Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4I007_LEIIN

TriTrypDb:

LINF_220020900

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 19
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	21
GO:0031974	membrane-enclosed lumen	2	21
GO:0043233	organelle lumen	3	21
GO:0070013	intracellular organelle lumen	4	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

A4I007

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I007

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.536
CLV_NRD_NRD_1	129	131	PF00675	0.331
CLV_NRD_NRD_1	192	194	PF00675	0.293
CLV_NRD_NRD_1	250	252	PF00675	0.359
CLV_NRD_NRD_1	3	5	PF00675	0.520
CLV_NRD_NRD_1	36	38	PF00675	0.563
CLV_PCSK_FUR_1	130	134	PF00082	0.247
CLV_PCSK_KEX2_1	132	134	PF00082	0.369
CLV_PCSK_KEX2_1	180	182	PF00082	0.320
CLV_PCSK_KEX2_1	191	193	PF00082	0.320
CLV_PCSK_KEX2_1	3	5	PF00082	0.516
CLV_PCSK_KEX2_1	36	38	PF00082	0.555
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.247
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.306
CLV_PCSK_PC7_1	32	38	PF00082	0.646
CLV_PCSK_SKI1_1	55	59	PF00082	0.479
CLV_PCSK_SKI1_1	61	65	PF00082	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DOC_MAPK_gen_1	3	11	PF00069	0.620
DOC_MAPK_MEF2A_6	3	11	PF00069	0.434
DOC_MAPK_NFAT4_5	4	12	PF00069	0.436
DOC_PP4_FxxP_1	57	60	PF00568	0.474
DOC_USP7_MATH_1	163	167	PF00917	0.517
DOC_USP7_MATH_1	22	26	PF00917	0.674
DOC_USP7_MATH_1	30	34	PF00917	0.675
DOC_USP7_MATH_1	73	77	PF00917	0.472
LIG_14-3-3_CanoR_1	4	10	PF00244	0.575
LIG_14-3-3_CterR_2	251	255	PF00244	0.559
LIG_BRCT_BRCA1_1	75	79	PF00533	0.424
LIG_eIF4E_1	122	128	PF01652	0.491
LIG_FHA_1	24	30	PF00498	0.710
LIG_FHA_1	4	10	PF00498	0.554
LIG_FHA_2	142	148	PF00498	0.484
LIG_FHA_2	43	49	PF00498	0.463
LIG_FHA_2	97	103	PF00498	0.499
LIG_LIR_Apic_2	196	201	PF02991	0.483
LIG_LIR_Apic_2	56	60	PF02991	0.470
LIG_LIR_Gen_1	119	129	PF02991	0.471
LIG_LIR_Gen_1	76	87	PF02991	0.390
LIG_LIR_Nem_3	119	125	PF02991	0.499
LIG_LIR_Nem_3	76	82	PF02991	0.507
LIG_SH2_CRK	198	202	PF00017	0.496
LIG_SH2_GRB2like	122	125	PF00017	0.559
LIG_SH2_GRB2like	243	246	PF00017	0.491
LIG_SH2_SRC	50	53	PF00017	0.366
LIG_SH2_STAP1	5	9	PF00017	0.577
LIG_SH2_STAT5	122	125	PF00017	0.502
LIG_SH2_STAT5	217	220	PF00017	0.458
LIG_SH2_STAT5	243	246	PF00017	0.479
LIG_SH2_STAT5	5	8	PF00017	0.600
LIG_SH3_3	56	62	PF00018	0.454
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.467
LIG_TRAF2_1	159	162	PF00917	0.559
LIG_WW_3	58	62	PF00397	0.372
MOD_CK1_1	142	148	PF00069	0.433
MOD_CK2_1	22	28	PF00069	0.746
MOD_CK2_1	42	48	PF00069	0.456
MOD_CK2_1	96	102	PF00069	0.457
MOD_GlcNHglycan	165	168	PF01048	0.304
MOD_GlcNHglycan	186	189	PF01048	0.334
MOD_GlcNHglycan	73	76	PF01048	0.537
MOD_GSK3_1	153	160	PF00069	0.568
MOD_GSK3_1	96	103	PF00069	0.519
MOD_NEK2_1	100	105	PF00069	0.605
MOD_NEK2_1	139	144	PF00069	0.484
MOD_NEK2_1	15	20	PF00069	0.661
MOD_NEK2_1	183	188	PF00069	0.531
MOD_NEK2_2	42	47	PF00069	0.554
MOD_PKA_1	3	9	PF00069	0.588
MOD_PKA_2	3	9	PF00069	0.589
MOD_PKB_1	191	199	PF00069	0.419
MOD_Plk_1	139	145	PF00069	0.517
MOD_Plk_2-3	208	214	PF00069	0.491
TRG_DiLeu_BaEn_4	118	124	PF01217	0.559
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.491
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.503
TRG_ENDOCYTIC_2	122	125	PF00928	0.479
TRG_ER_diArg_1	191	193	PF00400	0.502
TRG_ER_diArg_1	2	4	PF00400	0.542
TRG_ER_diArg_1	35	37	PF00400	0.583
TRG_NES_CRM1_1	147	161	PF08389	0.530
TRG_NLS_MonoCore_2	129	134	PF00514	0.467
TRG_NLS_MonoExtC_3	130	135	PF00514	0.467
TRG_NLS_MonoExtN_4	130	135	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	28%	100%
A0A0N1HS24	Leptomonas seymouri	67%	100%
A0A0S4ITN8	Bodo saltans	31%	100%
A0A1X0NTH7	Trypanosomatidae	65%	98%
A0A1X0P207	Trypanosomatidae	28%	100%
A0A3Q8IBW7	Leishmania donovani	27%	100%
A0A3Q8IFM4	Leishmania donovani	100%	100%
A0A422NJ89	Trypanosoma rangeli	26%	75%
A4HCI6	Leishmania braziliensis	85%	100%
A4HI52	Leishmania braziliensis	28%	85%
A4I5C8	Leishmania infantum	27%	100%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	69%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
Q4Q7K6	Leishmania major	28%	86%
Q4QBJ9	Leishmania major	93%	100%
V5BDB3	Trypanosoma cruzi	64%	98%