Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase/Methyltransferase small domain/Methyltransferase domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I047_LEIIN

TriTrypDb:

LINF_230006000

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I047

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I047

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.391
CLV_PCSK_SKI1_1	105	109	PF00082	0.327
CLV_PCSK_SKI1_1	201	205	PF00082	0.402
CLV_PCSK_SKI1_1	57	61	PF00082	0.461
CLV_PCSK_SKI1_1	8	12	PF00082	0.508
DEG_Nend_UBRbox_1	1	4	PF02207	0.569
DOC_CKS1_1	43	48	PF01111	0.413
DOC_CKS1_1	63	68	PF01111	0.353
DOC_MAPK_gen_1	221	229	PF00069	0.420
DOC_MAPK_MEF2A_6	221	229	PF00069	0.420
DOC_MAPK_MEF2A_6	35	43	PF00069	0.453
DOC_PP4_FxxP_1	43	46	PF00568	0.401
DOC_WW_Pin1_4	131	136	PF00397	0.361
DOC_WW_Pin1_4	42	47	PF00397	0.401
DOC_WW_Pin1_4	62	67	PF00397	0.442
LIG_14-3-3_CanoR_1	57	66	PF00244	0.360
LIG_Actin_WH2_2	179	196	PF00022	0.302
LIG_AP2alpha_2	247	249	PF02296	0.420
LIG_BRCT_BRCA1_1	183	187	PF00533	0.267
LIG_BRCT_BRCA1_1	98	102	PF00533	0.361
LIG_Clathr_ClatBox_1	29	33	PF01394	0.398
LIG_CtBP_PxDLS_1	135	139	PF00389	0.343
LIG_HCF-1_HBM_1	17	20	PF13415	0.395
LIG_LIR_Apic_2	40	46	PF02991	0.378
LIG_LIR_Gen_1	17	26	PF02991	0.415
LIG_LIR_Gen_1	176	186	PF02991	0.302
LIG_LIR_Gen_1	33	43	PF02991	0.237
LIG_LIR_Gen_1	70	75	PF02991	0.243
LIG_LIR_Nem_3	17	23	PF02991	0.424
LIG_LIR_Nem_3	176	181	PF02991	0.302
LIG_LIR_Nem_3	247	252	PF02991	0.360
LIG_LIR_Nem_3	33	39	PF02991	0.233
LIG_LIR_Nem_3	70	74	PF02991	0.294
LIG_Pex14_1	85	89	PF04695	0.295
LIG_SH2_GRB2like	20	23	PF00017	0.414
LIG_SH2_NCK_1	20	24	PF00017	0.417
LIG_SH2_PTP2	83	86	PF00017	0.361
LIG_SH2_SRC	20	23	PF00017	0.414
LIG_SH2_STAT5	188	191	PF00017	0.267
LIG_SH2_STAT5	252	255	PF00017	0.395
LIG_SH2_STAT5	83	86	PF00017	0.302
LIG_SH3_3	242	248	PF00018	0.431
LIG_SH3_3	36	42	PF00018	0.393
LIG_SH3_3	60	66	PF00018	0.435
LIG_SUMO_SIM_anti_2	137	144	PF11976	0.343
LIG_SUMO_SIM_anti_2	70	79	PF11976	0.417
LIG_TRAF2_1	233	236	PF00917	0.410
LIG_WRC_WIRS_1	175	180	PF05994	0.361
MOD_CDK_SPxxK_3	42	49	PF00069	0.409
MOD_CK1_1	134	140	PF00069	0.302
MOD_CK1_1	44	50	PF00069	0.530
MOD_CK2_1	61	67	PF00069	0.477
MOD_GlcNHglycan	201	204	PF01048	0.453
MOD_GlcNHglycan	46	49	PF01048	0.448
MOD_GSK3_1	215	222	PF00069	0.333
MOD_GSK3_1	57	64	PF00069	0.532
MOD_NEK2_1	117	122	PF00069	0.343
MOD_NEK2_1	187	192	PF00069	0.319
MOD_NEK2_1	215	220	PF00069	0.354
MOD_NEK2_1	240	245	PF00069	0.369
MOD_PKB_1	55	63	PF00069	0.438
MOD_Plk_4	240	246	PF00069	0.383
MOD_ProDKin_1	131	137	PF00069	0.361
MOD_ProDKin_1	42	48	PF00069	0.403
MOD_ProDKin_1	62	68	PF00069	0.434
MOD_SUMO_for_1	169	172	PF00179	0.343
TRG_DiLeu_BaEn_2	66	72	PF01217	0.265
TRG_ENDOCYTIC_2	20	23	PF00928	0.432
TRG_ENDOCYTIC_2	36	39	PF00928	0.409
TRG_ER_diArg_1	54	57	PF00400	0.431
TRG_NES_CRM1_1	223	236	PF08389	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I266	Leptomonas seymouri	54%	100%
A0A0S4J1S6	Bodo saltans	36%	84%
A0A1X0NX63	Trypanosomatidae	43%	100%
A0A3S7WXK7	Leishmania donovani	100%	100%
A4HCM3	Leishmania braziliensis	79%	100%
E9AW10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBG6	Leishmania major	94%	100%
Q86JB0	Dictyostelium discoideum	24%	72%