Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I025_LEIIN

TriTrypDb:

LINF_220022900

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I025

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I025

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.560
CLV_C14_Caspase3-7	281	285	PF00656	0.581
CLV_C14_Caspase3-7	513	517	PF00656	0.435
CLV_C14_Caspase3-7	567	571	PF00656	0.472
CLV_C14_Caspase3-7	78	82	PF00656	0.581
CLV_NRD_NRD_1	385	387	PF00675	0.503
CLV_NRD_NRD_1	416	418	PF00675	0.393
CLV_NRD_NRD_1	435	437	PF00675	0.222
CLV_NRD_NRD_1	50	52	PF00675	0.478
CLV_NRD_NRD_1	527	529	PF00675	0.370
CLV_PCSK_KEX2_1	385	387	PF00082	0.503
CLV_PCSK_KEX2_1	416	418	PF00082	0.393
CLV_PCSK_KEX2_1	435	437	PF00082	0.222
CLV_PCSK_KEX2_1	527	529	PF00082	0.370
CLV_PCSK_SKI1_1	217	221	PF00082	0.428
CLV_PCSK_SKI1_1	386	390	PF00082	0.589
CLV_PCSK_SKI1_1	416	420	PF00082	0.466
CLV_PCSK_SKI1_1	534	538	PF00082	0.358
DEG_APCC_DBOX_1	415	423	PF00400	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.669
DEG_SPOP_SBC_1	117	121	PF00917	0.522
DEG_SPOP_SBC_1	186	190	PF00917	0.625
DEG_SPOP_SBC_1	569	573	PF00917	0.414
DOC_CKS1_1	540	545	PF01111	0.455
DOC_CYCLIN_RxL_1	214	221	PF00134	0.393
DOC_CYCLIN_RxL_1	230	240	PF00134	0.269
DOC_CYCLIN_RxL_1	413	421	PF00134	0.478
DOC_CYCLIN_RxL_1	528	542	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.431
DOC_MAPK_gen_1	320	329	PF00069	0.449
DOC_MAPK_gen_1	342	352	PF00069	0.365
DOC_MAPK_gen_1	416	424	PF00069	0.350
DOC_MAPK_MEF2A_6	320	329	PF00069	0.449
DOC_MAPK_MEF2A_6	345	352	PF00069	0.419
DOC_PP1_RVXF_1	231	238	PF00149	0.388
DOC_PP2B_LxvP_1	126	129	PF13499	0.516
DOC_PP2B_LxvP_1	144	147	PF13499	0.378
DOC_USP7_MATH_1	110	114	PF00917	0.582
DOC_USP7_MATH_1	118	122	PF00917	0.565
DOC_USP7_MATH_1	139	143	PF00917	0.544
DOC_USP7_MATH_1	157	161	PF00917	0.535
DOC_USP7_MATH_1	177	181	PF00917	0.575
DOC_USP7_MATH_1	186	190	PF00917	0.626
DOC_USP7_MATH_1	222	226	PF00917	0.479
DOC_USP7_MATH_1	461	465	PF00917	0.535
DOC_USP7_MATH_1	498	502	PF00917	0.517
DOC_USP7_MATH_1	526	530	PF00917	0.408
DOC_USP7_MATH_1	93	97	PF00917	0.427
DOC_WW_Pin1_4	135	140	PF00397	0.441
DOC_WW_Pin1_4	218	223	PF00397	0.473
DOC_WW_Pin1_4	502	507	PF00397	0.603
DOC_WW_Pin1_4	539	544	PF00397	0.451
DOC_WW_Pin1_4	588	593	PF00397	0.479
DOC_WW_Pin1_4	72	77	PF00397	0.528
LIG_14-3-3_CanoR_1	179	184	PF00244	0.644
LIG_14-3-3_CanoR_1	37	45	PF00244	0.646
LIG_14-3-3_CanoR_1	385	389	PF00244	0.545
LIG_14-3-3_CanoR_1	395	399	PF00244	0.476
LIG_14-3-3_CanoR_1	417	423	PF00244	0.379
LIG_14-3-3_CanoR_1	527	535	PF00244	0.384
LIG_Actin_WH2_2	411	428	PF00022	0.437
LIG_APCC_ABBA_1	22	27	PF00400	0.487
LIG_APCC_ABBA_1	303	308	PF00400	0.394
LIG_APCC_ABBA_1	518	523	PF00400	0.432
LIG_BRCT_BRCA1_1	466	470	PF00533	0.287
LIG_CaM_IQ_9	259	274	PF13499	0.418
LIG_DLG_GKlike_1	179	187	PF00625	0.559
LIG_EH1_1	575	583	PF00400	0.396
LIG_eIF4E_1	576	582	PF01652	0.399
LIG_FHA_1	139	145	PF00498	0.470
LIG_FHA_1	189	195	PF00498	0.562
LIG_FHA_1	243	249	PF00498	0.486
LIG_FHA_1	273	279	PF00498	0.392
LIG_FHA_1	299	305	PF00498	0.374
LIG_FHA_1	400	406	PF00498	0.497
LIG_FHA_1	535	541	PF00498	0.390
LIG_FHA_1	594	600	PF00498	0.363
LIG_IBAR_NPY_1	23	25	PF08397	0.492
LIG_LIR_Gen_1	160	170	PF02991	0.387
LIG_LIR_Gen_1	323	332	PF02991	0.380
LIG_LIR_Gen_1	428	433	PF02991	0.395
LIG_LIR_Gen_1	464	471	PF02991	0.378
LIG_LIR_Nem_3	160	165	PF02991	0.380
LIG_LIR_Nem_3	323	327	PF02991	0.400
LIG_LIR_Nem_3	397	401	PF02991	0.461
LIG_LIR_Nem_3	428	432	PF02991	0.400
LIG_LIR_Nem_3	464	468	PF02991	0.407
LIG_LIR_Nem_3	559	564	PF02991	0.321
LIG_NRBOX	418	424	PF00104	0.458
LIG_PCNA_yPIPBox_3	342	356	PF02747	0.352
LIG_PCNA_yPIPBox_3	579	588	PF02747	0.453
LIG_PDZ_Class_2	611	616	PF00595	0.464
LIG_Pex14_1	384	388	PF04695	0.473
LIG_REV1ctd_RIR_1	559	567	PF16727	0.312
LIG_SH2_PTP2	162	165	PF00017	0.380
LIG_SH2_PTP2	324	327	PF00017	0.427
LIG_SH2_SRC	98	101	PF00017	0.384
LIG_SH2_STAP1	401	405	PF00017	0.399
LIG_SH2_STAT3	576	579	PF00017	0.468
LIG_SH2_STAT5	162	165	PF00017	0.409
LIG_SH2_STAT5	168	171	PF00017	0.418
LIG_SH2_STAT5	324	327	PF00017	0.427
LIG_SH2_STAT5	401	404	PF00017	0.359
LIG_SH2_STAT5	576	579	PF00017	0.479
LIG_SH2_STAT5	601	604	PF00017	0.378
LIG_SH2_STAT5	98	101	PF00017	0.457
LIG_SH3_3	169	175	PF00018	0.397
LIG_SH3_3	199	205	PF00018	0.364
LIG_SH3_3	224	230	PF00018	0.363
LIG_SH3_3	245	251	PF00018	0.407
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.420
LIG_WRC_WIRS_1	254	259	PF05994	0.317
MOD_CDK_SPxxK_3	588	595	PF00069	0.477
MOD_CDK_SPxxK_3	72	79	PF00069	0.541
MOD_CK1_1	138	144	PF00069	0.498
MOD_CK1_1	188	194	PF00069	0.619
MOD_CK1_1	316	322	PF00069	0.598
MOD_CK1_1	464	470	PF00069	0.453
MOD_CK1_1	501	507	PF00069	0.614
MOD_CK1_1	75	81	PF00069	0.706
MOD_CK1_1	82	88	PF00069	0.646
MOD_CK2_1	3	9	PF00069	0.530
MOD_CK2_1	40	46	PF00069	0.498
MOD_CK2_1	425	431	PF00069	0.385
MOD_CK2_1	507	513	PF00069	0.568
MOD_GlcNHglycan	120	123	PF01048	0.738
MOD_GlcNHglycan	141	144	PF01048	0.435
MOD_GlcNHglycan	155	158	PF01048	0.521
MOD_GlcNHglycan	159	162	PF01048	0.462
MOD_GlcNHglycan	199	202	PF01048	0.609
MOD_GlcNHglycan	213	216	PF01048	0.329
MOD_GlcNHglycan	239	242	PF01048	0.437
MOD_GlcNHglycan	298	301	PF01048	0.379
MOD_GlcNHglycan	315	318	PF01048	0.331
MOD_GlcNHglycan	337	340	PF01048	0.469
MOD_GlcNHglycan	528	531	PF01048	0.447
MOD_GlcNHglycan	572	575	PF01048	0.405
MOD_GlcNHglycan	68	71	PF01048	0.511
MOD_GlcNHglycan	95	98	PF01048	0.539
MOD_GSK3_1	135	142	PF00069	0.444
MOD_GSK3_1	153	160	PF00069	0.583
MOD_GSK3_1	175	182	PF00069	0.594
MOD_GSK3_1	184	191	PF00069	0.603
MOD_GSK3_1	218	225	PF00069	0.509
MOD_GSK3_1	23	30	PF00069	0.572
MOD_GSK3_1	457	464	PF00069	0.447
MOD_GSK3_1	492	499	PF00069	0.484
MOD_GSK3_1	501	508	PF00069	0.603
MOD_GSK3_1	593	600	PF00069	0.464
MOD_GSK3_1	68	75	PF00069	0.647
MOD_GSK3_1	89	96	PF00069	0.470
MOD_LATS_1	532	538	PF00433	0.302
MOD_N-GLC_1	588	593	PF02516	0.435
MOD_NEK2_1	185	190	PF00069	0.512
MOD_NEK2_1	2	7	PF00069	0.715
MOD_NEK2_1	237	242	PF00069	0.366
MOD_NEK2_1	289	294	PF00069	0.390
MOD_NEK2_1	298	303	PF00069	0.302
MOD_NEK2_1	371	376	PF00069	0.409
MOD_NEK2_1	418	423	PF00069	0.436
MOD_NEK2_1	425	430	PF00069	0.448
MOD_NEK2_1	492	497	PF00069	0.472
MOD_NEK2_1	599	604	PF00069	0.580
MOD_NEK2_1	91	96	PF00069	0.400
MOD_NEK2_2	110	115	PF00069	0.557
MOD_NEK2_2	3	8	PF00069	0.593
MOD_NEK2_2	401	406	PF00069	0.364
MOD_NEK2_2	474	479	PF00069	0.209
MOD_PIKK_1	291	297	PF00454	0.324
MOD_PIKK_1	79	85	PF00454	0.685
MOD_PKA_2	178	184	PF00069	0.661
MOD_PKA_2	344	350	PF00069	0.353
MOD_PKA_2	384	390	PF00069	0.533
MOD_PKA_2	394	400	PF00069	0.512
MOD_PKA_2	425	431	PF00069	0.480
MOD_PKA_2	492	498	PF00069	0.491
MOD_PKA_2	526	532	PF00069	0.391
MOD_Plk_1	18	24	PF00069	0.518
MOD_Plk_1	8	14	PF00069	0.652
MOD_Plk_4	223	229	PF00069	0.482
MOD_Plk_4	27	33	PF00069	0.488
MOD_Plk_4	418	424	PF00069	0.374
MOD_Plk_4	464	470	PF00069	0.521
MOD_Plk_4	8	14	PF00069	0.667
MOD_ProDKin_1	135	141	PF00069	0.440
MOD_ProDKin_1	218	224	PF00069	0.471
MOD_ProDKin_1	502	508	PF00069	0.595
MOD_ProDKin_1	539	545	PF00069	0.463
MOD_ProDKin_1	588	594	PF00069	0.480
MOD_ProDKin_1	72	78	PF00069	0.536
MOD_SUMO_rev_2	591	596	PF00179	0.559
TRG_DiLeu_BaEn_1	531	536	PF01217	0.402
TRG_DiLeu_BaEn_1	560	565	PF01217	0.357
TRG_DiLeu_BaEn_2	465	471	PF01217	0.277
TRG_DiLeu_BaEn_4	358	364	PF01217	0.405
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.364
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.424
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.388
TRG_DiLeu_LyEn_5	531	536	PF01217	0.304
TRG_ENDOCYTIC_2	162	165	PF00928	0.409
TRG_ENDOCYTIC_2	25	28	PF00928	0.486
TRG_ENDOCYTIC_2	324	327	PF00928	0.405
TRG_ER_diArg_1	384	386	PF00400	0.511
TRG_ER_diArg_1	416	418	PF00400	0.395
TRG_ER_diArg_1	434	436	PF00400	0.234
TRG_ER_diArg_1	48	51	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK4	Leptomonas seymouri	47%	99%
A0A1X0NU19	Trypanosomatidae	29%	100%
A0A3R7K6E0	Trypanosoma rangeli	28%	100%
A0A3S5H7B4	Leishmania donovani	100%	100%
A4HCK7	Leishmania braziliensis	76%	100%
E9AVZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBI1	Leishmania major	92%	100%