Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I072_LEIIN

TriTrypDb:

LINF_230008500

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I072

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I072

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.591
CLV_C14_Caspase3-7	184	188	PF00656	0.735
CLV_NRD_NRD_1	154	156	PF00675	0.419
CLV_NRD_NRD_1	176	178	PF00675	0.711
CLV_NRD_NRD_1	243	245	PF00675	0.519
CLV_NRD_NRD_1	44	46	PF00675	0.573
CLV_PCSK_KEX2_1	156	158	PF00082	0.560
CLV_PCSK_KEX2_1	176	178	PF00082	0.711
CLV_PCSK_KEX2_1	243	245	PF00082	0.519
CLV_PCSK_KEX2_1	44	46	PF00082	0.575
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.560
DOC_CKS1_1	197	202	PF01111	0.608
DOC_CKS1_1	5	10	PF01111	0.673
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.672
DOC_MAPK_DCC_7	218	226	PF00069	0.570
DOC_MAPK_MEF2A_6	218	226	PF00069	0.570
DOC_PP2B_LxvP_1	74	77	PF13499	0.450
DOC_USP7_MATH_1	104	108	PF00917	0.688
DOC_USP7_MATH_1	112	116	PF00917	0.430
DOC_USP7_MATH_1	142	146	PF00917	0.551
DOC_USP7_MATH_1	150	154	PF00917	0.499
DOC_USP7_MATH_1	172	176	PF00917	0.670
DOC_USP7_MATH_1	64	68	PF00917	0.496
DOC_USP7_UBL2_3	152	156	PF12436	0.555
DOC_WW_Pin1_4	165	170	PF00397	0.658
DOC_WW_Pin1_4	196	201	PF00397	0.614
DOC_WW_Pin1_4	211	216	PF00397	0.453
DOC_WW_Pin1_4	4	9	PF00397	0.672
DOC_WW_Pin1_4	88	93	PF00397	0.688
LIG_14-3-3_CanoR_1	14	20	PF00244	0.637
LIG_14-3-3_CanoR_1	218	222	PF00244	0.571
LIG_14-3-3_CanoR_1	44	50	PF00244	0.620
LIG_Actin_WH2_2	128	143	PF00022	0.508
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_eIF4E_1	234	240	PF01652	0.604
LIG_FHA_1	208	214	PF00498	0.465
LIG_FHA_2	129	135	PF00498	0.409
LIG_FHA_2	57	63	PF00498	0.542
LIG_Integrin_RGD_1	244	246	PF01839	0.566
LIG_LIR_Apic_2	194	200	PF02991	0.662
LIG_LIR_Apic_2	252	258	PF02991	0.569
LIG_LIR_Gen_1	67	77	PF02991	0.515
LIG_LIR_Nem_3	67	72	PF02991	0.508
LIG_NRP_CendR_1	271	273	PF00754	0.524
LIG_SH2_CRK	197	201	PF00017	0.623
LIG_SH2_CRK	69	73	PF00017	0.484
LIG_SH2_NCK_1	255	259	PF00017	0.535
LIG_SH2_STAT5	69	72	PF00017	0.522
LIG_SH3_3	28	34	PF00018	0.662
LIG_SH3_3	5	11	PF00018	0.712
LIG_SH3_3	84	90	PF00018	0.728
MOD_CDK_SPxK_1	170	176	PF00069	0.567
MOD_CDK_SPxxK_3	170	177	PF00069	0.568
MOD_CDK_SPxxK_3	196	203	PF00069	0.607
MOD_CDK_SPxxK_3	211	218	PF00069	0.553
MOD_CDK_SPxxK_3	7	14	PF00069	0.640
MOD_CK1_1	107	113	PF00069	0.678
MOD_CK1_1	12	18	PF00069	0.708
MOD_CK1_1	168	174	PF00069	0.631
MOD_CK2_1	112	118	PF00069	0.714
MOD_CK2_1	128	134	PF00069	0.396
MOD_GlcNHglycan	1	4	PF01048	0.728
MOD_GlcNHglycan	114	117	PF01048	0.668
MOD_GlcNHglycan	15	18	PF01048	0.593
MOD_GlcNHglycan	170	173	PF01048	0.743
MOD_GlcNHglycan	236	239	PF01048	0.468
MOD_GlcNHglycan	28	31	PF01048	0.592
MOD_GSK3_1	104	111	PF00069	0.747
MOD_GSK3_1	164	171	PF00069	0.660
MOD_GSK3_1	207	214	PF00069	0.504
MOD_GSK3_1	265	272	PF00069	0.501
MOD_GSK3_1	3	10	PF00069	0.754
MOD_GSK3_1	64	71	PF00069	0.463
MOD_GSK3_1	75	82	PF00069	0.547
MOD_N-GLC_1	185	190	PF02516	0.561
MOD_NEK2_1	108	113	PF00069	0.711
MOD_NEK2_1	209	214	PF00069	0.482
MOD_PIKK_1	79	85	PF00454	0.709
MOD_PKA_2	13	19	PF00069	0.638
MOD_PKA_2	217	223	PF00069	0.583
MOD_PKA_2	43	49	PF00069	0.661
MOD_Plk_1	128	134	PF00069	0.510
MOD_Plk_2-3	185	191	PF00069	0.561
MOD_Plk_4	128	134	PF00069	0.446
MOD_Plk_4	217	223	PF00069	0.541
MOD_Plk_4	68	74	PF00069	0.485
MOD_ProDKin_1	165	171	PF00069	0.660
MOD_ProDKin_1	196	202	PF00069	0.600
MOD_ProDKin_1	211	217	PF00069	0.451
MOD_ProDKin_1	4	10	PF00069	0.673
MOD_ProDKin_1	88	94	PF00069	0.688
MOD_SUMO_rev_2	148	158	PF00179	0.544
TRG_ENDOCYTIC_2	69	72	PF00928	0.503
TRG_ER_diArg_1	242	244	PF00400	0.523
TRG_ER_diArg_1	43	45	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y3	Leptomonas seymouri	53%	93%
A0A1X0NXL5	Trypanosomatidae	34%	100%
A0A3Q8ICG3	Leishmania donovani	100%	100%
A0A422NW27	Trypanosoma rangeli	25%	100%
A4HCP6	Leishmania braziliensis	72%	98%
C9ZUY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AW35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBE2	Leishmania major	94%	100%