by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 32 |
NetGPI | no | yes: 0, no: 32 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 33 |
GO:0110165 | cellular anatomical entity | 1 | 33 |
GO:0005886 | plasma membrane | 3 | 1 |
Related structures:
AlphaFold database: A4I001
Term | Name | Level | Count |
---|---|---|---|
GO:0006810 | transport | 3 | 2 |
GO:0006833 | water transport | 5 | 2 |
GO:0042044 | fluid transport | 4 | 2 |
GO:0051179 | localization | 1 | 2 |
GO:0051234 | establishment of localization | 2 | 2 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005215 | transporter activity | 1 | 33 |
GO:0015267 | channel activity | 4 | 33 |
GO:0022803 | passive transmembrane transporter activity | 3 | 33 |
GO:0022857 | transmembrane transporter activity | 2 | 33 |
GO:0005372 | water transmembrane transporter activity | 4 | 2 |
GO:0015250 | water channel activity | 5 | 2 |
GO:0015318 | inorganic molecular entity transmembrane transporter activity | 3 | 2 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 32 | 36 | PF00656 | 0.677 |
CLV_NRD_NRD_1 | 143 | 145 | PF00675 | 0.264 |
CLV_PCSK_KEX2_1 | 142 | 144 | PF00082 | 0.299 |
CLV_PCSK_PC1ET2_1 | 142 | 144 | PF00082 | 0.277 |
CLV_PCSK_SKI1_1 | 185 | 189 | PF00082 | 0.451 |
CLV_PCSK_SKI1_1 | 250 | 254 | PF00082 | 0.533 |
DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.572 |
DOC_CKS1_1 | 242 | 247 | PF01111 | 0.405 |
DOC_CYCLIN_RxL_1 | 247 | 257 | PF00134 | 0.211 |
DOC_CYCLIN_yCln2_LP_2 | 83 | 89 | PF00134 | 0.191 |
DOC_MAPK_gen_1 | 142 | 149 | PF00069 | 0.485 |
DOC_MAPK_MEF2A_6 | 20 | 27 | PF00069 | 0.532 |
DOC_PP2B_LxvP_1 | 83 | 86 | PF13499 | 0.231 |
DOC_PP2B_PxIxI_1 | 244 | 250 | PF00149 | 0.388 |
DOC_PP4_FxxP_1 | 171 | 174 | PF00568 | 0.263 |
DOC_USP7_MATH_1 | 23 | 27 | PF00917 | 0.681 |
DOC_USP7_MATH_1 | 262 | 266 | PF00917 | 0.254 |
DOC_USP7_MATH_1 | 66 | 70 | PF00917 | 0.450 |
DOC_WW_Pin1_4 | 241 | 246 | PF00397 | 0.408 |
DOC_WW_Pin1_4 | 258 | 263 | PF00397 | 0.157 |
LIG_14-3-3_CanoR_1 | 250 | 256 | PF00244 | 0.250 |
LIG_BRCT_BRCA1_1 | 105 | 109 | PF00533 | 0.302 |
LIG_BRCT_BRCA1_1 | 60 | 64 | PF00533 | 0.617 |
LIG_BRCT_BRCA1_1 | 98 | 102 | PF00533 | 0.321 |
LIG_FHA_1 | 122 | 128 | PF00498 | 0.344 |
LIG_FHA_1 | 192 | 198 | PF00498 | 0.276 |
LIG_FHA_1 | 22 | 28 | PF00498 | 0.658 |
LIG_FHA_1 | 242 | 248 | PF00498 | 0.299 |
LIG_FHA_1 | 47 | 53 | PF00498 | 0.656 |
LIG_FHA_1 | 76 | 82 | PF00498 | 0.286 |
LIG_GBD_Chelix_1 | 72 | 80 | PF00786 | 0.280 |
LIG_Integrin_isoDGR_2 | 167 | 169 | PF01839 | 0.520 |
LIG_LIR_Apic_2 | 170 | 174 | PF02991 | 0.262 |
LIG_LIR_Gen_1 | 135 | 145 | PF02991 | 0.461 |
LIG_LIR_Gen_1 | 179 | 188 | PF02991 | 0.268 |
LIG_LIR_Gen_1 | 190 | 201 | PF02991 | 0.310 |
LIG_LIR_Gen_1 | 281 | 290 | PF02991 | 0.384 |
LIG_LIR_Gen_1 | 61 | 72 | PF02991 | 0.499 |
LIG_LIR_Gen_1 | 78 | 87 | PF02991 | 0.247 |
LIG_LIR_Gen_1 | 99 | 109 | PF02991 | 0.338 |
LIG_LIR_Nem_3 | 110 | 114 | PF02991 | 0.281 |
LIG_LIR_Nem_3 | 135 | 140 | PF02991 | 0.485 |
LIG_LIR_Nem_3 | 190 | 196 | PF02991 | 0.274 |
LIG_LIR_Nem_3 | 281 | 287 | PF02991 | 0.301 |
LIG_LIR_Nem_3 | 61 | 67 | PF02991 | 0.518 |
LIG_LIR_Nem_3 | 78 | 82 | PF02991 | 0.253 |
LIG_PCNA_yPIPBox_3 | 178 | 188 | PF02747 | 0.314 |
LIG_PDZ_Class_3 | 289 | 294 | PF00595 | 0.588 |
LIG_Pex14_2 | 217 | 221 | PF04695 | 0.384 |
LIG_Pex14_2 | 75 | 79 | PF04695 | 0.297 |
LIG_SH2_STAT5 | 113 | 116 | PF00017 | 0.447 |
LIG_SH2_STAT5 | 148 | 151 | PF00017 | 0.297 |
LIG_SH2_STAT5 | 162 | 165 | PF00017 | 0.286 |
LIG_SH2_STAT5 | 284 | 287 | PF00017 | 0.497 |
LIG_SH3_3 | 234 | 240 | PF00018 | 0.405 |
LIG_SH3_3 | 37 | 43 | PF00018 | 0.610 |
LIG_SH3_3 | 7 | 13 | PF00018 | 0.715 |
LIG_SUMO_SIM_anti_2 | 244 | 250 | PF11976 | 0.298 |
LIG_SUMO_SIM_anti_2 | 78 | 84 | PF11976 | 0.304 |
LIG_SUMO_SIM_par_1 | 121 | 126 | PF11976 | 0.383 |
LIG_SUMO_SIM_par_1 | 23 | 29 | PF11976 | 0.523 |
LIG_SUMO_SIM_par_1 | 78 | 84 | PF11976 | 0.291 |
LIG_TYR_ITIM | 282 | 287 | PF00017 | 0.305 |
LIG_WRC_WIRS_1 | 108 | 113 | PF05994 | 0.241 |
LIG_WRC_WIRS_1 | 137 | 142 | PF05994 | 0.457 |
LIG_WRC_WIRS_1 | 192 | 197 | PF05994 | 0.276 |
LIG_WRC_WIRS_1 | 252 | 257 | PF05994 | 0.242 |
LIG_WRC_WIRS_1 | 76 | 81 | PF05994 | 0.277 |
MOD_CK1_1 | 191 | 197 | PF00069 | 0.255 |
MOD_CK1_1 | 21 | 27 | PF00069 | 0.655 |
MOD_CK2_1 | 129 | 135 | PF00069 | 0.373 |
MOD_CK2_1 | 251 | 257 | PF00069 | 0.251 |
MOD_CMANNOS | 267 | 270 | PF00535 | 0.276 |
MOD_GlcNHglycan | 114 | 117 | PF01048 | 0.234 |
MOD_GlcNHglycan | 20 | 23 | PF01048 | 0.458 |
MOD_GlcNHglycan | 233 | 236 | PF01048 | 0.443 |
MOD_GlcNHglycan | 68 | 71 | PF01048 | 0.207 |
MOD_GSK3_1 | 103 | 110 | PF00069 | 0.304 |
MOD_GSK3_1 | 258 | 265 | PF00069 | 0.248 |
MOD_GSK3_1 | 54 | 61 | PF00069 | 0.600 |
MOD_GSK3_1 | 81 | 88 | PF00069 | 0.283 |
MOD_NEK2_1 | 103 | 108 | PF00069 | 0.261 |
MOD_NEK2_1 | 129 | 134 | PF00069 | 0.464 |
MOD_NEK2_1 | 176 | 181 | PF00069 | 0.267 |
MOD_NEK2_1 | 188 | 193 | PF00069 | 0.251 |
MOD_NEK2_1 | 75 | 80 | PF00069 | 0.285 |
MOD_NEK2_1 | 81 | 86 | PF00069 | 0.289 |
MOD_NEK2_2 | 58 | 63 | PF00069 | 0.646 |
MOD_OFUCOSY | 225 | 230 | PF10250 | 0.211 |
MOD_PIKK_1 | 204 | 210 | PF00454 | 0.526 |
MOD_PKA_1 | 54 | 60 | PF00069 | 0.482 |
MOD_Plk_2-3 | 29 | 35 | PF00069 | 0.642 |
MOD_Plk_4 | 103 | 109 | PF00069 | 0.279 |
MOD_Plk_4 | 123 | 129 | PF00069 | 0.131 |
MOD_Plk_4 | 188 | 194 | PF00069 | 0.275 |
MOD_Plk_4 | 196 | 202 | PF00069 | 0.274 |
MOD_Plk_4 | 262 | 268 | PF00069 | 0.254 |
MOD_Plk_4 | 278 | 284 | PF00069 | 0.252 |
MOD_Plk_4 | 48 | 54 | PF00069 | 0.502 |
MOD_Plk_4 | 75 | 81 | PF00069 | 0.283 |
MOD_Plk_4 | 85 | 91 | PF00069 | 0.283 |
MOD_ProDKin_1 | 241 | 247 | PF00069 | 0.408 |
MOD_ProDKin_1 | 258 | 264 | PF00069 | 0.157 |
TRG_DiLeu_BaLyEn_6 | 141 | 146 | PF01217 | 0.525 |
TRG_DiLeu_BaLyEn_6 | 242 | 247 | PF01217 | 0.347 |
TRG_ENDOCYTIC_2 | 137 | 140 | PF00928 | 0.504 |
TRG_ENDOCYTIC_2 | 162 | 165 | PF00928 | 0.283 |
TRG_ENDOCYTIC_2 | 284 | 287 | PF00928 | 0.447 |
TRG_ER_diArg_1 | 143 | 145 | PF00400 | 0.518 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N1I1D2 | Leptomonas seymouri | 78% | 100% |
A0A0N1ILB4 | Leptomonas seymouri | 42% | 100% |
A0A0N1PB10 | Leptomonas seymouri | 39% | 100% |
A0A0S4IS36 | Bodo saltans | 36% | 84% |
A0A0S4IS78 | Bodo saltans | 38% | 100% |
A0A0S4JRP5 | Bodo saltans | 27% | 88% |
A0A0S4KLV5 | Bodo saltans | 41% | 100% |
A0A1X0ND19 | Trypanosomatidae | 42% | 100% |
A0A1X0NT73 | Trypanosomatidae | 38% | 100% |
A0A1X0NTY8 | Trypanosomatidae | 65% | 100% |
A0A3R7RFH0 | Trypanosoma rangeli | 39% | 100% |
A0A3S5H7B2 | Leishmania donovani | 100% | 100% |
A0A3S5H7S4 | Leishmania donovani | 36% | 100% |
A0A3S7X8F2 | Leishmania donovani | 41% | 100% |
A0A422N493 | Trypanosoma rangeli | 64% | 100% |
A0A422N886 | Trypanosoma rangeli | 38% | 70% |
A0A422NSX8 | Trypanosoma rangeli | 42% | 100% |
A0A6M3QG69 | Musa acuminata | 26% | 100% |
A0A804KTT0 | Musa acuminata subsp. malaccensis | 24% | 100% |
A4HBA6 | Leishmania braziliensis | 40% | 100% |
A4HCI0 | Leishmania braziliensis | 77% | 100% |
A4HKM8 | Leishmania braziliensis | 36% | 100% |
A4HKM9 | Leishmania braziliensis | 36% | 73% |
A4I859 | Leishmania infantum | 36% | 100% |
A4IAF4 | Leishmania infantum | 41% | 100% |
A4L9J0 | Oryctolagus cuniculus | 28% | 100% |
B1VB61 | Citrobacter freundii | 27% | 100% |
E9AVX4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 94% | 100% |
E9B316 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 100% |
E9B5H8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 100% |
F9UUD2 | Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) | 28% | 100% |
O26206 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 27% | 100% |
O62735 | Ovis aries | 27% | 100% |
O68874 | Shigella flexneri | 25% | 100% |
O94778 | Homo sapiens | 27% | 100% |
P06624 | Bos taurus | 28% | 100% |
P08995 | Glycine max | 27% | 100% |
P0AER0 | Escherichia coli (strain K12) | 26% | 100% |
P0AER1 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 26% | 100% |
P0AER2 | Escherichia coli O157:H7 | 26% | 100% |
P0C112 | Brucella abortus biovar 1 (strain 9-941) | 29% | 100% |
P25794 | Pisum sativum | 28% | 100% |
P25818 | Arabidopsis thaliana | 30% | 100% |
P29972 | Homo sapiens | 25% | 100% |
P29975 | Rattus norvegicus | 26% | 100% |
