LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I063_LEIIN
TriTrypDb:
LINF_230007600
Length:
185

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4I063
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I063

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.591
CLV_NRD_NRD_1 154 156 PF00675 0.500
CLV_NRD_NRD_1 24 26 PF00675 0.664
CLV_NRD_NRD_1 39 41 PF00675 0.556
CLV_PCSK_FUR_1 22 26 PF00082 0.743
CLV_PCSK_KEX2_1 10 12 PF00082 0.594
CLV_PCSK_KEX2_1 125 127 PF00082 0.373
CLV_PCSK_KEX2_1 154 156 PF00082 0.481
CLV_PCSK_KEX2_1 24 26 PF00082 0.720
CLV_PCSK_KEX2_1 39 41 PF00082 0.572
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.373
CLV_PCSK_PC7_1 6 12 PF00082 0.594
CLV_PCSK_SKI1_1 144 148 PF00082 0.430
DOC_MAPK_gen_1 10 17 PF00069 0.413
DOC_MAPK_MEF2A_6 10 17 PF00069 0.427
DOC_MAPK_NFAT4_5 10 18 PF00069 0.427
DOC_PP1_RVXF_1 73 80 PF00149 0.294
LIG_14-3-3_CanoR_1 6 10 PF00244 0.390
LIG_BIR_II_1 1 5 PF00653 0.403
LIG_FHA_1 26 32 PF00498 0.495
LIG_FHA_1 89 95 PF00498 0.340
LIG_LIR_Apic_2 55 61 PF02991 0.419
LIG_LIR_Gen_1 80 89 PF02991 0.387
LIG_LIR_Nem_3 80 84 PF02991 0.385
LIG_Pex14_2 88 92 PF04695 0.420
LIG_SH2_STAP1 139 143 PF00017 0.512
LIG_SH2_STAT5 14 17 PF00017 0.481
LIG_SH3_3 79 85 PF00018 0.315
LIG_UBA3_1 69 75 PF00899 0.380
LIG_WRC_WIRS_1 89 94 PF05994 0.383
MOD_CK2_1 177 183 PF00069 0.761
MOD_GlcNHglycan 54 57 PF01048 0.634
MOD_N-GLC_1 25 30 PF02516 0.695
MOD_NEK2_1 15 20 PF00069 0.412
MOD_NEK2_1 52 57 PF00069 0.436
MOD_NEK2_1 77 82 PF00069 0.481
MOD_NEK2_1 88 93 PF00069 0.360
MOD_PKA_2 5 11 PF00069 0.398
MOD_Plk_4 142 148 PF00069 0.597
MOD_Plk_4 88 94 PF00069 0.331
TRG_DiLeu_BaEn_1 142 147 PF01217 0.532
TRG_ENDOCYTIC_2 14 17 PF00928 0.429
TRG_ER_diArg_1 154 156 PF00400 0.700
TRG_ER_diArg_1 24 27 PF00400 0.556
TRG_ER_diArg_1 9 12 PF00400 0.389
TRG_Pf-PMV_PEXEL_1 126 130 PF00026 0.425
TRG_Pf-PMV_PEXEL_1 148 152 PF00026 0.453
TRG_Pf-PMV_PEXEL_1 173 177 PF00026 0.354
TRG_PTS2 1 35 PF00400 0.421

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Y2 Leptomonas seymouri 46% 100%
A0A0S4JFQ3 Bodo saltans 33% 100%
A0A3S7WXI2 Leishmania donovani 98% 100%
A4HCN8 Leishmania braziliensis 66% 100%
E9AW26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QBF1 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS