Gamma-glutamylcyclotransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ChaC-like protein - putative

Species:

Leishmania infantum

UniProt:

A4HZZ0_LEIIN

TriTrypDb:

LINF_220017900

Length:

229

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HZZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	14
GO:0006575	cellular modified amino acid metabolic process	3	14
GO:0006749	glutathione metabolic process	4	14
GO:0006751	glutathione catabolic process	5	14
GO:0006790	sulfur compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	14
GO:0042219	cellular modified amino acid catabolic process	4	14
GO:0043171	peptide catabolic process	4	14
GO:0043603	amide metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044273	sulfur compound catabolic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901565	organonitrogen compound catabolic process	4	14
GO:1901575	organic substance catabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0003839	gamma-glutamylcyclotransferase activity	5	14
GO:0016829	lyase activity	2	14
GO:0016840	carbon-nitrogen lyase activity	3	14
GO:0016842	amidine-lyase activity	4	14
GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	5	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	56	58	PF00082	0.244
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.277
CLV_PCSK_SKI1_1	180	184	PF00082	0.265
CLV_PCSK_SKI1_1	56	60	PF00082	0.235
CLV_PCSK_SKI1_1	75	79	PF00082	0.235
DEG_APCC_DBOX_1	192	200	PF00400	0.517
DOC_CKS1_1	148	153	PF01111	0.367
DOC_MAPK_gen_1	102	112	PF00069	0.502
DOC_PP4_FxxP_1	18	21	PF00568	0.456
DOC_USP7_MATH_1	128	132	PF00917	0.463
DOC_WW_Pin1_4	147	152	PF00397	0.409
LIG_14-3-3_CanoR_1	75	80	PF00244	0.439
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BIR_III_2	127	131	PF00653	0.402
LIG_FHA_2	122	128	PF00498	0.469
LIG_LIR_Apic_2	16	21	PF02991	0.477
LIG_LIR_Apic_2	168	172	PF02991	0.468
LIG_LIR_Gen_1	119	130	PF02991	0.513
LIG_LIR_Gen_1	25	36	PF02991	0.467
LIG_LIR_Nem_3	119	125	PF02991	0.513
LIG_LIR_Nem_3	25	31	PF02991	0.497
LIG_LIR_Nem_3	45	51	PF02991	0.385
LIG_Pex14_1	38	42	PF04695	0.439
LIG_SH2_CRK	33	37	PF00017	0.435
LIG_SH2_CRK	55	59	PF00017	0.435
LIG_SH2_CRK	94	98	PF00017	0.509
LIG_SH2_STAP1	118	122	PF00017	0.402
LIG_SH2_STAP1	48	52	PF00017	0.484
LIG_SH2_STAT3	14	17	PF00017	0.453
LIG_SH2_STAT5	169	172	PF00017	0.452
LIG_SH2_STAT5	195	198	PF00017	0.435
LIG_SH2_STAT5	51	54	PF00017	0.479
LIG_SH3_1	67	73	PF00018	0.452
LIG_SH3_1	94	100	PF00018	0.467
LIG_SH3_2	70	75	PF14604	0.452
LIG_SH3_2	97	102	PF14604	0.517
LIG_SH3_3	222	228	PF00018	0.348
LIG_SH3_3	67	73	PF00018	0.435
LIG_SH3_3	94	100	PF00018	0.488
LIG_UBA3_1	106	115	PF00899	0.402
LIG_WRC_WIRS_1	20	25	PF05994	0.446
MOD_CDK_SPxK_1	147	153	PF00069	0.396
MOD_CK1_1	2	8	PF00069	0.473
MOD_GlcNHglycan	188	191	PF01048	0.255
MOD_GSK3_1	182	189	PF00069	0.422
MOD_GSK3_1	2	9	PF00069	0.548
MOD_GSK3_1	75	82	PF00069	0.455
MOD_N-GLC_1	160	165	PF02516	0.202
MOD_N-GLC_1	183	188	PF02516	0.173
MOD_NEK2_1	121	126	PF00069	0.466
MOD_NEK2_1	183	188	PF00069	0.465
MOD_PKA_2	9	15	PF00069	0.482
MOD_Plk_4	121	127	PF00069	0.457
MOD_Plk_4	32	38	PF00069	0.440
MOD_Plk_4	47	53	PF00069	0.435
MOD_Plk_4	75	81	PF00069	0.441
MOD_ProDKin_1	147	153	PF00069	0.409
TRG_ENDOCYTIC_2	118	121	PF00928	0.452
TRG_ENDOCYTIC_2	33	36	PF00928	0.452
TRG_ENDOCYTIC_2	55	58	PF00928	0.435
TRG_NES_CRM1_1	101	114	PF08389	0.506
TRG_NES_CRM1_1	215	226	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P815	Leptomonas seymouri	56%	84%
A0A1X0NTG7	Trypanosomatidae	52%	100%
A0A3Q8ILN3	Leishmania donovani	100%	100%
A0A3R7NMW8	Trypanosoma rangeli	52%	100%
A0A3S5H7B1	Leishmania donovani	64%	82%
A4HCF7	Leishmania braziliensis	61%	100%
A4HZZ1	Leishmania infantum	62%	71%
B3STU3	Rattus norvegicus	38%	100%
C9ZSN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AVV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AVV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
P32656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	99%
P87305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q0IIH4	Bos taurus	37%	100%
Q4KMJ1	Danio rerio	44%	100%
Q4QBM7	Leishmania major	61%	100%
Q4QBM8	Leishmania major	95%	100%
Q5PPV4	Xenopus laevis	45%	100%
Q5SPB6	Danio rerio	38%	100%
Q5ZI66	Gallus gallus	41%	100%
Q641Z5	Rattus norvegicus	42%	100%
Q84MC1	Arabidopsis thaliana	37%	100%
Q84QC1	Arabidopsis thaliana	40%	100%
Q8GY54	Arabidopsis thaliana	35%	100%
Q8R3J5	Mus musculus	39%	100%
Q8WUX2	Homo sapiens	43%	100%
Q9BUX1	Homo sapiens	39%	100%
Q9CQG1	Mus musculus	42%	100%