP_1 664 667 PF13499 0.769
DOC_PP4_FxxP_1 66 69 PF00568 0.450
DOC_PP4_FxxP_1 94 97 PF00568 0.466
DOC_USP7_MATH_1 106 110 PF00917 0.506
DOC_USP7_MATH_1 333 337 PF00917 0.557
DOC_USP7_MATH_1 497 501 PF00917 0.712
DOC_USP7_MATH_1 524 528 PF00917 0.762
DOC_USP7_MATH_1 535 539 PF00917 0.699
DOC_USP7_MATH_1 542 546 PF00917 0.628
DOC_USP7_MATH_1 548 552 PF00917 0.590
DOC_USP7_MATH_1 573 577 PF00917 0.754
DOC_USP7_MATH_1 622 626 PF00917 0.808
DOC_USP7_MATH_1 672 676 PF00917 0.757
DOC_USP7_MATH_1 707 711 PF00917 0.655
DOC_USP7_MATH_1 854 858 PF00917 0.624
DOC_USP7_UBL2_3 280 284 PF12436 0.520
DOC_USP7_UBL2_3 387 391 PF12436 0.661
DOC_USP7_UBL2_3 86 90 PF12436 0.499
DOC_WW_Pin1_4 135 140 PF00397 0.524
DOC_WW_Pin1_4 439 444 PF00397 0.644
DOC_WW_Pin1_4 479 484 PF00397 0.690
DOC_WW_Pin1_4 514 519 PF00397 0.664
DOC_WW_Pin1_4 529 534 PF00397 0.716
DOC_WW_Pin1_4 569 574 PF00397 0.642
DOC_WW_Pin1_4 580 585 PF00397 0.615
DOC_WW_Pin1_4 607 612 PF00397 0.691
DOC_WW_Pin1_4 616 621 PF00397 0.759
DOC_WW_Pin1_4 648 653 PF00397 0.694
DOC_WW_Pin1_4 65 70 PF00397 0.463
DOC_WW_Pin1_4 667 672 PF00397 0.692
DOC_WW_Pin1_4 682 687 PF00397 0.720
DOC_WW_Pin1_4 813 818 PF00397 0.654
DOC_WW_Pin1_4 871 876 PF00397 0.566
LIG_14-3-3_CanoR_1 166 173 PF00244 0.573
LIG_14-3-3_CanoR_1 225 229 PF00244 0.541
LIG_14-3-3_CanoR_1 637 645 PF00244 0.668
LIG_14-3-3_CanoR_1 842 849 PF00244 0.589
LIG_14-3-3_CterR_2 879 882 PF00244 0.582
LIG_APCC_ABBA_1 777 782 PF00400 0.622
LIG_APCC_ABBA_1 865 870 PF00400 0.483
LIG_BIR_III_4 158 162 PF00653 0.681
LIG_BIR_III_4 469 473 PF00653 0.729
LIG_BIR_III_4 52 56 PF00653 0.515
LIG_BRCT_BRCA1_1 226 230 PF00533 0.563
LIG_CSL_BTD_1 834 837 PF09270 0.538
LIG_FHA_1 224 230 PF00498 0.511
LIG_FHA_1 242 248 PF00498 0.456
LIG_FHA_1 354 360 PF00498 0.554
LIG_FHA_1 397 403 PF00498 0.537
LIG_FHA_1 460 466 PF00498 0.764
LIG_FHA_1 469 475 PF00498 0.659
LIG_FHA_1 570 576 PF00498 0.629
LIG_FHA_1 844 850 PF00498 0.482
LIG_FHA_2 232 238 PF00498 0.474
LIG_FHA_2 504 510 PF00498 0.768
LIG_FHA_2 90 96 PF00498 0.418
LIG_KLC1_Yacidic_2 778 782 PF13176 0.588
LIG_LIR_Apic_2 506 511 PF02991 0.713
LIG_LIR_Apic_2 63 69 PF02991 0.501
LIG_LIR_Apic_2 763 769 PF02991 0.589
LIG_LIR_Apic_2 92 97 PF02991 0.465
LIG_LIR_Gen_1 22 28 PF02991 0.410
LIG_LIR_Gen_1 383 393 PF02991 0.572
LIG_LIR_Gen_1 799 807 PF02991 0.520
LIG_LIR_Nem_3 22 27 PF02991 0.410
LIG_LIR_Nem_3 383 388 PF02991 0.577
LIG_LIR_Nem_3 759 765 PF02991 0.616
LIG_LIR_Nem_3 870 876 PF02991 0.573
LIG_MYND_1 689 693 PF01753 0.625
LIG_PDZ_Class_2 877 882 PF00595 0.572
LIG_Pex14_2 62 66 PF04695 0.477
LIG_Pex14_2 876 880 PF04695 0.559
LIG_PTB_Apo_2 794 801 PF02174 0.532
LIG_PTB_Phospho_1 794 800 PF10480 0.529
LIG_SH2_CRK 766 770 PF00017 0.578
LIG_SH2_NCK_1 376 380 PF00017 0.626
LIG_SH2_PTP2 24 27 PF00017 0.404
LIG_SH2_SRC 376 379 PF00017 0.671
LIG_SH2_SRC 508 511 PF00017 0.760
LIG_SH2_SRC 780 783 PF00017 0.612
LIG_SH2_STAP1 252 256 PF00017 0.554
LIG_SH2_STAP1 4 8 PF00017 0.405
LIG_SH2_STAT3 252 255 PF00017 0.551
LIG_SH2_STAT3 721 724 PF00017 0.648
LIG_SH2_STAT3 732 735 PF00017 0.694
LIG_SH2_STAT5 16 19 PF00017 0.438
LIG_SH2_STAT5 24 27 PF00017 0.404
LIG_SH2_STAT5 313 316 PF00017 0.499
LIG_SH2_STAT5 417 420 PF00017 0.660
LIG_SH2_STAT5 762 765 PF00017 0.556
LIG_SH2_STAT5 780 783 PF00017 0.360
LIG_SH2_STAT5 866 869 PF00017 0.545
LIG_SH2_STAT5 873 876 PF00017 0.442
LIG_SH3_2 139 144 PF14604 0.463
LIG_SH3_3 133 139 PF00018 0.501
LIG_SH3_3 225 231 PF00018 0.476
LIG_SH3_3 489 495 PF00018 0.757
LIG_SH3_3 516 522 PF00018 0.737
LIG_SH3_3 572 578 PF00018 0.820
LIG_SH3_3 596 602 PF00018 0.699
LIG_SH3_3 656 662 PF00018 0.748
LIG_SH3_3 683 689 PF00018 0.728
LIG_SH3_3 703 709 PF00018 0.724
LIG_SH3_3 742 748 PF00018 0.719
LIG_SH3_3 848 854 PF00018 0.620
LIG_SUMO_SIM_par_1 356 364 PF11976 0.558
LIG_TRAF2_1 756 759 PF00917 0.691
LIG_UBA3_1 357 362 PF00899 0.560
MOD_CDK_SPK_2 65 70 PF00069 0.515
MOD_CDK_SPxxK_3 65 72 PF00069 0.498
MOD_CK1_1 121 127 PF00069 0.540
MOD_CK1_1 164 170 PF00069 0.681
MOD_CK1_1 172 178 PF00069 0.636
MOD_CK1_1 266 272 PF00069 0.526
MOD_CK1_1 451 457 PF00069 0.649
MOD_CK1_1 523 529 PF00069 0.642
MOD_CK1_1 569 575 PF00069 0.807
MOD_CK1_1 643 649 PF00069 0.748
MOD_CK1_1 65 71 PF00069 0.507
MOD_CK1_1 682 688 PF00069 0.760
MOD_CK1_1 821 827 PF00069 0.685
MOD_CK1_1 841 847 PF00069 0.257
MOD_CK2_1 106 112 PF00069 0.488
MOD_CK2_1 204 210 PF00069 0.438
MOD_CK2_1 231 237 PF00069 0.473
MOD_CK2_1 394 400 PF00069 0.540
MOD_CK2_1 41 47 PF00069 0.548
MOD_CK2_1 503 509 PF00069 0.737
MOD_CK2_1 678 684 PF00069 0.767
MOD_CK2_1 753 759 PF00069 0.717
MOD_CK2_1 89 95 PF00069 0.424
MOD_GlcNHglycan 120 123 PF01048 0.504
MOD_GlcNHglycan 166 169 PF01048 0.674
MOD_GlcNHglycan 174 177 PF01048 0.605
MOD_GlcNHglycan 265 268 PF01048 0.508
MOD_GlcNHglycan 287 292 PF01048 0.505
MOD_GlcNHglycan 522 525 PF01048 0.809
MOD_GlcNHglycan 526 529 PF01048 0.708
MOD_GlcNHglycan 544 547 PF01048 0.807
MOD_GlcNHglycan 57 60 PF01048 0.568
MOD_GlcNHglycan 575 578 PF01048 0.791
MOD_GlcNHglycan 642 645 PF01048 0.801
MOD_GlcNHglycan 646 649 PF01048 0.824
MOD_GlcNHglycan 729 732 PF01048 0.627
MOD_GlcNHglycan 820 823 PF01048 0.666
MOD_GSK3_1 114 121 PF00069 0.493
MOD_GSK3_1 182 189 PF00069 0.670
MOD_GSK3_1 37 44 PF00069 0.460
MOD_GSK3_1 448 455 PF00069 0.754
MOD_GSK3_1 497 504 PF00069 0.775
MOD_GSK3_1 520 527 PF00069 0.752
MOD_GSK3_1 537 544 PF00069 0.592
MOD_GSK3_1 569 576 PF00069 0.732
MOD_GSK3_1 636 643 PF00069 0.778
MOD_GSK3_1 644 651 PF00069 0.817
MOD_GSK3_1 672 679 PF00069 0.767
MOD_GSK3_1 707 714 PF00069 0.610
MOD_GSK3_1 874 881 PF00069 0.523
MOD_N-GLC_1 148 153 PF02516 0.586
