TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I006_LEIIN

TriTrypDb:

LINF_220020800

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I006

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I006

PDB structure(s): 7am2_BQ

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.532
CLV_C14_Caspase3-7	97	101	PF00656	0.418
CLV_MEL_PAP_1	425	431	PF00089	0.404
CLV_NRD_NRD_1	184	186	PF00675	0.393
CLV_NRD_NRD_1	3	5	PF00675	0.630
CLV_NRD_NRD_1	313	315	PF00675	0.626
CLV_NRD_NRD_1	427	429	PF00675	0.421
CLV_PCSK_KEX2_1	184	186	PF00082	0.396
CLV_PCSK_KEX2_1	3	5	PF00082	0.572
CLV_PCSK_KEX2_1	427	429	PF00082	0.421
CLV_PCSK_SKI1_1	152	156	PF00082	0.442
CLV_PCSK_SKI1_1	188	192	PF00082	0.505
CLV_PCSK_SKI1_1	241	245	PF00082	0.544
CLV_PCSK_SKI1_1	387	391	PF00082	0.524
CLV_PCSK_SKI1_1	99	103	PF00082	0.377
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DOC_CYCLIN_RxL_1	382	393	PF00134	0.499
DOC_MAPK_gen_1	184	191	PF00069	0.536
DOC_MAPK_gen_1	3	9	PF00069	0.598
DOC_MAPK_MEF2A_6	211	218	PF00069	0.522
DOC_MAPK_NFAT4_5	211	219	PF00069	0.435
DOC_PP1_RVXF_1	186	192	PF00149	0.461
DOC_PP2B_LxvP_1	195	198	PF13499	0.566
DOC_PP4_FxxP_1	131	134	PF00568	0.488
DOC_PP4_FxxP_1	37	40	PF00568	0.367
DOC_PP4_FxxP_1	65	68	PF00568	0.401
DOC_USP7_MATH_1	101	105	PF00917	0.492
DOC_USP7_MATH_1	177	181	PF00917	0.481
DOC_USP7_MATH_1	230	234	PF00917	0.567
DOC_USP7_MATH_1	310	314	PF00917	0.522
DOC_USP7_MATH_1	366	370	PF00917	0.551
DOC_WW_Pin1_4	154	159	PF00397	0.424
DOC_WW_Pin1_4	178	183	PF00397	0.356
DOC_WW_Pin1_4	224	229	PF00397	0.500
DOC_WW_Pin1_4	369	374	PF00397	0.560
LIG_14-3-3_CanoR_1	194	198	PF00244	0.578
LIG_14-3-3_CanoR_1	211	217	PF00244	0.487
LIG_14-3-3_CanoR_1	241	247	PF00244	0.479
LIG_Actin_WH2_2	84	101	PF00022	0.482
LIG_APCC_ABBA_1	345	350	PF00400	0.525
LIG_BRCT_BRCA1_1	265	269	PF00533	0.458
LIG_deltaCOP1_diTrp_1	400	406	PF00928	0.373
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.403
LIG_FHA_1	100	106	PF00498	0.475
LIG_FHA_1	29	35	PF00498	0.381
LIG_FHA_1	374	380	PF00498	0.670
LIG_FHA_2	230	236	PF00498	0.395
LIG_FHA_2	243	249	PF00498	0.326
LIG_FHA_2	57	63	PF00498	0.346
LIG_IBAR_NPY_1	93	95	PF08397	0.438
LIG_LIR_Apic_2	129	134	PF02991	0.506
LIG_LIR_Apic_2	224	228	PF02991	0.614
LIG_LIR_Apic_2	62	68	PF02991	0.399
LIG_LIR_Gen_1	257	267	PF02991	0.452
LIG_LIR_Gen_1	398	406	PF02991	0.370
LIG_LIR_Nem_3	118	124	PF02991	0.470
LIG_LIR_Nem_3	257	263	PF02991	0.450
LIG_LIR_Nem_3	398	404	PF02991	0.367
LIG_LIR_Nem_3	424	429	PF02991	0.405
LIG_NRBOX	238	244	PF00104	0.366
LIG_PDZ_Class_3	440	445	PF00595	0.474
LIG_Pex14_1	86	90	PF04695	0.387
LIG_Pex14_2	397	401	PF04695	0.376
LIG_PTB_Apo_2	405	412	PF02174	0.389
LIG_PTB_Phospho_1	405	411	PF10480	0.392
LIG_Rb_LxCxE_1	102	123	PF01857	0.418
LIG_SH2_CRK	225	229	PF00017	0.507
LIG_SH2_NCK_1	225	229	PF00017	0.507
LIG_SH2_NCK_1	256	260	PF00017	0.334
LIG_SH2_STAP1	256	260	PF00017	0.416
LIG_SH2_STAT3	74	77	PF00017	0.517
LIG_SH2_STAT5	321	324	PF00017	0.436
LIG_SH2_STAT5	33	36	PF00017	0.380
LIG_SH2_STAT5	46	49	PF00017	0.342
LIG_SH3_3	141	147	PF00018	0.484
