Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I083_LEIIN

TriTrypDb:

LINF_230009600

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I083

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I083

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.435
CLV_C14_Caspase3-7	55	59	PF00656	0.467
CLV_NRD_NRD_1	10	12	PF00675	0.479
CLV_NRD_NRD_1	92	94	PF00675	0.541
CLV_PCSK_FUR_1	89	93	PF00082	0.641
CLV_PCSK_KEX2_1	187	189	PF00082	0.621
CLV_PCSK_KEX2_1	91	93	PF00082	0.601
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.487
CLV_PCSK_SKI1_1	65	69	PF00082	0.556
DEG_Nend_UBRbox_3	1	3	PF02207	0.291
DOC_CYCLIN_yClb3_PxF_3	224	230	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	222	225	PF00134	0.202
DOC_MAPK_gen_1	187	194	PF00069	0.477
DOC_MAPK_MEF2A_6	187	196	PF00069	0.502
DOC_MAPK_MEF2A_6	92	101	PF00069	0.523
DOC_PP2B_LxvP_1	156	159	PF13499	0.416
DOC_PP2B_LxvP_1	205	208	PF13499	0.440
DOC_PP2B_LxvP_1	222	225	PF13499	0.202
DOC_USP7_MATH_1	292	296	PF00917	0.553
DOC_USP7_UBL2_3	183	187	PF12436	0.537
DOC_WW_Pin1_4	134	139	PF00397	0.439
DOC_WW_Pin1_4	200	205	PF00397	0.404
LIG_14-3-3_CanoR_1	125	129	PF00244	0.412
LIG_14-3-3_CanoR_1	151	157	PF00244	0.442
LIG_14-3-3_CanoR_1	181	186	PF00244	0.708
LIG_14-3-3_CanoR_1	309	314	PF00244	0.442
LIG_Actin_WH2_2	50	67	PF00022	0.281
LIG_APCC_ABBA_1	108	113	PF00400	0.450
LIG_FHA_1	169	175	PF00498	0.556
LIG_FHA_2	195	201	PF00498	0.356
LIG_FHA_2	260	266	PF00498	0.420
LIG_LIR_Apic_2	133	138	PF02991	0.426
LIG_LIR_Gen_1	218	228	PF02991	0.467
LIG_LIR_Gen_1	254	263	PF02991	0.438
LIG_LIR_Gen_1	58	68	PF02991	0.386
LIG_LIR_Nem_3	113	117	PF02991	0.339
LIG_LIR_Nem_3	218	223	PF02991	0.449
LIG_LIR_Nem_3	254	259	PF02991	0.444
LIG_LIR_Nem_3	5	10	PF02991	0.298
LIG_LIR_Nem_3	58	63	PF02991	0.335
LIG_PCNA_PIPBox_1	1	10	PF02747	0.305
LIG_PTB_Apo_2	67	74	PF02174	0.511
LIG_SH2_GRB2like	117	120	PF00017	0.455
LIG_SH2_STAP1	111	115	PF00017	0.291
LIG_SH2_STAP1	117	121	PF00017	0.318
LIG_SH2_STAP1	60	64	PF00017	0.382
LIG_SH2_STAT3	117	120	PF00017	0.462
LIG_SH2_STAT5	135	138	PF00017	0.342
LIG_SH2_STAT5	256	259	PF00017	0.424
LIG_SH2_STAT5	7	10	PF00017	0.318
LIG_SH3_3	218	224	PF00018	0.370
LIG_SH3_3	231	237	PF00018	0.343
LIG_SH3_3	94	100	PF00018	0.472
LIG_TRFH_1	220	224	PF08558	0.419
LIG_TYR_ITSM	3	10	PF00017	0.307
MOD_CK1_1	77	83	PF00069	0.614
MOD_CK2_1	141	147	PF00069	0.397
MOD_CK2_1	194	200	PF00069	0.367
MOD_GlcNHglycan	105	108	PF01048	0.347
MOD_GlcNHglycan	143	146	PF01048	0.515
MOD_GlcNHglycan	183	186	PF01048	0.711
MOD_GlcNHglycan	253	256	PF01048	0.508
MOD_GSK3_1	120	127	PF00069	0.489
MOD_GSK3_1	194	201	PF00069	0.326
MOD_GSK3_1	226	233	PF00069	0.390
MOD_GSK3_1	251	258	PF00069	0.412
MOD_GSK3_1	309	316	PF00069	0.433
MOD_GSK3_1	74	81	PF00069	0.618
MOD_N-GLC_1	74	79	PF02516	0.599
MOD_NEK2_1	141	146	PF00069	0.466
MOD_NEK2_1	150	155	PF00069	0.424
MOD_NEK2_1	194	199	PF00069	0.356
MOD_NEK2_1	230	235	PF00069	0.389
MOD_NEK2_1	251	256	PF00069	0.415
MOD_NEK2_1	79	84	PF00069	0.694
MOD_NEK2_2	46	51	PF00069	0.375
MOD_PKA_2	124	130	PF00069	0.371
MOD_PKA_2	150	156	PF00069	0.542
MOD_PKA_2	213	219	PF00069	0.335
MOD_Plk_1	284	290	PF00069	0.446
MOD_Plk_1	74	80	PF00069	0.594
MOD_Plk_4	124	130	PF00069	0.393
MOD_Plk_4	226	232	PF00069	0.383
MOD_Plk_4	3	9	PF00069	0.317
MOD_ProDKin_1	134	140	PF00069	0.441
MOD_ProDKin_1	200	206	PF00069	0.405
TRG_ENDOCYTIC_2	111	114	PF00928	0.323
TRG_ENDOCYTIC_2	256	259	PF00928	0.367
TRG_ENDOCYTIC_2	60	63	PF00928	0.330
TRG_ENDOCYTIC_2	7	10	PF00928	0.318
TRG_ER_diArg_1	89	92	PF00400	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K0	Leptomonas seymouri	58%	100%
A0A0S4JDC4	Bodo saltans	34%	100%
A0A1X0NXD8	Trypanosomatidae	45%	100%
A0A3R7MEG1	Trypanosoma rangeli	44%	100%
A0A3S5H7B7	Leishmania donovani	100%	100%
A4HCQ8	Leishmania braziliensis	81%	100%
C9ZV00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AW47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBD0	Leishmania major	95%	100%
V5ASF5	Trypanosoma cruzi	43%	100%