RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I003_LEIIN

TriTrypDb:

LINF_220020500

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I003

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I003

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.542
CLV_C14_Caspase3-7	440	444	PF00656	0.716
CLV_NRD_NRD_1	274	276	PF00675	0.478
CLV_NRD_NRD_1	282	284	PF00675	0.426
CLV_NRD_NRD_1	311	313	PF00675	0.625
CLV_PCSK_KEX2_1	274	276	PF00082	0.461
CLV_PCSK_KEX2_1	282	284	PF00082	0.438
CLV_PCSK_KEX2_1	311	313	PF00082	0.589
CLV_PCSK_KEX2_1	334	336	PF00082	0.547
CLV_PCSK_KEX2_1	50	52	PF00082	0.708
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.596
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.750
CLV_PCSK_SKI1_1	274	278	PF00082	0.483
CLV_PCSK_SKI1_1	295	299	PF00082	0.442
CLV_PCSK_SKI1_1	334	338	PF00082	0.493
CLV_PCSK_SKI1_1	342	346	PF00082	0.360
CLV_PCSK_SKI1_1	4	8	PF00082	0.781
CLV_PCSK_SKI1_1	426	430	PF00082	0.742
CLV_PCSK_SKI1_1	50	54	PF00082	0.728
DEG_APCC_DBOX_1	198	206	PF00400	0.529
DEG_APCC_DBOX_1	274	282	PF00400	0.520
DOC_CKS1_1	389	394	PF01111	0.563
DOC_MAPK_DCC_7	199	207	PF00069	0.553
DOC_MAPK_MEF2A_6	199	207	PF00069	0.498
DOC_PP1_RVXF_1	340	346	PF00149	0.448
DOC_PP2B_LxvP_1	158	161	PF13499	0.642
DOC_PP4_FxxP_1	492	495	PF00568	0.617
DOC_USP7_MATH_1	161	165	PF00917	0.644
DOC_USP7_MATH_1	304	308	PF00917	0.575
DOC_USP7_MATH_1	364	368	PF00917	0.563
DOC_USP7_MATH_1	405	409	PF00917	0.694
DOC_USP7_MATH_1	436	440	PF00917	0.728
DOC_USP7_MATH_1	45	49	PF00917	0.693
DOC_USP7_MATH_1	455	459	PF00917	0.716
DOC_USP7_UBL2_3	4	8	PF12436	0.663
DOC_WW_Pin1_4	14	19	PF00397	0.736
DOC_WW_Pin1_4	23	28	PF00397	0.684
DOC_WW_Pin1_4	240	245	PF00397	0.636
DOC_WW_Pin1_4	388	393	PF00397	0.524
DOC_WW_Pin1_4	448	453	PF00397	0.683
LIG_14-3-3_CanoR_1	153	162	PF00244	0.671
LIG_14-3-3_CanoR_1	163	168	PF00244	0.566
LIG_14-3-3_CanoR_1	199	203	PF00244	0.510
LIG_14-3-3_CanoR_1	204	208	PF00244	0.494
LIG_14-3-3_CanoR_1	424	433	PF00244	0.651
LIG_BRCT_BRCA1_1	135	139	PF00533	0.795
LIG_BRCT_BRCA1_1	392	396	PF00533	0.701
LIG_BRCT_BRCA1_1	87	91	PF00533	0.761
LIG_Clathr_ClatBox_1	305	309	PF01394	0.484
LIG_deltaCOP1_diTrp_1	172	181	PF00928	0.603
LIG_FHA_1	157	163	PF00498	0.607
LIG_FHA_1	282	288	PF00498	0.497
LIG_FHA_1	384	390	PF00498	0.493
LIG_FHA_1	415	421	PF00498	0.689
LIG_FHA_1	68	74	PF00498	0.675
LIG_FHA_1	80	86	PF00498	0.626
LIG_FHA_2	10	16	PF00498	0.734
LIG_FHA_2	167	173	PF00498	0.616
LIG_FHA_2	324	330	PF00498	0.482
LIG_FHA_2	467	473	PF00498	0.767
LIG_IBAR_NPY_1	501	503	PF08397	0.618
LIG_LIR_Apic_2	243	248	PF02991	0.598
LIG_LIR_Apic_2	352	358	PF02991	0.459
LIG_LIR_Apic_2	491	495	PF02991	0.630
LIG_LIR_Gen_1	172	183	PF02991	0.598
LIG_LIR_Nem_3	172	178	PF02991	0.588
LIG_LIR_Nem_3	472	476	PF02991	0.744
LIG_LIR_Nem_3	481	485	PF02991	0.541
LIG_Pex14_1	175	179	PF04695	0.584
LIG_SH2_CRK	485	489	PF00017	0.675
LIG_SH2_NCK_1	108	112	PF00017	0.777
LIG_SH2_NCK_1	433	437	PF00017	0.696
LIG_SH2_NCK_1	476	480	PF00017	0.598
LIG_SH2_STAP1	503	507	PF00017	0.650
LIG_SH2_STAT5	167	170	PF00017	0.638
LIG_SH2_STAT5	485	488	PF00017	0.597
LIG_SH2_STAT5	503	506	PF00017	0.618
LIG_SH3_3	386	392	PF00018	0.492
LIG_SH3_3	395	401	PF00018	0.623
LIG_SH3_3	449	455	PF00018	0.701
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.598
LIG_SUMO_SIM_par_1	304	309	PF11976	0.484
LIG_SUMO_SIM_par_1	385	391	PF11976	0.489
LIG_TRAF2_1	458	461	PF00917	0.755
LIG_TRFH_1	498	502	PF08558	0.653
LIG_WRC_WIRS_1	178	183	PF05994	0.532
MOD_CDC14_SPxK_1	17	20	PF00782	0.659
MOD_CDC14_SPxK_1	26	29	PF00782	0.572
MOD_CDK_SPxK_1	14	20	PF00069	0.735
MOD_CDK_SPxK_1	23	29	PF00069	0.657
MOD_CK1_1	101	107	PF00069	0.783
MOD_CK1_1	109	115	PF00069	0.685
MOD_CK1_1	127	133	PF00069	0.449
MOD_CK1_1	156	162	PF00069	0.713
MOD_CK1_1	23	29	PF00069	0.784
MOD_CK1_1	367	373	PF00069	0.583
MOD_CK1_1	434	440	PF00069	0.751
MOD_CK1_1	442	448	PF00069	0.711
MOD_CK1_1	78	84	PF00069	0.653
MOD_CK2_1	166	172	PF00069	0.665
MOD_CK2_1	455	461	PF00069	0.760
MOD_CK2_1	466	472	PF00069	0.743
MOD_CK2_1	9	15	PF00069	0.734
MOD_Cter_Amidation	272	275	PF01082	0.416
MOD_GlcNHglycan	109	112	PF01048	0.704
MOD_GlcNHglycan	22	25	PF01048	0.686
MOD_GlcNHglycan	271	274	PF01048	0.568
MOD_GlcNHglycan	300	303	PF01048	0.392
MOD_GlcNHglycan	407	410	PF01048	0.614
MOD_GlcNHglycan	426	429	PF01048	0.712
MOD_GlcNHglycan	433	436	PF01048	0.703
MOD_GSK3_1	106	113	PF00069	0.649
MOD_GSK3_1	120	127	PF00069	0.598
MOD_GSK3_1	437	444	PF00069	0.730
MOD_GSK3_1	75	82	PF00069	0.644
MOD_GSK3_1	98	105	PF00069	0.722
MOD_N-GLC_1	298	303	PF02516	0.555
MOD_N-GLC_1	9	14	PF02516	0.745
MOD_N-GLC_1	98	103	PF02516	0.763
MOD_N-GLC_2	263	265	PF02516	0.601
MOD_NEK2_1	198	203	PF00069	0.477
MOD_NEK2_1	281	286	PF00069	0.498
MOD_NEK2_1	298	303	PF00069	0.350
MOD_NEK2_1	344	349	PF00069	0.498
MOD_NEK2_1	431	436	PF00069	0.748
MOD_NEK2_2	2	7	PF00069	0.701
MOD_PIKK_1	153	159	PF00454	0.701
MOD_PIKK_1	313	319	PF00454	0.635
MOD_PIKK_1	434	440	PF00454	0.739
MOD_PKA_1	311	317	PF00069	0.645
MOD_PKA_2	198	204	PF00069	0.538
MOD_PKA_2	281	287	PF00069	0.548
MOD_PKA_2	311	317	PF00069	0.585
MOD_PKA_2	383	389	PF00069	0.555
MOD_PKA_2	46	52	PF00069	0.707
MOD_PKA_2	93	99	PF00069	0.731
MOD_PKB_1	424	432	PF00069	0.603
MOD_Plk_1	329	335	PF00069	0.529
MOD_Plk_1	367	373	PF00069	0.631
MOD_Plk_1	442	448	PF00069	0.723
MOD_Plk_1	55	61	PF00069	0.651
MOD_Plk_1	9	15	PF00069	0.746
MOD_Plk_4	103	109	PF00069	0.742
MOD_Plk_4	163	169	PF00069	0.618
MOD_Plk_4	383	389	PF00069	0.476
MOD_Plk_4	478	484	PF00069	0.649
MOD_Plk_4	501	507	PF00069	0.689
MOD_Plk_4	75	81	PF00069	0.677
MOD_Plk_4	9	15	PF00069	0.785
MOD_ProDKin_1	14	20	PF00069	0.738
MOD_ProDKin_1	23	29	PF00069	0.685
MOD_ProDKin_1	240	246	PF00069	0.633
MOD_ProDKin_1	388	394	PF00069	0.536
MOD_ProDKin_1	448	454	PF00069	0.682
MOD_SUMO_for_1	97	100	PF00179	0.776
TRG_DiLeu_BaEn_1	352	357	PF01217	0.497
TRG_DiLeu_BaEn_1	56	61	PF01217	0.541
TRG_ENDOCYTIC_2	503	506	PF00928	0.695
TRG_ER_diArg_1	274	276	PF00400	0.475
TRG_ER_diArg_1	281	283	PF00400	0.413
TRG_ER_diArg_1	91	94	PF00400	0.790
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J803	Bodo saltans	35%	97%
A0A1X0NV61	Trypanosomatidae	38%	100%
A0A3Q8ICC1	Leishmania donovani	100%	100%
A4HCI4	Leishmania braziliensis	84%	99%
E9AVX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBK3	Leishmania major	94%	100%
V5ANV0	Trypanosoma cruzi	34%	100%