LeishMANIAdb
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Putative trypanothione synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative trypanothione synthetase
Gene product:
trypanothione synthetase - putative
Species:
Leishmania infantum
UniProt:
A4I085_LEIIN
TriTrypDb:
LINF_230009800
Length:
325

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I085
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I085

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016874 ligase activity 2 7
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 7
GO:0016880 acid-ammonia (or amide) ligase activity 4 7
GO:0047479 trypanothione synthase activity 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 198 202 PF00656 0.212
CLV_NRD_NRD_1 123 125 PF00675 0.440
CLV_NRD_NRD_1 313 315 PF00675 0.502
CLV_NRD_NRD_1 37 39 PF00675 0.757
CLV_PCSK_KEX2_1 123 125 PF00082 0.440
CLV_PCSK_KEX2_1 318 320 PF00082 0.432
CLV_PCSK_KEX2_1 37 39 PF00082 0.719
CLV_PCSK_PC1ET2_1 318 320 PF00082 0.510
CLV_PCSK_PC7_1 314 320 PF00082 0.409
CLV_PCSK_SKI1_1 131 135 PF00082 0.460
CLV_PCSK_SKI1_1 209 213 PF00082 0.456
DEG_MDM2_SWIB_1 121 128 PF02201 0.320
DEG_SPOP_SBC_1 14 18 PF00917 0.515
DEG_SPOP_SBC_1 67 71 PF00917 0.665
DOC_CYCLIN_RxL_1 128 138 PF00134 0.253
DOC_CYCLIN_yCln2_LP_2 216 219 PF00134 0.288
DOC_PP2B_LxvP_1 132 135 PF13499 0.240
DOC_PP2B_LxvP_1 216 219 PF13499 0.239
DOC_SPAK_OSR1_1 280 284 PF12202 0.337
DOC_USP7_MATH_1 135 139 PF00917 0.239
DOC_USP7_MATH_1 14 18 PF00917 0.562
DOC_USP7_MATH_1 67 71 PF00917 0.603
DOC_USP7_UBL2_3 205 209 PF12436 0.292
DOC_WW_Pin1_4 154 159 PF00397 0.393
DOC_WW_Pin1_4 175 180 PF00397 0.275
DOC_WW_Pin1_4 230 235 PF00397 0.330
LIG_14-3-3_CanoR_1 68 76 PF00244 0.533
LIG_BRCT_BRCA1_1 268 272 PF00533 0.305
LIG_deltaCOP1_diTrp_1 201 210 PF00928 0.320
LIG_FHA_1 127 133 PF00498 0.334
LIG_FHA_2 168 174 PF00498 0.239
LIG_FHA_2 196 202 PF00498 0.239
LIG_FHA_2 240 246 PF00498 0.334
LIG_FHA_2 296 302 PF00498 0.524
LIG_LIR_Apic_2 230 234 PF02991 0.334
LIG_LIR_Gen_1 201 211 PF02991 0.346
LIG_LIR_Gen_1 267 274 PF02991 0.310
LIG_LIR_Nem_3 108 114 PF02991 0.378
LIG_LIR_Nem_3 180 185 PF02991 0.194
LIG_LIR_Nem_3 201 206 PF02991 0.346
LIG_LIR_Nem_3 233 238 PF02991 0.308
LIG_LIR_Nem_3 267 271 PF02991 0.420
LIG_Pex14_2 121 125 PF04695 0.240
LIG_SH2_CRK 268 272 PF00017 0.438
LIG_SH2_GRB2like 197 200 PF00017 0.194
LIG_SH2_GRB2like 92 95 PF00017 0.380
LIG_SH2_NCK_1 268 272 PF00017 0.405
LIG_SH2_STAP1 148 152 PF00017 0.317
LIG_SH2_STAP1 268 272 PF00017 0.311
LIG_SH2_STAT3 114 117 PF00017 0.240
LIG_SH2_STAT5 141 144 PF00017 0.334
LIG_SH2_STAT5 197 200 PF00017 0.293
LIG_SH2_STAT5 259 262 PF00017 0.476
LIG_SH2_STAT5 282 285 PF00017 0.342
LIG_SH2_STAT5 84 87 PF00017 0.497
LIG_SH3_3 23 29 PF00018 0.587
LIG_TRAF2_1 43 46 PF00917 0.559
MOD_CK1_1 144 150 PF00069 0.279
MOD_CK1_1 157 163 PF00069 0.387
MOD_CK1_1 178 184 PF00069 0.239
MOD_CK1_1 230 236 PF00069 0.330
MOD_CK1_1 24 30 PF00069 0.531
MOD_CK1_1 63 69 PF00069 0.683
MOD_CK1_1 93 99 PF00069 0.420
MOD_CK2_1 167 173 PF00069 0.230
MOD_CK2_1 178 184 PF00069 0.329
MOD_CK2_1 2 8 PF00069 0.587
MOD_CK2_1 295 301 PF00069 0.446
MOD_GlcNHglycan 17 20 PF01048 0.535
MOD_GlcNHglycan 268 271 PF01048 0.310
MOD_GSK3_1 15 22 PF00069 0.652
MOD_GSK3_1 167 174 PF00069 0.339
MOD_GSK3_1 63 70 PF00069 0.658
MOD_GSK3_1 90 97 PF00069 0.519
MOD_N-GLC_1 93 98 PF02516 0.438
MOD_NEK2_1 1 6 PF00069 0.630
MOD_NEK2_1 126 131 PF00069 0.334
MOD_NEK2_1 167 172 PF00069 0.194
MOD_NEK2_1 21 26 PF00069 0.627
MOD_NEK2_2 74 79 PF00069 0.531
MOD_NMyristoyl 1 7 PF02799 0.586
MOD_OFUCOSY 139 146 PF10250 0.535
MOD_PIKK_1 157 163 PF00454 0.257
MOD_PIKK_1 82 88 PF00454 0.313
MOD_PKA_2 19 25 PF00069 0.741
MOD_PKA_2 60 66 PF00069 0.518
MOD_PKA_2 67 73 PF00069 0.564
MOD_Plk_4 212 218 PF00069 0.308
MOD_Plk_4 220 226 PF00069 0.259
MOD_Plk_4 60 66 PF00069 0.746
MOD_ProDKin_1 154 160 PF00069 0.393
MOD_ProDKin_1 175 181 PF00069 0.275
MOD_ProDKin_1 230 236 PF00069 0.330
MOD_SUMO_rev_2 184 194 PF00179 0.194
MOD_SUMO_rev_2 5 11 PF00179 0.586
TRG_DiLeu_BaLyEn_6 128 133 PF01217 0.334
TRG_ENDOCYTIC_2 268 271 PF00928 0.444
TRG_ER_diArg_1 123 125 PF00400 0.241
TRG_ER_diArg_1 23 26 PF00400 0.515
TRG_ER_diArg_1 37 40 PF00400 0.452
TRG_ER_diArg_1 59 62 PF00400 0.638
TRG_Pf-PMV_PEXEL_1 131 136 PF00026 0.485

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II02 Leptomonas seymouri 60% 100%
A0A0S4IVA9 Bodo saltans 36% 100%
A0A3S7WXK4 Leishmania donovani 98% 100%
A0A422N6B5 Trypanosoma rangeli 39% 100%
A4HCR0 Leishmania braziliensis 71% 100%
C9ZV01 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AW49 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 95%
Q4QBC8 Leishmania major 84% 100%
V5BCE6 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS