I/6 autoantigen-like protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

i/6 autoantigen-like protein

Species:

Leishmania infantum

UniProt:

A4I005_LEIIN

TriTrypDb:

LINF_220020700

Length:

207

Annotations

Annotations by Jardim et al.

Metal Binding, I/6 autoantigen-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 112
Promastigote/Amastigote: 41

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I005

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I005

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.325
CLV_C14_Caspase3-7	114	118	PF00656	0.286
CLV_C14_Caspase3-7	4	8	PF00656	0.485
CLV_NRD_NRD_1	152	154	PF00675	0.417
CLV_NRD_NRD_1	162	164	PF00675	0.466
CLV_NRD_NRD_1	180	182	PF00675	0.622
CLV_NRD_NRD_1	94	96	PF00675	0.461
CLV_PCSK_KEX2_1	11	13	PF00082	0.450
CLV_PCSK_KEX2_1	152	154	PF00082	0.461
CLV_PCSK_KEX2_1	161	163	PF00082	0.505
CLV_PCSK_KEX2_1	94	96	PF00082	0.461
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.450
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.579
CLV_PCSK_SKI1_1	108	112	PF00082	0.459
CLV_PCSK_SKI1_1	12	16	PF00082	0.416
CLV_PCSK_SKI1_1	201	205	PF00082	0.568
CLV_PCSK_SKI1_1	6	10	PF00082	0.466
DEG_APCC_DBOX_1	151	159	PF00400	0.398
DEG_APCC_DBOX_1	93	101	PF00400	0.403
DEG_Nend_Nbox_1	1	3	PF02207	0.547
DOC_USP7_MATH_1	102	106	PF00917	0.374
DOC_USP7_MATH_1	189	193	PF00917	0.670
DOC_USP7_UBL2_3	103	107	PF12436	0.442
DOC_USP7_UBL2_3	195	199	PF12436	0.742
DOC_WW_Pin1_4	38	43	PF00397	0.508
LIG_14-3-3_CanoR_1	25	31	PF00244	0.430
LIG_14-3-3_CanoR_1	70	74	PF00244	0.536
LIG_14-3-3_CanoR_1	94	98	PF00244	0.317
LIG_FHA_2	13	19	PF00498	0.524
LIG_FHA_2	130	136	PF00498	0.429
LIG_FHA_2	41	47	PF00498	0.463
LIG_FHA_2	56	62	PF00498	0.295
LIG_LIR_Gen_1	117	126	PF02991	0.330
LIG_LIR_Gen_1	61	68	PF02991	0.412
LIG_LIR_Nem_3	117	123	PF02991	0.330
LIG_LIR_Nem_3	61	65	PF02991	0.475
LIG_SH2_STAT3	53	56	PF00017	0.536
LIG_SH2_STAT5	37	40	PF00017	0.487
LIG_SH3_3	82	88	PF00018	0.440
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.480
LIG_TRAF2_1	112	115	PF00917	0.330
LIG_TRAF2_1	96	99	PF00917	0.330
LIG_UBA3_1	119	128	PF00899	0.475
MOD_CK1_1	40	46	PF00069	0.477
MOD_CK1_1	49	55	PF00069	0.525
MOD_CK1_1	72	78	PF00069	0.539
MOD_CK2_1	109	115	PF00069	0.330
MOD_CK2_1	40	46	PF00069	0.448
MOD_CK2_1	55	61	PF00069	0.370
MOD_CK2_1	93	99	PF00069	0.330
MOD_GlcNHglycan	74	77	PF01048	0.529
MOD_GSK3_1	118	125	PF00069	0.374
MOD_GSK3_1	68	75	PF00069	0.513
MOD_N-GLC_1	68	73	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.601
MOD_PKA_2	69	75	PF00069	0.580
MOD_PKA_2	93	99	PF00069	0.330
MOD_Plk_1	68	74	PF00069	0.487
MOD_Plk_2-3	109	115	PF00069	0.351
MOD_Plk_4	69	75	PF00069	0.553
MOD_ProDKin_1	38	44	PF00069	0.505
MOD_SUMO_for_1	171	174	PF00179	0.570
MOD_SUMO_for_1	194	197	PF00179	0.661
MOD_SUMO_rev_2	121	130	PF00179	0.397
MOD_SUMO_rev_2	174	184	PF00179	0.603
TRG_ENDOCYTIC_2	141	144	PF00928	0.501
TRG_NLS_MonoExtN_4	199	204	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S4	Leptomonas seymouri	68%	92%
A0A1X0NTK1	Trypanosomatidae	44%	94%
A0A3Q8IAT1	Leishmania donovani	100%	100%
A0A422N4A4	Trypanosoma rangeli	45%	100%
A4HCI3	Leishmania braziliensis	69%	100%
C9ZSQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	85%
C9ZSQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q26768	Trypanosoma brucei brucei	40%	85%
Q4QBK1	Leishmania major	85%	99%