LIG_SH3_3	37	43	PF00018	0.367
LIG_SH3_3	88	94	PF00018	0.431
LIG_SUMO_SIM_par_1	79	85	PF11976	0.386
LIG_TRAF2_1	329	332	PF00917	0.456
LIG_TRAF2_1	356	359	PF00917	0.516
LIG_TRAF2_1	94	97	PF00917	0.403
LIG_UBA3_1	288	294	PF00899	0.429
LIG_WRC_WIRS_1	128	133	PF05994	0.505
LIG_WRC_WIRS_1	243	248	PF05994	0.405
MOD_CDK_SPxK_1	178	184	PF00069	0.357
MOD_CDK_SPxxK_3	154	161	PF00069	0.471
MOD_CDK_SPxxK_3	178	185	PF00069	0.357
MOD_CK1_1	123	129	PF00069	0.538
MOD_CK1_1	204	210	PF00069	0.618
MOD_CK1_1	224	230	PF00069	0.505
MOD_CK1_1	258	264	PF00069	0.456
MOD_CK1_1	265	271	PF00069	0.435
MOD_CK1_1	281	287	PF00069	0.373
MOD_CK1_1	313	319	PF00069	0.560
MOD_CK1_1	369	375	PF00069	0.603
MOD_CK1_1	393	399	PF00069	0.465
MOD_CK2_1	230	236	PF00069	0.499
MOD_CK2_1	242	248	PF00069	0.348
MOD_CK2_1	353	359	PF00069	0.466
MOD_CK2_1	415	421	PF00069	0.424
MOD_CK2_1	56	62	PF00069	0.334
MOD_GlcNHglycan	125	128	PF01048	0.546
MOD_GlcNHglycan	175	178	PF01048	0.413
MOD_GlcNHglycan	257	260	PF01048	0.429
MOD_GlcNHglycan	283	286	PF01048	0.434
MOD_GlcNHglycan	315	318	PF01048	0.483
MOD_GlcNHglycan	369	372	PF01048	0.598
MOD_GlcNHglycan	392	395	PF01048	0.453
MOD_GSK3_1	123	130	PF00069	0.502
MOD_GSK3_1	173	180	PF00069	0.453
MOD_GSK3_1	212	219	PF00069	0.571
MOD_GSK3_1	24	31	PF00069	0.400
MOD_GSK3_1	258	265	PF00069	0.404
MOD_GSK3_1	349	356	PF00069	0.460
MOD_GSK3_1	369	376	PF00069	0.491
MOD_GSK3_1	434	441	PF00069	0.441
MOD_LATS_1	22	28	PF00433	0.414
MOD_N-GLC_1	171	176	PF02516	0.451
MOD_N-GLC_1	201	206	PF02516	0.547
MOD_N-GLC_1	230	235	PF02516	0.396
MOD_N-GLC_1	281	286	PF02516	0.432
MOD_NEK2_1	218	223	PF00069	0.616
MOD_NEK2_1	242	247	PF00069	0.323
MOD_NEK2_1	262	267	PF00069	0.204
MOD_NEK2_1	323	328	PF00069	0.467
MOD_NEK2_1	378	383	PF00069	0.445
MOD_NEK2_1	390	395	PF00069	0.448
MOD_NEK2_1	70	75	PF00069	0.370
MOD_PKA_2	12	18	PF00069	0.464
MOD_PKA_2	193	199	PF00069	0.536
MOD_PKA_2	212	218	PF00069	0.376
MOD_PKA_2	313	319	PF00069	0.551
MOD_PKA_2	335	341	PF00069	0.387
MOD_Plk_1	171	177	PF00069	0.459
MOD_Plk_2-3	353	359	PF00069	0.410
MOD_Plk_4	101	107	PF00069	0.373
MOD_Plk_4	28	34	PF00069	0.381
MOD_Plk_4	421	427	PF00069	0.412
MOD_ProDKin_1	154	160	PF00069	0.418
MOD_ProDKin_1	178	184	PF00069	0.357
MOD_ProDKin_1	224	230	PF00069	0.499
MOD_ProDKin_1	369	375	PF00069	0.557
MOD_SUMO_rev_2	233	240	PF00179	0.401
MOD_SUMO_rev_2	350	357	PF00179	0.468
MOD_SUMO_rev_2	96	101	PF00179	0.461
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.480
TRG_ENDOCYTIC_2	121	124	PF00928	0.428
TRG_ENDOCYTIC_2	95	98	PF00928	0.548
TRG_ER_diArg_1	184	186	PF00400	0.382
TRG_ER_diArg_1	2	4	PF00400	0.635
TRG_ER_diArg_1	210	213	PF00400	0.481
TRG_ER_diArg_1	426	428	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGW5	Leptomonas seymouri	70%	100%
A0A1X0NU50	Trypanosomatidae	50%	99%
A0A3R7M6E1	Trypanosoma rangeli	52%	100%
A0A3S7WXB0	Leishmania donovani	100%	100%
A4HCI5	Leishmania braziliensis	84%	100%
C9ZSQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AVX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBK0	Leishmania major	96%	100%
V5B8Q9	Trypanosoma cruzi	49%	98%