LeishMANIAdb
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Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidyl-prolyl cis-trans isomerase
Gene product:
cyclophilin 11 - putative
Species:
Leishmania infantum
UniProt:
A4I042_LEIIN
TriTrypDb:
LINF_230005500
Length:
296

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, Peptidyl-prolyl cis-trans isomerase CYP11

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 40
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 20
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 5
GO:0005737 cytoplasm 2 3
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I042
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I042

PDB structure(s): 2hqj_A

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 22
GO:0006457 protein folding 2 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0018193 peptidyl-amino acid modification 5 22
GO:0018208 peptidyl-proline modification 6 22
GO:0019538 protein metabolic process 3 22
GO:0036211 protein modification process 4 22
GO:0043170 macromolecule metabolic process 3 22
GO:0043412 macromolecule modification 4 22
GO:0044238 primary metabolic process 2 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 22
GO:0003824 catalytic activity 1 22
GO:0016853 isomerase activity 2 22
GO:0016859 cis-trans isomerase activity 3 22
GO:0140096 catalytic activity, acting on a protein 2 22
GO:0005488 binding 1 3
GO:0016018 cyclosporin A binding 4 3
GO:0033218 amide binding 2 3
GO:0042277 peptide binding 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 263 265 PF00082 0.414
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.414
CLV_PCSK_SKI1_1 25 29 PF00082 0.323
CLV_PCSK_SKI1_1 281 285 PF00082 0.387
DOC_MAPK_gen_1 181 188 PF00069 0.216
DOC_MAPK_MEF2A_6 20 28 PF00069 0.250
DOC_MAPK_MEF2A_6 9 18 PF00069 0.598
DOC_PP1_RVXF_1 153 160 PF00149 0.297
DOC_PP1_RVXF_1 23 29 PF00149 0.325
DOC_PP2B_PxIxI_1 13 19 PF00149 0.601
DOC_USP7_MATH_1 196 200 PF00917 0.431
DOC_USP7_MATH_1 212 216 PF00917 0.442
DOC_USP7_MATH_1 256 260 PF00917 0.634
DOC_USP7_MATH_1 287 291 PF00917 0.556
DOC_WW_Pin1_4 146 151 PF00397 0.205
DOC_WW_Pin1_4 233 238 PF00397 0.605
LIG_14-3-3_CanoR_1 174 182 PF00244 0.297
LIG_14-3-3_CanoR_1 185 194 PF00244 0.418
LIG_14-3-3_CanoR_1 243 252 PF00244 0.453
LIG_14-3-3_CanoR_1 3 7 PF00244 0.574
LIG_APCC_ABBA_1 42 47 PF00400 0.297
LIG_BIR_II_1 1 5 PF00653 0.526
LIG_BRCT_BRCA1_1 139 143 PF00533 0.297
LIG_FHA_1 147 153 PF00498 0.265
LIG_FHA_2 107 113 PF00498 0.274
LIG_FHA_2 98 104 PF00498 0.274
LIG_LIR_Gen_1 78 88 PF02991 0.397
LIG_LIR_Nem_3 54 59 PF02991 0.256
LIG_LIR_Nem_3 78 83 PF02991 0.394
LIG_MLH1_MIPbox_1 139 143 PF16413 0.297
LIG_PTB_Apo_2 74 81 PF02174 0.256
LIG_SH2_STAP1 45 49 PF00017 0.216
LIG_SH3_3 231 237 PF00018 0.573
LIG_SH3_3 252 258 PF00018 0.671
LIG_SUMO_SIM_anti_2 164 170 PF11976 0.203
MOD_CK1_1 2 8 PF00069 0.486
MOD_CK2_1 97 103 PF00069 0.274
MOD_GlcNHglycan 115 118 PF01048 0.232
MOD_GlcNHglycan 178 181 PF01048 0.270
MOD_GlcNHglycan 214 217 PF01048 0.495
MOD_GlcNHglycan 245 248 PF01048 0.620
MOD_GlcNHglycan 290 293 PF01048 0.414
MOD_GlcNHglycan 68 71 PF01048 0.274
MOD_GSK3_1 45 52 PF00069 0.263
MOD_GSK3_1 97 104 PF00069 0.297
MOD_N-GLC_1 137 142 PF02516 0.297
MOD_N-GLC_1 97 102 PF02516 0.297
MOD_NEK2_1 143 148 PF00069 0.289
