LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Calpain-like cysteine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Calpain-like cysteine peptidase
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I010_LEIIN
TriTrypDb:
LINF_220021300
Length:
497

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I010
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I010

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 366 370 PF00656 0.469
CLV_NRD_NRD_1 222 224 PF00675 0.747
CLV_NRD_NRD_1 4 6 PF00675 0.524
CLV_PCSK_KEX2_1 383 385 PF00082 0.625
CLV_PCSK_PC1ET2_1 383 385 PF00082 0.625
CLV_PCSK_SKI1_1 176 180 PF00082 0.738
CLV_PCSK_SKI1_1 224 228 PF00082 0.622
CLV_PCSK_SKI1_1 240 244 PF00082 0.485
CLV_PCSK_SKI1_1 348 352 PF00082 0.451
CLV_PCSK_SKI1_1 392 396 PF00082 0.504
CLV_PCSK_SKI1_1 6 10 PF00082 0.551
DEG_MDM2_SWIB_1 404 411 PF02201 0.586
DEG_Nend_Nbox_1 1 3 PF02207 0.536
DEG_SCF_FBW7_1 281 288 PF00400 0.549
DOC_CKS1_1 282 287 PF01111 0.547
DOC_CKS1_1 326 331 PF01111 0.609
DOC_CYCLIN_RxL_1 2 11 PF00134 0.553
DOC_MAPK_FxFP_2 343 346 PF00069 0.452
DOC_PP4_FxxP_1 343 346 PF00568 0.441
DOC_PP4_FxxP_1 376 379 PF00568 0.592
DOC_USP7_MATH_1 114 118 PF00917 0.858
DOC_USP7_MATH_1 159 163 PF00917 0.757
DOC_USP7_MATH_1 189 193 PF00917 0.708
DOC_USP7_MATH_1 206 210 PF00917 0.667
DOC_USP7_MATH_1 268 272 PF00917 0.613
DOC_USP7_MATH_1 319 323 PF00917 0.561
DOC_USP7_MATH_1 59 63 PF00917 0.702
DOC_USP7_MATH_1 77 81 PF00917 0.541
DOC_USP7_MATH_1 93 97 PF00917 0.782
DOC_USP7_UBL2_3 176 180 PF12436 0.761
DOC_USP7_UBL2_3 392 396 PF12436 0.593
DOC_WW_Pin1_4 110 115 PF00397 0.743
DOC_WW_Pin1_4 127 132 PF00397 0.674
DOC_WW_Pin1_4 195 200 PF00397 0.714
DOC_WW_Pin1_4 228 233 PF00397 0.547
DOC_WW_Pin1_4 270 275 PF00397 0.578
DOC_WW_Pin1_4 281 286 PF00397 0.485
DOC_WW_Pin1_4 325 330 PF00397 0.535
DOC_WW_Pin1_4 409 414 PF00397 0.665
LIG_14-3-3_CanoR_1 401 411 PF00244 0.479
LIG_CtBP_PxDLS_1 488 492 PF00389 0.513
LIG_DCNL_PONY_1 1 4 PF03556 0.536
LIG_FHA_1 306 312 PF00498 0.523
LIG_FHA_1 357 363 PF00498 0.443
LIG_FHA_1 405 411 PF00498 0.496
LIG_FHA_1 453 459 PF00498 0.592
LIG_FHA_1 491 497 PF00498 0.680
LIG_FHA_1 61 67 PF00498 0.581
LIG_FHA_2 203 209 PF00498 0.639
LIG_FHA_2 286 292 PF00498 0.651
LIG_FHA_2 46 52 PF00498 0.633
LIG_IRF3_LxIS_1 483 490 PF10401 0.482
LIG_LIR_Apic_2 340 346 PF02991 0.441
LIG_LIR_Apic_2 375 379 PF02991 0.592
LIG_LIR_Gen_1 301 309 PF02991 0.464
LIG_LIR_Gen_1 405 415 PF02991 0.557
LIG_LIR_Nem_3 301 305 PF02991 0.439
LIG_LIR_Nem_3 405 411 PF02991 0.489
LIG_Pex14_1 68 72 PF04695 0.663
LIG_Pex14_2 345 349 PF04695 0.577
LIG_Pex14_2 404 408 PF04695 0.445
LIG_SH2_CRK 279 283 PF00017 0.484
LIG_SH2_SRC 140 143 PF00017 0.801
LIG_SH2_STAP1 279 283 PF00017 0.484
LIG_SH2_STAT5 344 347 PF00017 0.533
LIG_SH2_STAT5 356 359 PF00017 0.378
LIG_SH2_STAT5 403 406 PF00017 0.492
LIG_SH2_STAT5 414 417 PF00017 0.535
LIG_SH3_3 104 110 PF00018 0.816
LIG_SH3_3 146 152 PF00018 0.769
LIG_SH3_3 193 199 PF00018 0.678
LIG_SH3_3 407 413 PF00018 0.635
LIG_SH3_3 446 452 PF00018 0.627
LIG_SH3_3 49 55 PF00018 0.652
LIG_SUMO_SIM_anti_2 445 451 PF11976 0.532
LIG_SUMO_SIM_par_1 307 313 PF11976 0.428
LIG_SUMO_SIM_par_1 487 493 PF11976 0.510
LIG_TRAF2_1 205 208 PF00917 0.639
LIG_TRAF2_1 73 76 PF00917 0.772
LIG_TRAF2_1 83 86 PF00917 0.609
LIG_UBA3_1 1 6 PF00899 0.542
MOD_CDK_SPK_2 270 275 PF00069 0.500
MOD_CDK_SPxK_1 325 331 PF00069 0.616
MOD_CK1_1 113 119 PF00069 0.848
MOD_CK1_1 162 168 PF00069 0.768
MOD_CK1_1 198 204 PF00069 0.716
MOD_CK1_1 217 223 PF00069 0.681
MOD_CK1_1 228 234 PF00069 0.536
MOD_CK1_1 292 298 PF00069 0.584
MOD_CK1_1 339 345 PF00069 0.557
MOD_CK1_1 368 374 PF00069 0.503
MOD_CK1_1 423 429 PF00069 0.620
MOD_CK1_1 454 460 PF00069 0.582
MOD_CK1_1 490 496 PF00069 0.561
MOD_CK2_1 202 208 PF00069 0.679
MOD_CK2_1 261 267 PF00069 0.641
MOD_CK2_1 285 291 PF00069 0.641
MOD_CK2_1 84 90 PF00069 0.766
MOD_CK2_1 93 99 PF00069 0.784
MOD_GlcNHglycan 116 119 PF01048 0.811
MOD_GlcNHglycan 144 147 PF01048 0.771
MOD_GlcNHglycan 191 194 PF01048 0.784
MOD_GlcNHglycan 207 211 PF01048 0.647
MOD_GlcNHglycan 216 219 PF01048 0.621
MOD_GlcNHglycan 227 230 PF01048 0.544
MOD_GlcNHglycan 291 294 PF01048 0.650
MOD_GlcNHglycan 319 322 PF01048 0.480
MOD_GlcNHglycan 426 429 PF01048 0.700
MOD_GSK3_1 110 117 PF00069 0.700
MOD_GSK3_1 165 172 PF00069 0.788
MOD_GSK3_1 198 205 PF00069 0.682
MOD_GSK3_1 246 253 PF00069 0.483
MOD_GSK3_1 281 288 PF00069 0.589
MOD_GSK3_1 313 320 PF00069 0.500
MOD_GSK3_1 332 339 PF00069 0.528
MOD_GSK3_1 344 351 PF00069 0.486
MOD_GSK3_1 420 427 PF00069 0.725
MOD_GSK3_1 60 67 PF00069 0.629
MOD_N-GLC_1 125 130 PF02516 0.708
MOD_N-GLC_1 189 194 PF02516 0.649
MOD_N-GLC_1 471 476 PF02516 0.493
MOD_N-GLC_2 473 475 PF02516 0.576
MOD_NEK2_1 300 305 PF00069 0.438
MOD_NEK2_1 317 322 PF00069 0.517
MOD_NEK2_1 45 50 PF00069 0.517
MOD_NEK2_1 84 89 PF00069 0.709
MOD_PIKK_1 420 426 PF00454 0.733
MOD_Plk_1 162 168 PF00069 0.811
MOD_Plk_1 300 306 PF00069 0.442
MOD_Plk_1 368 374 PF00069 0.580
MOD_Plk_1 84 90 PF00069 0.682
MOD_Plk_4 14 20 PF00069 0.643
MOD_Plk_4 183 189 PF00069 0.821
MOD_Plk_4 261 267 PF00069 0.641
MOD_Plk_4 310 316 PF00069 0.584
MOD_Plk_4 339 345 PF00069 0.550
MOD_Plk_4 64 70 PF00069 0.500
MOD_ProDKin_1 110 116 PF00069 0.743
MOD_ProDKin_1 127 133 PF00069 0.672
MOD_ProDKin_1 195 201 PF00069 0.716
MOD_ProDKin_1 228 234 PF00069 0.546
MOD_ProDKin_1 270 276 PF00069 0.568
MOD_ProDKin_1 281 287 PF00069 0.498
MOD_ProDKin_1 325 331 PF00069 0.540
MOD_ProDKin_1 409 415 PF00069 0.667
MOD_SUMO_for_1 150 153 PF00179 0.639
MOD_SUMO_rev_2 103 113 PF00179 0.659
MOD_SUMO_rev_2 375 385 PF00179 0.595
TRG_ENDOCYTIC_2 279 282 PF00928 0.488
TRG_ENDOCYTIC_2 29 32 PF00928 0.625
TRG_ENDOCYTIC_2 323 326 PF00928 0.649
TRG_ENDOCYTIC_2 461 464 PF00928 0.566
TRG_Pf-PMV_PEXEL_1 82 86 PF00026 0.662

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC61 Leptomonas seymouri 41% 91%
A0A3Q8IBJ7 Leishmania donovani 100% 100%
E9AVY3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QBJ6 Leishmania major 92% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS