Putative ser/thr protein phosphatase

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I019_LEIIN

TriTrypDb:

LINF_220022300

Length:

811

Annotations

Annotations by Jardim et al.

Phosphatase, ser/thr phosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 21
Promastigote: 29
Promastigote/Amastigote: 32, 91

Expansion

Sequence features

A4I019

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I019

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8
GO:0000298	endopolyphosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.437
CLV_NRD_NRD_1	254	256	PF00675	0.678
CLV_NRD_NRD_1	414	416	PF00675	0.296
CLV_NRD_NRD_1	480	482	PF00675	0.374
CLV_NRD_NRD_1	75	77	PF00675	0.692
CLV_NRD_NRD_1	777	779	PF00675	0.485
CLV_PCSK_FUR_1	411	415	PF00082	0.351
CLV_PCSK_KEX2_1	413	415	PF00082	0.351
CLV_PCSK_KEX2_1	427	429	PF00082	0.351
CLV_PCSK_KEX2_1	480	482	PF00082	0.374
CLV_PCSK_KEX2_1	75	77	PF00082	0.692
CLV_PCSK_KEX2_1	799	801	PF00082	0.470
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.351
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.456
CLV_PCSK_PC7_1	423	429	PF00082	0.351
CLV_PCSK_SKI1_1	361	365	PF00082	0.357
CLV_PCSK_SKI1_1	415	419	PF00082	0.351
CLV_PCSK_SKI1_1	6	10	PF00082	0.668
CLV_PCSK_SKI1_1	611	615	PF00082	0.631
CLV_PCSK_SKI1_1	663	667	PF00082	0.612
CLV_PCSK_SKI1_1	739	743	PF00082	0.403
CLV_PCSK_SKI1_1	785	789	PF00082	0.425
CLV_PCSK_SKI1_1	800	804	PF00082	0.382
CLV_Separin_Metazoa	333	337	PF03568	0.476
DEG_APCC_DBOX_1	5	13	PF00400	0.665
DEG_APCC_DBOX_1	687	695	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.683
DEG_SCF_FBW7_1	652	659	PF00400	0.646
DEG_SPOP_SBC_1	153	157	PF00917	0.588
DEG_SPOP_SBC_1	172	176	PF00917	0.613
DEG_SPOP_SBC_1	267	271	PF00917	0.618
DEG_SPOP_SBC_1	293	297	PF00917	0.589
DEG_SPOP_SBC_1	45	49	PF00917	0.615
DEG_SPOP_SBC_1	656	660	PF00917	0.601
DOC_CDC14_PxL_1	557	565	PF14671	0.389
DOC_CKS1_1	416	421	PF01111	0.351
DOC_CKS1_1	653	658	PF01111	0.643
DOC_CKS1_1	664	669	PF01111	0.644
DOC_CYCLIN_RxL_1	3	13	PF00134	0.665
DOC_CYCLIN_yClb5_NLxxxL_5	4	12	PF00134	0.660
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.632
DOC_MAPK_gen_1	361	371	PF00069	0.360
DOC_MAPK_gen_1	449	458	PF00069	0.292
DOC_MAPK_gen_1	506	516	PF00069	0.402
DOC_MAPK_gen_1	799	810	PF00069	0.422
DOC_MAPK_MEF2A_6	698	707	PF00069	0.417
DOC_PP2B_LxvP_1	573	576	PF13499	0.496
DOC_PP2B_LxvP_1	615	618	PF13499	0.571
DOC_PP2B_LxvP_1	707	710	PF13499	0.448
DOC_PP4_FxxP_1	558	561	PF00568	0.382
DOC_PP4_FxxP_1	733	736	PF00568	0.339
DOC_USP7_MATH_1	116	120	PF00917	0.675
DOC_USP7_MATH_1	153	157	PF00917	0.577
DOC_USP7_MATH_1	171	175	PF00917	0.773
DOC_USP7_MATH_1	205	209	PF00917	0.748
DOC_USP7_MATH_1	221	225	PF00917	0.510
DOC_USP7_MATH_1	236	240	PF00917	0.655
DOC_USP7_MATH_1	266	270	PF00917	0.665
DOC_USP7_MATH_1	281	285	PF00917	0.703
DOC_USP7_MATH_1	293	297	PF00917	0.660
DOC_USP7_MATH_1	38	42	PF00917	0.735
DOC_USP7_MATH_1	464	468	PF00917	0.236
DOC_USP7_MATH_1	57	61	PF00917	0.607
DOC_USP7_MATH_1	624	628	PF00917	0.658
DOC_USP7_MATH_1	92	96	PF00917	0.724
DOC_USP7_UBL2_3	493	497	PF12436	0.456
DOC_USP7_UBL2_3	799	803	PF12436	0.385
DOC_WW_Pin1_4	141	146	PF00397	0.709
DOC_WW_Pin1_4	158	163	PF00397	0.611
DOC_WW_Pin1_4	193	198	PF00397	0.639
DOC_WW_Pin1_4	271	276	PF00397	0.739
DOC_WW_Pin1_4	29	34	PF00397	0.651
DOC_WW_Pin1_4	41	46	PF00397	0.716
DOC_WW_Pin1_4	415	420	PF00397	0.351
DOC_WW_Pin1_4	549	554	PF00397	0.457
DOC_WW_Pin1_4	597	602	PF00397	0.630
DOC_WW_Pin1_4	652	657	PF00397	0.627
DOC_WW_Pin1_4	663	668	PF00397	0.649
DOC_WW_Pin1_4	791	796	PF00397	0.508
DOC_WW_Pin1_4	88	93	PF00397	0.723
LIG_14-3-3_CanoR_1	16	23	PF00244	0.607
LIG_14-3-3_CanoR_1	166	171	PF00244	0.745
LIG_14-3-3_CanoR_1	6	15	PF00244	0.735
LIG_14-3-3_CanoR_1	688	692	PF00244	0.448
LIG_14-3-3_CanoR_1	698	707	PF00244	0.417
LIG_BIR_III_4	127	131	PF00653	0.536
LIG_BIR_III_4	313	317	PF00653	0.451
LIG_deltaCOP1_diTrp_1	502	508	PF00928	0.399
LIG_deltaCOP1_diTrp_1	731	737	PF00928	0.422
LIG_FHA_1	175	181	PF00498	0.758
LIG_FHA_1	232	238	PF00498	0.621
LIG_FHA_1	322	328	PF00498	0.433
LIG_FHA_1	533	539	PF00498	0.328
LIG_FHA_1	542	548	PF00498	0.327
LIG_FHA_1	598	604	PF00498	0.520
LIG_FHA_1	61	67	PF00498	0.670
LIG_FHA_1	642	648	PF00498	0.670
LIG_FHA_1	657	663	PF00498	0.590
LIG_FHA_1	666	672	PF00498	0.747
LIG_FHA_1	676	682	PF00498	0.420
LIG_FHA_1	695	701	PF00498	0.299
LIG_FHA_1	736	742	PF00498	0.393
LIG_FHA_1	760	766	PF00498	0.360
LIG_FHA_1	805	811	PF00498	0.440
LIG_FHA_1	91	97	PF00498	0.643
LIG_FHA_2	416	422	PF00498	0.304
LIG_LIR_Apic_2	556	561	PF02991	0.443
LIG_LIR_Apic_2	731	736	PF02991	0.428
LIG_LIR_Gen_1	337	346	PF02991	0.305
LIG_LIR_Gen_1	402	410	PF02991	0.351
LIG_LIR_Gen_1	502	511	PF02991	0.395
LIG_LIR_Gen_1	735	745	PF02991	0.402
LIG_LIR_Nem_3	313	318	PF02991	0.445
LIG_LIR_Nem_3	337	343	PF02991	0.305
LIG_LIR_Nem_3	402	406	PF02991	0.351
LIG_LIR_Nem_3	502	507	PF02991	0.405
LIG_LIR_Nem_3	519	524	PF02991	0.517
LIG_LIR_Nem_3	556	560	PF02991	0.437
LIG_LIR_Nem_3	731	737	PF02991	0.420
LIG_MYND_1	145	149	PF01753	0.669
LIG_MYND_3	563	567	PF01753	0.480
LIG_PCNA_PIPBox_1	781	790	PF02747	0.433
LIG_PCNA_yPIPBox_3	210	219	PF02747	0.594
LIG_PCNA_yPIPBox_3	470	481	PF02747	0.437
LIG_PCNA_yPIPBox_3	778	788	PF02747	0.444
LIG_PDZ_Class_2	806	811	PF00595	0.433
LIG_Pex14_2	733	737	PF04695	0.333
LIG_PTB_Apo_2	397	404	PF02174	0.351
LIG_PTB_Phospho_1	397	403	PF10480	0.351
LIG_REV1ctd_RIR_1	214	223	PF16727	0.607
LIG_SH2_CRK	395	399	PF00017	0.351
LIG_SH2_CRK	403	407	PF00017	0.351
LIG_SH2_GRB2like	375	378	PF00017	0.357
LIG_SH2_PTP2	340	343	PF00017	0.292
LIG_SH2_SRC	340	343	PF00017	0.292
LIG_SH2_STAP1	712	716	PF00017	0.443
LIG_SH2_STAT5	340	343	PF00017	0.328
LIG_SH2_STAT5	362	365	PF00017	0.377
LIG_SH2_STAT5	375	378	PF00017	0.351
LIG_SH2_STAT5	403	406	PF00017	0.354
LIG_SH2_STAT5	440	443	PF00017	0.292
LIG_SH3_1	329	335	PF00018	0.460
LIG_SH3_1	413	419	PF00018	0.351
LIG_SH3_3	165	171	PF00018	0.712
LIG_SH3_3	175	181	PF00018	0.654
LIG_SH3_3	223	229	PF00018	0.782
LIG_SH3_3	329	335	PF00018	0.460
LIG_SH3_3	413	419	PF00018	0.351
LIG_SH3_3	445	451	PF00018	0.351
LIG_SH3_3	483	489	PF00018	0.492
LIG_SH3_3	558	564	PF00018	0.486
LIG_SH3_3	650	656	PF00018	0.747
LIG_Sin3_3	702	709	PF02671	0.425
LIG_SUMO_SIM_anti_2	701	707	PF11976	0.417
LIG_SUMO_SIM_anti_2	738	744	PF11976	0.397
LIG_SUMO_SIM_par_1	690	695	PF11976	0.371
LIG_UBA3_1	491	497	PF00899	0.465
MOD_CDC14_SPxK_1	660	663	PF00782	0.627
MOD_CDK_SPxK_1	657	663	PF00069	0.622
MOD_CK1_1	10	16	PF00069	0.685
MOD_CK1_1	119	125	PF00069	0.715
MOD_CK1_1	132	138	PF00069	0.604
MOD_CK1_1	156	162	PF00069	0.617
MOD_CK1_1	174	180	PF00069	0.757
MOD_CK1_1	18	24	PF00069	0.674
MOD_CK1_1	193	199	PF00069	0.497
MOD_CK1_1	269	275	PF00069	0.676
MOD_CK1_1	29	35	PF00069	0.793
MOD_CK1_1	294	300	PF00069	0.638
MOD_CK1_1	37	43	PF00069	0.825
MOD_CK1_1	49	55	PF00069	0.658
MOD_CK1_1	60	66	PF00069	0.572
MOD_CK1_1	607	613	PF00069	0.680
MOD_CK1_1	641	647	PF00069	0.676
MOD_CK1_1	91	97	PF00069	0.628
MOD_CK2_1	721	727	PF00069	0.395
MOD_Cter_Amidation	253	256	PF01082	0.635
MOD_Cter_Amidation	776	779	PF01082	0.377
MOD_DYRK1A_RPxSP_1	415	419	PF00069	0.351
MOD_GlcNHglycan	113	116	PF01048	0.798
MOD_GlcNHglycan	118	121	PF01048	0.720
MOD_GlcNHglycan	12	15	PF01048	0.681
MOD_GlcNHglycan	192	195	PF01048	0.691
MOD_GlcNHglycan	238	241	PF01048	0.639
MOD_GlcNHglycan	271	274	PF01048	0.586
MOD_GlcNHglycan	28	31	PF01048	0.652
MOD_GlcNHglycan	288	291	PF01048	0.637
MOD_GlcNHglycan	36	39	PF01048	0.607
MOD_GlcNHglycan	55	58	PF01048	0.536
MOD_GlcNHglycan	606	609	PF01048	0.618
MOD_GlcNHglycan	694	697	PF01048	0.376
MOD_GlcNHglycan	700	703	PF01048	0.333
MOD_GlcNHglycan	723	726	PF01048	0.500
MOD_GSK3_1	107	114	PF00069	0.801
MOD_GSK3_1	129	136	PF00069	0.803
MOD_GSK3_1	141	148	PF00069	0.786
MOD_GSK3_1	152	159	PF00069	0.697
MOD_GSK3_1	160	167	PF00069	0.677
MOD_GSK3_1	188	195	PF00069	0.619
MOD_GSK3_1	267	274	PF00069	0.665
MOD_GSK3_1	282	289	PF00069	0.585
MOD_GSK3_1	300	307	PF00069	0.427
MOD_GSK3_1	34	41	PF00069	0.806
MOD_GSK3_1	44	51	PF00069	0.663
MOD_GSK3_1	53	60	PF00069	0.556
MOD_GSK3_1	593	600	PF00069	0.575
MOD_GSK3_1	630	637	PF00069	0.593
MOD_GSK3_1	641	648	PF00069	0.611
MOD_GSK3_1	652	659	PF00069	0.609
MOD_GSK3_1	694	701	PF00069	0.414
MOD_GSK3_1	791	798	PF00069	0.456
MOD_GSK3_1	88	95	PF00069	0.721
MOD_N-GLC_1	604	609	PF02516	0.742
MOD_N-GLC_1	641	646	PF02516	0.624
MOD_N-GLC_1	66	71	PF02516	0.644
MOD_NEK2_1	111	116	PF00069	0.670
MOD_NEK2_1	192	197	PF00069	0.592
MOD_NEK2_1	321	326	PF00069	0.461
MOD_NEK2_1	643	648	PF00069	0.589
MOD_NEK2_1	66	71	PF00069	0.644
MOD_NEK2_1	675	680	PF00069	0.574
MOD_NEK2_1	692	697	PF00069	0.296
MOD_PIKK_1	66	72	PF00454	0.568
MOD_PIKK_1	7	13	PF00454	0.659
MOD_PIKK_1	726	732	PF00454	0.473
MOD_PK_1	182	188	PF00069	0.667
MOD_PKA_2	15	21	PF00069	0.594
MOD_PKA_2	593	599	PF00069	0.548
MOD_PKA_2	687	693	PF00069	0.449
MOD_Plk_1	401	407	PF00069	0.292
MOD_Plk_1	759	765	PF00069	0.430
MOD_Plk_4	129	135	PF00069	0.594
MOD_Plk_4	18	24	PF00069	0.646
MOD_Plk_4	401	407	PF00069	0.292
MOD_Plk_4	687	693	PF00069	0.390
MOD_Plk_4	804	810	PF00069	0.404
MOD_ProDKin_1	141	147	PF00069	0.711
MOD_ProDKin_1	158	164	PF00069	0.611
MOD_ProDKin_1	193	199	PF00069	0.640
MOD_ProDKin_1	271	277	PF00069	0.739
MOD_ProDKin_1	29	35	PF00069	0.654
MOD_ProDKin_1	41	47	PF00069	0.716
MOD_ProDKin_1	415	421	PF00069	0.351
MOD_ProDKin_1	549	555	PF00069	0.453
MOD_ProDKin_1	597	603	PF00069	0.633
MOD_ProDKin_1	652	658	PF00069	0.625
MOD_ProDKin_1	663	669	PF00069	0.647
MOD_ProDKin_1	791	797	PF00069	0.500
MOD_ProDKin_1	88	94	PF00069	0.714
MOD_SUMO_for_1	564	567	PF00179	0.494
MOD_SUMO_rev_2	567	573	PF00179	0.497
TRG_DiLeu_BaEn_2	782	788	PF01217	0.432
TRG_DiLeu_BaEn_4	474	480	PF01217	0.422
TRG_DiLeu_BaLyEn_6	736	741	PF01217	0.500
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.593
TRG_ENDOCYTIC_2	340	343	PF00928	0.340
TRG_ENDOCYTIC_2	395	398	PF00928	0.351
TRG_ENDOCYTIC_2	403	406	PF00928	0.351
TRG_ENDOCYTIC_2	521	524	PF00928	0.434
TRG_ER_diArg_1	411	414	PF00400	0.350
TRG_ER_diArg_1	479	481	PF00400	0.375
TRG_NES_CRM1_1	699	713	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	778	783	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q2	Leptomonas seymouri	64%	100%
A0A3Q8IBC4	Leishmania donovani	100%	100%
A0A3R7K273	Trypanosoma rangeli	42%	100%
A4HCK0	Leishmania braziliensis	83%	100%
E9AVZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBI7	Leishmania major	95%	100%