Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I056_LEIIN

TriTrypDb:

LINF_230006900

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I056

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I056

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.603
CLV_NRD_NRD_1	219	221	PF00675	0.319
CLV_NRD_NRD_1	251	253	PF00675	0.511
CLV_NRD_NRD_1	260	262	PF00675	0.441
CLV_NRD_NRD_1	57	59	PF00675	0.332
CLV_NRD_NRD_1	79	81	PF00675	0.418
CLV_PCSK_KEX2_1	251	253	PF00082	0.509
CLV_PCSK_KEX2_1	260	262	PF00082	0.441
CLV_PCSK_KEX2_1	57	59	PF00082	0.568
CLV_PCSK_KEX2_1	79	81	PF00082	0.515
DEG_APCC_DBOX_1	259	267	PF00400	0.509
DEG_APCC_DBOX_1	27	35	PF00400	0.465
DEG_Nend_UBRbox_4	1	3	PF02207	0.500
DEG_SPOP_SBC_1	110	114	PF00917	0.701
DOC_MAPK_gen_1	220	226	PF00069	0.346
DOC_PP2B_LxvP_1	127	130	PF13499	0.468
DOC_PP2B_LxvP_1	146	149	PF13499	0.457
DOC_PP4_FxxP_1	5	8	PF00568	0.465
DOC_USP7_MATH_1	110	114	PF00917	0.738
DOC_USP7_MATH_1	196	200	PF00917	0.419
DOC_USP7_MATH_1	94	98	PF00917	0.442
DOC_WW_Pin1_4	10	15	PF00397	0.462
DOC_WW_Pin1_4	111	116	PF00397	0.697
DOC_WW_Pin1_4	4	9	PF00397	0.468
DOC_WW_Pin1_4	51	56	PF00397	0.547
LIG_14-3-3_CanoR_1	28	32	PF00244	0.687
LIG_14-3-3_CanoR_1	79	88	PF00244	0.446
LIG_APCC_ABBA_1	88	93	PF00400	0.349
LIG_FHA_1	28	34	PF00498	0.473
LIG_FHA_2	148	154	PF00498	0.561
LIG_LIR_Apic_2	4	8	PF02991	0.430
LIG_LIR_Gen_1	159	170	PF02991	0.524
LIG_LIR_Gen_1	241	250	PF02991	0.356
LIG_LIR_Gen_1	282	290	PF02991	0.460
LIG_LIR_Nem_3	128	134	PF02991	0.516
LIG_LIR_Nem_3	150	154	PF02991	0.453
LIG_LIR_Nem_3	157	161	PF02991	0.432
LIG_LIR_Nem_3	241	247	PF02991	0.423
LIG_LIR_Nem_3	282	288	PF02991	0.487
LIG_MYND_1	273	277	PF01753	0.595
LIG_SH2_CRK	285	289	PF00017	0.418
LIG_SH2_STAP1	151	155	PF00017	0.506
LIG_SH2_STAP1	158	162	PF00017	0.489
LIG_SH2_STAP1	167	171	PF00017	0.491
LIG_SH2_STAP1	244	248	PF00017	0.369
LIG_SH2_STAT5	145	148	PF00017	0.294
LIG_SH2_STAT5	154	157	PF00017	0.374
LIG_SH2_STAT5	158	161	PF00017	0.379
LIG_TRFH_1	145	149	PF08558	0.408
LIG_TYR_ITIM	242	247	PF00017	0.353
LIG_UBA3_1	71	77	PF00899	0.366
MOD_CDC14_SPxK_1	54	57	PF00782	0.378
MOD_CDK_SPK_2	10	15	PF00069	0.451
MOD_CDK_SPxK_1	51	57	PF00069	0.424
MOD_CDK_SPxxK_3	10	17	PF00069	0.491
MOD_CDK_SPxxK_3	51	58	PF00069	0.497
MOD_CK1_1	113	119	PF00069	0.605
MOD_CK1_1	82	88	PF00069	0.503
MOD_CK2_1	41	47	PF00069	0.563
MOD_GlcNHglycan	107	110	PF01048	0.624
MOD_GlcNHglycan	118	122	PF01048	0.509
MOD_GlcNHglycan	35	38	PF01048	0.617
MOD_GlcNHglycan	81	84	PF01048	0.589
MOD_GSK3_1	105	112	PF00069	0.605
MOD_GSK3_1	113	120	PF00069	0.552
MOD_N-GLC_2	10	12	PF02516	0.448
MOD_NEK2_1	156	161	PF00069	0.432
MOD_NEK2_1	62	67	PF00069	0.336
MOD_NEK2_2	189	194	PF00069	0.379
MOD_PKA_1	79	85	PF00069	0.391
MOD_PKA_2	27	33	PF00069	0.653
MOD_PKA_2	62	68	PF00069	0.325
MOD_PKA_2	79	85	PF00069	0.445
MOD_Plk_1	156	162	PF00069	0.488
MOD_Plk_1	196	202	PF00069	0.496
MOD_Plk_4	156	162	PF00069	0.491
MOD_ProDKin_1	111	117	PF00069	0.699
MOD_ProDKin_1	4	10	PF00069	0.472
MOD_ProDKin_1	51	57	PF00069	0.533
TRG_ENDOCYTIC_2	145	148	PF00928	0.314
TRG_ENDOCYTIC_2	167	170	PF00928	0.555
TRG_ENDOCYTIC_2	244	247	PF00928	0.364
TRG_ENDOCYTIC_2	285	288	PF00928	0.519
TRG_ER_diArg_1	14	17	PF00400	0.463
TRG_ER_diArg_1	56	58	PF00400	0.593
TRG_ER_diArg_1	60	63	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY1	Leptomonas seymouri	56%	100%
A0A1X0NG66	Trypanosomatidae	36%	100%
A0A3Q8ICJ3	Leishmania donovani	99%	100%
A0A422NVZ5	Trypanosoma rangeli	37%	100%
A4HCN2	Leishmania braziliensis	76%	100%
E9AW19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBF7	Leishmania major	92%	100%
V5AYT6	Trypanosoma cruzi	36%	100%
V5D0F5	Trypanosoma cruzi	37%	100%