P30302 | Arabidopsis thaliana | 27% | 100% |
P31140 | Shigella flexneri | 26% | 100% |
P34080 | Rattus norvegicus | 28% | 100% |
P41181 | Homo sapiens | 27% | 100% |
P42767 | Atriplex canescens | 27% | 100% |
P43286 | Arabidopsis thaliana | 23% | 100% |
P43287 | Arabidopsis thaliana | 26% | 100% |
P47863 | Rattus norvegicus | 27% | 91% |
P47864 | Rattus norvegicus | 26% | 100% |
P47865 | Bos taurus | 26% | 100% |
P49173 | Nicotiana alata | 23% | 100% |
P50501 | Pelophylax lessonae | 25% | 100% |
P55064 | Homo sapiens | 26% | 100% |
P55087 | Homo sapiens | 27% | 91% |
P55088 | Mus musculus | 28% | 91% |
P56401 | Ovis aries | 25% | 100% |
P56402 | Mus musculus | 28% | 100% |
P56404 | Mus musculus | 24% | 100% |
P56405 | Rattus norvegicus | 27% | 100% |
P60844 | Escherichia coli (strain K12) | 25% | 100% |
P60845 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 25% | 100% |
P61837 | Arabidopsis thaliana | 24% | 100% |
P61838 | Vicia faba | 24% | 100% |
P73809 | Synechocystis sp. (strain PCC 6803 / Kazusa) | 28% | 100% |
P79099 | Bos taurus | 27% | 100% |
P93004 | Arabidopsis thaliana | 25% | 100% |
Q02013 | Mus musculus | 25% | 100% |
Q06611 | Arabidopsis thaliana | 26% | 100% |
Q08451 | Solanum lycopersicum | 24% | 100% |
Q08733 | Arabidopsis thaliana | 25% | 100% |
Q0DK16 | Oryza sativa subsp. japonica | 27% | 100% |
Q0IWF3 | Oryza sativa subsp. japonica | 26% | 95% |
Q0JPT5 | Oryza sativa subsp. japonica | 25% | 97% |
Q19KC1 | Zea mays | 24% | 100% |
Q23808 | Cicadella viridis | 29% | 100% |
Q25074 | Haematobia irritans exigua | 27% | 100% |
Q2YR68 | Brucella abortus (strain 2308) | 29% | 100% |
Q39196 | Arabidopsis thaliana | 25% | 100% |
Q41951 | Arabidopsis thaliana | 28% | 100% |
Q41963 | Arabidopsis thaliana | 30% | 100% |
Q4Q2F7 | Leishmania major | 41% | 100% |
Q4Q538 | Leishmania major | 36% | 100% |
Q4QBK5 | Leishmania major | 94% | 100% |
Q54WT8 | Dictyostelium discoideum | 25% | 100% |
Q5I4F8 | Notomys alexis | 26% | 100% |
Q5I4F9 | Notomys alexis | 27% | 90% |
Q5R819 | Pongo abelii | 26% | 100% |
Q5Z6F0 | Oryza sativa subsp. japonica | 28% | 100% |
Q5Z9E2 | Oryza sativa subsp. japonica | 28% | 100% |
Q651D5 | Oryza sativa subsp. japonica | 26% | 100% |
Q67WJ8 | Oryza sativa subsp. japonica | 25% | 99% |
Q6EU94 | Oryza sativa subsp. japonica | 25% | 100% |
Q6J8I9 | Ovis aries | 28% | 100% |
Q6K215 | Oryza sativa subsp. japonica | 24% | 100% |
Q6PQZ1 | Sus scrofa | 26% | 100% |
Q6Z2T3 | Oryza sativa subsp. japonica | 26% | 99% |
Q7EYH7 | Oryza sativa subsp. japonica | 27% | 96% |
Q7MIV9 | Vibrio vulnificus (strain YJ016) | 25% | 100% |
Q7N5C1 | Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) | 25% | 100% |
Q7NNP3 | Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) | 28% | 100% |
Q7NU39 | Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) | 27% | 100% |
Q7PWV1 | Anopheles gambiae | 28% | 100% |
Q7XLR1 | Oryza sativa subsp. japonica | 27% | 100% |
Q7XSQ9 | Oryza sativa subsp. japonica | 24% | 100% |
Q7XUA6 | Oryza sativa subsp. japonica | 26% | 100% |
Q7Y1E6 | Oryza sativa subsp. japonica | 27% | 100% |
Q84RL6 | Zea mays | 30% | 100% |
Q84RL7 | Zea mays | 25% | 100% |
Q84S07 | Oryza sativa subsp. japonica | 24% | 100% |
Q866S3 | Ovis aries | 26% | 100% |
Q87MQ5 | Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) | 26% | 100% |
Q88F17 | Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) | 26% | 100% |
Q89EG9 | Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) | 26% | 100% |
Q8DB17 | Vibrio vulnificus (strain CMCP6) | 26% | 100% |
Q8EHC1 | Shewanella oneidensis (strain MR-1) | 26% | 100% |
Q8FY85 | Brucella suis biovar 1 (strain 1330) | 30% | 100% |
Q8GRI8 | Oryza sativa subsp. japonica | 24% | 100% |
Q8GRT8 | Oryza sativa subsp. japonica | 24% | 100% |
Q8H5N9 | Oryza sativa subsp. japonica | 26% | 100% |
Q8LAA6 | Arabidopsis thaliana | 26% | 100% |
Q8LAI1 | Arabidopsis thaliana | 26% | 100% |
Q8LFP7 | Arabidopsis thaliana | 27% | 100% |
Q8VZW1 | Arabidopsis thaliana | 28% | 99% |
Q8W036 | Arabidopsis thaliana | 23% | 100% |
Q8X6K6 | Escherichia coli O157:H7 | 25% | 100% |
Q923J4 | Dipodomys merriami | 27% | 91% |
Q92NM3 | Rhizobium meliloti (strain 1021) | 26% | 100% |
Q9AQU5 | Zea mays | 24% | 100% |
Q9AR14 | Zea mays | 25% | 100% |
Q9AT74 | Zea mays | 26% | 98% |
Q9ATM4 | Zea mays | 25% | 100% |
Q9ATM5 | Zea mays | 24% | 100% |
Q9ATM8 | Zea mays | 25% | 100% |
Q9ATN1 | Zea mays | 26% | 97% |
Q9ATN2 | Zea mays | 26% | 100% |
Q9C4Z5 | Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) | 26% | 100% |
Q9C6T0 | Arabidopsis thaliana | 26% | 91% |
Q9FF53 | Arabidopsis thaliana | 26% | 100% |
Q9FIZ9 | Arabidopsis thaliana | 24% | 100% |
Q9FY14 | Medicago truncatula | 26% | 100% |
Q9HWZ3 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 27% | 100% |
Q9L772 | Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) | 29% | 100% |
Q9N2J4 | Canis lupus familiaris | 25% | 100% |
Q9NHW7 | Aedes aegypti | 27% | 100% |
Q9SAI4 | Arabidopsis thaliana | 26% | 96% |
Q9SV84 | Arabidopsis thaliana | 27% | 97% |
Q9SXF8 | Oryza sativa subsp. japonica | 25% | 100% |
Q9U8P7 | Dictyostelium discoideum | 27% | 100% |
Q9V5Z7 | Drosophila melanogaster | 27% | 100% |
Q9WTY4 | Mus musculus | 26% | 100% |
Q9XF59 | Zea mays | 24% | 100% |
Q9ZV07 | Arabidopsis thaliana | 28% | 100% |
Q9ZVX8 | Arabidopsis thaliana | 26% | 100% |
S5ZH89 | Musa acuminata | 25% | 100% |
V5ANF5 | Trypanosoma cruzi | 39% | 100% |
V5B469 | Trypanosoma cruzi | 67% | 100% |
V5BW46 | Trypanosoma cruzi | 40% | 100% |