MOD_NEK2_1 175 180 PF00069 0.349
MOD_NEK2_1 232 237 PF00069 0.458
MOD_NEK2_1 288 293 PF00069 0.576
MOD_NEK2_2 101 106 PF00069 0.297
MOD_NEK2_2 75 80 PF00069 0.344
MOD_PIKK_1 137 143 PF00454 0.297
MOD_PKA_2 120 126 PF00069 0.252
MOD_PKA_2 2 8 PF00069 0.619
MOD_PKA_2 273 279 PF00069 0.425
MOD_PKA_2 288 294 PF00069 0.389
MOD_Plk_1 111 117 PF00069 0.297
MOD_Plk_1 28 34 PF00069 0.266
MOD_Plk_4 101 107 PF00069 0.297
MOD_Plk_4 75 81 PF00069 0.344
MOD_ProDKin_1 146 152 PF00069 0.205
MOD_ProDKin_1 233 239 PF00069 0.605
MOD_SUMO_for_1 247 250 PF00179 0.684
MOD_SUMO_rev_2 215 221 PF00179 0.730
MOD_SUMO_rev_2 223 233 PF00179 0.451
MOD_SUMO_rev_2 29 37 PF00179 0.232
TRG_ER_diArg_1 182 185 PF00400 0.227
TRG_NLS_Bipartite_1 248 266 PF00514 0.596
TRG_NLS_MonoExtC_3 261 266 PF00514 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P364 Leptomonas seymouri 44% 100%
A0A0N0P523 Leptomonas seymouri 75% 100%
A0A0N1I8P9 Leptomonas seymouri 58% 100%
A0A1X0NXG7 Trypanosomatidae 60% 100%
A0A3Q8ICB3 Leishmania donovani 47% 100%
A0A3Q8IDR1 Leishmania donovani 36% 100%
A0A3R7RE54 Trypanosoma rangeli 61% 100%
A0A3S5H7U6 Leishmania donovani 66% 100%
A0A3S7WXF4 Leishmania donovani 100% 100%
A0A3S7WYD9 Leishmania donovani 31% 100%
A0A3S7X325 Leishmania donovani 35% 100%
A0A3S7X410 Leishmania donovani 58% 100%
A0A3S7XB52 Leishmania donovani 40% 100%
A4H8P7 Leishmania braziliensis 33% 100%
A4HCI8 Leishmania braziliensis 48% 100%
A4HCL8 Leishmania braziliensis 83% 99%
A4HHU7 Leishmania braziliensis 36% 100%
A4HIW9 Leishmania braziliensis 56% 100%
A4HLM4 Leishmania braziliensis 73% 100%
A4HPH9 Leishmania braziliensis 41% 100%
A4I004 Leishmania infantum 48% 100%
A4I0X0 Leishmania infantum 31% 100%
A4I4Z7 Leishmania infantum 35% 100%
A4I698 Leishmania infantum 58% 100%
A4I935 Leishmania infantum 66% 100%
A4IDA1 Leishmania infantum 40% 100%
C9ZUX8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 98%
D4AY02 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) 53% 100%
E9AQT1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AT91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AVX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AW05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 98%
E9AWX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B0C7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B1F3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9B400 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
O65220 Arabidopsis thaliana 27% 100%
O93826 Arthroderma benhamiae 53% 100%
P35176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 49% 100%
Q11004 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 83%
Q4G338 Haemonchus contortus 50% 91%
Q4P0V4 Ustilago maydis (strain 521 / FGSC 9021) 48% 74%
Q4Q1A6 Leishmania major 40% 100%
Q4Q424 Leishmania major 66% 100%
Q4Q6Q9 Leishmania major 59% 100%
Q4Q7V7 Leishmania major 35% 100%
Q4QAK0 Leishmania major 31% 100%
Q4QBH1 Leishmania major 91% 100%
Q4QBK2 Leishmania major 48% 100%
Q4QEP7 Leishmania major 34% 100%
Q5UP71 Acanthamoeba polyphaga mimivirus 29% 100%
Q7S7Z6 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 54% 100%
Q9P3X9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 51% 79%
V5B2A0 Trypanosoma cruzi 60% 100%
V5DJ29 Trypanosoma cruzi 38% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS