Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I061_LEIIN

TriTrypDb:

LINF_230007400

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I061

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I061

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.551
CLV_PCSK_KEX2_1	126	128	PF00082	0.655
CLV_PCSK_KEX2_1	2	4	PF00082	0.551
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.655
CLV_PCSK_SKI1_1	46	50	PF00082	0.413
CLV_PCSK_SKI1_1	8	12	PF00082	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.666
DOC_CKS1_1	67	72	PF01111	0.688
DOC_PP1_RVXF_1	1	8	PF00149	0.674
DOC_PP4_FxxP_1	109	112	PF00568	0.412
DOC_USP7_MATH_1	20	24	PF00917	0.703
DOC_WW_Pin1_4	66	71	PF00397	0.660
DOC_WW_Pin1_4	83	88	PF00397	0.717
LIG_14-3-3_CanoR_1	25	31	PF00244	0.698
LIG_14-3-3_CanoR_1	60	67	PF00244	0.669
LIG_BRCT_BRCA1_1	44	48	PF00533	0.672
LIG_FHA_2	84	90	PF00498	0.678
LIG_FHA_2	9	15	PF00498	0.652
LIG_RPA_C_Fungi	55	67	PF08784	0.515
LIG_SH2_STAT5	116	119	PF00017	0.527
LIG_SH3_3	64	70	PF00018	0.561
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.444
MOD_CDK_SPxK_1	66	72	PF00069	0.606
MOD_CK1_1	23	29	PF00069	0.568
MOD_CK1_1	52	58	PF00069	0.670
MOD_CK2_1	141	147	PF00069	0.698
MOD_CK2_1	83	89	PF00069	0.590
MOD_CK2_1	92	98	PF00069	0.476
MOD_GlcNHglycan	118	121	PF01048	0.409
MOD_GlcNHglycan	17	20	PF01048	0.600
MOD_GlcNHglycan	36	39	PF01048	0.579
MOD_GlcNHglycan	52	55	PF01048	0.468
MOD_GlcNHglycan	57	60	PF01048	0.611
MOD_GlcNHglycan	98	102	PF01048	0.415
MOD_GSK3_1	20	27	PF00069	0.582
MOD_GSK3_1	36	43	PF00069	0.684
MOD_GSK3_1	44	51	PF00069	0.623
MOD_GSK3_1	92	99	PF00069	0.559
MOD_NEK2_1	36	41	PF00069	0.569
MOD_NEK2_1	42	47	PF00069	0.535
MOD_NEK2_1	48	53	PF00069	0.478
MOD_NEK2_2	20	25	PF00069	0.584
MOD_PKA_2	24	30	PF00069	0.582
MOD_PKA_2	92	98	PF00069	0.610
MOD_Plk_4	29	35	PF00069	0.553
MOD_Plk_4	99	105	PF00069	0.462
MOD_ProDKin_1	66	72	PF00069	0.565
MOD_ProDKin_1	83	89	PF00069	0.645
MOD_SUMO_rev_2	119	128	PF00179	0.554
MOD_SUMO_rev_2	144	152	PF00179	0.676
TRG_ER_diArg_1	1	3	PF00400	0.696
TRG_ER_diArg_1	80	83	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFQ1	Leishmania donovani	100%	100%
A4HCN6	Leishmania braziliensis	64%	100%
E9ACS2	Leishmania major	91%	100%
E9AW24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%