ATP-binding cassette protein subfamily G, member 5

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily G - member 5

Species:

Leishmania infantum

UniProt:

A4I078_LEIIN

TriTrypDb:

LINF_230009200

Length:

1246

Annotations

Annotations by Jardim et al.

Transporters, ATP-binding cassette G, member 5 ABCG5

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0020016	ciliary pocket	2	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	10

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I078

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I078

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0009987	cellular process	1	1
GO:0015886	heme transport	5	1
GO:0030001	metal ion transport	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	1
GO:0005215	transporter activity	1	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	1
GO:0005524	ATP binding	5	10
GO:0015399	primary active transmembrane transporter activity	4	10
GO:0016787	hydrolase activity	2	1
GO:0017076	purine nucleotide binding	4	10
GO:0020037	heme binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.404
CLV_C14_Caspase3-7	71	75	PF00656	0.525
CLV_C14_Caspase3-7	764	768	PF00656	0.564
CLV_NRD_NRD_1	1041	1043	PF00675	0.266
CLV_NRD_NRD_1	207	209	PF00675	0.677
CLV_NRD_NRD_1	295	297	PF00675	0.376
CLV_NRD_NRD_1	5	7	PF00675	0.591
CLV_NRD_NRD_1	529	531	PF00675	0.566
CLV_NRD_NRD_1	572	574	PF00675	0.405
CLV_NRD_NRD_1	708	710	PF00675	0.326

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R3	Leptomonas seymouri	70%	99%
A0A3S7WXM3	Leishmania donovani	100%	100%
A0A422NW91	Trypanosoma rangeli	52%	100%
A4HCQ3	Leishmania braziliensis	74%	98%
C9ZUZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AW42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QBD6	Leishmania major	94%	100%
V5BCE1	Trypanosoma cruzi	49%	100%

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