MOD_N-GLC_1 42 47 PF02516 0.432
MOD_N-GLC_1 622 627 PF02516 0.768
MOD_NEK2_1 11 16 PF00069 0.477
MOD_NEK2_1 118 123 PF00069 0.501
MOD_NEK2_1 402 407 PF00069 0.549
MOD_NEK2_1 41 46 PF00069 0.404
MOD_NEK2_1 425 430 PF00069 0.626
MOD_NEK2_1 503 508 PF00069 0.771
MOD_NEK2_1 62 67 PF00069 0.481
MOD_NEK2_1 676 681 PF00069 0.660
MOD_PIKK_1 307 313 PF00454 0.697
MOD_PIKK_1 497 503 PF00454 0.585
MOD_PIKK_1 535 541 PF00454 0.759
MOD_PIKK_1 676 682 PF00454 0.736
MOD_PIKK_1 824 830 PF00454 0.673
MOD_PK_1 19 25 PF00069 0.429
MOD_PK_1 855 861 PF00069 0.545
MOD_PKA_2 118 124 PF00069 0.502
MOD_PKA_2 186 192 PF00069 0.566
MOD_PKA_2 224 230 PF00069 0.611
MOD_PKA_2 636 642 PF00069 0.703
MOD_PKA_2 787 793 PF00069 0.588
MOD_PKA_2 841 847 PF00069 0.585
MOD_PKA_2 854 860 PF00069 0.392
MOD_Plk_1 148 154 PF00069 0.585
MOD_Plk_1 192 198 PF00069 0.454
MOD_Plk_1 548 554 PF00069 0.767
MOD_Plk_1 62 68 PF00069 0.487
MOD_Plk_1 622 628 PF00069 0.644
MOD_Plk_1 790 796 PF00069 0.562
MOD_Plk_2-3 327 333 PF00069 0.518
MOD_Plk_2-3 394 400 PF00069 0.540
MOD_Plk_4 100 106 PF00069 0.507
MOD_Plk_4 19 25 PF00069 0.429
MOD_Plk_4 224 230 PF00069 0.611
MOD_Plk_4 353 359 PF00069 0.492
MOD_Plk_4 402 408 PF00069 0.551
MOD_Plk_4 790 796 PF00069 0.562
MOD_Plk_4 855 861 PF00069 0.586
MOD_ProDKin_1 135 141 PF00069 0.521
MOD_ProDKin_1 439 445 PF00069 0.647
MOD_ProDKin_1 479 485 PF00069 0.693
MOD_ProDKin_1 514 520 PF00069 0.668
MOD_ProDKin_1 529 535 PF00069 0.717
MOD_ProDKin_1 569 575 PF00069 0.643
MOD_ProDKin_1 580 586 PF00069 0.613
MOD_ProDKin_1 607 613 PF00069 0.692
MOD_ProDKin_1 616 622 PF00069 0.756
MOD_ProDKin_1 648 654 PF00069 0.692
MOD_ProDKin_1 65 71 PF00069 0.455
MOD_ProDKin_1 667 673 PF00069 0.693
MOD_ProDKin_1 682 688 PF00069 0.722
MOD_ProDKin_1 813 819 PF00069 0.655
MOD_ProDKin_1 871 877 PF00069 0.568
MOD_SUMO_for_1 361 364 PF00179 0.603
MOD_SUMO_for_1 809 812 PF00179 0.592
MOD_SUMO_rev_2 108 116 PF00179 0.473
MOD_SUMO_rev_2 281 291 PF00179 0.541
MOD_SUMO_rev_2 778 786 PF00179 0.646
TRG_DiLeu_BaLyEn_6 343 348 PF01217 0.567
TRG_DiLeu_BaLyEn_6 686 691 PF01217 0.621
TRG_ENDOCYTIC_2 24 27 PF00928 0.404
TRG_ENDOCYTIC_2 762 765 PF00928 0.584
TRG_ENDOCYTIC_2 800 803 PF00928 0.523
TRG_ENDOCYTIC_2 873 876 PF00928 0.556
TRG_ER_diArg_1 72 74 PF00400 0.543
TRG_ER_diArg_1 752 754 PF00400 0.711
TRG_NES_CRM1_1 208 221 PF08389 0.540
TRG_NES_CRM1_1 349 360 PF08389 0.465
TRG_Pf-PMV_PEXEL_1 241 246 PF00026 0.572
TRG_Pf-PMV_PEXEL_1 329 334 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.557

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRN9 Leptomonas seymouri 62% 100%
A0A3S7WXK3 Leishmania donovani 100% 100%
A4HCS2 Leishmania braziliensis 63% 100%
E9AW60 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QBB8 Leishmania major 89% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS