LeishMANIAdb
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Putative 40S ribosomal protein L14

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein L14
Gene product:
60S ribosomal protein L14 - putative
Species:
Leishmania infantum
UniProt:
A4I011_LEIIN
TriTrypDb:
LINF_220021800 *
Length:
233

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal L14

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 14
GO:0032991 protein-containing complex 1 15
GO:0043226 organelle 2 15
GO:0043228 non-membrane-bounded organelle 3 15
GO:0043229 intracellular organelle 3 15
GO:0043232 intracellular non-membrane-bounded organelle 4 15
GO:0110165 cellular anatomical entity 1 15
GO:1990904 ribonucleoprotein complex 2 15
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1

Expansion

Sequence features

A4I011
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I011

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 15
GO:0006518 peptide metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009058 biosynthetic process 2 15
GO:0009059 macromolecule biosynthetic process 4 15
GO:0009987 cellular process 1 15
GO:0019538 protein metabolic process 3 15
GO:0034641 cellular nitrogen compound metabolic process 3 15
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 15
GO:0043043 peptide biosynthetic process 5 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043603 amide metabolic process 3 15
GO:0043604 amide biosynthetic process 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0044249 cellular biosynthetic process 3 15
GO:0044260 obsolete cellular macromolecule metabolic process 3 15
GO:0044271 cellular nitrogen compound biosynthetic process 4 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
GO:1901566 organonitrogen compound biosynthetic process 4 15
GO:1901576 organic substance biosynthetic process 3 15
GO:0022613 ribonucleoprotein complex biogenesis 4 1
GO:0042273 ribosomal large subunit biogenesis 5 1
GO:0044085 cellular component biogenesis 3 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 15
GO:0003723 RNA binding 4 15
GO:0003735 structural constituent of ribosome 2 15
GO:0005198 structural molecule activity 1 15
GO:0005488 binding 1 15
GO:0097159 organic cyclic compound binding 2 15
GO:1901363 heterocyclic compound binding 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 187 191 PF00656 0.609
CLV_C14_Caspase3-7 35 39 PF00656 0.460
CLV_C14_Caspase3-7 87 91 PF00656 0.432
CLV_NRD_NRD_1 175 177 PF00675 0.357
CLV_NRD_NRD_1 182 184 PF00675 0.423
CLV_NRD_NRD_1 220 222 PF00675 0.552
CLV_NRD_NRD_1 228 230 PF00675 0.466
CLV_PCSK_KEX2_1 175 177 PF00082 0.335
CLV_PCSK_KEX2_1 219 221 PF00082 0.519
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.519
CLV_PCSK_SKI1_1 130 134 PF00082 0.354
CLV_PCSK_SKI1_1 144 148 PF00082 0.304
CLV_PCSK_SKI1_1 183 187 PF00082 0.513
CLV_PCSK_SKI1_1 189 193 PF00082 0.553
CLV_PCSK_SKI1_1 199 203 PF00082 0.454
CLV_PCSK_SKI1_1 208 212 PF00082 0.480
CLV_PCSK_SKI1_1 229 233 PF00082 0.548
DEG_APCC_DBOX_1 2 10 PF00400 0.439
DEG_Nend_Nbox_1 1 3 PF02207 0.452
DOC_MAPK_gen_1 75 84 PF00069 0.392
DOC_MAPK_MEF2A_6 78 86 PF00069 0.380
DOC_PP2B_LxvP_1 27 30 PF13499 0.485
DOC_USP7_MATH_1 135 139 PF00917 0.409
DOC_USP7_MATH_1 174 178 PF00917 0.332
DOC_USP7_UBL2_3 140 144 PF12436 0.325
DOC_USP7_UBL2_3 199 203 PF12436 0.458
DOC_USP7_UBL2_3 204 208 PF12436 0.469
DOC_WW_Pin1_4 190 195 PF00397 0.609
DOC_WW_Pin1_4 42 47 PF00397 0.522
DOC_WW_Pin1_4 8 13 PF00397 0.440
LIG_14-3-3_CanoR_1 125 132 PF00244 0.371
LIG_14-3-3_CanoR_1 18 23 PF00244 0.468
LIG_BRCT_BRCA1_1 162 166 PF00533 0.325
LIG_Clathr_ClatBox_1 6 10 PF01394 0.437
LIG_DLG_GKlike_1 18 26 PF00625 0.469
LIG_FHA_2 162 168 PF00498 0.331
LIG_FHA_2 33 39 PF00498 0.540
LIG_LIR_Apic_2 37 43 PF02991 0.453
LIG_LIR_Gen_1 196 205 PF02991 0.473
LIG_LIR_Nem_3 163 169 PF02991 0.325
LIG_LIR_Nem_3 196 200 PF02991 0.471
LIG_RPA_C_Fungi 120 132 PF08784 0.368
LIG_SH2_CRK 40 44 PF00017 0.714
LIG_SH2_STAT5 119 122 PF00017 0.477
LIG_SH2_STAT5 64 67 PF00017 0.419
LIG_SH3_1 40 46 PF00018 0.441
LIG_SH3_3 40 46 PF00018 0.441
LIG_SH3_3 6 12 PF00018 0.438
LIG_SH3_3 93 99 PF00018 0.383
LIG_SUMO_SIM_par_1 84 90 PF11976 0.392
LIG_WW_3 15 19 PF00397 0.448
MOD_CK1_1 21 27 PF00069 0.726
MOD_CK2_1 161 167 PF00069 0.325
MOD_GlcNHglycan 127 130 PF01048 0.498
MOD_GSK3_1 121 128 PF00069 0.360
MOD_GSK3_1 16 23 PF00069 0.700
MOD_GSK3_1 28 35 PF00069 0.731
MOD_GSK3_1 42 49 PF00069 0.674
MOD_N-GLC_1 125 130 PF02516 0.347
MOD_NEK2_1 136 141 PF00069 0.469
MOD_NEK2_1 22 27 PF00069 0.474
MOD_NEK2_1 59 64 PF00069 0.597
MOD_PKA_2 174 180 PF00069 0.472
MOD_Plk_4 22 28 PF00069 0.484
MOD_ProDKin_1 190 196 PF00069 0.605
MOD_ProDKin_1 42 48 PF00069 0.523
MOD_ProDKin_1 8 14 PF00069 0.442
MOD_SUMO_rev_2 187 194 PF00179 0.453
MOD_SUMO_rev_2 97 104 PF00179 0.441
TRG_DiLeu_BaLyEn_6 2 7 PF01217 0.442
TRG_DiLeu_BaLyEn_6 43 48 PF01217 0.431
TRG_ER_diArg_1 175 178 PF00400 0.485
TRG_ER_diArg_1 2 5 PF00400 0.444
TRG_ER_diArg_1 220 222 PF00400 0.591
TRG_NLS_Bipartite_1 203 223 PF00514 0.589
TRG_NLS_MonoExtC_3 228 233 PF00514 0.671
TRG_Pf-PMV_PEXEL_1 5 10 PF00026 0.437
TRG_Pf-PMV_PEXEL_1 93 97 PF00026 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P212 Leptomonas seymouri 87% 100%
A0A0S4IV19 Bodo saltans 52% 94%
A0A1X0NR58 Trypanosomatidae 75% 100%
A0A1X0NTL1 Trypanosomatidae 75% 100%
A0A3Q8ICC3 Leishmania donovani 100% 100%
A0A3R7RDB6 Trypanosoma rangeli 71% 100%
A0A422NG13 Trypanosoma rangeli 72% 100%
A4HCJ1 Leishmania braziliensis 95% 100%
C9ZQ81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
D0A8Y5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 100%
E9AVY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P55842 Trypanosoma brucei brucei 76% 100%
P55843 Trypanosoma congolense 75% 100%
Q25278 Leishmania donovani 100% 100%
Q4QBJ1 Leishmania major 99% 100%
V5D9P7 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS