Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZZ4_LEIIN

TriTrypDb:

LINF_220018400

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.748
CLV_C14_Caspase3-7	306	310	PF00656	0.789
CLV_C14_Caspase3-7	411	415	PF00656	0.613
CLV_NRD_NRD_1	191	193	PF00675	0.612
CLV_NRD_NRD_1	2	4	PF00675	0.620
CLV_NRD_NRD_1	34	36	PF00675	0.664
CLV_NRD_NRD_1	341	343	PF00675	0.684
CLV_NRD_NRD_1	540	542	PF00675	0.431
CLV_NRD_NRD_1	558	560	PF00675	0.427
CLV_NRD_NRD_1	63	65	PF00675	0.743
CLV_NRD_NRD_1	649	651	PF00675	0.511
CLV_NRD_NRD_1	670	672	PF00675	0.527
CLV_NRD_NRD_1	847	849	PF00675	0.525
CLV_NRD_NRD_1	855	857	PF00675	0.699
CLV_NRD_NRD_1	968	970	PF00675	0.515
CLV_PCSK_KEX2_1	191	193	PF00082	0.612
CLV_PCSK_KEX2_1	2	4	PF00082	0.620
CLV_PCSK_KEX2_1	271	273	PF00082	0.765
CLV_PCSK_KEX2_1	34	36	PF00082	0.706
CLV_PCSK_KEX2_1	341	343	PF00082	0.737
CLV_PCSK_KEX2_1	402	404	PF00082	0.702
CLV_PCSK_KEX2_1	527	529	PF00082	0.474
CLV_PCSK_KEX2_1	540	542	PF00082	0.457
CLV_PCSK_KEX2_1	558	560	PF00082	0.427
CLV_PCSK_KEX2_1	63	65	PF00082	0.776
CLV_PCSK_KEX2_1	649	651	PF00082	0.511
CLV_PCSK_KEX2_1	669	671	PF00082	0.273
CLV_PCSK_KEX2_1	855	857	PF00082	0.738
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.765
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.702
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.467
CLV_PCSK_PC7_1	398	404	PF00082	0.692
CLV_PCSK_SKI1_1	129	133	PF00082	0.607
CLV_PCSK_SKI1_1	324	328	PF00082	0.705
CLV_PCSK_SKI1_1	398	402	PF00082	0.695
CLV_PCSK_SKI1_1	610	614	PF00082	0.549
CLV_PCSK_SKI1_1	633	637	PF00082	0.686
CLV_PCSK_SKI1_1	695	699	PF00082	0.531
CLV_PCSK_SKI1_1	817	821	PF00082	0.526
CLV_PCSK_SKI1_1	823	827	PF00082	0.523
CLV_PCSK_SKI1_1	848	852	PF00082	0.564
CLV_PCSK_SKI1_1	92	96	PF00082	0.684
CLV_PCSK_SKI1_1	957	961	PF00082	0.541
DEG_APCC_DBOX_1	190	198	PF00400	0.561
DEG_APCC_DBOX_1	397	405	PF00400	0.690
DEG_Nend_UBRbox_1	1	4	PF02207	0.628
DEG_SPOP_SBC_1	164	168	PF00917	0.649
DEG_SPOP_SBC_1	374	378	PF00917	0.712
DEG_SPOP_SBC_1	66	70	PF00917	0.721
DOC_CKS1_1	298	303	PF01111	0.830
DOC_CKS1_1	392	397	PF01111	0.692
DOC_CKS1_1	71	76	PF01111	0.721
DOC_CYCLIN_RxL_1	201	211	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.606
DOC_MAPK_DCC_7	67	77	PF00069	0.733
DOC_MAPK_FxFP_2	132	135	PF00069	0.526
DOC_MAPK_gen_1	2	9	PF00069	0.628
DOC_MAPK_MEF2A_6	710	718	PF00069	0.462
DOC_PP1_RVXF_1	127	133	PF00149	0.612
DOC_PP2B_LxvP_1	170	173	PF13499	0.515
DOC_PP2B_LxvP_1	519	522	PF13499	0.531
DOC_PP4_FxxP_1	132	135	PF00568	0.526
DOC_USP7_MATH_1	117	121	PF00917	0.745
DOC_USP7_MATH_1	160	164	PF00917	0.581
DOC_USP7_MATH_1	17	21	PF00917	0.535
DOC_USP7_MATH_1	375	379	PF00917	0.581
DOC_USP7_MATH_1	426	430	PF00917	0.692
DOC_USP7_MATH_1	437	441	PF00917	0.543
DOC_USP7_MATH_1	753	757	PF00917	0.502
DOC_USP7_MATH_1	8	12	PF00917	0.625
DOC_USP7_MATH_1	930	934	PF00917	0.555
DOC_USP7_UBL2_3	175	179	PF12436	0.619
DOC_USP7_UBL2_3	966	970	PF12436	0.532
DOC_WW_Pin1_4	108	113	PF00397	0.596
DOC_WW_Pin1_4	179	184	PF00397	0.642
DOC_WW_Pin1_4	278	283	PF00397	0.744
DOC_WW_Pin1_4	297	302	PF00397	0.572
DOC_WW_Pin1_4	391	396	PF00397	0.699
DOC_WW_Pin1_4	464	469	PF00397	0.717
DOC_WW_Pin1_4	70	75	PF00397	0.725
DOC_WW_Pin1_4	716	721	PF00397	0.535
DOC_WW_Pin1_4	772	777	PF00397	0.707
DOC_WW_Pin1_4	782	787	PF00397	0.494
DOC_WW_Pin1_4	810	815	PF00397	0.486
DOC_WW_Pin1_4	838	843	PF00397	0.561
LIG_14-3-3_CanoR_1	103	112	PF00244	0.573
LIG_14-3-3_CanoR_1	230	239	PF00244	0.729
LIG_14-3-3_CanoR_1	249	253	PF00244	0.514
LIG_14-3-3_CanoR_1	344	352	PF00244	0.731
LIG_14-3-3_CanoR_1	358	366	PF00244	0.715
LIG_14-3-3_CanoR_1	403	413	PF00244	0.605
LIG_14-3-3_CanoR_1	452	458	PF00244	0.665
LIG_14-3-3_CanoR_1	461	469	PF00244	0.534
LIG_14-3-3_CanoR_1	477	481	PF00244	0.728
LIG_14-3-3_CanoR_1	528	538	PF00244	0.521
LIG_14-3-3_CanoR_1	64	74	PF00244	0.751
LIG_14-3-3_CanoR_1	661	668	PF00244	0.507
LIG_14-3-3_CanoR_1	678	687	PF00244	0.501
LIG_14-3-3_CanoR_1	882	890	PF00244	0.537
LIG_Actin_WH2_2	544	560	PF00022	0.496
LIG_Actin_WH2_2	589	604	PF00022	0.695
LIG_APCC_ABBA_1	561	566	PF00400	0.518
LIG_BIR_III_2	465	469	PF00653	0.594
LIG_CtBP_PxDLS_1	626	630	PF00389	0.532
LIG_eIF4E_1	662	668	PF01652	0.601
LIG_FHA_1	165	171	PF00498	0.607
LIG_FHA_1	552	558	PF00498	0.503
LIG_FHA_1	611	617	PF00498	0.562
LIG_FHA_1	67	73	PF00498	0.739
LIG_FHA_1	962	968	PF00498	0.535
LIG_FHA_2	108	114	PF00498	0.719
LIG_FHA_2	120	126	PF00498	0.577
LIG_FHA_2	183	189	PF00498	0.633
LIG_FHA_2	291	297	PF00498	0.766
LIG_FHA_2	298	304	PF00498	0.759
LIG_FHA_2	382	388	PF00498	0.654
LIG_FHA_2	496	502	PF00498	0.497
LIG_FHA_2	569	575	PF00498	0.557
LIG_FHA_2	719	725	PF00498	0.611
LIG_FHA_2	869	875	PF00498	0.789
LIG_FHA_2	902	908	PF00498	0.560
LIG_IBAR_NPY_1	781	783	PF08397	0.528
LIG_LIR_Apic_2	622	626	PF02991	0.459
LIG_LIR_Apic_2	780	786	PF02991	0.640
LIG_LIR_Gen_1	125	135	PF02991	0.612
LIG_LIR_Gen_1	166	177	PF02991	0.545
LIG_LIR_Gen_1	363	374	PF02991	0.665
LIG_LIR_Gen_1	4	10	PF02991	0.565
LIG_LIR_Gen_1	456	462	PF02991	0.626
LIG_LIR_Gen_1	501	511	PF02991	0.478
LIG_LIR_Gen_1	573	584	PF02991	0.646
LIG_LIR_Gen_1	654	662	PF02991	0.488
LIG_LIR_Gen_1	712	720	PF02991	0.476
LIG_LIR_Gen_1	93	100	PF02991	0.522
LIG_LIR_Nem_3	125	130	PF02991	0.624
LIG_LIR_Nem_3	363	369	PF02991	0.607
LIG_LIR_Nem_3	4	9	PF02991	0.567
LIG_LIR_Nem_3	456	460	PF02991	0.676
LIG_LIR_Nem_3	501	506	PF02991	0.468
LIG_LIR_Nem_3	573	579	PF02991	0.649
LIG_LIR_Nem_3	622	627	PF02991	0.459
LIG_LIR_Nem_3	654	658	PF02991	0.468
LIG_LIR_Nem_3	659	665	PF02991	0.518
LIG_LIR_Nem_3	712	718	PF02991	0.443
LIG_LIR_Nem_3	93	98	PF02991	0.524
LIG_LIR_Nem_3	940	945	PF02991	0.514
LIG_LYPXL_yS_3	436	439	PF13949	0.629
LIG_MYND_1	50	54	PF01753	0.693
LIG_Pex14_1	679	683	PF04695	0.504
LIG_Pex14_2	127	131	PF04695	0.559
LIG_Pex14_2	647	651	PF04695	0.588
LIG_Pex14_2	831	835	PF04695	0.515
LIG_SH2_CRK	242	246	PF00017	0.587
LIG_SH2_CRK	366	370	PF00017	0.653
LIG_SH2_CRK	783	787	PF00017	0.640
LIG_SH2_NCK_1	662	666	PF00017	0.616
LIG_SH2_PTP2	473	476	PF00017	0.629
LIG_SH2_PTP2	508	511	PF00017	0.482
LIG_SH2_PTP2	713	716	PF00017	0.470
LIG_SH2_PTP2	795	798	PF00017	0.486
LIG_SH2_SRC	508	511	PF00017	0.482
LIG_SH2_SRC	713	716	PF00017	0.563
LIG_SH2_STAP1	462	466	PF00017	0.626
LIG_SH2_STAT5	359	362	PF00017	0.639
LIG_SH2_STAT5	399	402	PF00017	0.692
LIG_SH2_STAT5	473	476	PF00017	0.629
LIG_SH2_STAT5	508	511	PF00017	0.482
LIG_SH2_STAT5	545	548	PF00017	0.407
LIG_SH2_STAT5	623	626	PF00017	0.451
LIG_SH2_STAT5	634	637	PF00017	0.587
LIG_SH2_STAT5	713	716	PF00017	0.454
LIG_SH2_STAT5	795	798	PF00017	0.486
LIG_SH2_STAT5	807	810	PF00017	0.518
LIG_SH2_STAT5	941	944	PF00017	0.512
LIG_SH3_1	752	758	PF00018	0.522
LIG_SH3_3	291	297	PF00018	0.804
LIG_SH3_3	298	304	PF00018	0.721
LIG_SH3_3	351	357	PF00018	0.804
LIG_SH3_3	559	565	PF00018	0.504
LIG_SH3_3	597	603	PF00018	0.719
LIG_SH3_3	68	74	PF00018	0.737
LIG_SH3_3	752	758	PF00018	0.522
LIG_SH3_3	816	822	PF00018	0.567
LIG_SH3_3	847	853	PF00018	0.670
LIG_SH3_3	918	924	PF00018	0.616
LIG_SUMO_SIM_anti_2	788	793	PF11976	0.486
LIG_SUMO_SIM_par_1	625	630	PF11976	0.529
LIG_SxIP_EBH_1	658	671	PF03271	0.601
LIG_TRAF2_1	123	126	PF00917	0.666
LIG_TRAF2_1	571	574	PF00917	0.667
LIG_TRAF2_1	721	724	PF00917	0.609
LIG_TRAF2_1	904	907	PF00917	0.588
LIG_TYR_ITIM	506	511	PF00017	0.485
LIG_TYR_ITSM	362	369	PF00017	0.608
LIG_ULM_U2AF65_1	34	39	PF00076	0.664
LIG_WW_3	467	471	PF00397	0.618
LIG_WW_3	64	68	PF00397	0.772
LIG_WW_3	820	824	PF00397	0.651
MOD_CDC14_SPxK_1	467	470	PF00782	0.722
MOD_CDK_SPK_2	782	787	PF00069	0.638
MOD_CDK_SPxK_1	464	470	PF00069	0.723
MOD_CDK_SPxK_1	70	76	PF00069	0.684
MOD_CDK_SPxxK_3	179	186	PF00069	0.636
MOD_CDK_SPxxK_3	391	398	PF00069	0.700
MOD_CDK_SPxxK_3	810	817	PF00069	0.486
MOD_CK1_1	120	126	PF00069	0.689
MOD_CK1_1	163	169	PF00069	0.652
MOD_CK1_1	182	188	PF00069	0.421
MOD_CK1_1	275	281	PF00069	0.780
MOD_CK1_1	283	289	PF00069	0.663
MOD_CK1_1	292	298	PF00069	0.547
MOD_CK1_1	347	353	PF00069	0.742
MOD_CK1_1	44	50	PF00069	0.784
MOD_CK1_1	55	61	PF00069	0.629
MOD_CK1_1	660	666	PF00069	0.614
MOD_CK1_1	881	887	PF00069	0.674
MOD_CK2_1	119	125	PF00069	0.683
MOD_CK2_1	229	235	PF00069	0.697
MOD_CK2_1	263	269	PF00069	0.730
MOD_CK2_1	290	296	PF00069	0.818
MOD_CK2_1	297	303	PF00069	0.761
MOD_CK2_1	381	387	PF00069	0.711
MOD_CK2_1	404	410	PF00069	0.620
MOD_CK2_1	568	574	PF00069	0.559
MOD_CK2_1	716	722	PF00069	0.496
MOD_CK2_1	782	788	PF00069	0.635
MOD_CK2_1	8	14	PF00069	0.621
MOD_CK2_1	901	907	PF00069	0.581
MOD_CK2_1	916	922	PF00069	0.513
MOD_GlcNHglycan	115	118	PF01048	0.729
MOD_GlcNHglycan	119	122	PF01048	0.691
MOD_GlcNHglycan	162	165	PF01048	0.684
MOD_GlcNHglycan	282	285	PF01048	0.734
MOD_GlcNHglycan	346	349	PF01048	0.800
MOD_GlcNHglycan	377	380	PF01048	0.737
MOD_GlcNHglycan	426	429	PF01048	0.786
MOD_GlcNHglycan	675	678	PF01048	0.647
MOD_GlcNHglycan	883	886	PF01048	0.754
MOD_GlcNHglycan	918	921	PF01048	0.516
MOD_GSK3_1	104	111	PF00069	0.717
MOD_GSK3_1	113	120	PF00069	0.644
MOD_GSK3_1	159	166	PF00069	0.675
MOD_GSK3_1	357	364	PF00069	0.687
MOD_GSK3_1	373	380	PF00069	0.500
MOD_GSK3_1	404	411	PF00069	0.636
MOD_GSK3_1	418	425	PF00069	0.599
MOD_GSK3_1	460	467	PF00069	0.684
MOD_GSK3_1	491	498	PF00069	0.603
MOD_GSK3_1	52	59	PF00069	0.682
MOD_GSK3_1	656	663	PF00069	0.493
MOD_GSK3_1	66	73	PF00069	0.703
MOD_GSK3_1	957	964	PF00069	0.561
MOD_LATS_1	529	535	PF00433	0.514
MOD_N-GLC_1	551	556	PF02516	0.642
MOD_N-GLC_1	637	642	PF02516	0.532
MOD_NEK2_1	277	282	PF00069	0.805
MOD_NEK2_1	404	409	PF00069	0.616
MOD_NEK2_1	557	562	PF00069	0.526
MOD_NEK2_1	608	613	PF00069	0.531
MOD_NEK2_1	627	632	PF00069	0.499
MOD_NEK2_1	700	705	PF00069	0.453
MOD_NEK2_1	878	883	PF00069	0.694
MOD_NEK2_1	928	933	PF00069	0.537
MOD_NEK2_2	843	848	PF00069	0.642
MOD_PIKK_1	198	204	PF00454	0.471
MOD_PIKK_1	229	235	PF00454	0.800
MOD_PIKK_1	272	278	PF00454	0.781
MOD_PKA_2	229	235	PF00069	0.734
MOD_PKA_2	248	254	PF00069	0.515
MOD_PKA_2	357	363	PF00069	0.699
MOD_PKA_2	36	42	PF00069	0.599
MOD_PKA_2	404	410	PF00069	0.607
MOD_PKA_2	447	453	PF00069	0.612
MOD_PKA_2	460	466	PF00069	0.496
MOD_PKA_2	476	482	PF00069	0.613
MOD_PKA_2	530	536	PF00069	0.616
MOD_PKA_2	557	563	PF00069	0.493
MOD_PKA_2	601	607	PF00069	0.720
MOD_PKA_2	66	72	PF00069	0.692
MOD_PKA_2	660	666	PF00069	0.513
MOD_PKA_2	868	874	PF00069	0.760
MOD_PKA_2	881	887	PF00069	0.552
MOD_PKB_1	342	350	PF00069	0.712
MOD_PKB_1	403	411	PF00069	0.672
MOD_Plk_1	608	614	PF00069	0.532
MOD_Plk_1	769	775	PF00069	0.649
MOD_Plk_4	165	171	PF00069	0.607
MOD_Plk_4	361	367	PF00069	0.539
MOD_Plk_4	408	414	PF00069	0.658
MOD_Plk_4	453	459	PF00069	0.664
MOD_Plk_4	491	497	PF00069	0.632
MOD_Plk_4	532	538	PF00069	0.517
MOD_Plk_4	587	593	PF00069	0.550
MOD_Plk_4	619	625	PF00069	0.552
MOD_Plk_4	67	73	PF00069	0.780
MOD_Plk_4	823	829	PF00069	0.523
MOD_ProDKin_1	108	114	PF00069	0.598
MOD_ProDKin_1	179	185	PF00069	0.635
MOD_ProDKin_1	278	284	PF00069	0.742
MOD_ProDKin_1	297	303	PF00069	0.571
MOD_ProDKin_1	391	397	PF00069	0.689
MOD_ProDKin_1	464	470	PF00069	0.723
MOD_ProDKin_1	70	76	PF00069	0.725
MOD_ProDKin_1	716	722	PF00069	0.535
MOD_ProDKin_1	772	778	PF00069	0.704
MOD_ProDKin_1	782	788	PF00069	0.490
MOD_ProDKin_1	810	816	PF00069	0.483
MOD_ProDKin_1	838	844	PF00069	0.562
MOD_SUMO_rev_2	266	273	PF00179	0.751
MOD_SUMO_rev_2	302	310	PF00179	0.698
TRG_DiLeu_BaEn_1	587	592	PF01217	0.608
TRG_DiLeu_BaEn_1	922	927	PF01217	0.504
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.696
TRG_ENDOCYTIC_2	171	174	PF00928	0.474
TRG_ENDOCYTIC_2	242	245	PF00928	0.611
TRG_ENDOCYTIC_2	359	362	PF00928	0.639
TRG_ENDOCYTIC_2	366	369	PF00928	0.554
TRG_ENDOCYTIC_2	436	439	PF00928	0.629
TRG_ENDOCYTIC_2	503	506	PF00928	0.474
TRG_ENDOCYTIC_2	508	511	PF00928	0.482
TRG_ENDOCYTIC_2	545	548	PF00928	0.415
TRG_ENDOCYTIC_2	662	665	PF00928	0.626
TRG_ENDOCYTIC_2	713	716	PF00928	0.466
TRG_ENDOCYTIC_2	729	732	PF00928	0.350
TRG_ER_diArg_1	1	3	PF00400	0.634
TRG_ER_diArg_1	190	192	PF00400	0.611
TRG_ER_diArg_1	34	37	PF00400	0.660
TRG_ER_diArg_1	403	406	PF00400	0.689
TRG_ER_diArg_1	539	541	PF00400	0.432
TRG_ER_diArg_1	557	559	PF00400	0.423
TRG_ER_diArg_1	63	65	PF00400	0.776
TRG_ER_diArg_1	648	650	PF00400	0.503
TRG_ER_diArg_1	668	671	PF00400	0.263
TRG_ER_diArg_1	854	856	PF00400	0.727
TRG_NLS_MonoExtN_4	523	530	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	678	682	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	913	918	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB4	Leptomonas seymouri	48%	100%
A0A3S7WXE8	Leishmania donovani	100%	100%
A4HCG3	Leishmania braziliensis	81%	98%
E9AVV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QBM4	Leishmania major	93%	100%